Find Protein-Protein Interactions (PPI) Network

Choose & Enter

Choose animal:			Visualization driver:
Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Zzz3
Level of PPIs:		or Upload text file:	Update repository

Visible interactions:

Visible interactors:

Size of node:

Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Zzz3 (from a repository: Thu Apr 19 10:21:45 2018)

	Examples
	Layout Breadthfirst Circle Concentric Cose Grid Random
	Export graph PNG file JPG file JSON file

Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	14
The number (and %) of the onco-proteins	2 (14.29 %)
The number (and %) of the tumor suppressors	1 (7.14 %)
Total number of binary PPIs (saturation %)	31 (34.07 %)
The number (and %) of affected PPIs	13 (41.94 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	3.571
Assortativity coefficient	-0.3959
The network average Clustering coefficient	0.592
The number (and %) of a zero Clustering coefficients	4 (28.57 %)
The number (and %) of a zero Betweenness Centrality	9 (64.29 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Zzz3

XP_017657556.1

Domain structure obtained by HMM

Protein ID: XP_017657556.1 - ZZ-type zinc finger-containing protein 3 isoform X3

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Myb_DNA-binding	PF00249	47	5.5e-16	44.800	160	208	158	209	Myb-like DNA-binding domain
ZZ	PF00569	45	0.00000000017	26.900	324	370	323	371	Zinc finger, ZZ type

user protein

0.154

125.500

Myb_DNA-binding (PF00249): Myb-like DNA-binding domain
ZZ (PF00569): Zinc finger, ZZ type

Brca1

XP_008853744.1

Domain structure obtained by HMM

Protein ID: XP_008853744.1 - breast cancer type 1 susceptibility protein
KEEG Ortholog ID: K10605

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
zf-C3HC4	PF00097	41	0.00000000000033	35.700	7	47	7	47	Zinc finger, C3HC4 type (RING finger)
S36_mt	PF10937	115	0.0079	4.100	132	201	107	210	Ribosomal protein S36, mitochondrial
BRCT_assoc	PF12820	164	2.4e-68	215.300	323	483	323	483	Serine-rich domain associated with BRCT
S36_mt	PF10937	115	0.063	1.200	1224	1296	1156	1300	Ribosomal protein S36, mitochondrial
BRCT	PF00533	79	0.00000000005	29.200	1466	1537	1461	1537	BRCA1 C Terminus (BRCT) domain
RTT107_BRCT_5	PF16770	100	0.0000095	11.800	1511	1549	1447	1550	Regulator of Ty1 transposition protein 107 BRCT domain
BRCT	PF00533	79	0.000000000000025	39.800	1570	1655	1569	1655	BRCA1 C Terminus (BRCT) domain

oncogene, tumor suppressor

1.000

zf-C3HC4 (PF00097): Zinc finger, C3HC4 type (RING finger)
S36_mt (PF10937): Ribosomal protein S36, mitochondrial
BRCT_assoc (PF12820): Serine-rich domain associated with BRCT
BRCT (PF00533): BRCA1 C Terminus (BRCT) domain
RTT107_BRCT_5 (PF16770): Regulator of Ty1 transposition protein 107 BRCT domain

Eps8

XP_008854254.1

Domain structure obtained by HMM

Protein ID: XP_008854254.1 - epidermal growth factor receptor kinase substrate 8
KEEG Ortholog ID: K17277

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PTB	PF08416	131	5.2e-58	181.100	81	211	81	211	Phosphotyrosine-binding domain
Mito_fiss_reg	PF05308	244	0.0018	4.500	212	279	184	284	Mitochondrial fission regulator
Med2	PF11214	100	0.000017	11.300	283	325	269	330	Mediator complex subunit 2
SH3_3	PF08239	55	0.0074	2.900	392	434	391	444	Bacterial SH3 domain
SH3_1	PF00018	48	0.0000000000000048	41.300	557	598	554	599	SH3 domain
DEC-1_N	PF04625	403	0.000023	9.600	637	686	622	745	DEC-1 protein, N-terminal region

oncogene

PTB (PF08416): Phosphotyrosine-binding domain
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
Med2 (PF11214): Mediator complex subunit 2
SH3_3 (PF08239): Bacterial SH3 domain
SH3_1 (PF00018): SH3 domain
DEC-1_N (PF04625): DEC-1 protein, N-terminal region

Hecw2

XP_017654326.1

Domain structure obtained by HMM

Protein ID: XP_017654326.1 - E3 ubiquitin-protein ligase HECW2 isoform X1
KEEG Ortholog ID: K12168

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
HECW_N	PF16562	120	7.6e-63	196.000	45	164	45	164	N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
C2	PF00168	103	0.0000000000000011	44.100	187	296	185	300	C2 domain
Cep57_CLD	PF14073	178	0.000004	13.100	630	666	600	667	Centrosome localisation domain of Cep57
WW	PF00397	31	0.000000000000035	38.900	817	846	817	846	WW domain
WW	PF00397	31	0.0000000013	24.200	995	1024	995	1024	WW domain
RFXA_RFXANK_bdg	PF15289	124	0.000013	11.800	1068	1118	1040	1125	Regulatory factor X-associated C-terminal binding domain
HECT	PF00632	307	1.7e-108	348.800	1276	1580	1275	1580	HECT-domain (ubiquitin-transferase)

interactor

0.667

1.000

HECW_N (PF16562): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
C2 (PF00168): C2 domain
Cep57_CLD (PF14073): Centrosome localisation domain of Cep57
WW (PF00397): WW domain
RFXA_RFXANK_bdg (PF15289): Regulatory factor X-associated C-terminal binding domain
HECT (PF00632): HECT-domain (ubiquitin-transferase)

Ikzf5

XP_008825479.1

Domain structure obtained by HMM

Protein ID: XP_008825479.1 - zinc finger protein Pegasus
KEEG Ortholog ID: K09220

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
zf-H2C2_5	PF13909	26	0.0000000012	24.100	83	106	82	106	C2H2-type zinc-finger domain
zf-H2C2_2	PF13465	26	0.00000000037	26.300	97	119	96	121	Zinc-finger double domain
zf-H2C2_2	PF13465	26	0.000000000024	30.100	124	145	124	148	Zinc-finger double domain
zf-H2C2_5	PF13909	26	0.00000049	15.800	138	162	138	163	C2H2-type zinc-finger domain
zf-C2H2_7	PF15269	54	0.0091	2.400	270	288	268	292	Zinc-finger
zf-C2H2	PF00096	23	0.00013	8.800	363	382	363	383	Zinc finger, C2H2 type
zf-H2C2_2	PF13465	26	0.007	3.300	381	397	378	404	Zinc-finger double domain
zf-C2H2_4	PF13894	24	0.0044	4.500	391	411	391	412	C2H2-type zinc finger

interactor

1.000

zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2_7 (PF15269): Zinc-finger
zf-C2H2 (PF00096): Zinc finger, C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger

Kat2a

XP_008833507.1

Domain structure obtained by HMM

Protein ID: XP_008833507.1 - histone acetyltransferase KAT2A isoform X1
KEEG Ortholog ID: K06062

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
NICE-1	PF15845	89	0.011	2.800	34	72	31	95	Cysteine-rich C-terminal 1 family
PCAF_N	PF06466	251	1.1e-120	388.000	84	334	84	334	PCAF (P300/CBP-associated factor) N-terminal domain
Acetyltransf_1	PF00583	117	0.000000000000097	37.900	542	626	516	626	Acetyltransferase (GNAT) family
Bromodomain	PF00439	84	1.9e-26	78.300	736	817	736	819	Bromodomain

interactor

0.667

4.500

NICE-1 (PF15845): Cysteine-rich C-terminal 1 family
PCAF_N (PF06466): PCAF (P300/CBP-associated factor) N-terminal domain
Acetyltransf_1 (PF00583): Acetyltransferase (GNAT) family
Bromodomain (PF00439): Bromodomain

Maml3

XP_008841652.1

Domain structure obtained by HMM

Protein ID: XP_008841652.1 - mastermind-like protein 3
KEEG Ortholog ID: K06061

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
MamL-1	PF09596	58	6.6e-27	79.900	68	125	68	125	MamL-1 domain
Rtf2	PF04641	262	0.00013	7.500	89	152	72	187	Rtf2 RING-finger
SRRM_C	PF15230	67	0.0021	4.900	183	202	159	203	Serine/arginine repetitive matrix protein C-terminus
Drf_GBD	PF06371	188	0.028	0.100	306	338	300	370	Diaphanous GTPase-binding Domain
TERB2	PF15101	207	0.000013	11.500	464	513	437	543	Telomere-associated protein TERB2
PNISR	PF15996	203	0.0013	5.100	624	673	570	677	Arginine/serine-rich protein PNISR
AAA_23	PF13476	200	0.0086	2.700	643	777	601	791	AAA domain
TERB2	PF15101	207	0.0057	2.900	729	797	727	813	Telomere-associated protein TERB2
SurA_N_2	PF13623	145	0.009	2.100	784	838	782	841	SurA N-terminal domain
TFIIA	PF03153	415	0.017	1.100	818	1060	813	1101	Transcription factor IIA, alpha/beta subunit

interactor

MamL-1 (PF09596): MamL-1 domain
Rtf2 (PF04641): Rtf2 RING-finger
SRRM_C (PF15230): Serine/arginine repetitive matrix protein C-terminus
Drf_GBD (PF06371): Diaphanous GTPase-binding Domain
TERB2 (PF15101): Telomere-associated protein TERB2
PNISR (PF15996): Arginine/serine-rich protein PNISR
AAA_23 (PF13476): AAA domain
SurA_N_2 (PF13623): SurA N-terminal domain
TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit

Rfpl4b

XP_017658492.1

Domain structure obtained by HMM

Protein ID: XP_017658492.1 - LOW QUALITY PROTEIN: ret finger protein-like 4B

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
zf-C3HC4_4	PF15227	42	0.0000000035	23.000	41	68	33	68	zinc finger of C3HC4-type, RING
PRY	PF13765	49	0.0000066	12.000	86	101	66	101	SPRY-associated domain
SPRY	PF00622	120	0.000003	13.600	107	133	105	139	SPRY domain
zf-RING_UBOX	PF13445	38	0.048	0.100	122	136	121	137	RING-type zinc-finger

interactor

zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRY (PF13765): SPRY-associated domain
SPRY (PF00622): SPRY domain
zf-RING_UBOX (PF13445): RING-type zinc-finger

Tada2a

XP_008846309.1

Domain structure obtained by HMM

Protein ID: XP_008846309.1 - transcriptional adapter 2-alpha
KEEG Ortholog ID: K11314

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Myb_DNA-binding	PF00249	47	0.0000000000000018	43.200	74	117	72	118	Myb-like DNA-binding domain
SWIRM	PF04433	89	0.0000000000063	32.000	374	440	371	441	SWIRM domain

interactor

0.900

0.500

Myb_DNA-binding (PF00249): Myb-like DNA-binding domain
SWIRM (PF04433): SWIRM domain

Tada3

XP_008853071.1

Domain structure obtained by HMM

Protein ID: XP_008853071.1 - transcriptional adapter 3 isoform X1
KEEG Ortholog ID: K11315

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Ada3	PF10198	131	0.011	2.100	41	67	22	125	Histone acetyltransferases subunit 3
GvpL_GvpF	PF06386	244	0.018	1.100	167	223	157	246	Gas vesicle synthesis protein GvpL/GvpF
Ada3	PF10198	131	4.2e-30	90.800	310	416	309	429	Histone acetyltransferases subunit 3

interactor

0.900

0.500

Ada3 (PF10198): Histone acetyltransferases subunit 3
GvpL_GvpF (PF06386): Gas vesicle synthesis protein GvpL/GvpF

Tfap4

XP_008844481.1

Domain structure obtained by HMM

Protein ID: XP_008844481.1 - transcription factor AP-4
KEEG Ortholog ID: K09108

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
HLH	PF00010	55	5.1e-21	60.800	49	99	49	100	Helix-loop-helix DNA-binding domain
DivIC	PF04977	80	0.00054	6.100	89	122	84	132	Septum formation initiator
DivIC	PF04977	80	0.00029	6.900	149	179	146	188	Septum formation initiator
DUF2407	PF10302	104	0.00061	6.600	190	237	184	297	DUF2407 ubiquitin-like domain
DUF972	PF06156	102	0.018	2.000	261	306	251	330	Protein of unknown function (DUF972)

oncogene

1.000

HLH (PF00010): Helix-loop-helix DNA-binding domain
DivIC (PF04977): Septum formation initiator
DUF2407 (PF10302): DUF2407 ubiquitin-like domain
DUF972 (PF06156): Protein of unknown function (DUF972)

Wdr5

XP_008842146.1

Domain structure obtained by HMM

Protein ID: XP_008842146.1 - WD repeat-containing protein 5
KEEG Ortholog ID: K14963

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
WD40	PF00400	38	0.00000000000039	36.200	39	72	35	72	WD domain, G-beta repeat
WD40	PF00400	38	0.00000000000044	36.000	79	115	77	115	WD domain, G-beta repeat
WD40	PF00400	38	0.000000000000028	39.800	119	157	119	157	WD domain, G-beta repeat
WD40	PF00400	38	0.00000000000026	36.800	161	199	161	199	WD domain, G-beta repeat
WD40	PF00400	38	0.0000000012	25.200	203	242	203	242	WD domain, G-beta repeat
WD40	PF00400	38	0.0000000012	25.100	246	287	246	287	WD domain, G-beta repeat
WD40	PF00400	38	0.00000066	16.500	293	331	291	331	WD domain, G-beta repeat

interactor

1.000

WD40 (PF00400): WD domain, G-beta repeat

Zbtb9

XP_017655364.1

Domain structure obtained by HMM

Protein ID: XP_017655364.1 - zinc finger and BTB domain-containing protein 9
KEEG Ortholog ID: K10496

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
BTB	PF00651	111	4.4e-26	77.600	38	140	38	142	BTB/POZ domain
Myc_N	PF01056	332	0.00000094	15.000	152	239	126	251	Myc amino-terminal region
zf-C2HC_2	PF13913	25	0.01	2.200	393	403	393	403	zinc-finger of a C2HC-type
zf-C2H2	PF00096	23	0.044	0.900	395	409	393	411	Zinc finger, C2H2 type
zf-C2H2	PF00096	23	0.00000014	18.100	420	440	418	440	Zinc finger, C2H2 type
zf-C2HC_2	PF13913	25	0.0000046	12.800	444	459	443	468	zinc-finger of a C2HC-type

interactor

1.000

BTB (PF00651): BTB/POZ domain
Myc_N (PF01056): Myc amino-terminal region
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
zf-C2H2 (PF00096): Zinc finger, C2H2 type

Znf496

XP_008838519.2

Domain structure obtained by HMM

Protein ID: XP_008838519.2 - zinc finger protein 496 isoform X1
KEEG Ortholog ID: K09229

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Rpr2	PF04032	91	0.0091	2.700	28	59	21	60	RNAse P Rpr2/Rpp21/SNM1 subunit domain
SCAN	PF02023	90	3.2e-43	131.800	108	195	108	197	SCAN domain
KRAB	PF01352	42	0.00000000068	24.800	289	314	288	322	KRAB box
zf-C2H2	PF00096	23	0.0000012	15.300	469	489	469	490	Zinc finger, C2H2 type
zf-C2H2_4	PF13894	24	0.00000073	16.200	497	519	497	520	C2H2-type zinc finger
zf-H2C2_2	PF13465	26	0.000000082	18.900	512	534	511	535	Zinc-finger double domain
zf-C2H2	PF00096	23	0.000000067	19.200	525	547	525	547	Zinc finger, C2H2 type
zf-H2C2_2	PF13465	26	0.0041	4.100	542	593	539	595	Zinc-finger double domain
zf-C2H2	PF00096	23	0.0000036	13.700	585	607	584	607	Zinc finger, C2H2 type
zf-H2C2_2	PF13465	26	0.00029	7.700	599	625	598	626	Zinc-finger double domain
zf-C2H2_4	PF13894	24	0.0000022	14.800	616	637	615	638	C2H2-type zinc finger
zf-H2C2_2	PF13465	26	0.048	0.700	630	639	629	644	Zinc-finger double domain

interactor

Rpr2 (PF04032): RNAse P Rpr2/Rpp21/SNM1 subunit domain
SCAN (PF02023): SCAN domain
KRAB (PF01352): KRAB box
zf-C2H2 (PF00096): Zinc finger, C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_2 (PF13465): Zinc-finger double domain

B a c k t o T o p ⇑