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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Zzz3 (from a repository: Thu Apr 19 10:21:45 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins2 (14.29 %)
The number (and %) of the tumor suppressors1 (7.14 %)
Total number of binary PPIs (saturation %)31 (34.07 %)
The number (and %) of affected PPIs13 (41.94 %)
PPI diameter2
PPI radius1
The average degree of PPI3.571
Assortativity coefficient-0.3959
The network average Clustering coefficient0.592
The number (and %) of a zero Clustering coefficients4 (28.57 %)
The number (and %) of a zero Betweenness Centrality9 (64.29 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure		 Type Number
of PPI (degree)		 Clustering
Coefficient		 Betweenness
Centrality		 Domains (Pfam ID): description
Zzz3

Domain structure obtained by HMM

Protein ID: XP_017657556.1 - ZZ-type zinc finger-containing protein 3 isoform X3
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Myb_DNA-bindingPF00249475.5e-1644.800160208158209Myb-like DNA-binding domain
ZZPF00569450.0000000001726.900324370323371Zinc finger, ZZ type
user protein130.154125.500Myb_DNA-binding (PF00249): Myb-like DNA-binding domain
ZZ (PF00569): Zinc finger, ZZ type
Brca1

Domain structure obtained by HMM

Protein ID: XP_008853744.1 - breast cancer type 1 susceptibility protein
KEEG Ortholog ID: K10605
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
zf-C3HC4PF00097410.0000000000003335.700747747Zinc finger, C3HC4 type (RING finger)
S36_mtPF109371150.00794.100132201107210Ribosomal protein S36, mitochondrial
BRCT_assocPF128201642.4e-68215.300323483323483Serine-rich domain associated with BRCT
S36_mtPF109371150.0631.2001224129611561300Ribosomal protein S36, mitochondrial
BRCTPF00533790.0000000000529.2001466153714611537BRCA1 C Terminus (BRCT) domain
RTT107_BRCT_5PF167701000.000009511.8001511154914471550Regulator of Ty1 transposition protein 107 BRCT domain
BRCTPF00533790.00000000000002539.8001570165515691655BRCA1 C Terminus (BRCT) domain
oncogene, tumor suppressor31.0000zf-C3HC4 (PF00097): Zinc finger, C3HC4 type (RING finger)
S36_mt (PF10937): Ribosomal protein S36, mitochondrial
BRCT_assoc (PF12820): Serine-rich domain associated with BRCT
BRCT (PF00533): BRCA1 C Terminus (BRCT) domain
RTT107_BRCT_5 (PF16770): Regulator of Ty1 transposition protein 107 BRCT domain
Eps8

Domain structure obtained by HMM

Protein ID: XP_008854254.1 - epidermal growth factor receptor kinase substrate 8
KEEG Ortholog ID: K17277
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PTBPF084161315.2e-58181.1008121181211Phosphotyrosine-binding domain
Mito_fiss_regPF053082440.00184.500212279184284Mitochondrial fission regulator
Med2PF112141000.00001711.300283325269330Mediator complex subunit 2
SH3_3PF08239550.00742.900392434391444Bacterial SH3 domain
SH3_1PF00018480.000000000000004841.300557598554599SH3 domain
DEC-1_NPF046254030.0000239.600637686622745DEC-1 protein, N-terminal region
oncogene200PTB (PF08416): Phosphotyrosine-binding domain
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
Med2 (PF11214): Mediator complex subunit 2
SH3_3 (PF08239): Bacterial SH3 domain
SH3_1 (PF00018): SH3 domain
DEC-1_N (PF04625): DEC-1 protein, N-terminal region
Hecw2

Domain structure obtained by HMM

Protein ID: XP_017654326.1 - E3 ubiquitin-protein ligase HECW2 isoform X1
KEEG Ortholog ID: K12168
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
HECW_NPF165621207.6e-63196.0004516445164N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
C2PF001681030.000000000000001144.100187296185300C2 domain
Cep57_CLDPF140731780.00000413.100630666600667Centrosome localisation domain of Cep57
WWPF00397310.00000000000003538.900817846817846WW domain
WWPF00397310.000000001324.20099510249951024WW domain
RFXA_RFXANK_bdgPF152891240.00001311.8001068111810401125Regulatory factor X-associated C-terminal binding domain
HECTPF006323071.7e-108348.8001276158012751580HECT-domain (ubiquitin-transferase)
interactor40.6671.000HECW_N (PF16562): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
C2 (PF00168): C2 domain
Cep57_CLD (PF14073): Centrosome localisation domain of Cep57
WW (PF00397): WW domain
RFXA_RFXANK_bdg (PF15289): Regulatory factor X-associated C-terminal binding domain
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Ikzf5

Domain structure obtained by HMM

Protein ID: XP_008825479.1 - zinc finger protein Pegasus
KEEG Ortholog ID: K09220
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
zf-H2C2_5PF13909260.000000001224.1008310682106C2H2-type zinc-finger domain
zf-H2C2_2PF13465260.0000000003726.3009711996121Zinc-finger double domain
zf-H2C2_2PF13465260.00000000002430.100124145124148Zinc-finger double domain
zf-H2C2_5PF13909260.0000004915.800138162138163C2H2-type zinc-finger domain
zf-C2H2_7PF15269540.00912.400270288268292Zinc-finger
zf-C2H2PF00096230.000138.800363382363383Zinc finger, C2H2 type
zf-H2C2_2PF13465260.0073.300381397378404Zinc-finger double domain
zf-C2H2_4PF13894240.00444.500391411391412C2H2-type zinc finger
interactor51.0000zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2_7 (PF15269): Zinc-finger
zf-C2H2 (PF00096): Zinc finger, C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Kat2a

Domain structure obtained by HMM

Protein ID: XP_008833507.1 - histone acetyltransferase KAT2A isoform X1
KEEG Ortholog ID: K06062
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
NICE-1PF15845890.0112.80034723195Cysteine-rich C-terminal 1 family
PCAF_NPF064662511.1e-120388.0008433484334PCAF (P300/CBP-associated factor) N-terminal domain
Acetyltransf_1PF005831170.00000000000009737.900542626516626Acetyltransferase (GNAT) family
BromodomainPF00439841.9e-2678.300736817736819Bromodomain
interactor70.6674.500NICE-1 (PF15845): Cysteine-rich C-terminal 1 family
PCAF_N (PF06466): PCAF (P300/CBP-associated factor) N-terminal domain
Acetyltransf_1 (PF00583): Acetyltransferase (GNAT) family
Bromodomain (PF00439): Bromodomain
Maml3

Domain structure obtained by HMM

Protein ID: XP_008841652.1 - mastermind-like protein 3
KEEG Ortholog ID: K06061
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
MamL-1PF09596586.6e-2779.9006812568125MamL-1 domain
Rtf2PF046412620.000137.5008915272187Rtf2 RING-finger
SRRM_CPF15230670.00214.900183202159203Serine/arginine repetitive matrix protein C-terminus
Drf_GBDPF063711880.0280.100306338300370Diaphanous GTPase-binding Domain
TERB2PF151012070.00001311.500464513437543Telomere-associated protein TERB2
PNISRPF159962030.00135.100624673570677Arginine/serine-rich protein PNISR
AAA_23PF134762000.00862.700643777601791AAA domain
TERB2PF151012070.00572.900729797727813Telomere-associated protein TERB2
SurA_N_2PF136231450.0092.100784838782841SurA N-terminal domain
TFIIAPF031534150.0171.10081810608131101Transcription factor IIA, alpha/beta subunit
interactor100MamL-1 (PF09596): MamL-1 domain
Rtf2 (PF04641): Rtf2 RING-finger
SRRM_C (PF15230): Serine/arginine repetitive matrix protein C-terminus
Drf_GBD (PF06371): Diaphanous GTPase-binding Domain
TERB2 (PF15101): Telomere-associated protein TERB2
PNISR (PF15996): Arginine/serine-rich protein PNISR
AAA_23 (PF13476): AAA domain
SurA_N_2 (PF13623): SurA N-terminal domain
TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
Rfpl4b

Domain structure obtained by HMM

Protein ID: XP_017658492.1 - LOW QUALITY PROTEIN: ret finger protein-like 4B
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
zf-C3HC4_4PF15227420.000000003523.00041683368zinc finger of C3HC4-type, RING
PRYPF13765490.000006612.0008610166101SPRY-associated domain
SPRYPF006221200.00000313.600107133105139SPRY domain
zf-RING_UBOXPF13445380.0480.100122136121137RING-type zinc-finger
interactor100zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRY (PF13765): SPRY-associated domain
SPRY (PF00622): SPRY domain
zf-RING_UBOX (PF13445): RING-type zinc-finger
Tada2a

Domain structure obtained by HMM

Protein ID: XP_008846309.1 - transcriptional adapter 2-alpha
KEEG Ortholog ID: K11314
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Myb_DNA-bindingPF00249470.000000000000001843.2007411772118Myb-like DNA-binding domain
SWIRMPF04433890.000000000006332.000374440371441SWIRM domain
interactor50.9000.500Myb_DNA-binding (PF00249): Myb-like DNA-binding domain
SWIRM (PF04433): SWIRM domain
Tada3

Domain structure obtained by HMM

Protein ID: XP_008853071.1 - transcriptional adapter 3 isoform X1
KEEG Ortholog ID: K11315
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Ada3PF101981310.0112.100416722125Histone acetyltransferases subunit 3
GvpL_GvpFPF063862440.0181.100167223157246Gas vesicle synthesis protein GvpL/GvpF
Ada3PF101981314.2e-3090.800310416309429Histone acetyltransferases subunit 3
interactor50.9000.500Ada3 (PF10198): Histone acetyltransferases subunit 3
GvpL_GvpF (PF06386): Gas vesicle synthesis protein GvpL/GvpF
Tfap4

Domain structure obtained by HMM

Protein ID: XP_008844481.1 - transcription factor AP-4
KEEG Ortholog ID: K09108
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
HLHPF00010555.1e-2160.800499949100Helix-loop-helix DNA-binding domain
DivICPF04977800.000546.1008912284132Septum formation initiator
DivICPF04977800.000296.900149179146188Septum formation initiator
DUF2407PF103021040.000616.600190237184297DUF2407 ubiquitin-like domain
DUF972PF061561020.0182.000261306251330Protein of unknown function (DUF972)
oncogene21.0000HLH (PF00010): Helix-loop-helix DNA-binding domain
DivIC (PF04977): Septum formation initiator
DUF2407 (PF10302): DUF2407 ubiquitin-like domain
DUF972 (PF06156): Protein of unknown function (DUF972)
Wdr5

Domain structure obtained by HMM

Protein ID: XP_008842146.1 - WD repeat-containing protein 5
KEEG Ortholog ID: K14963
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
WD40PF00400380.0000000000003936.20039723572WD domain, G-beta repeat
WD40PF00400380.0000000000004436.0007911577115WD domain, G-beta repeat
WD40PF00400380.00000000000002839.800119157119157WD domain, G-beta repeat
WD40PF00400380.0000000000002636.800161199161199WD domain, G-beta repeat
WD40PF00400380.000000001225.200203242203242WD domain, G-beta repeat
WD40PF00400380.000000001225.100246287246287WD domain, G-beta repeat
WD40PF00400380.0000006616.500293331291331WD domain, G-beta repeat
interactor41.0000WD40 (PF00400): WD domain, G-beta repeat
Zbtb9

Domain structure obtained by HMM

Protein ID: XP_017655364.1 - zinc finger and BTB domain-containing protein 9
KEEG Ortholog ID: K10496
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
BTBPF006511114.4e-2677.6003814038142BTB/POZ domain
Myc_NPF010563320.0000009415.000152239126251Myc amino-terminal region
zf-C2HC_2PF13913250.012.200393403393403zinc-finger of a C2HC-type
zf-C2H2PF00096230.0440.900395409393411Zinc finger, C2H2 type
zf-C2H2PF00096230.0000001418.100420440418440Zinc finger, C2H2 type
zf-C2HC_2PF13913250.000004612.800444459443468zinc-finger of a C2HC-type
interactor21.0000BTB (PF00651): BTB/POZ domain
Myc_N (PF01056): Myc amino-terminal region
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
zf-C2H2 (PF00096): Zinc finger, C2H2 type
Znf496

Domain structure obtained by HMM

Protein ID: XP_008838519.2 - zinc finger protein 496 isoform X1
KEEG Ortholog ID: K09229
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Rpr2PF04032910.00912.70028592160RNAse P Rpr2/Rpp21/SNM1 subunit domain
SCANPF02023903.2e-43131.800108195108197SCAN domain
KRABPF01352420.0000000006824.800289314288322KRAB box
zf-C2H2PF00096230.000001215.300469489469490Zinc finger, C2H2 type
zf-C2H2_4PF13894240.0000007316.200497519497520C2H2-type zinc finger
zf-H2C2_2PF13465260.00000008218.900512534511535Zinc-finger double domain
zf-C2H2PF00096230.00000006719.200525547525547Zinc finger, C2H2 type
zf-H2C2_2PF13465260.00414.100542593539595Zinc-finger double domain
zf-C2H2PF00096230.000003613.700585607584607Zinc finger, C2H2 type
zf-H2C2_2PF13465260.000297.700599625598626Zinc-finger double domain
zf-C2H2_4PF13894240.000002214.800616637615638C2H2-type zinc finger
zf-H2C2_2PF13465260.0480.700630639629644Zinc-finger double domain
interactor200Rpr2 (PF04032): RNAse P Rpr2/Rpp21/SNM1 subunit domain
SCAN (PF02023): SCAN domain
KRAB (PF01352): KRAB box
zf-C2H2 (PF00096): Zinc finger, C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_2 (PF13465): Zinc-finger double domain

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