Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Zzef1 (from a repository: Fri Apr 20 23:09:09 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)49
The number (and %) of the onco-proteins6 (12.24 %)
The number (and %) of the tumor suppressors4 (8.16 %)
Total number of binary PPIs (saturation %)87 (7.40 %)
The number (and %) of affected PPIs48 (55.17 %)
PPI diameter2
PPI radius1
The average degree of PPI3.265
Assortativity coefficient-0.7245
The network average Clustering coefficient0.594
The number (and %) of a zero Clustering coefficients17 (34.69 %)
The number (and %) of a zero Betweenness Centrality44 (89.80 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Zzef1
user protein480.0281890.000EF-hand_6 (PF13405): EF-hand domain
ANAPC10 (PF03256): Anaphase-promoting complex, subunit 10 (APC10)
CUB (PF00431): CUB domain
ZZ (PF00569): Zinc finger, ZZ type
Acsbg2
interactor100AMP-binding (PF00501): AMP-binding enzyme
Angpt2
interactor21.0000CENP-Q (PF13094): CENP-Q, a CENPA-CAD centromere complex subunit
IncA (PF04156): IncA protein
SlyX (PF04102): SlyX
Spc29 (PF17082): Spindle Pole Component 29
Fibrinogen_C (PF00147): Fibrinogen beta and gamma chains, C-terminal globular domain
Cavin1
interactor40.6672.000PTRF_SDPR (PF15237): PTRF/SDPR family
Ccdc130
interactor21.0000DUF572 (PF04502): Family of unknown function (DUF572)
Ccng1
oncogene21.0000Cyclin_N (PF00134): Cyclin, N-terminal domain
Cyclin_C (PF02984): Cyclin, C-terminal domain
Cdk5rap1
interactor21.0000UPF0004 (PF00919): Uncharacterized protein family UPF0004
Radical_SAM (PF04055): Radical SAM superfamily
TRAM (PF01938): TRAM domain
Chrdl1
interactor21.0000DUF1496 (PF07383): Protein of unknown function (DUF1496)
VWC (PF00093): von Willebrand factor type C domain
Amnionless (PF14828): Amnionless
Pacifastin_I (PF05375): Pacifastin inhibitor (LCMII)
Clec3a
interactor21.0000DUF3545 (PF12065): Protein of unknown function (DUF3545)
Lectin_C (PF00059): Lectin C-type domain
Dcaf12
interactor100WD40_like (PF17005): WD40-like domain
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Dlk1
tumor suppressor100hEGF (PF12661): Human growth factor-like EGF
EGF_2 (PF07974): EGF-like domain
EGF (PF00008): EGF-like domain
cEGF (PF12662): Complement Clr-like EGF-like
Egfl6
oncogene21.0000EGF_2 (PF07974): EGF-like domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
EGF (PF00008): EGF-like domain
cEGF (PF12662): Complement Clr-like EGF-like
EGF_CA (PF07645): Calcium-binding EGF domain
MAM (PF00629): MAM domain, meprin/A5/mu
Eps15l1
oncogene100EF-hand_4 (PF12763): Cytoskeletal-regulatory complex EF hand
EzrA (PF06160): Septation ring formation regulator, EzrA
UIM (PF02809): Ubiquitin interaction motif
ATP-synt_E (PF05680): ATP synthase E chain
Fgfrl1
interactor100HRM (PF02793): Hormone receptor domain
I-set (PF07679): Immunoglobulin I-set domain
Ig_3 (PF13927): Immunoglobulin domain
Fosl2
oncogene100bZIP_1 (PF00170): bZIP transcription factor
Gan
interactor31.0000BTB (PF00651): BTB/POZ domain
BACK (PF07707): BTB And C-terminal Kelch
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_1 (PF01344): Kelch motif
Kelch_5 (PF13854): Kelch motif
Gas2l1
interactor21.0000CH (PF00307): Calponin homology (CH) domain
GAS2 (PF02187): Growth-Arrest-Specific Protein 2 Domain
MSA-2c (PF12238): Merozoite surface antigen 2c
Gast
interactor21.0000Gastrin (PF00918): Gastrin/cholecystokinin family
Glipr1l2
interactor100CAP (PF00188): Cysteine-rich secretory protein family
DUF1510 (PF07423): Protein of unknown function (DUF1510)
Gmnn
interactor100Geminin (PF07412): Geminin
Gpr156
interactor1007tm_3 (PF00003): 7 transmembrane sweet-taste receptor of 3 GCPR
NYD-SP28 (PF14772): Sperm tail
Hectd3
interactor260.086297.000ANAPC10 (PF03256): Anaphase-promoting complex, subunit 10 (APC10)
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Hspb3
heat shock100HSP20 (PF00011): Hsp20/alpha crystallin family
LOC103737722
interactor21.0000Serpin (PF00079): Serpin (serine protease inhibitor)
LOC103741684
interactor31.0000Lys (PF00062): C-type lysozyme/alpha-lactalbumin family
LOC103744001
interactor100Trypsin (PF00089): Trypsin
Lmnb1
interactor21.0000Filament (PF00038): Intermediate filament protein
LTD (PF00932): Lamin Tail Domain
Mad1l1
oncogene, tumor suppressor31.0000Tropomyosin_1 (PF12718): Tropomyosin like
MAD (PF05557): Mitotic checkpoint protein
Mrm1
interactor21.0000SpoU_sub_bind (PF08032): RNA 2'-O ribose methyltransferase substrate binding
SpoU_methylase (PF00588): SpoU rRNA Methylase family
Mrps24
interactor31.0000MRP-S24 (PF14955): Mitochondrial ribosome subunit S24
Mrps34
interactor31.0000MRP-S34 (PF16053): Mitochondrial 28S ribosomal protein S34
Ncaph
interactor30.6671.000Cnd2 (PF05786): Condensin complex subunit 2
Nkap
interactor31.0000Transformer (PF06495): Fruit fly transformer protein
MMU163 (PF17119): Mitochondrial protein up-regulated during meiosis
NKAP (PF15692): NF-kappa-B-activating protein
Dsh_C (PF12316): Segment polarity protein dishevelled (Dsh) C terminal
SynMuv_product (PF06047): Ras-induced vulval development antagonist
Pard6b
interactor21.0000PB1 (PF00564): PB1 domain
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Pdgfrb
oncogene200ig (PF00047): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
V-set (PF07686): Immunoglobulin V-set domain
I-set (PF07679): Immunoglobulin I-set domain
C1-set (PF07654): Immunoglobulin C1-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Phyhip
interactor100fn3 (PF00041): Fibronectin type III domain
Poglut1
interactor31.0000Glyco_transf_90 (PF05686): Glycosyl transferase family 90
Rbfa
interactor21.0000RBFA (PF02033): Ribosome-binding factor A
GATA (PF00320): GATA zinc finger
Rps4x
interactor40.6672.000RS4NT (PF08071): RS4NT (NUC023) domain
S4 (PF01479): S4 domain
Ribosomal_S4e (PF00900): Ribosomal family S4e
KOW (PF00467): KOW motif
40S_S4_C (PF16121): 40S ribosomal protein S4 C-terminus
Rspo1
oncogene21.0000Furin-like_2 (PF15913): Furin-like repeat, cysteine-rich
TSP_1 (PF00090): Thrombospondin type 1 domain
S100a4
interactor100S_100 (PF01023): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499): EF-hand domain pair
EF-hand_4 (PF12763): Cytoskeletal-regulatory complex EF hand
Sccpdh
interactor21.0000Sacchrp_dh_NADP (PF03435): Saccharopine dehydrogenase NADP binding domain
Skil
oncogene, tumor suppressor200Ski_Sno (PF02437): SKI/SNO/DAC family
c-SKI_SMAD_bind (PF08782): c-SKI Smad4 binding domain
Clr5 (PF14420): Clr5 domain
Presenilin (PF01080): Presenilin
DUF489 (PF04356): Protein of unknown function (DUF489)
Tgs1
interactor100SRP72 (PF08492): SRP72 RNA-binding domain
DUF1754 (PF08555): Eukaryotic family of unknown function (DUF1754)
PGM_PMM_II (PF02879): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
N6_N4_Mtase (PF01555): DNA methylase
Methyltransf_15 (PF09445): RNA cap guanine-N2 methyltransferase
Thoc1
interactor200efThoc1 (PF11957): THO complex subunit 1 transcription elongation factor
Death (PF00531): Death domain
Trmt10c
interactor21.0000tRNA_m1G_MT (PF01746): tRNA (Guanine-1)-methyltransferase
Ttc25
interactor21.0000MAS20 (PF02064): MAS20 protein import receptor
TPR_2 (PF07719): Tetratricopeptide repeat
TPR_1 (PF00515): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
RPN7 (PF10602): 26S proteasome subunit RPN7
TPR_20 (PF14561): Tetratricopeptide repeat
Wnt9b
interactor21.0000wnt (PF00110): wnt family
Xrcc5
tumor suppressor31.0000Ku_N (PF03731): Ku70/Ku80 N-terminal alpha/beta domain
Ku (PF02735): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730): Ku70/Ku80 C-terminal arm
Ku_PK_bind (PF08785): Ku C terminal domain like

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