Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Zyx (from a repository: Fri Apr 13 07:29:16 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)15
The number (and %) of the onco-proteins1 (6.67 %)
The number (and %) of the tumor suppressors2 (13.33 %)
Total number of binary PPIs (saturation %)24 (22.86 %)
The number (and %) of affected PPIs14 (58.33 %)
PPI diameter2
PPI radius1
The average degree of PPI2.800
Assortativity coefficient-0.6376
The network average Clustering coefficient0.432
The number (and %) of a zero Clustering coefficients6 (40.00 %)
The number (and %) of a zero Betweenness Centrality10 (66.67 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Zyx
user protein, tumor suppressor140.077159.000LIM (PF00412): LIM domain
Acta2
interactor100Actin (PF00022): Actin
Actn1
interactor200CH (PF00307): Calponin homology (CH) domain
Dak2 (PF02734): DAK2 domain
Uds1 (PF15456): Up-regulated During Septation
Spectrin (PF00435): Spectrin repeat
EF-hand_7 (PF13499): EF-hand domain pair
EFhand_Ca_insen (PF08726): Ca2+ insensitive EF hand
Coro1b
interactor21.0000DUF1899 (PF08953): Domain of unknown function (DUF1899)
WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Trimer_CC (PF08954): Trimerisation motif
WD40_4 (PF16300): Type of WD40 repeat
Fam129b
interactor100PH (PF00169): PH domain
TOM_sub5 (PF15178): Mitochondrial import receptor subunit TOM5 homolog
Fermt2
interactor21.0000FERM_N (PF09379): FERM N-terminal domain
FERM_M (PF00373): FERM central domain
Fhl3
interactor200LIM (PF00412): LIM domain
Med27 (PF11571): Mediator complex subunit 27
Hipk3
interactor100Pkinase (PF00069): Protein kinase domain
Lats2
oncogene, tumor suppressor31.0000UBA (PF00627): UBA/TS-N domain
Cas_Cas6 (PF01881): CRISPR associated protein Cas6
Pkinase (PF00069): Protein kinase domain
Pkinase_C (PF00433): Protein kinase C terminal domain
Pdlim5
interactor30.6671.000DUF4749 (PF15936): Domain of unknown function (DUF4749)
LIM (PF00412): LIM domain
Pxn
oncogene21.0000Paxillin (PF03535): Paxillin family
Gin (PF10764): Inhibitor of sigma-G Gin
LIM (PF00412): LIM domain
Rad23b
oncogene, tumor suppressor30.6671.000ubiquitin (PF00240): Ubiquitin family
Shisa (PF13908): Wnt and FGF inhibitory regulator
UBA (PF00627): UBA/TS-N domain
LCE6A (PF15858): Late cornified envelope protein 6A family
XPC-binding (PF09280): XPC-binding domain
FoP_duplication (PF13865): C-terminal duplication domain of Friend of PRMT1
Tanc2
interactor30.6671.000AAA_16 (PF13191): AAA ATPase domain
Ank (PF00023): Ankyrin repeat
Ank_2 (PF12796): Ankyrin repeats (3 copies)
TPR_11 (PF13414): TPR repeat
TPR_8 (PF13181): Tetratricopeptide repeat
TPR_9 (PF13371): Tetratricopeptide repeat
RCDG1 (PF15725): Renal cancer differentiation gene 1 protein
RNA_pol_Rpb1_R (PF05001): RNA polymerase Rpb1 C-terminal repeat
Xpo1
interactor50.4006.000IBN_N (PF03810): Importin-beta N-terminal domain
Xpo1 (PF08389): Exportin 1-like protein
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
Hydrolase_3 (PF08282): haloacid dehalogenase-like hydrolase
CRM1_C (PF08767): CRM1 C terminal
Zfr
interactor100Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
K_channel_TID (PF07941): Potassium channel Kv1.4 tandem inactivation domain
TAT_signal (PF10518): TAT (twin-arginine translocation) pathway signal sequence
zf-met (PF12874): Zinc-finger of C2H2 type
ANAPC_CDC26 (PF10471): Anaphase-promoting complex APC subunit CDC26
DZF (PF07528): DZF domain

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