Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Zwint (from a repository: Fri Apr 13 07:53:28 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)81
The number (and %) of the onco-proteins15 (18.52 %)
The number (and %) of the tumor suppressors3 (3.70 %)
Total number of binary PPIs (saturation %)212 (6.54 %)
The number (and %) of affected PPIs81 (38.21 %)
PPI diameter2
PPI radius1
The average degree of PPI4.716
Assortativity coefficient-0.6350
The network average Clustering coefficient0.474
The number (and %) of a zero Clustering coefficients30 (37.04 %)
The number (and %) of a zero Betweenness Centrality50 (61.73 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Zwint
user protein810.0355767.372VIT1 (PF01988): VIT family
Zwint (PF15556): ZW10 interactor
Ap3s1
interactor21.0000Clat_adaptor_s (PF01217): Clathrin adaptor complex small chain
App
interactor160.17183.333APP_N (PF02177): Amyloid A4 N-terminal heparin-binding
APP_Cu_bd (PF12924): Copper-binding of amyloid precursor, CuBD
SDA1 (PF05285): SDA1
YtxH (PF12732): YtxH-like protein
Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2 (PF12925): E2 domain of amyloid precursor protein
Beta-APP (PF03494): Beta-amyloid peptide (beta-APP)
APP_amyloid (PF10515): beta-amyloid precursor protein C-terminus
Arhgap32
oncogene100PX (PF00787): PX domain
SH3_9 (PF14604): Variant SH3 domain
RPEL (PF02755): RPEL repeat
RhoGAP (PF00620): RhoGAP domain
Arpc5
interactor100P16-Arc (PF04699): ARP2/3 complex 16 kDa subunit (p16-Arc)
Aste1
interactor100XPG_N (PF00752): XPG N-terminal domain
XPG_I_2 (PF12813): XPG domain containing
IL4 (PF00727): Interleukin 4
Baiap2l1
interactor21.0000IMD (PF08397): IRSp53/MIM homology domain
SH3_9 (PF14604): Variant SH3 domain
Becn1
tumor suppressor31.0000Ima1_N (PF09779): Ima1 N-terminal domain
BH3 (PF15285): Beclin-1 BH3 domain, Bcl-2-interacting
APG6 (PF04111): Autophagy protein Apg6
Bub1
oncogene110.68910.250Mad3_BUB1_I (PF08311): Mad3/BUB1 homology region 1
Pkinase (PF00069): Protein kinase domain
Bub1b
oncogene100.7787.222Mad3_BUB1_I (PF08311): Mad3/BUB1 homology region 1
OmpH (PF03938): Outer membrane protein (OmpH-like)
Mad3_BUB1_II (PF08171): Mad3/BUB1 homology region 2
XhlA (PF10779): Haemolysin XhlA
Pkinase (PF00069): Protein kinase domain
Ccdc14
interactor31.0000CCDC14 (PF15254): Coiled-coil domain-containing protein 14
Ccdc174
interactor1005_3_exonuc (PF01367): 5'-3' exonuclease, C-terminal SAM fold
TPX2 (PF06886): Targeting protein for Xklp2 (TPX2)
DUF4078 (PF13300): Domain of unknown function (DUF4078)
Ccdc22
interactor100DUF812 (PF05667): Protein of unknown function (DUF812)
ATG16 (PF08614): Autophagy protein 16 (ATG16)
Cenpc
interactor80.6079.667CENP_C_N (PF15622): Kinetochore assembly subunit CENP-C N-terminal
CENP-C_mid (PF15620): Centromere assembly component CENP-C middle DNMT3B-binding region
CENP-C_C (PF11699): Mif2/CENP-C like
Clu
oncogene, tumor suppressor40.6670.667Clusterin (PF01093): Clusterin
Cnbp
oncogene100zf-CCHC (PF00098): Zinc knuckle
zf-ribbon_3 (PF13248): zinc-ribbon domain
Col1a2
oncogene21.0000Collagen (PF01391): Collagen triple helix repeat (20 copies)
COLFI (PF01410): Fibrillar collagen C-terminal domain
Cyr61
oncogene100IGFBP (PF00219): Insulin-like growth factor binding protein
VWC (PF00093): von Willebrand factor type C domain
TSP_1 (PF00090): Thrombospondin type 1 domain
Cys_knot (PF00007): Cystine-knot domain
Ddx17
interactor70.8001.333Flavi_DEAD (PF07652): Flavivirus DEAD domain
DEAD (PF00270): DEAD/DEAH box helicase
Ferritin (PF00210): Ferritin-like domain
Helicase_C (PF00271): Helicase conserved C-terminal domain
Ddx5
oncogene80.7622.667DEAD (PF00270): DEAD/DEAH box helicase
ResIII (PF04851): Type III restriction enzyme, res subunit
Helicase_C (PF00271): Helicase conserved C-terminal domain
P68HR (PF08061): P68HR (NUC004) repeat
Dgcr8
interactor60.6003.500WW (PF00397): WW domain
dsrm (PF00035): Double-stranded RNA binding motif
Dsn1
interactor130.62815.706MIS13 (PF08202): Mis12-Mtw1 protein family
Eif2b3
interactor21.0000NTP_transferase (PF00483): Nucleotidyl transferase
NAGPA (PF09992): Phosphodiester glycosidase
CTP_transf_3 (PF02348): Cytidylyltransferase
Hexapep (PF00132): Bacterial transferase hexapeptide (six repeats)
DUF4954 (PF16314): Domain of unknown function (DUF4954)
Epb41l5
interactor21.0000FERM_N (PF09379): FERM N-terminal domain
FERM_M (PF00373): FERM central domain
FERM_C (PF09380): FERM C-terminal PH-like domain
FA (PF08736): FERM adjacent (FA)
ACBP (PF00887): Acyl CoA binding protein
Exoc1
interactor40.6671.333Sec3-PIP2_bind (PF15277): Exocyst complex component SEC3 N-terminal PIP2 binding PH
Cor1 (PF04803): Cor1/Xlr/Xmr conserved region
Sec3_C (PF09763): Exocyst complex component Sec3
Fam167a
interactor100LURAP (PF14854): Leucine rich adaptor protein
FAM167 (PF11652): FAM167
Fbxo28
interactor21.0000F-box (PF00646): F-box domain
CENP-H (PF05837): Centromere protein H (CENP-H)
ING (PF12998): Inhibitor of growth proteins N-terminal histone-binding
FAM76 (PF16046): FAM76 protein
TRAF_BIRC3_bd (PF16673): TNF receptor-associated factor BIRC3 binding domain
Hnrnpa1
interactor130.30341.333RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627): Nuclear factor hnRNPA1
Hnrnpf
interactor51.0000RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080): RNPHF zinc finger
Hnrnph1
oncogene70.7622.667RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080): RNPHF zinc finger
Ipo4
interactor21.0000IBN_N (PF03810): Importin-beta N-terminal domain
RIX1 (PF08167): rRNA processing/ribosome biogenesis
HEAT (PF02985): HEAT repeat
DUF3385 (PF11865): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
UME (PF08064): UME (NUC010) domain
HEAT_2 (PF13646): HEAT repeats
HEAT_PBS (PF03130): PBS lyase HEAT-like repeat
Kifc3
oncogene60.5005.000HALZ (PF02183): Homeobox associated leucine zipper
Spc7 (PF08317): Spc7 kinetochore protein
KxDL (PF10241): Uncharacterized conserved protein
HIP1_clath_bdg (PF16515): Clathrin-binding domain of Huntingtin-interacting protein 1
DUF4200 (PF13863): Domain of unknown function (DUF4200)
Kinesin (PF00225): Kinesin motor domain
LOC103750566
interactor120.60616.250MtmB (PF05369): Monomethylamine methyltransferase MtmB
Nnf1 (PF03980): Nnf1
CCAP (PF11105): Arthropod cardioacceleratory peptide 2a
NYD-SP28_assoc (PF14775): Sperm tail C-terminal domain
Leng8
interactor21.0000HJURP_mid (PF12346): Holliday junction recognition protein-associated repeat
SAC3_GANP (PF03399): SAC3/GANP family
Lig4
interactor40.5002.667DNA_ligase_A_N (PF04675): DNA ligase N terminus
APG17 (PF04108): Autophagy protein Apg17
DNA_ligase_A_M (PF01068): ATP dependent DNA ligase domain
DNA_ligase_A_C (PF04679): ATP dependent DNA ligase C terminal region
BRCT_2 (PF16589): BRCT domain, a BRCA1 C-terminus domain
DNA_ligase_IV (PF11411): DNA ligase IV
BRCT (PF00533): BRCA1 C Terminus (BRCT) domain
RTT107_BRCT_5 (PF16770): Regulator of Ty1 transposition protein 107 BRCT domain
Lmnb1
interactor30.6671.000Filament (PF00038): Intermediate filament protein
LTD (PF00932): Lamin Tail Domain
Lyrm4
interactor31.0000Complex1_LYR (PF05347): Complex 1 protein (LYR family)
Mafb
oncogene200Maf_N (PF08383): Maf N-terminal region
bZIP_Maf (PF03131): bZIP Maf transcription factor
Map3k20
interactor200Pkinase_Tyr (PF07714): Protein tyrosine kinase
DUF3552 (PF12072): Domain of unknown function (DUF3552)
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
SAM_2 (PF07647): SAM domain (Sterile alpha motif)
Med24
interactor21.0000Med24_N (PF11277): Mediator complex subunit 24 N-terminal
Mis12
interactor110.72710.872Mis12 (PF05859): Mis12 protein
DUF349 (PF03993): Domain of Unknown Function (DUF349)
Mlf1
oncogene50.9000.222Mlf1IP (PF10248): Myelodysplasia-myeloid leukemia factor 1-interacting protein
Mtmr6
interactor200Myotub-related (PF06602): Myotubularin-like phosphatase domain
DUF5082 (PF16888): Domain of unknown function (DUF5082)
Ndc80
interactor150.54925.539Ndc80_HEC (PF03801): HEC/Ndc80p family
ADIP (PF11559): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325): TATA element modulatory factor 1 TATA binding
DUF3810 (PF12725): Protein of unknown function (DUF3810)
SlyX (PF04102): SlyX
CREPT (PF16566): Cell-cycle alteration and expression-elevated protein in tumour
HTH_40 (PF14493): Helix-turn-helix domain
Neu2
interactor100BNR_2 (PF13088): BNR repeat-like domain
Nfs1
interactor21.0000Aminotran_5 (PF00266): Aminotransferase class-V
Nsl1
interactor90.9440.472Mis14 (PF08641): Kinetochore protein Mis14 like
Nuf2
interactor120.68210.206Nuf2 (PF03800): Nuf2 family
DUF3106 (PF11304): Protein of unknown function (DUF3106)
ApoLp-III (PF07464): Apolipophorin-III precursor (apoLp-III)
Spc7 (PF08317): Spc7 kinetochore protein
Syntaxin (PF00804): Syntaxin
Pcolce2
interactor100CUB (PF00431): CUB domain
NTR (PF01759): UNC-6/NTR/C345C module
Phax
interactor100RNA_GG_bind (PF10258): PHAX RNA-binding domain
Ppa2
interactor100Pyrophosphatase (PF00719): Inorganic pyrophosphatase
Ppp1cc
oncogene90.44418.333STPPase_N (PF16891): Serine-threonine protein phosphatase N-terminal domain
Metallophos (PF00149): Calcineurin-like phosphoesterase
Rabl6
oncogene40.5003.000Roc (PF08477): Ras of Complex, Roc, domain of DAPkinase
Eapp_C (PF10238): E2F-associated phosphoprotein
Ras (PF00071): Ras family
RP-C_C (PF11800): Replication protein C C-terminal region
Histone (PF00125): Core histone H2A/H2B/H3/H4
CDC27 (PF09507): DNA polymerase subunit Cdc27
eIF3_subunit (PF08597): Translation initiation factor eIF3 subunit
Rasip1
interactor100DIL (PF01843): DIL domain
Rbm25
interactor100RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
VID27 (PF08553): VID27 cytoplasmic protein
SMN (PF06003): Survival motor neuron protein (SMN)
PRP38_assoc (PF12871): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
U1snRNP70_N (PF12220): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF3441 (PF11923): Domain of unknown function (DUF3441)
DUF4778 (PF16008): Domain of unknown function (DUF4778)
Vfa1 (PF08432): AAA-ATPase Vps4-associated protein 1
PWI (PF01480): PWI domain
Rcn1
interactor100EF-hand_7 (PF13499): EF-hand domain pair
EF-hand_6 (PF13405): EF-hand domain
EF-hand_4 (PF12763): Cytoskeletal-regulatory complex EF hand
Rin1
interactor100SH2 (PF00017): SH2 domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
VPS9 (PF02204): Vacuolar sorting protein 9 (VPS9) domain
RA (PF00788): Ras association (RalGDS/AF-6) domain
Scmh1
interactor200MBT (PF02820): mbt repeat
RBR (PF17208): RNA binding Region
SLED (PF12140): SLED domain
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
Slc25a19
interactor100Mito_carr (PF00153): Mitochondrial carrier protein
Smg5
interactor30.6670.500EST1 (PF10374): Telomerase activating protein Est1
EST1_DNA_bind (PF10373): Est1 DNA/RNA binding domain
PIN_4 (PF13638): PIN domain
Smtn
interactor100Smoothelin (PF12510): Smoothelin cytoskeleton protein
Nop25 (PF09805): Nucleolar protein 12 (25kDa)
CH (PF00307): Calponin homology (CH) domain
Snap29
interactor70.3339.500V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus
DUF1664 (PF07889): Protein of unknown function (DUF1664)
Spc25
interactor90.7786.556DUF3800 (PF12686): Protein of unknown function (DUF3800)
Spc7 (PF08317): Spc7 kinetochore protein
Spindle_Spc25 (PF08234): Chromosome segregation protein Spc25
Sqor
interactor100Spermine_synth (PF01564): Spermine/spermidine synthase
Pyr_redox_2 (PF07992): Pyridine nucleotide-disulphide oxidoreductase
Ssr3
interactor100TRAP-gamma (PF07074): Translocon-associated protein, gamma subunit (TRAP-gamma)
Stx11
interactor40.6670.500Syntaxin (PF00804): Syntaxin
SNARE (PF05739): SNARE domain
Stx18
interactor40.5002.667Syntaxin-18_N (PF10496): SNARE-complex protein Syntaxin-18 N-terminus
Phage_Integr_2 (PF13009): Putative phage integrase
Stx19
interactor100Syntaxin (PF00804): Syntaxin
SNARE (PF05739): SNARE domain
Stx3
interactor21.0000DUF4162 (PF13732): Domain of unknown function (DUF4162)
Syntaxin (PF00804): Syntaxin
SNARE (PF05739): SNARE domain
Sugp1
interactor100ATP-synt_E (PF05680): ATP synthase E chain
Surp (PF01805): Surp module
G-patch_2 (PF12656): G-patch domain
RtcB (PF01139): tRNA-splicing ligase RtcB
G-patch (PF01585): G-patch domain
Syce3
interactor21.0000Synaptonemal_3 (PF15191): Synaptonemal complex central element protein 3
Taf12
interactor100TFIID_20kDa (PF03847): Transcription initiation factor TFIID subunit A
Tcf12
oncogene200HLH (PF00010): Helix-loop-helix DNA-binding domain
CDC45 (PF02724): CDC45-like protein
Thbs2
oncogene100Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
VWC (PF00093): von Willebrand factor type C domain
TSP_1 (PF00090): Thrombospondin type 1 domain
EGF_3 (PF12947): EGF domain
cEGF (PF12662): Complement Clr-like EGF-like
EGF_CA (PF07645): Calcium-binding EGF domain
TSP_3 (PF02412): Thrombospondin type 3 repeat
TSP_C (PF05735): Thrombospondin C-terminal region
Tjap1
interactor21.0000HMMR_N (PF15905): Hyaluronan mediated motility receptor N-terminal
DUF342 (PF03961): Protein of unknown function (DUF342)
Pilt (PF15453): Protein incorporated later into Tight Junctions
Tmem126a
interactor100TMEM126 (PF07114): Transmembrane protein 126
Tmpo
interactor21.0000Thymopoietin (PF08198): Thymopoietin protein
LEM (PF03020): LEM domain
OPT (PF03169): OPT oligopeptide transporter protein
Tp53
tumor suppressor120.30937.000P53_TAD (PF08563): P53 transactivation motif
P53 (PF00870): P53 DNA-binding domain
P53_tetramer (PF07710): P53 tetramerisation motif
Trim28
interactor41.0000zf-RING_5 (PF14634): zinc-RING finger domain
DUF1178 (PF06676): Protein of unknown function (DUF1178)
zf-B_box (PF00643): B-box zinc finger
FYVE_2 (PF02318): FYVE-type zinc finger
SKA2 (PF16740): Spindle and kinetochore-associated protein 2
K_channel_TID (PF07941): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628): PHD-finger
Tyw3
interactor21.0000TYW3 (PF02676): Methyltransferase TYW3
Zw10
interactor30.6670.667Zw10 (PF06248): Centromere/kinetochore Zw10
DUF4363 (PF14276): Domain of unknown function (DUF4363)
RST (PF12174): RCD1-SRO-TAF4 (RST) plant domain

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