Find Protein-Protein Interactions (PPI) Network

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Choose animal:			Visualization driver:
Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Zwint
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Visible interactions:

Visible interactors:

Size of node:

Visualization interactions

Cytoscape Web taxid = 1026970 for: protein(s) Zwint (from a repository: Fri Apr 13 07:53:28 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	81
The number (and %) of the onco-proteins	15 (18.52 %)
The number (and %) of the tumor suppressors	3 (3.70 %)
Total number of binary PPIs (saturation %)	212 (6.54 %)
The number (and %) of affected PPIs	81 (38.21 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	4.716
Assortativity coefficient	-0.6350
The network average Clustering coefficient	0.474
The number (and %) of a zero Clustering coefficients	30 (37.04 %)
The number (and %) of a zero Betweenness Centrality	50 (61.73 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Zwint

XP_017652612.1

Domain structure obtained by HMM

Protein ID: XP_017652612.1 - ZW10 interactor isoform X2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
VIT1	PF01988	214	0.0026	3.700	12	62	3	117	VIT family
Zwint	PF15556	252	2.4e-93	298.300	28	233	28	240	ZW10 interactor

user protein

0.035

5767.372

VIT1 (PF01988): VIT family
Zwint (PF15556): ZW10 interactor

Ap3s1

XP_008823495.1

Domain structure obtained by HMM

Protein ID: XP_008823495.1 - AP-3 complex subunit sigma-1 isoform X1
KEEG Ortholog ID: K12399

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Clat_adaptor_s	PF01217	142	3.5e-58	181.800	1	147	1	148	Clathrin adaptor complex small chain

interactor

1.000

Clat_adaptor_s (PF01217): Clathrin adaptor complex small chain

App

XP_017657176.1

Domain structure obtained by HMM

Protein ID: XP_017657176.1 - amyloid beta A4 protein
KEEG Ortholog ID: K04520

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
APP_N	PF02177	100	8.1e-49	150.500	31	131	31	131	Amyloid A4 N-terminal heparin-binding
APP_Cu_bd	PF12924	57	1.8e-29	88.600	132	188	132	188	Copper-binding of amyloid precursor, CuBD
SDA1	PF05285	347	0.0000059	12.000	193	270	155	307	SDA1
YtxH	PF12732	75	0.0048	3.800	251	291	245	298	YtxH-like protein
Kunitz_BPTI	PF00014	53	1.4e-23	69.200	291	342	291	343	Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2	PF12925	190	1e-78	249.500	365	547	365	547	E2 domain of amyloid precursor protein
YtxH	PF12732	75	0.029	1.300	520	565	516	576	YtxH-like protein
Beta-APP	PF03494	39	3.3e-28	83.600	676	712	674	712	Beta-amyloid peptide (beta-APP)
APP_amyloid	PF10515	52	3.7e-29	87.400	715	765	715	765	beta-amyloid precursor protein C-terminus

interactor

0.171

83.333

APP_N (PF02177): Amyloid A4 N-terminal heparin-binding
APP_Cu_bd (PF12924): Copper-binding of amyloid precursor, CuBD
SDA1 (PF05285): SDA1
YtxH (PF12732): YtxH-like protein
Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2 (PF12925): E2 domain of amyloid precursor protein
Beta-APP (PF03494): Beta-amyloid peptide (beta-APP)
APP_amyloid (PF10515): beta-amyloid precursor protein C-terminus

Arhgap32

XP_008839592.2

Domain structure obtained by HMM

Protein ID: XP_008839592.2 - rho GTPase-activating protein 32 isoform X2
KEEG Ortholog ID: K20647

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PX	PF00787	113	0.0000000075	21.900	75	149	58	152	PX domain
SH3_9	PF14604	49	0.000000000004	32.200	192	243	192	243	Variant SH3 domain
RPEL	PF02755	24	0.0000019	13.800	276	293	271	294	RPEL repeat
RhoGAP	PF00620	152	6.3e-49	151.900	312	460	312	464	RhoGAP domain

oncogene

PX (PF00787): PX domain
SH3_9 (PF14604): Variant SH3 domain
RPEL (PF02755): RPEL repeat
RhoGAP (PF00620): RhoGAP domain

Arpc5

XP_008822514.1

Domain structure obtained by HMM

Protein ID: XP_008822514.1 - actin-related protein 2/3 complex subunit 5
KEEG Ortholog ID: K05754

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
P16-Arc	PF04699	147	1e-64	203.700	10	151	10	151	ARP2/3 complex 16 kDa subunit (p16-Arc)

interactor

P16-Arc (PF04699): ARP2/3 complex 16 kDa subunit (p16-Arc)

Aste1

XP_017651590.1

Domain structure obtained by HMM

Protein ID: XP_017651590.1 - protein asteroid homolog 1 isoform X1

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
XPG_N	PF00752	101	0.0000000042	23.200	1	97	1	102	XPG N-terminal domain
XPG_I_2	PF12813	249	0.000000000000015	40.200	116	226	115	241	XPG domain containing
IL4	PF00727	109	0.0086	2.600	274	303	252	317	Interleukin 4

interactor

XPG_N (PF00752): XPG N-terminal domain
XPG_I_2 (PF12813): XPG domain containing
IL4 (PF00727): Interleukin 4

Baiap2l1

XP_008822246.2

Domain structure obtained by HMM

Protein ID: XP_008822246.2 - brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 isoform X1
KEEG Ortholog ID: K20127

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
IMD	PF08397	219	4e-67	211.900	16	236	16	236	IRSp53/MIM homology domain
SH3_9	PF14604	49	3e-16	45.400	347	398	346	398	Variant SH3 domain

interactor

1.000

IMD (PF08397): IRSp53/MIM homology domain
SH3_9 (PF14604): Variant SH3 domain

Becn1

XP_008833560.1

Domain structure obtained by HMM

Protein ID: XP_008833560.1 - beclin-1 isoform X1
KEEG Ortholog ID: K08334

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Ima1_N	PF09779	136	0.0009	6.300	8	73	2	183	Ima1 N-terminal domain
BH3	PF15285	25	4.6e-21	60.600	103	127	103	127	Beclin-1 BH3 domain, Bcl-2-interacting
APG6	PF04111	312	1.3e-134	434.600	133	444	133	444	Autophagy protein Apg6

tumor suppressor

1.000

Ima1_N (PF09779): Ima1 N-terminal domain
BH3 (PF15285): Beclin-1 BH3 domain, Bcl-2-interacting
APG6 (PF04111): Autophagy protein Apg6

Bub1

XP_008847440.1

Domain structure obtained by HMM

Protein ID: XP_008847440.1 - mitotic checkpoint serine/threonine-protein kinase BUB1
KEEG Ortholog ID: K02178

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Mad3_BUB1_I	PF08311	124	1.8e-41	127.200	8	126	6	126	Mad3/BUB1 homology region 1
Pkinase	PF00069	264	8.6e-23	67.100	570	785	567	797	Protein kinase domain

oncogene

0.689

10.250

Mad3_BUB1_I (PF08311): Mad3/BUB1 homology region 1
Pkinase (PF00069): Protein kinase domain

Bub1b

XP_008840535.1

Domain structure obtained by HMM

Protein ID: XP_008840535.1 - mitotic checkpoint serine/threonine-protein kinase BUB1 beta
KEEG Ortholog ID: K06637

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Mad3_BUB1_I	PF08311	124	9.9e-48	147.500	58	180	58	180	Mad3/BUB1 homology region 1
OmpH	PF03938	156	0.00034	6.800	165	284	151	286	Outer membrane protein (OmpH-like)
Mad3_BUB1_II	PF08171	68	0.0000075	12.300	388	430	374	432	Mad3/BUB1 homology region 2
XhlA	PF10779	67	0.0002	7.900	430	461	420	480	Haemolysin XhlA
Pkinase	PF00069	264	0.000000000000077	37.700	820	919	813	968	Protein kinase domain

oncogene

0.778

7.222

Mad3_BUB1_I (PF08311): Mad3/BUB1 homology region 1
OmpH (PF03938): Outer membrane protein (OmpH-like)
Mad3_BUB1_II (PF08171): Mad3/BUB1 homology region 2
XhlA (PF10779): Haemolysin XhlA
Pkinase (PF00069): Protein kinase domain

Ccdc14

XP_008841185.1

Domain structure obtained by HMM

Protein ID: XP_008841185.1 - coiled-coil domain-containing protein 14
KEEG Ortholog ID: K16541

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
CCDC14	PF15254	882	0	1316.100	49	896	49	896	Coiled-coil domain-containing protein 14

interactor

1.000

CCDC14 (PF15254): Coiled-coil domain-containing protein 14

Ccdc174

XP_008853157.1

Domain structure obtained by HMM

Protein ID: XP_008853157.1 - coiled-coil domain-containing protein 174

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
5_3_exonuc	PF01367	97	0.00018	8.400	60	99	55	134	5'-3' exonuclease, C-terminal SAM fold
TPX2	PF06886	57	0.035	0.700	114	142	112	148	Targeting protein for Xklp2 (TPX2)
TPX2	PF06886	57	0.000044	10.000	198	226	191	230	Targeting protein for Xklp2 (TPX2)
DUF4078	PF13300	86	1.5e-31	94.900	212	300	212	300	Domain of unknown function (DUF4078)

interactor

5_3_exonuc (PF01367): 5'-3' exonuclease, C-terminal SAM fold
TPX2 (PF06886): Targeting protein for Xklp2 (TPX2)
DUF4078 (PF13300): Domain of unknown function (DUF4078)

Ccdc22

XP_008840822.1

Domain structure obtained by HMM

Protein ID: XP_008840822.1 - coiled-coil domain-containing protein 22

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF812	PF05667	598	1.6e-212	693.600	1	597	1	597	Protein of unknown function (DUF812)
ATG16	PF08614	203	0.000031	10.400	548	624	537	625	Autophagy protein 16 (ATG16)

interactor

DUF812 (PF05667): Protein of unknown function (DUF812)
ATG16 (PF08614): Autophagy protein 16 (ATG16)

Cenpc

XP_008852050.1

Domain structure obtained by HMM

Protein ID: XP_008852050.1 - centromere protein C isoform X1
KEEG Ortholog ID: K11497

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
CENP_C_N	PF15622	288	3.2e-116	373.800	7	281	7	282	Kinetochore assembly subunit CENP-C N-terminal
CENP-C_mid	PF15620	260	1.6e-113	365.100	286	543	286	543	Centromere assembly component CENP-C middle DNMT3B-binding region
CENP-C_mid	PF15620	260	0.02	1.000	684	743	671	746	Centromere assembly component CENP-C middle DNMT3B-binding region
CENP-C_C	PF11699	85	1.4e-30	91.700	849	932	848	932	Mif2/CENP-C like

interactor

0.607

9.667

CENP_C_N (PF15622): Kinetochore assembly subunit CENP-C N-terminal
CENP-C_mid (PF15620): Centromere assembly component CENP-C middle DNMT3B-binding region
CENP-C_C (PF11699): Mif2/CENP-C like

Clu

XP_008826365.1

Domain structure obtained by HMM

Protein ID: XP_008826365.1 - clusterin
KEEG Ortholog ID: K17252

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Clusterin	PF01093	427	1.6e-160	520.800	29	444	29	445	Clusterin

oncogene, tumor suppressor

0.667

Clusterin (PF01093): Clusterin

Cnbp

XP_008826765.1

Domain structure obtained by HMM

Protein ID: XP_008826765.1 - cellular nucleic acid-binding protein isoform X2
KEEG Ortholog ID: K09250

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
zf-CCHC	PF00098	18	0.0000000000047	31.900	5	20	4	21	Zinc knuckle
zf-CCHC	PF00098	18	0.000000000011	30.800	53	68	52	69	Zinc knuckle
zf-CCHC	PF00098	18	0.000000000051	28.700	73	89	72	89	Zinc knuckle
zf-ribbon_3	PF13248	26	0.000045	9.200	87	104	86	104	zinc-ribbon domain
zf-CCHC	PF00098	18	0.000000000021	29.900	97	113	96	113	Zinc knuckle
zf-CCHC	PF00098	18	0.000000000073	28.200	117	134	117	134	Zinc knuckle
zf-CCHC	PF00098	18	0.00000000013	27.300	136	152	135	152	Zinc knuckle
zf-CCHC	PF00098	18	0.0000000000058	31.700	157	172	156	173	Zinc knuckle

oncogene

zf-CCHC (PF00098): Zinc knuckle
zf-ribbon_3 (PF13248): zinc-ribbon domain

Col1a2

XP_008820781.1

Domain structure obtained by HMM

Protein ID: XP_008820781.1 - collagen alpha-2(I) chain
KEEG Ortholog ID: K06236

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Collagen	PF01391	60	0.000000000048	28.600	32	75	27	82	Collagen triple helix repeat (20 copies)
Collagen	PF01391	60	0.00000000000021	36.200	91	149	87	150	Collagen triple helix repeat (20 copies)
Collagen	PF01391	60	0.000000000063	28.200	148	204	130	207	Collagen triple helix repeat (20 copies)
Collagen	PF01391	60	0.0000000000012	33.800	313	370	310	372	Collagen triple helix repeat (20 copies)
Collagen	PF01391	60	0.028	0.600	496	532	460	580	Collagen triple helix repeat (20 copies)
Collagen	PF01391	60	0.00000000000086	34.200	990	1046	985	1053	Collagen triple helix repeat (20 copies)
Collagen	PF01391	60	0.0000000000094	30.900	1045	1102	1045	1109	Collagen triple helix repeat (20 copies)
COLFI	PF01410	233	3.2e-108	346.500	1131	1364	1130	1364	Fibrillar collagen C-terminal domain

oncogene

1.000

Collagen (PF01391): Collagen triple helix repeat (20 copies)
COLFI (PF01410): Fibrillar collagen C-terminal domain

Cyr61

XP_008824468.1

Domain structure obtained by HMM

Protein ID: XP_008824468.1 - protein CYR61
KEEG Ortholog ID: K06829

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
IGFBP	PF00219	55	0.000000000000013	40.900	26	78	26	78	Insulin-like growth factor binding protein
VWC	PF00093	57	0.000000000000034	39.300	100	163	100	163	von Willebrand factor type C domain
TSP_1	PF00090	49	0.000000012	21.400	233	272	232	272	Thrombospondin type 1 domain
Cys_knot	PF00007	105	1.2e-20	60.100	284	371	283	376	Cystine-knot domain

oncogene

IGFBP (PF00219): Insulin-like growth factor binding protein
VWC (PF00093): von Willebrand factor type C domain
TSP_1 (PF00090): Thrombospondin type 1 domain
Cys_knot (PF00007): Cystine-knot domain

Ddx17

XP_017658240.1

Domain structure obtained by HMM

Protein ID: XP_017658240.1 - probable ATP-dependent RNA helicase DDX17 isoform X3

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Flavi_DEAD	PF07652	148	0.0026	3.900	96	123	89	133	Flavivirus DEAD domain
DEAD	PF00270	176	3.9e-53	165.900	116	286	116	287	DEAD/DEAH box helicase
Ferritin	PF00210	142	0.000015	11.100	303	342	248	350	Ferritin-like domain
Helicase_C	PF00271	111	2.7e-19	55.900	325	405	322	409	Helicase conserved C-terminal domain

interactor

0.800

1.333

Flavi_DEAD (PF07652): Flavivirus DEAD domain
DEAD (PF00270): DEAD/DEAH box helicase
Ferritin (PF00210): Ferritin-like domain
Helicase_C (PF00271): Helicase conserved C-terminal domain

Ddx5

XP_008839826.1

Domain structure obtained by HMM

Protein ID: XP_008839826.1 - probable ATP-dependent RNA helicase DDX5
KEEG Ortholog ID: K12823

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DEAD	PF00270	176	7.5e-51	158.500	118	288	118	289	DEAD/DEAH box helicase
ResIII	PF04851	171	0.035	0.300	310	336	291	392	Type III restriction enzyme, res subunit
Helicase_C	PF00271	111	5.3e-35	106.500	327	435	324	436	Helicase conserved C-terminal domain
P68HR	PF08061	33	3.9e-22	64.500	498	532	498	532	P68HR (NUC004) repeat
P68HR	PF08061	33	8.7e-21	60.200	551	583	551	583	P68HR (NUC004) repeat

oncogene

0.762

2.667

DEAD (PF00270): DEAD/DEAH box helicase
ResIII (PF04851): Type III restriction enzyme, res subunit
Helicase_C (PF00271): Helicase conserved C-terminal domain
P68HR (PF08061): P68HR (NUC004) repeat

Dgcr8

XP_008841237.1

Domain structure obtained by HMM

Protein ID: XP_008841237.1 - microprocessor complex subunit DGCR8
KEEG Ortholog ID: K18419

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
WW	PF00397	31	0.00000019	17.300	303	332	303	332	WW domain
dsrm	PF00035	67	7.1e-17	48.200	514	576	512	576	Double-stranded RNA binding motif
dsrm	PF00035	67	0.0000000081	22.400	620	684	620	684	Double-stranded RNA binding motif
dsrm	PF00035	67	0.017	2.100	717	730	713	771	Double-stranded RNA binding motif

interactor

0.600

3.500

WW (PF00397): WW domain
dsrm (PF00035): Double-stranded RNA binding motif

Dsn1

XP_008849386.2

Domain structure obtained by HMM

Protein ID: XP_008849386.2 - kinetochore-associated protein DSN1 homolog
KEEG Ortholog ID: K11544

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
MIS13	PF08202	301	1.4e-60	191.200	79	341	74	344	Mis12-Mtw1 protein family

interactor

0.628

15.706

MIS13 (PF08202): Mis12-Mtw1 protein family

Eif2b3

XP_008847079.1

Domain structure obtained by HMM

Protein ID: XP_008847079.1 - translation initiation factor eIF-2B subunit gamma isoform X1
KEEG Ortholog ID: K03241

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
NTP_transferase	PF00483	248	1.3e-20	60.100	5	130	4	139	Nucleotidyl transferase
NAGPA	PF09992	170	0.000014	11.500	129	173	96	183	Phosphodiester glycosidase
CTP_transf_3	PF02348	221	0.021	0.800	215	268	201	277	Cytidylyltransferase
Hexapep	PF00132	36	0.017	1.300	351	368	336	372	Bacterial transferase hexapeptide (six repeats)
DUF4954	PF16314	655	0.00000042	14.500	356	448	318	451	Domain of unknown function (DUF4954)

interactor

1.000

NTP_transferase (PF00483): Nucleotidyl transferase
NAGPA (PF09992): Phosphodiester glycosidase
CTP_transf_3 (PF02348): Cytidylyltransferase
Hexapep (PF00132): Bacterial transferase hexapeptide (six repeats)
DUF4954 (PF16314): Domain of unknown function (DUF4954)

Epb41l5

XP_017653061.1

Domain structure obtained by HMM

Protein ID: XP_017653061.1 - band 4.1-like protein 5 isoform X3

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
FERM_N	PF09379	65	1e-18	53.400	47	108	47	109	FERM N-terminal domain
FERM_M	PF00373	118	7.9e-24	70.600	127	235	126	235	FERM central domain
FERM_C	PF09380	94	5.1e-26	77.200	241	330	239	331	FERM C-terminal PH-like domain
FA	PF08736	44	2.7e-18	52.200	337	378	337	378	FERM adjacent (FA)
ACBP	PF00887	85	0.038	0.600	445	481	422	483	Acyl CoA binding protein

interactor

1.000

FERM_N (PF09379): FERM N-terminal domain
FERM_M (PF00373): FERM central domain
FERM_C (PF09380): FERM C-terminal PH-like domain
FA (PF08736): FERM adjacent (FA)
ACBP (PF00887): Acyl CoA binding protein

Exoc1

XP_008831524.1

Domain structure obtained by HMM

Protein ID: XP_008831524.1 - exocyst complex component 1 isoform X1
KEEG Ortholog ID: K19983

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Sec3-PIP2_bind	PF15277	90	2.4e-30	90.900	32	121	32	121	Exocyst complex component SEC3 N-terminal PIP2 binding PH
Cor1	PF04803	132	0.0026	4.200	165	258	142	262	Cor1/Xlr/Xmr conserved region
Sec3_C	PF09763	700	9.2e-183	595.300	191	896	190	896	Exocyst complex component Sec3

interactor

0.667

1.333

Sec3-PIP2_bind (PF15277): Exocyst complex component SEC3 N-terminal PIP2 binding PH
Cor1 (PF04803): Cor1/Xlr/Xmr conserved region
Sec3_C (PF09763): Exocyst complex component Sec3

Fam167a

XP_017652392.1

Domain structure obtained by HMM

Protein ID: XP_017652392.1 - protein FAM167A

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
LURAP	PF14854	117	0.00000054	15.800	113	155	103	181	Leucine rich adaptor protein
FAM167	PF11652	85	2.3e-44	136.100	131	215	131	215	FAM167

interactor

LURAP (PF14854): Leucine rich adaptor protein
FAM167 (PF11652): FAM167

Fbxo28

XP_008821962.1

Domain structure obtained by HMM

Protein ID: XP_008821962.1 - F-box only protein 28
KEEG Ortholog ID: K10306

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
F-box	PF00646	48	0.0000000093	21.400	67	93	62	94	F-box domain
CENP-H	PF05837	112	0.052	0.200	111	141	87	160	Centromere protein H (CENP-H)
ING	PF12998	102	0.0026	4.600	183	215	91	218	Inhibitor of growth proteins N-terminal histone-binding
FAM76	PF16046	300	0.0000000027	22.800	267	332	198	363	FAM76 protein
TRAF_BIRC3_bd	PF16673	64	0.021	1.000	340	359	312	367	TNF receptor-associated factor BIRC3 binding domain

interactor

1.000

F-box (PF00646): F-box domain
CENP-H (PF05837): Centromere protein H (CENP-H)
ING (PF12998): Inhibitor of growth proteins N-terminal histone-binding
FAM76 (PF16046): FAM76 protein
TRAF_BIRC3_bd (PF16673): TNF receptor-associated factor BIRC3 binding domain

Hnrnpa1

XP_008837331.1

Domain structure obtained by HMM

Protein ID: XP_008837331.1 - heterogeneous nuclear ribonucleoprotein A1 isoform X2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
RRM_1	PF00076	70	5.2e-22	63.800	16	82	16	85	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_1	PF00076	70	2.4e-20	58.500	107	167	107	176	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1	PF11627	38	2.2e-24	71.700	255	292	255	292	Nuclear factor hnRNPA1

interactor

0.303

41.333

RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627): Nuclear factor hnRNPA1

Hnrnpf

XP_008830911.1

Domain structure obtained by HMM

Protein ID: XP_008830911.1 - heterogeneous nuclear ribonucleoprotein F
KEEG Ortholog ID: K12898

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
RRM_1	PF00076	70	0.00000018	17.200	15	83	13	84	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14	PF07084	152	0.013	1.900	70	101	53	117	Thyroid hormone-inducible hepatic protein Spot 14
RRM_1	PF00076	70	2e-16	45.900	114	181	113	182	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF	PF08080	36	1.2e-26	78.700	255	290	255	290	RNPHF zinc finger
RRM_1	PF00076	70	0.00000000000077	34.500	293	356	291	358	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

interactor

1.000

RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080): RNPHF zinc finger

Hnrnph1

XP_008850480.1

Domain structure obtained by HMM

Protein ID: XP_008850480.1 - heterogeneous nuclear ribonucleoprotein H isoform X1
KEEG Ortholog ID: K12898

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
RRM_1	PF00076	70	0.00000000045	25.600	14	82	13	84	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_1	PF00076	70	5.2e-17	47.800	114	181	113	182	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF	PF08080	36	5e-27	80.000	255	290	255	290	RNPHF zinc finger
RRM_1	PF00076	70	0.00000000000043	35.300	293	355	291	358	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

oncogene

0.762

2.667

RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080): RNPHF zinc finger

Ipo4

XP_008838050.1

Domain structure obtained by HMM

Protein ID: XP_008838050.1 - importin-4 isoform X1
KEEG Ortholog ID: K20221

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
IBN_N	PF03810	74	0.000000000041	29.000	24	88	24	90	Importin-beta N-terminal domain
RIX1	PF08167	190	0.0000026	13.400	82	252	57	257	rRNA processing/ribosome biogenesis
HEAT	PF02985	31	0.0000000017	23.900	395	424	395	425	HEAT repeat
DUF3385	PF11865	161	0.00000029	16.600	422	508	345	512	Domain of unknown function (DUF3385)
HEAT_EZ	PF13513	55	0.0000073	12.700	495	550	486	551	HEAT-like repeat
UME	PF08064	102	0.00094	5.400	517	612	514	623	UME (NUC010) domain
HEAT_2	PF13646	88	0.000032	10.600	676	727	665	776	HEAT repeats
HEAT_PBS	PF03130	27	0.038	1.500	713	746	713	750	PBS lyase HEAT-like repeat
HEAT_EZ	PF13513	55	0.056	0.300	742	778	739	786	HEAT-like repeat
HEAT_EZ	PF13513	55	0.000000000012	31.200	912	967	912	967	HEAT-like repeat
IBN_N	PF03810	74	0.036	0.300	1020	1073	1017	1077	Importin-beta N-terminal domain

interactor

1.000

IBN_N (PF03810): Importin-beta N-terminal domain
RIX1 (PF08167): rRNA processing/ribosome biogenesis
HEAT (PF02985): HEAT repeat
DUF3385 (PF11865): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
UME (PF08064): UME (NUC010) domain
HEAT_2 (PF13646): HEAT repeats
HEAT_PBS (PF03130): PBS lyase HEAT-like repeat

Kifc3

XP_008833098.1

Domain structure obtained by HMM

Protein ID: XP_008833098.1 - kinesin-like protein KIFC3 isoform X5

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
HALZ	PF02183	43	0.00033	7.200	7	26	3	27	Homeobox associated leucine zipper
Spc7	PF08317	310	0.0000000084	20.800	69	188	67	193	Spc7 kinetochore protein
KxDL	PF10241	86	0.000029	10.600	204	253	193	259	Uncharacterized conserved protein
HIP1_clath_bdg	PF16515	99	0.000014	12.000	257	327	255	331	Clathrin-binding domain of Huntingtin-interacting protein 1
DUF4200	PF13863	119	0.00096	5.800	343	387	333	396	Domain of unknown function (DUF4200)
Kinesin	PF00225	333	6.7e-111	356.400	389	706	389	706	Kinesin motor domain

oncogene

0.500

5.000

HALZ (PF02183): Homeobox associated leucine zipper
Spc7 (PF08317): Spc7 kinetochore protein
KxDL (PF10241): Uncharacterized conserved protein
HIP1_clath_bdg (PF16515): Clathrin-binding domain of Huntingtin-interacting protein 1
DUF4200 (PF13863): Domain of unknown function (DUF4200)
Kinesin (PF00225): Kinesin motor domain

LOC103750566

XP_008851896.1

Domain structure obtained by HMM

Protein ID: XP_008851896.1 - polyamine-modulated factor 1-like isoform X1
KEEG Ortholog ID: K11546

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
MtmB	PF05369	450	0.0000084	10.800	28	82	18	85	Monomethylamine methyltransferase MtmB
Nnf1	PF03980	110	2.7e-26	78.400	70	167	68	168	Nnf1
CCAP	PF11105	128	0.00000055	15.800	132	194	112	197	Arthropod cardioacceleratory peptide 2a
NYD-SP28_assoc	PF14775	60	0.0054	3.200	180	198	171	200	Sperm tail C-terminal domain

interactor

0.606

16.250

MtmB (PF05369): Monomethylamine methyltransferase MtmB
Nnf1 (PF03980): Nnf1
CCAP (PF11105): Arthropod cardioacceleratory peptide 2a
NYD-SP28_assoc (PF14775): Sperm tail C-terminal domain

Leng8

XP_008825981.1

Domain structure obtained by HMM

Protein ID: XP_008825981.1 - leukocyte receptor cluster member 8

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
HJURP_mid	PF12346	115	0.0000066	12.900	469	548	458	551	Holliday junction recognition protein-associated repeat
SAC3_GANP	PF03399	293	4.4e-30	91.100	563	777	552	779	SAC3/GANP family

interactor

1.000

HJURP_mid (PF12346): Holliday junction recognition protein-associated repeat
SAC3_GANP (PF03399): SAC3/GANP family

Lig4

XP_008853418.1

Domain structure obtained by HMM

Protein ID: XP_008853418.1 - DNA ligase 4
KEEG Ortholog ID: K10777

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DNA_ligase_A_N	PF04675	173	9.6e-46	142.400	15	208	15	208	DNA ligase N terminus
APG17	PF04108	394	0.0000051	11.800	200	266	146	292	Autophagy protein Apg17
DNA_ligase_A_M	PF01068	204	3.3e-58	182.800	248	451	248	451	ATP dependent DNA ligase domain
DNA_ligase_A_C	PF04679	99	1.3e-21	63.400	476	588	476	588	ATP dependent DNA ligase C terminal region
BRCT_2	PF16589	85	0.0000000000013	34.300	657	740	655	742	BRCT domain, a BRCA1 C-terminus domain
DNA_ligase_IV	PF11411	34	4.6e-21	61.000	750	782	750	783	DNA ligase IV
BRCT	PF00533	79	0.0000000018	24.300	845	898	811	898	BRCA1 C Terminus (BRCT) domain
RTT107_BRCT_5	PF16770	100	0.00009	8.600	878	911	820	911	Regulator of Ty1 transposition protein 107 BRCT domain

interactor

0.500

2.667

DNA_ligase_A_N (PF04675): DNA ligase N terminus
APG17 (PF04108): Autophagy protein Apg17
DNA_ligase_A_M (PF01068): ATP dependent DNA ligase domain
DNA_ligase_A_C (PF04679): ATP dependent DNA ligase C terminal region
BRCT_2 (PF16589): BRCT domain, a BRCA1 C-terminus domain
DNA_ligase_IV (PF11411): DNA ligase IV
BRCT (PF00533): BRCA1 C Terminus (BRCT) domain
RTT107_BRCT_5 (PF16770): Regulator of Ty1 transposition protein 107 BRCT domain

Lmnb1

XP_008839204.1

Domain structure obtained by HMM

Protein ID: XP_008839204.1 - lamin-B1
KEEG Ortholog ID: K07611

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Filament	PF00038	312	3.7e-101	324.800	31	387	31	387	Intermediate filament protein
LTD	PF00932	111	5.6e-22	64.500	436	543	435	545	Lamin Tail Domain

interactor

0.667

1.000

Filament (PF00038): Intermediate filament protein
LTD (PF00932): Lamin Tail Domain

Lyrm4

XP_017653268.1

Domain structure obtained by HMM

Protein ID: XP_017653268.1 - LYR motif-containing protein 4 isoform X1

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Complex1_LYR	PF05347	59	2.6e-29	87.400	8	64	7	65	Complex 1 protein (LYR family)

interactor

1.000

Complex1_LYR (PF05347): Complex 1 protein (LYR family)

Mafb

XP_008847806.1

Domain structure obtained by HMM

Protein ID: XP_008847806.1 - transcription factor MafB
KEEG Ortholog ID: K09036

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Maf_N	PF08383	34	8.4e-26	75.800	81	113	80	113	Maf N-terminal region
bZIP_Maf	PF03131	92	1.8e-39	120.500	211	301	211	302	bZIP Maf transcription factor

oncogene

Maf_N (PF08383): Maf N-terminal region
bZIP_Maf (PF03131): bZIP Maf transcription factor

Map3k20

XP_008853497.1

Domain structure obtained by HMM

Protein ID: XP_008853497.1 - mitogen-activated protein kinase kinase kinase MLT isoform X2
KEEG Ortholog ID: K04424

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pkinase_Tyr	PF07714	260	7.5e-67	211.400	17	260	16	260	Protein tyrosine kinase
DUF3552	PF12072	201	0.00012	7.700	284	326	271	329	Domain of unknown function (DUF3552)
SAM_1	PF00536	64	0.00000000000017	37.200	339	407	337	408	SAM domain (Sterile alpha motif)
SAM_2	PF07647	66	0.023	1.200	571	583	565	587	SAM domain (Sterile alpha motif)

interactor

Pkinase_Tyr (PF07714): Protein tyrosine kinase
DUF3552 (PF12072): Domain of unknown function (DUF3552)
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
SAM_2 (PF07647): SAM domain (Sterile alpha motif)

Med24

XP_008827642.1

Domain structure obtained by HMM

Protein ID: XP_008827642.1 - mediator of RNA polymerase II transcription subunit 24 isoform X1
KEEG Ortholog ID: K15167

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Med24_N	PF11277	996	0	1310.300	1	1004	1	1004	Mediator complex subunit 24 N-terminal

interactor

1.000

Med24_N (PF11277): Mediator complex subunit 24 N-terminal

Mis12

XP_008854176.1

Domain structure obtained by HMM

Protein ID: XP_008854176.1 - protein MIS12 homolog
KEEG Ortholog ID: K11543

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Mis12	PF05859	135	2.6e-33	101.200	8	140	8	141	Mis12 protein
DUF349	PF03993	75	0.000041	10.200	115	163	108	170	Domain of Unknown Function (DUF349)

interactor

0.727

10.872

Mis12 (PF05859): Mis12 protein
DUF349 (PF03993): Domain of Unknown Function (DUF349)

Mlf1

XP_008835681.1

Domain structure obtained by HMM

Protein ID: XP_008835681.1 - myeloid leukemia factor 1 isoform X1
KEEG Ortholog ID: K15622

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Mlf1IP	PF10248	171	1.7e-79	251.900	26	202	26	202	Myelodysplasia-myeloid leukemia factor 1-interacting protein

oncogene

0.900

0.222

Mlf1IP (PF10248): Myelodysplasia-myeloid leukemia factor 1-interacting protein

Mtmr6

XP_008823214.1

Domain structure obtained by HMM

Protein ID: XP_008823214.1 - myotubularin-related protein 6
KEEG Ortholog ID: K18083

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Myotub-related	PF06602	341	3.1e-146	472.700	107	446	107	446	Myotubularin-like phosphatase domain
DUF5082	PF16888	123	0.0000026	14.000	509	547	472	550	Domain of unknown function (DUF5082)

interactor

Myotub-related (PF06602): Myotubularin-like phosphatase domain
DUF5082 (PF16888): Domain of unknown function (DUF5082)

Ndc80

XP_008832832.1

Domain structure obtained by HMM

Protein ID: XP_008832832.1 - kinetochore protein NDC80 homolog
KEEG Ortholog ID: K11547

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Ndc80_HEC	PF03801	153	2e-54	169.600	53	202	51	206	HEC/Ndc80p family
ADIP	PF11559	152	0.0000002	17.400	270	348	263	351	Afadin- and alpha -actinin-Binding
TMF_TATA_bd	PF12325	115	0.0000025	14.000	326	393	315	409	TATA element modulatory factor 1 TATA binding
DUF3810	PF12725	310	0.0001	7.800	364	433	352	441	Protein of unknown function (DUF3810)
SlyX	PF04102	67	0.0000057	13.200	482	522	469	535	SlyX
CREPT	PF16566	147	0.00005	9.700	531	611	527	628	Cell-cycle alteration and expression-elevated protein in tumour
HTH_40	PF14493	88	0.000021	11.300	582	638	567	642	Helix-turn-helix domain

interactor

0.549

25.539

Ndc80_HEC (PF03801): HEC/Ndc80p family
ADIP (PF11559): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325): TATA element modulatory factor 1 TATA binding
DUF3810 (PF12725): Protein of unknown function (DUF3810)
SlyX (PF04102): SlyX
CREPT (PF16566): Cell-cycle alteration and expression-elevated protein in tumour
HTH_40 (PF14493): Helix-turn-helix domain

Neu2

XP_008836328.1

Domain structure obtained by HMM

Protein ID: XP_008836328.1 - sialidase-2
KEEG Ortholog ID: K12357

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
BNR_2	PF13088	278	3.7e-49	153.600	33	342	32	345	BNR repeat-like domain

interactor

BNR_2 (PF13088): BNR repeat-like domain

Nfs1

XP_008838982.1

Domain structure obtained by HMM

Protein ID: XP_008838982.1 - cysteine desulfurase, mitochondrial
KEEG Ortholog ID: K04487

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Aminotran_5	PF00266	371	6.4e-97	310.800	62	423	61	424	Aminotransferase class-V

interactor

1.000

Aminotran_5 (PF00266): Aminotransferase class-V

Nsl1

XP_008823063.1

Domain structure obtained by HMM

Protein ID: XP_008823063.1 - kinetochore-associated protein NSL1 homolog isoform X1
KEEG Ortholog ID: K11545

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Mis14	PF08641	133	0.000000000000019	40.300	83	150	82	177	Kinetochore protein Mis14 like

interactor

0.944

0.472

Mis14 (PF08641): Kinetochore protein Mis14 like

Nuf2

XP_008846443.1

Domain structure obtained by HMM

Protein ID: XP_008846443.1 - kinetochore protein Nuf2
KEEG Ortholog ID: K11548

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Nuf2	PF03800	139	8.6e-40	122.300	4	144	3	146	Nuf2 family
DUF3106	PF11304	104	0.000029	10.800	151	226	142	230	Protein of unknown function (DUF3106)
ApoLp-III	PF07464	146	0.0000073	12.300	234	283	227	285	Apolipophorin-III precursor (apoLp-III)
Spc7	PF08317	310	0.000027	9.200	296	433	287	440	Spc7 kinetochore protein
Syntaxin	PF00804	200	0.00000018	17.200	387	455	384	463	Syntaxin

interactor

0.682

10.206

Nuf2 (PF03800): Nuf2 family
DUF3106 (PF11304): Protein of unknown function (DUF3106)
ApoLp-III (PF07464): Apolipophorin-III precursor (apoLp-III)
Spc7 (PF08317): Spc7 kinetochore protein
Syntaxin (PF00804): Syntaxin

Pcolce2

XP_017650657.1

Domain structure obtained by HMM

Protein ID: XP_017650657.1 - procollagen C-endopeptidase enhancer 2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
CUB	PF00431	110	1.9e-31	94.900	5	113	5	113	CUB domain
CUB	PF00431	110	2e-34	104.600	126	234	126	237	CUB domain
NTR	PF01759	107	6.7e-21	60.400	282	383	281	384	UNC-6/NTR/C345C module

interactor

CUB (PF00431): CUB domain
NTR (PF01759): UNC-6/NTR/C345C module

Phax

XP_008839216.1

Domain structure obtained by HMM

Protein ID: XP_008839216.1 - phosphorylated adapter RNA export protein
KEEG Ortholog ID: K14291

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
RNA_GG_bind	PF10258	84	1.4e-37	113.900	230	312	230	313	PHAX RNA-binding domain

interactor

RNA_GG_bind (PF10258): PHAX RNA-binding domain

Ppa2

XP_008839496.1

Domain structure obtained by HMM

Protein ID: XP_008839496.1 - inorganic pyrophosphatase 2, mitochondrial
KEEG Ortholog ID: K01507

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pyrophosphatase	PF00719	160	3.7e-62	195.000	98	280	98	280	Inorganic pyrophosphatase

interactor

Pyrophosphatase (PF00719): Inorganic pyrophosphatase

Ppp1cc

XP_008837623.1

Domain structure obtained by HMM

Protein ID: XP_008837623.1 - serine/threonine-protein phosphatase PP1-gamma catalytic subunit
KEEG Ortholog ID: K06269

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
STPPase_N	PF16891	48	2.5e-27	81.400	9	56	9	56	Serine-threonine protein phosphatase N-terminal domain
Metallophos	PF00149	204	6.7e-45	140.200	60	249	57	252	Calcineurin-like phosphoesterase

oncogene

0.444

18.333

STPPase_N (PF16891): Serine-threonine protein phosphatase N-terminal domain
Metallophos (PF00149): Calcineurin-like phosphoesterase

Rabl6

XP_008840142.1

Domain structure obtained by HMM

Protein ID: XP_008840142.1 - rab-like protein 6

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Roc	PF08477	120	0.00000000003	29.900	45	102	45	112	Ras of Complex, Roc, domain of DAPkinase
Eapp_C	PF10238	149	0.028	0.700	112	159	81	161	E2F-associated phosphoprotein
Ras	PF00071	162	0.000000061	18.600	136	218	132	228	Ras family
RP-C_C	PF11800	206	0.01	2.000	237	314	233	339	Replication protein C C-terminal region
Histone	PF00125	132	0.0063	3.100	458	507	450	513	Core histone H2A/H2B/H3/H4
CDC27	PF09507	427	0.0082	1.600	475	586	444	620	DNA polymerase subunit Cdc27
eIF3_subunit	PF08597	242	0.0000014	14.500	612	708	598	713	Translation initiation factor eIF3 subunit

oncogene

0.500

3.000

Roc (PF08477): Ras of Complex, Roc, domain of DAPkinase
Eapp_C (PF10238): E2F-associated phosphoprotein
Ras (PF00071): Ras family
RP-C_C (PF11800): Replication protein C C-terminal region
Histone (PF00125): Core histone H2A/H2B/H3/H4
CDC27 (PF09507): DNA polymerase subunit Cdc27
eIF3_subunit (PF08597): Translation initiation factor eIF3 subunit

Rasip1

XP_008843224.1

Domain structure obtained by HMM

Protein ID: XP_008843224.1 - ras-interacting protein 1

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DIL	PF01843	104	1.5e-27	82.300	426	531	426	533	DIL domain

interactor

DIL (PF01843): DIL domain

Rbm25

XP_008848013.1

Domain structure obtained by HMM

Protein ID: XP_008848013.1 - RNA-binding protein 25 isoform X1
KEEG Ortholog ID: K12822

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
RRM_1	PF00076	70	0.00000000000049	35.100	89	157	89	158	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
VID27	PF08553	803	0.0015	3.100	112	239	98	249	VID27 cytoplasmic protein
SMN	PF06003	264	0.018	0.400	211	256	177	268	Survival motor neuron protein (SMN)
PRP38_assoc	PF12871	99	0.000018	11.600	270	353	261	355	Pre-mRNA-splicing factor 38-associated hydrophilic C-term
U1snRNP70_N	PF12220	93	0.027	1.500	453	505	452	505	U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF3441	PF11923	116	0.017	1.400	488	545	486	553	Domain of unknown function (DUF3441)
DUF4778	PF16008	299	0.00031	6.900	524	740	493	746	Domain of unknown function (DUF4778)
Vfa1	PF08432	181	0.053	0.000	717	755	669	775	AAA-ATPase Vps4-associated protein 1
PWI	PF01480	69	9.6e-18	50.600	768	832	766	835	PWI domain

interactor

RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
VID27 (PF08553): VID27 cytoplasmic protein
SMN (PF06003): Survival motor neuron protein (SMN)
PRP38_assoc (PF12871): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
U1snRNP70_N (PF12220): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF3441 (PF11923): Domain of unknown function (DUF3441)
DUF4778 (PF16008): Domain of unknown function (DUF4778)
Vfa1 (PF08432): AAA-ATPase Vps4-associated protein 1
PWI (PF01480): PWI domain

Rcn1

XP_008849642.1

Domain structure obtained by HMM

Protein ID: XP_008849642.1 - reticulocalbin-1

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
EF-hand_7	PF13499	71	0.000000000019	30.600	83	140	77	141	EF-hand domain pair
EF-hand_7	PF13499	71	0.000000021	20.900	169	226	165	229	EF-hand domain pair
EF-hand_6	PF13405	31	0.00000062	15.600	245	269	244	274	EF-hand domain
EF-hand_7	PF13499	71	0.0000025	14.300	253	302	245	305	EF-hand domain pair
EF-hand_4	PF12763	104	0.036	0.400	295	315	285	324	Cytoskeletal-regulatory complex EF hand

interactor

EF-hand_7 (PF13499): EF-hand domain pair
EF-hand_6 (PF13405): EF-hand domain
EF-hand_4 (PF12763): Cytoskeletal-regulatory complex EF hand

Rin1

XP_008820481.1

Domain structure obtained by HMM

Protein ID: XP_008820481.1 - LOW QUALITY PROTEIN: ras and Rab interactor 1
KEEG Ortholog ID: K17638

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SH2	PF00017	77	0.000000088	18.500	101	170	92	170	SH2 domain
PRIMA1	PF16101	121	0.003	3.800	261	300	256	312	Proline-rich membrane anchor 1
VPS9	PF02204	104	1.2e-26	79.300	514	612	513	615	Vacuolar sorting protein 9 (VPS9) domain
RA	PF00788	93	0.000000045	20.000	646	729	645	735	Ras association (RalGDS/AF-6) domain

interactor

SH2 (PF00017): SH2 domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
VPS9 (PF02204): Vacuolar sorting protein 9 (VPS9) domain
RA (PF00788): Ras association (RalGDS/AF-6) domain

Scmh1

XP_008833645.1

Domain structure obtained by HMM

Protein ID: XP_008833645.1 - polycomb protein SCMH1 isoform X2
KEEG Ortholog ID: K11461

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
MBT	PF02820	69	3e-24	71.500	62	129	62	130	mbt repeat
MBT	PF02820	69	5.6e-30	89.900	171	236	171	238	mbt repeat
RBR	PF17208	57	6.4e-16	45.200	271	324	271	324	RNA binding Region
SLED	PF12140	112	1.7e-40	124.300	358	466	358	466	SLED domain
SAM_1	PF00536	64	2.9e-20	58.800	596	661	596	661	SAM domain (Sterile alpha motif)

interactor

MBT (PF02820): mbt repeat
RBR (PF17208): RNA binding Region
SLED (PF12140): SLED domain
SAM_1 (PF00536): SAM domain (Sterile alpha motif)

Slc25a19

XP_008829636.1

Domain structure obtained by HMM

Protein ID: XP_008829636.1 - mitochondrial thiamine pyrophosphate carrier isoform X1
KEEG Ortholog ID: K15108

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Mito_carr	PF00153	97	7.3e-22	63.500	27	118	21	119	Mitochondrial carrier protein
Mito_carr	PF00153	97	1.4e-25	75.300	125	209	122	212	Mitochondrial carrier protein
Mito_carr	PF00153	97	5.4e-26	76.700	221	318	220	320	Mitochondrial carrier protein

interactor

Mito_carr (PF00153): Mitochondrial carrier protein

Smg5

XP_008851847.1

Domain structure obtained by HMM

Protein ID: XP_008851847.1 - protein SMG5
KEEG Ortholog ID: K11125

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
EST1	PF10374	136	1.5e-28	86.400	77	188	77	189	Telomerase activating protein Est1
EST1_DNA_bind	PF10373	283	6.9e-36	110.200	197	400	197	426	Est1 DNA/RNA binding domain
EST1_DNA_bind	PF10373	283	0.0000000011	24.300	650	743	573	745	Est1 DNA/RNA binding domain
PIN_4	PF13638	131	0.00000000077	25.400	859	941	858	966	PIN domain

interactor

0.667

0.500

EST1 (PF10374): Telomerase activating protein Est1
EST1_DNA_bind (PF10373): Est1 DNA/RNA binding domain
PIN_4 (PF13638): PIN domain

Smtn

XP_017655598.1

Domain structure obtained by HMM

Protein ID: XP_017655598.1 - smoothelin isoform X4

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Smoothelin	PF12510	50	0.0000000000000036	42.100	1	41	1	41	Smoothelin cytoskeleton protein
Smoothelin	PF12510	50	2.3e-19	55.500	74	122	73	122	Smoothelin cytoskeleton protein
Smoothelin	PF12510	50	1.6e-24	72.000	572	619	570	619	Smoothelin cytoskeleton protein
Nop25	PF09805	137	0.001	5.800	609	688	598	709	Nucleolar protein 12 (25kDa)
CH	PF00307	109	8.6e-20	57.300	802	870	800	878	Calponin homology (CH) domain

interactor

Smoothelin (PF12510): Smoothelin cytoskeleton protein
Nop25 (PF09805): Nucleolar protein 12 (25kDa)
CH (PF00307): Calponin homology (CH) domain

Snap29

XP_008840461.1

Domain structure obtained by HMM

Protein ID: XP_008840461.1 - synaptosomal-associated protein 29
KEEG Ortholog ID: K08509

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
V-SNARE_C	PF12352	66	0.0000000008	25.200	58	110	49	111	Snare region anchored in the vesicle membrane C-terminus
DUF1664	PF07889	124	0.000077	8.900	192	254	180	255	Protein of unknown function (DUF1664)

interactor

0.333

9.500

V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus
DUF1664 (PF07889): Protein of unknown function (DUF1664)

Spc25

XP_008836037.1

Domain structure obtained by HMM

Protein ID: XP_008836037.1 - kinetochore protein Spc25
KEEG Ortholog ID: K11550

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF3800	PF12686	239	0.0000086	11.700	23	80	15	94	Protein of unknown function (DUF3800)
Spc7	PF08317	310	0.000000012	20.300	62	160	28	162	Spc7 kinetochore protein
Spindle_Spc25	PF08234	73	4e-26	77.400	150	219	149	220	Chromosome segregation protein Spc25

interactor

0.778

6.556

DUF3800 (PF12686): Protein of unknown function (DUF3800)
Spc7 (PF08317): Spc7 kinetochore protein
Spindle_Spc25 (PF08234): Chromosome segregation protein Spc25

Sqor

XP_008847513.1

Domain structure obtained by HMM

Protein ID: XP_008847513.1 - sulfide:quinone oxidoreductase, mitochondrial
KEEG Ortholog ID: K17218

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Spermine_synth	PF01564	247	0.000013	10.400	38	59	32	76	Spermine/spermidine synthase
Pyr_redox_2	PF07992	292	0.000000000000092	37.400	45	161	45	193	Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_2	PF07992	292	0.00000015	17.000	241	348	215	355	Pyridine nucleotide-disulphide oxidoreductase

interactor

Spermine_synth (PF01564): Spermine/spermidine synthase
Pyr_redox_2 (PF07992): Pyridine nucleotide-disulphide oxidoreductase

Ssr3

XP_008835669.1

Domain structure obtained by HMM

Protein ID: XP_008835669.1 - translocon-associated protein subunit gamma
KEEG Ortholog ID: K13251

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
TRAP-gamma	PF07074	170	2.6e-88	280.100	12	183	12	183	Translocon-associated protein, gamma subunit (TRAP-gamma)

interactor

TRAP-gamma (PF07074): Translocon-associated protein, gamma subunit (TRAP-gamma)

Stx11

XP_008828031.1

Domain structure obtained by HMM

Protein ID: XP_008828031.1 - syntaxin-11
KEEG Ortholog ID: K08487

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Syntaxin	PF00804	200	3.5e-68	215.400	41	238	41	239	Syntaxin
SNARE	PF05739	53	0.00000000069	25.200	242	283	240	286	SNARE domain

interactor

0.667

0.500

Syntaxin (PF00804): Syntaxin
SNARE (PF05739): SNARE domain

Stx18

XP_008831338.1

Domain structure obtained by HMM

Protein ID: XP_008831338.1 - syntaxin-18
KEEG Ortholog ID: K08492

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Syntaxin-18_N	PF10496	84	3.3e-25	74.500	4	96	3	96	SNARE-complex protein Syntaxin-18 N-terminus
Phage_Integr_2	PF13009	324	0.00000067	14.800	91	163	56	191	Putative phage integrase

interactor

0.500

2.667

Syntaxin-18_N (PF10496): SNARE-complex protein Syntaxin-18 N-terminus
Phage_Integr_2 (PF13009): Putative phage integrase

Stx19

XP_008830463.1

Domain structure obtained by HMM

Protein ID: XP_008830463.1 - syntaxin-19
KEEG Ortholog ID: K08487

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Syntaxin	PF00804	200	2.3e-61	193.100	48	244	47	244	Syntaxin
SNARE	PF05739	53	0.0000027	13.600	247	288	245	291	SNARE domain

interactor

Syntaxin (PF00804): Syntaxin
SNARE (PF05739): SNARE domain

Stx3

XP_008840236.1

Domain structure obtained by HMM

Protein ID: XP_008840236.1 - syntaxin-3 isoform X1
KEEG Ortholog ID: K08486

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF4162	PF13732	81	0.00075	6.600	9	51	2	54	Domain of unknown function (DUF4162)
Syntaxin	PF00804	200	8.5e-65	204.300	32	226	32	226	Syntaxin
SNARE	PF05739	53	7.4e-17	47.500	227	265	227	267	SNARE domain

interactor

1.000

DUF4162 (PF13732): Domain of unknown function (DUF4162)
Syntaxin (PF00804): Syntaxin
SNARE (PF05739): SNARE domain

Sugp1

XP_008822703.2

Domain structure obtained by HMM

Protein ID: XP_008822703.2 - SURP and G-patch domain-containing protein 1
KEEG Ortholog ID: K13096

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
ATP-synt_E	PF05680	96	0.00026	7.600	22	61	10	80	ATP synthase E chain
Surp	PF01805	53	5.8e-20	57.400	185	236	185	237	Surp module
Surp	PF01805	53	0.0000000000000018	43.100	262	312	260	312	Surp module
G-patch_2	PF12656	61	0.031	0.800	416	429	416	448	G-patch domain
ATP-synt_E	PF05680	96	0.064	0.000	435	471	427	497	ATP synthase E chain
RtcB	PF01139	412	0.000011	10.800	448	523	420	527	tRNA-splicing ligase RtcB
G-patch	PF01585	45	3.3e-19	54.900	561	604	560	605	G-patch domain

interactor

ATP-synt_E (PF05680): ATP synthase E chain
Surp (PF01805): Surp module
G-patch_2 (PF12656): G-patch domain
RtcB (PF01139): tRNA-splicing ligase RtcB
G-patch (PF01585): G-patch domain

Syce3

XP_008833003.1

Domain structure obtained by HMM

Protein ID: XP_008833003.1 - synaptonemal complex central element protein 3
KEEG Ortholog ID: K19536

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Synaptonemal_3	PF15191	92	5e-43	131.200	10	94	10	94	Synaptonemal complex central element protein 3

interactor

1.000

Synaptonemal_3 (PF15191): Synaptonemal complex central element protein 3

Taf12

XP_008846165.1

Domain structure obtained by HMM

Protein ID: XP_008846165.1 - transcription initiation factor TFIID subunit 12 isoform X1
KEEG Ortholog ID: K03126

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
TFIID_20kDa	PF03847	68	3e-40	122.900	59	126	59	126	Transcription initiation factor TFIID subunit A

interactor

TFIID_20kDa (PF03847): Transcription initiation factor TFIID subunit A

Tcf12

XP_008845765.1

Domain structure obtained by HMM

Protein ID: XP_008845765.1 - transcription factor 12 isoform X13

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
HLH	PF00010	55	0.039	0.300	257	271	225	288	Helix-loop-helix DNA-binding domain
CDC45	PF02724	627	0.00038	4.900	375	445	339	505	CDC45-like protein
HLH	PF00010	55	0.000000000000016	39.900	432	485	432	485	Helix-loop-helix DNA-binding domain

oncogene

HLH (PF00010): Helix-loop-helix DNA-binding domain
CDC45 (PF02724): CDC45-like protein

Thbs2

XP_008841609.1

Domain structure obtained by HMM

Protein ID: XP_008841609.1 - thrombospondin-2
KEEG Ortholog ID: K04659

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Laminin_G_3	PF13385	152	0.0000038	13.300	107	211	70	213	Concanavalin A-like lectin/glucanases superfamily
VWC	PF00093	57	1.8e-16	46.600	320	374	320	374	von Willebrand factor type C domain
TSP_1	PF00090	49	2.9e-16	45.800	384	429	384	429	Thrombospondin type 1 domain
TSP_1	PF00090	49	5.3e-19	54.600	440	490	440	490	Thrombospondin type 1 domain
TSP_1	PF00090	49	1.1e-19	56.700	497	547	497	547	Thrombospondin type 1 domain
EGF_3	PF12947	36	0.0001	8.800	556	587	552	587	EGF domain
cEGF	PF12662	24	0.00000012	17.900	572	592	570	592	Complement Clr-like EGF-like
EGF_CA	PF07645	42	0.00000000011	27.900	589	626	589	645	Calcium-binding EGF domain
EGF_3	PF12947	36	0.0000000000036	32.700	651	690	651	690	EGF domain
TSP_3	PF02412	36	0.0000057	12.300	689	711	684	713	Thrombospondin type 3 repeat
TSP_3	PF02412	36	0.0017	4.400	716	727	715	727	Thrombospondin type 3 repeat
TSP_3	PF02412	36	0.00000000000015	36.500	728	763	728	763	Thrombospondin type 3 repeat
TSP_3	PF02412	36	0.000000037	19.300	764	786	762	786	Thrombospondin type 3 repeat
TSP_3	PF02412	36	0.0000000000055	31.500	788	822	787	822	Thrombospondin type 3 repeat
TSP_3	PF02412	36	0.000000023	20.000	823	845	822	845	Thrombospondin type 3 repeat
TSP_3	PF02412	36	0.000000000000066	37.700	846	883	846	883	Thrombospondin type 3 repeat
TSP_3	PF02412	36	0.0000000000007	34.400	885	919	884	919	Thrombospondin type 3 repeat
TSP_3	PF02412	36	0.0000000000018	33.100	920	951	920	955	Thrombospondin type 3 repeat
TSP_C	PF05735	198	6.3e-100	319.200	973	1170	973	1170	Thrombospondin C-terminal region

oncogene

Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
VWC (PF00093): von Willebrand factor type C domain
TSP_1 (PF00090): Thrombospondin type 1 domain
EGF_3 (PF12947): EGF domain
cEGF (PF12662): Complement Clr-like EGF-like
EGF_CA (PF07645): Calcium-binding EGF domain
TSP_3 (PF02412): Thrombospondin type 3 repeat
TSP_C (PF05735): Thrombospondin C-terminal region

Tjap1

XP_008827294.1

Domain structure obtained by HMM

Protein ID: XP_008827294.1 - tight junction-associated protein 1 isoform X1
KEEG Ortholog ID: K06105

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
HMMR_N	PF15905	335	0.000000032	19.400	49	180	45	224	Hyaluronan mediated motility receptor N-terminal
DUF342	PF03961	454	0.0043	1.700	146	194	134	213	Protein of unknown function (DUF342)
Pilt	PF15453	365	6.5e-58	182.900	295	457	284	473	Protein incorporated later into Tight Junctions
Pilt	PF15453	365	4.1e-24	71.700	486	562	468	562	Protein incorporated later into Tight Junctions

interactor

1.000

HMMR_N (PF15905): Hyaluronan mediated motility receptor N-terminal
DUF342 (PF03961): Protein of unknown function (DUF342)
Pilt (PF15453): Protein incorporated later into Tight Junctions

Tmem126a

XP_008842394.1

Domain structure obtained by HMM

Protein ID: XP_008842394.1 - transmembrane protein 126A isoform X1
KEEG Ortholog ID: K18157

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
TMEM126	PF07114	180	7.4e-46	141.900	52	170	51	174	Transmembrane protein 126
TMEM126	PF07114	180	1.7e-83	264.600	186	362	184	363	Transmembrane protein 126

interactor

TMEM126 (PF07114): Transmembrane protein 126

Tmpo

XP_017653378.1

Domain structure obtained by HMM

Protein ID: XP_017653378.1 - thymopoietin isoform X4

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Thymopoietin	PF08198	48	5.2e-33	98.800	2	49	2	49	Thymopoietin protein
LEM	PF03020	40	5.8e-23	66.500	110	149	110	149	LEM domain
OPT	PF03169	618	0.0000055	11.300	287	326	249	336	OPT oligopeptide transporter protein

interactor

1.000

Thymopoietin (PF08198): Thymopoietin protein
LEM (PF03020): LEM domain
OPT (PF03169): OPT oligopeptide transporter protein

Tp53

NP_001306217.1

Domain structure obtained by HMM

Protein ID: NP_001306217.1 - tumor protein p53
KEEG Ortholog ID: K04451

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
P53_TAD	PF08563	25	7.9e-17	46.700	5	29	5	29	P53 transactivation motif
P53	PF00870	196	1.9e-119	382.500	93	287	93	287	P53 DNA-binding domain
P53_tetramer	PF07710	42	2.2e-21	61.300	317	355	317	356	P53 tetramerisation motif

tumor suppressor

0.309

37.000

P53_TAD (PF08563): P53 transactivation motif
P53 (PF00870): P53 DNA-binding domain
P53_tetramer (PF07710): P53 tetramerisation motif

Trim28

XP_008821046.1

Domain structure obtained by HMM

Protein ID: XP_008821046.1 - transcription intermediary factor 1-beta
KEEG Ortholog ID: K08882

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
zf-RING_5	PF14634	44	0.000000000000023	39.400	48	106	48	106	zinc-RING finger domain
DUF1178	PF06676	150	0.0024	4.500	97	151	86	179	Protein of unknown function (DUF1178)
zf-B_box	PF00643	42	0.0000000001	28.000	134	177	132	179	B-box zinc finger
zf-B_box	PF00643	42	0.0000000000015	33.800	191	227	188	229	B-box zinc finger
FYVE_2	PF02318	118	0.00043	6.800	204	239	193	245	FYVE-type zinc finger
SKA2	PF16740	110	0.0019	4.300	230	287	217	289	Spindle and kinetochore-associated protein 2
SKA2	PF16740	110	0.002	4.200	281	330	269	346	Spindle and kinetochore-associated protein 2
K_channel_TID	PF07941	74	0.0028	4.400	506	526	499	533	Potassium channel Kv1.4 tandem inactivation domain
PHD	PF00628	52	0.0000000000064	31.600	609	652	609	654	PHD-finger

interactor

1.000

zf-RING_5 (PF14634): zinc-RING finger domain
DUF1178 (PF06676): Protein of unknown function (DUF1178)
zf-B_box (PF00643): B-box zinc finger
FYVE_2 (PF02318): FYVE-type zinc finger
SKA2 (PF16740): Spindle and kinetochore-associated protein 2
K_channel_TID (PF07941): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628): PHD-finger

Tyw3

XP_008851860.2

Domain structure obtained by HMM

Protein ID: XP_008851860.2 - tRNA wybutosine-synthesizing protein 3 homolog
KEEG Ortholog ID: K15450

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
TYW3	PF02676	214	3.2e-59	185.900	77	254	69	255	Methyltransferase TYW3

interactor

1.000

TYW3 (PF02676): Methyltransferase TYW3

Zw10

XP_008830971.1

Domain structure obtained by HMM

Protein ID: XP_008830971.1 - centromere/kinetochore protein zw10 homolog isoform X3

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Zw10	PF06248	595	2.6e-68	216.900	9	193	9	195	Centromere/kinetochore Zw10
Zw10	PF06248	595	2.4e-39	121.200	194	313	193	323	Centromere/kinetochore Zw10
Zw10	PF06248	595	7.9e-129	416.700	353	612	347	613	Centromere/kinetochore Zw10
DUF4363	PF14276	120	0.00032	7.000	593	627	589	631	Domain of unknown function (DUF4363)
RST	PF12174	67	0.000085	8.800	710	727	706	730	RCD1-SRO-TAF4 (RST) plant domain

interactor

0.667

Zw10 (PF06248): Centromere/kinetochore Zw10
DUF4363 (PF14276): Domain of unknown function (DUF4363)
RST (PF12174): RCD1-SRO-TAF4 (RST) plant domain

B a c k t o T o p ⇑