Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Zwint (from a repository: Fri Apr 13 07:53:28 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)81
The number (and %) of the onco-proteins15 (18.52 %)
The number (and %) of the tumor suppressors3 (3.70 %)
Total number of binary PPIs (saturation %)212 (6.54 %)
The number (and %) of affected PPIs81 (38.21 %)
PPI diameter2
PPI radius1
The average degree of PPI4.716
Assortativity coefficient-0.6350
The network average Clustering coefficient0.474
The number (and %) of a zero Clustering coefficients30 (37.04 %)
The number (and %) of a zero Betweenness Centrality50 (61.73 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure		 Type Number
of PPI (degree)		 Clustering
Coefficient		 Betweenness
Centrality		 Domains (Pfam ID): description
Zwint

Domain structure obtained by HMM

Protein ID: XP_017652612.1 - ZW10 interactor isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
VIT1PF019882140.00263.70012623117VIT family
ZwintPF155562522.4e-93298.3002823328240ZW10 interactor
user protein810.0355767.372VIT1 (PF01988): VIT family
Zwint (PF15556): ZW10 interactor
Ap3s1

Domain structure obtained by HMM

Protein ID: XP_008823495.1 - AP-3 complex subunit sigma-1 isoform X1
KEEG Ortholog ID: K12399
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Clat_adaptor_sPF012171423.5e-58181.80011471148Clathrin adaptor complex small chain
interactor21.0000Clat_adaptor_s (PF01217): Clathrin adaptor complex small chain
App

Domain structure obtained by HMM

Protein ID: XP_017657176.1 - amyloid beta A4 protein
KEEG Ortholog ID: K04520
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
APP_NPF021771008.1e-49150.5003113131131Amyloid A4 N-terminal heparin-binding
APP_Cu_bdPF12924571.8e-2988.600132188132188Copper-binding of amyloid precursor, CuBD
SDA1PF052853470.000005912.000193270155307SDA1
YtxHPF12732750.00483.800251291245298YtxH-like protein
Kunitz_BPTIPF00014531.4e-2369.200291342291343Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2PF129251901e-78249.500365547365547E2 domain of amyloid precursor protein
YtxHPF12732750.0291.300520565516576YtxH-like protein
Beta-APPPF03494393.3e-2883.600676712674712Beta-amyloid peptide (beta-APP)
APP_amyloidPF10515523.7e-2987.400715765715765beta-amyloid precursor protein C-terminus
interactor160.17183.333APP_N (PF02177): Amyloid A4 N-terminal heparin-binding
APP_Cu_bd (PF12924): Copper-binding of amyloid precursor, CuBD
SDA1 (PF05285): SDA1
YtxH (PF12732): YtxH-like protein
Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2 (PF12925): E2 domain of amyloid precursor protein
Beta-APP (PF03494): Beta-amyloid peptide (beta-APP)
APP_amyloid (PF10515): beta-amyloid precursor protein C-terminus
Arhgap32

Domain structure obtained by HMM

Protein ID: XP_008839592.2 - rho GTPase-activating protein 32 isoform X2
KEEG Ortholog ID: K20647
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PXPF007871130.000000007521.9007514958152PX domain
SH3_9PF14604490.00000000000432.200192243192243Variant SH3 domain
RPELPF02755240.000001913.800276293271294RPEL repeat
RhoGAPPF006201526.3e-49151.900312460312464RhoGAP domain
oncogene100PX (PF00787): PX domain
SH3_9 (PF14604): Variant SH3 domain
RPEL (PF02755): RPEL repeat
RhoGAP (PF00620): RhoGAP domain
Arpc5

Domain structure obtained by HMM

Protein ID: XP_008822514.1 - actin-related protein 2/3 complex subunit 5
KEEG Ortholog ID: K05754
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
P16-ArcPF046991471e-64203.7001015110151ARP2/3 complex 16 kDa subunit (p16-Arc)
interactor100P16-Arc (PF04699): ARP2/3 complex 16 kDa subunit (p16-Arc)
Aste1

Domain structure obtained by HMM

Protein ID: XP_017651590.1 - protein asteroid homolog 1 isoform X1
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
XPG_NPF007521010.000000004223.2001971102XPG N-terminal domain
XPG_I_2PF128132490.00000000000001540.200116226115241XPG domain containing
IL4PF007271090.00862.600274303252317Interleukin 4
interactor100XPG_N (PF00752): XPG N-terminal domain
XPG_I_2 (PF12813): XPG domain containing
IL4 (PF00727): Interleukin 4
Baiap2l1

Domain structure obtained by HMM

Protein ID: XP_008822246.2 - brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 isoform X1
KEEG Ortholog ID: K20127
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
IMDPF083972194e-67211.9001623616236IRSp53/MIM homology domain
SH3_9PF14604493e-1645.400347398346398Variant SH3 domain
interactor21.0000IMD (PF08397): IRSp53/MIM homology domain
SH3_9 (PF14604): Variant SH3 domain
Becn1

Domain structure obtained by HMM

Protein ID: XP_008833560.1 - beclin-1 isoform X1
KEEG Ortholog ID: K08334
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Ima1_NPF097791360.00096.3008732183Ima1 N-terminal domain
BH3PF15285254.6e-2160.600103127103127Beclin-1 BH3 domain, Bcl-2-interacting
APG6PF041113121.3e-134434.600133444133444Autophagy protein Apg6
tumor suppressor31.0000Ima1_N (PF09779): Ima1 N-terminal domain
BH3 (PF15285): Beclin-1 BH3 domain, Bcl-2-interacting
APG6 (PF04111): Autophagy protein Apg6
Bub1

Domain structure obtained by HMM

Protein ID: XP_008847440.1 - mitotic checkpoint serine/threonine-protein kinase BUB1
KEEG Ortholog ID: K02178
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Mad3_BUB1_IPF083111241.8e-41127.20081266126Mad3/BUB1 homology region 1
PkinasePF000692648.6e-2367.100570785567797Protein kinase domain
oncogene110.68910.250Mad3_BUB1_I (PF08311): Mad3/BUB1 homology region 1
Pkinase (PF00069): Protein kinase domain
Bub1b

Domain structure obtained by HMM

Protein ID: XP_008840535.1 - mitotic checkpoint serine/threonine-protein kinase BUB1 beta
KEEG Ortholog ID: K06637
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Mad3_BUB1_IPF083111249.9e-48147.5005818058180Mad3/BUB1 homology region 1
OmpHPF039381560.000346.800165284151286Outer membrane protein (OmpH-like)
Mad3_BUB1_IIPF08171680.000007512.300388430374432Mad3/BUB1 homology region 2
XhlAPF10779670.00027.900430461420480Haemolysin XhlA
PkinasePF000692640.00000000000007737.700820919813968Protein kinase domain
oncogene100.7787.222Mad3_BUB1_I (PF08311): Mad3/BUB1 homology region 1
OmpH (PF03938): Outer membrane protein (OmpH-like)
Mad3_BUB1_II (PF08171): Mad3/BUB1 homology region 2
XhlA (PF10779): Haemolysin XhlA
Pkinase (PF00069): Protein kinase domain
Ccdc14

Domain structure obtained by HMM

Protein ID: XP_008841185.1 - coiled-coil domain-containing protein 14
KEEG Ortholog ID: K16541
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
CCDC14PF1525488201316.1004989649896Coiled-coil domain-containing protein 14
interactor31.0000CCDC14 (PF15254): Coiled-coil domain-containing protein 14
Ccdc174

Domain structure obtained by HMM

Protein ID: XP_008853157.1 - coiled-coil domain-containing protein 174
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
5_3_exonucPF01367970.000188.4006099551345'-3' exonuclease, C-terminal SAM fold
TPX2PF06886570.0350.700114142112148Targeting protein for Xklp2 (TPX2)
TPX2PF06886570.00004410.000198226191230Targeting protein for Xklp2 (TPX2)
DUF4078PF13300861.5e-3194.900212300212300Domain of unknown function (DUF4078)
interactor1005_3_exonuc (PF01367): 5'-3' exonuclease, C-terminal SAM fold
TPX2 (PF06886): Targeting protein for Xklp2 (TPX2)
DUF4078 (PF13300): Domain of unknown function (DUF4078)
Ccdc22

Domain structure obtained by HMM

Protein ID: XP_008840822.1 - coiled-coil domain-containing protein 22
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF812PF056675981.6e-212693.60015971597Protein of unknown function (DUF812)
ATG16PF086142030.00003110.400548624537625Autophagy protein 16 (ATG16)
interactor100DUF812 (PF05667): Protein of unknown function (DUF812)
ATG16 (PF08614): Autophagy protein 16 (ATG16)
Cenpc

Domain structure obtained by HMM

Protein ID: XP_008852050.1 - centromere protein C isoform X1
KEEG Ortholog ID: K11497
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
CENP_C_NPF156222883.2e-116373.80072817282Kinetochore assembly subunit CENP-C N-terminal
CENP-C_midPF156202601.6e-113365.100286543286543Centromere assembly component CENP-C middle DNMT3B-binding region
CENP-C_midPF156202600.021.000684743671746Centromere assembly component CENP-C middle DNMT3B-binding region
CENP-C_CPF11699851.4e-3091.700849932848932Mif2/CENP-C like
interactor80.6079.667CENP_C_N (PF15622): Kinetochore assembly subunit CENP-C N-terminal
CENP-C_mid (PF15620): Centromere assembly component CENP-C middle DNMT3B-binding region
CENP-C_C (PF11699): Mif2/CENP-C like
Clu

Domain structure obtained by HMM

Protein ID: XP_008826365.1 - clusterin
KEEG Ortholog ID: K17252
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
ClusterinPF010934271.6e-160520.8002944429445Clusterin
oncogene, tumor suppressor40.6670.667Clusterin (PF01093): Clusterin
Cnbp

Domain structure obtained by HMM

Protein ID: XP_008826765.1 - cellular nucleic acid-binding protein isoform X2
KEEG Ortholog ID: K09250
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
zf-CCHCPF00098180.000000000004731.900520421Zinc knuckle
zf-CCHCPF00098180.00000000001130.80053685269Zinc knuckle
zf-CCHCPF00098180.00000000005128.70073897289Zinc knuckle
zf-ribbon_3PF13248260.0000459.2008710486104zinc-ribbon domain
zf-CCHCPF00098180.00000000002129.9009711396113Zinc knuckle
zf-CCHCPF00098180.00000000007328.200117134117134Zinc knuckle
zf-CCHCPF00098180.0000000001327.300136152135152Zinc knuckle
zf-CCHCPF00098180.000000000005831.700157172156173Zinc knuckle
oncogene100zf-CCHC (PF00098): Zinc knuckle
zf-ribbon_3 (PF13248): zinc-ribbon domain
Col1a2

Domain structure obtained by HMM

Protein ID: XP_008820781.1 - collagen alpha-2(I) chain
KEEG Ortholog ID: K06236
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
CollagenPF01391600.00000000004828.60032752782Collagen triple helix repeat (20 copies)
CollagenPF01391600.0000000000002136.2009114987150Collagen triple helix repeat (20 copies)
CollagenPF01391600.00000000006328.200148204130207Collagen triple helix repeat (20 copies)
CollagenPF01391600.000000000001233.800313370310372Collagen triple helix repeat (20 copies)
CollagenPF01391600.0280.600496532460580Collagen triple helix repeat (20 copies)
CollagenPF01391600.0000000000008634.20099010469851053Collagen triple helix repeat (20 copies)
CollagenPF01391600.000000000009430.9001045110210451109Collagen triple helix repeat (20 copies)
COLFIPF014102333.2e-108346.5001131136411301364Fibrillar collagen C-terminal domain
oncogene21.0000Collagen (PF01391): Collagen triple helix repeat (20 copies)
COLFI (PF01410): Fibrillar collagen C-terminal domain
Cyr61

Domain structure obtained by HMM

Protein ID: XP_008824468.1 - protein CYR61
KEEG Ortholog ID: K06829
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
IGFBPPF00219550.00000000000001340.90026782678Insulin-like growth factor binding protein
VWCPF00093570.00000000000003439.300100163100163von Willebrand factor type C domain
TSP_1PF00090490.00000001221.400233272232272Thrombospondin type 1 domain
Cys_knotPF000071051.2e-2060.100284371283376Cystine-knot domain
oncogene100IGFBP (PF00219): Insulin-like growth factor binding protein
VWC (PF00093): von Willebrand factor type C domain
TSP_1 (PF00090): Thrombospondin type 1 domain
Cys_knot (PF00007): Cystine-knot domain
Ddx17

Domain structure obtained by HMM

Protein ID: XP_017658240.1 - probable ATP-dependent RNA helicase DDX17 isoform X3
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Flavi_DEADPF076521480.00263.9009612389133Flavivirus DEAD domain
DEADPF002701763.9e-53165.900116286116287DEAD/DEAH box helicase
FerritinPF002101420.00001511.100303342248350Ferritin-like domain
Helicase_CPF002711112.7e-1955.900325405322409Helicase conserved C-terminal domain
interactor70.8001.333Flavi_DEAD (PF07652): Flavivirus DEAD domain
DEAD (PF00270): DEAD/DEAH box helicase
Ferritin (PF00210): Ferritin-like domain
Helicase_C (PF00271): Helicase conserved C-terminal domain
Ddx5

Domain structure obtained by HMM

Protein ID: XP_008839826.1 - probable ATP-dependent RNA helicase DDX5
KEEG Ortholog ID: K12823
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DEADPF002701767.5e-51158.500118288118289DEAD/DEAH box helicase
ResIIIPF048511710.0350.300310336291392Type III restriction enzyme, res subunit
Helicase_CPF002711115.3e-35106.500327435324436Helicase conserved C-terminal domain
P68HRPF08061333.9e-2264.500498532498532P68HR (NUC004) repeat
P68HRPF08061338.7e-2160.200551583551583P68HR (NUC004) repeat
oncogene80.7622.667DEAD (PF00270): DEAD/DEAH box helicase
ResIII (PF04851): Type III restriction enzyme, res subunit
Helicase_C (PF00271): Helicase conserved C-terminal domain
P68HR (PF08061): P68HR (NUC004) repeat
Dgcr8

Domain structure obtained by HMM

Protein ID: XP_008841237.1 - microprocessor complex subunit DGCR8
KEEG Ortholog ID: K18419
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
WWPF00397310.0000001917.300303332303332WW domain
dsrmPF00035677.1e-1748.200514576512576Double-stranded RNA binding motif
dsrmPF00035670.000000008122.400620684620684Double-stranded RNA binding motif
dsrmPF00035670.0172.100717730713771Double-stranded RNA binding motif
interactor60.6003.500WW (PF00397): WW domain
dsrm (PF00035): Double-stranded RNA binding motif
Dsn1

Domain structure obtained by HMM

Protein ID: XP_008849386.2 - kinetochore-associated protein DSN1 homolog
KEEG Ortholog ID: K11544
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
MIS13PF082023011.4e-60191.2007934174344Mis12-Mtw1 protein family
interactor130.62815.706MIS13 (PF08202): Mis12-Mtw1 protein family
Eif2b3

Domain structure obtained by HMM

Protein ID: XP_008847079.1 - translation initiation factor eIF-2B subunit gamma isoform X1
KEEG Ortholog ID: K03241
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
NTP_transferasePF004832481.3e-2060.10051304139Nucleotidyl transferase
NAGPAPF099921700.00001411.50012917396183Phosphodiester glycosidase
CTP_transf_3PF023482210.0210.800215268201277Cytidylyltransferase
HexapepPF00132360.0171.300351368336372Bacterial transferase hexapeptide (six repeats)
DUF4954PF163146550.0000004214.500356448318451Domain of unknown function (DUF4954)
interactor21.0000NTP_transferase (PF00483): Nucleotidyl transferase
NAGPA (PF09992): Phosphodiester glycosidase
CTP_transf_3 (PF02348): Cytidylyltransferase
Hexapep (PF00132): Bacterial transferase hexapeptide (six repeats)
DUF4954 (PF16314): Domain of unknown function (DUF4954)
Epb41l5

Domain structure obtained by HMM

Protein ID: XP_017653061.1 - band 4.1-like protein 5 isoform X3
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
FERM_NPF09379651e-1853.4004710847109FERM N-terminal domain
FERM_MPF003731187.9e-2470.600127235126235FERM central domain
FERM_CPF09380945.1e-2677.200241330239331FERM C-terminal PH-like domain
FAPF08736442.7e-1852.200337378337378FERM adjacent (FA)
ACBPPF00887850.0380.600445481422483Acyl CoA binding protein
interactor21.0000FERM_N (PF09379): FERM N-terminal domain
FERM_M (PF00373): FERM central domain
FERM_C (PF09380): FERM C-terminal PH-like domain
FA (PF08736): FERM adjacent (FA)
ACBP (PF00887): Acyl CoA binding protein
Exoc1

Domain structure obtained by HMM

Protein ID: XP_008831524.1 - exocyst complex component 1 isoform X1
KEEG Ortholog ID: K19983
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Sec3-PIP2_bindPF15277902.4e-3090.9003212132121Exocyst complex component SEC3 N-terminal PIP2 binding PH
Cor1PF048031320.00264.200165258142262Cor1/Xlr/Xmr conserved region
Sec3_CPF097637009.2e-183595.300191896190896Exocyst complex component Sec3
interactor40.6671.333Sec3-PIP2_bind (PF15277): Exocyst complex component SEC3 N-terminal PIP2 binding PH
Cor1 (PF04803): Cor1/Xlr/Xmr conserved region
Sec3_C (PF09763): Exocyst complex component Sec3
Fam167a

Domain structure obtained by HMM

Protein ID: XP_017652392.1 - protein FAM167A
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
LURAPPF148541170.0000005415.800113155103181Leucine rich adaptor protein
FAM167PF11652852.3e-44136.100131215131215FAM167
interactor100LURAP (PF14854): Leucine rich adaptor protein
FAM167 (PF11652): FAM167
Fbxo28

Domain structure obtained by HMM

Protein ID: XP_008821962.1 - F-box only protein 28
KEEG Ortholog ID: K10306
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
F-boxPF00646480.000000009321.40067936294F-box domain
CENP-HPF058371120.0520.20011114187160Centromere protein H (CENP-H)
INGPF129981020.00264.60018321591218Inhibitor of growth proteins N-terminal histone-binding
FAM76PF160463000.000000002722.800267332198363FAM76 protein
TRAF_BIRC3_bdPF16673640.0211.000340359312367TNF receptor-associated factor BIRC3 binding domain
interactor21.0000F-box (PF00646): F-box domain
CENP-H (PF05837): Centromere protein H (CENP-H)
ING (PF12998): Inhibitor of growth proteins N-terminal histone-binding
FAM76 (PF16046): FAM76 protein
TRAF_BIRC3_bd (PF16673): TNF receptor-associated factor BIRC3 binding domain
Hnrnpa1

Domain structure obtained by HMM

Protein ID: XP_008837331.1 - heterogeneous nuclear ribonucleoprotein A1 isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
RRM_1PF00076705.2e-2263.80016821685RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_1PF00076702.4e-2058.500107167107176RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1PF11627382.2e-2471.700255292255292Nuclear factor hnRNPA1
interactor130.30341.333RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627): Nuclear factor hnRNPA1
Hnrnpf

Domain structure obtained by HMM

Protein ID: XP_008830911.1 - heterogeneous nuclear ribonucleoprotein F
KEEG Ortholog ID: K12898
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
RRM_1PF00076700.0000001817.20015831384RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14PF070841520.0131.9007010153117Thyroid hormone-inducible hepatic protein Spot 14
RRM_1PF00076702e-1645.900114181113182RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHFPF08080361.2e-2678.700255290255290RNPHF zinc finger
RRM_1PF00076700.0000000000007734.500293356291358RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
interactor51.0000RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080): RNPHF zinc finger
Hnrnph1

Domain structure obtained by HMM

Protein ID: XP_008850480.1 - heterogeneous nuclear ribonucleoprotein H isoform X1
KEEG Ortholog ID: K12898
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
RRM_1PF00076700.0000000004525.60014821384RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_1PF00076705.2e-1747.800114181113182RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHFPF08080365e-2780.000255290255290RNPHF zinc finger
RRM_1PF00076700.0000000000004335.300293355291358RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
oncogene70.7622.667RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080): RNPHF zinc finger
Ipo4

Domain structure obtained by HMM

Protein ID: XP_008838050.1 - importin-4 isoform X1
KEEG Ortholog ID: K20221
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
IBN_NPF03810740.00000000004129.00024882490Importin-beta N-terminal domain
RIX1PF081671900.000002613.4008225257257rRNA processing/ribosome biogenesis
HEATPF02985310.000000001723.900395424395425HEAT repeat
DUF3385PF118651610.0000002916.600422508345512Domain of unknown function (DUF3385)
HEAT_EZPF13513550.000007312.700495550486551HEAT-like repeat
UMEPF080641020.000945.400517612514623UME (NUC010) domain
HEAT_2PF13646880.00003210.600676727665776HEAT repeats
HEAT_PBSPF03130270.0381.500713746713750PBS lyase HEAT-like repeat
HEAT_EZPF13513550.0560.300742778739786HEAT-like repeat
HEAT_EZPF13513550.00000000001231.200912967912967HEAT-like repeat
IBN_NPF03810740.0360.3001020107310171077Importin-beta N-terminal domain
interactor21.0000IBN_N (PF03810): Importin-beta N-terminal domain
RIX1 (PF08167): rRNA processing/ribosome biogenesis
HEAT (PF02985): HEAT repeat
DUF3385 (PF11865): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
UME (PF08064): UME (NUC010) domain
HEAT_2 (PF13646): HEAT repeats
HEAT_PBS (PF03130): PBS lyase HEAT-like repeat
Kifc3

Domain structure obtained by HMM

Protein ID: XP_008833098.1 - kinesin-like protein KIFC3 isoform X5
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
HALZPF02183430.000337.200726327Homeobox associated leucine zipper
Spc7PF083173100.000000008420.8006918867193Spc7 kinetochore protein
KxDLPF10241860.00002910.600204253193259Uncharacterized conserved protein
HIP1_clath_bdgPF16515990.00001412.000257327255331Clathrin-binding domain of Huntingtin-interacting protein 1
DUF4200PF138631190.000965.800343387333396Domain of unknown function (DUF4200)
KinesinPF002253336.7e-111356.400389706389706Kinesin motor domain
oncogene60.5005.000HALZ (PF02183): Homeobox associated leucine zipper
Spc7 (PF08317): Spc7 kinetochore protein
KxDL (PF10241): Uncharacterized conserved protein
HIP1_clath_bdg (PF16515): Clathrin-binding domain of Huntingtin-interacting protein 1
DUF4200 (PF13863): Domain of unknown function (DUF4200)
Kinesin (PF00225): Kinesin motor domain
LOC103750566

Domain structure obtained by HMM

Protein ID: XP_008851896.1 - polyamine-modulated factor 1-like isoform X1
KEEG Ortholog ID: K11546
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
MtmBPF053694500.000008410.80028821885Monomethylamine methyltransferase MtmB
Nnf1PF039801102.7e-2678.4007016768168Nnf1
CCAPPF111051280.0000005515.800132194112197Arthropod cardioacceleratory peptide 2a
NYD-SP28_assocPF14775600.00543.200180198171200Sperm tail C-terminal domain
interactor120.60616.250MtmB (PF05369): Monomethylamine methyltransferase MtmB
Nnf1 (PF03980): Nnf1
CCAP (PF11105): Arthropod cardioacceleratory peptide 2a
NYD-SP28_assoc (PF14775): Sperm tail C-terminal domain
Leng8

Domain structure obtained by HMM

Protein ID: XP_008825981.1 - leukocyte receptor cluster member 8
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
HJURP_midPF123461150.000006612.900469548458551Holliday junction recognition protein-associated repeat
SAC3_GANPPF033992934.4e-3091.100563777552779SAC3/GANP family
interactor21.0000HJURP_mid (PF12346): Holliday junction recognition protein-associated repeat
SAC3_GANP (PF03399): SAC3/GANP family
Lig4

Domain structure obtained by HMM

Protein ID: XP_008853418.1 - DNA ligase 4
KEEG Ortholog ID: K10777
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DNA_ligase_A_NPF046751739.6e-46142.4001520815208DNA ligase N terminus
APG17PF041083940.000005111.800200266146292Autophagy protein Apg17
DNA_ligase_A_MPF010682043.3e-58182.800248451248451ATP dependent DNA ligase domain
DNA_ligase_A_CPF04679991.3e-2163.400476588476588ATP dependent DNA ligase C terminal region
BRCT_2PF16589850.000000000001334.300657740655742BRCT domain, a BRCA1 C-terminus domain
DNA_ligase_IVPF11411344.6e-2161.000750782750783DNA ligase IV
BRCTPF00533790.000000001824.300845898811898BRCA1 C Terminus (BRCT) domain
RTT107_BRCT_5PF167701000.000098.600878911820911Regulator of Ty1 transposition protein 107 BRCT domain
interactor40.5002.667DNA_ligase_A_N (PF04675): DNA ligase N terminus
APG17 (PF04108): Autophagy protein Apg17
DNA_ligase_A_M (PF01068): ATP dependent DNA ligase domain
DNA_ligase_A_C (PF04679): ATP dependent DNA ligase C terminal region
BRCT_2 (PF16589): BRCT domain, a BRCA1 C-terminus domain
DNA_ligase_IV (PF11411): DNA ligase IV
BRCT (PF00533): BRCA1 C Terminus (BRCT) domain
RTT107_BRCT_5 (PF16770): Regulator of Ty1 transposition protein 107 BRCT domain
Lmnb1

Domain structure obtained by HMM

Protein ID: XP_008839204.1 - lamin-B1
KEEG Ortholog ID: K07611
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
FilamentPF000383123.7e-101324.8003138731387Intermediate filament protein
LTDPF009321115.6e-2264.500436543435545Lamin Tail Domain
interactor30.6671.000Filament (PF00038): Intermediate filament protein
LTD (PF00932): Lamin Tail Domain
Lyrm4

Domain structure obtained by HMM

Protein ID: XP_017653268.1 - LYR motif-containing protein 4 isoform X1
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Complex1_LYRPF05347592.6e-2987.400864765Complex 1 protein (LYR family)
interactor31.0000Complex1_LYR (PF05347): Complex 1 protein (LYR family)
Mafb

Domain structure obtained by HMM

Protein ID: XP_008847806.1 - transcription factor MafB
KEEG Ortholog ID: K09036
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Maf_NPF08383348.4e-2675.8008111380113Maf N-terminal region
bZIP_MafPF03131921.8e-39120.500211301211302bZIP Maf transcription factor
oncogene200Maf_N (PF08383): Maf N-terminal region
bZIP_Maf (PF03131): bZIP Maf transcription factor
Map3k20

Domain structure obtained by HMM

Protein ID: XP_008853497.1 - mitogen-activated protein kinase kinase kinase MLT isoform X2
KEEG Ortholog ID: K04424
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Pkinase_TyrPF077142607.5e-67211.4001726016260Protein tyrosine kinase
DUF3552PF120722010.000127.700284326271329Domain of unknown function (DUF3552)
SAM_1PF00536640.0000000000001737.200339407337408SAM domain (Sterile alpha motif)
SAM_2PF07647660.0231.200571583565587SAM domain (Sterile alpha motif)
interactor200Pkinase_Tyr (PF07714): Protein tyrosine kinase
DUF3552 (PF12072): Domain of unknown function (DUF3552)
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
SAM_2 (PF07647): SAM domain (Sterile alpha motif)
Med24

Domain structure obtained by HMM

Protein ID: XP_008827642.1 - mediator of RNA polymerase II transcription subunit 24 isoform X1
KEEG Ortholog ID: K15167
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Med24_NPF1127799601310.3001100411004Mediator complex subunit 24 N-terminal
interactor21.0000Med24_N (PF11277): Mediator complex subunit 24 N-terminal
Mis12

Domain structure obtained by HMM

Protein ID: XP_008854176.1 - protein MIS12 homolog
KEEG Ortholog ID: K11543
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Mis12PF058591352.6e-33101.20081408141Mis12 protein
DUF349PF03993750.00004110.200115163108170Domain of Unknown Function (DUF349)
interactor110.72710.872Mis12 (PF05859): Mis12 protein
DUF349 (PF03993): Domain of Unknown Function (DUF349)
Mlf1

Domain structure obtained by HMM

Protein ID: XP_008835681.1 - myeloid leukemia factor 1 isoform X1
KEEG Ortholog ID: K15622
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Mlf1IPPF102481711.7e-79251.9002620226202Myelodysplasia-myeloid leukemia factor 1-interacting protein
oncogene50.9000.222Mlf1IP (PF10248): Myelodysplasia-myeloid leukemia factor 1-interacting protein
Mtmr6

Domain structure obtained by HMM

Protein ID: XP_008823214.1 - myotubularin-related protein 6
KEEG Ortholog ID: K18083
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Myotub-relatedPF066023413.1e-146472.700107446107446Myotubularin-like phosphatase domain
DUF5082PF168881230.000002614.000509547472550Domain of unknown function (DUF5082)
interactor200Myotub-related (PF06602): Myotubularin-like phosphatase domain
DUF5082 (PF16888): Domain of unknown function (DUF5082)
Ndc80

Domain structure obtained by HMM

Protein ID: XP_008832832.1 - kinetochore protein NDC80 homolog
KEEG Ortholog ID: K11547
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Ndc80_HECPF038011532e-54169.6005320251206HEC/Ndc80p family
ADIPPF115591520.000000217.400270348263351Afadin- and alpha -actinin-Binding
TMF_TATA_bdPF123251150.000002514.000326393315409TATA element modulatory factor 1 TATA binding
DUF3810PF127253100.00017.800364433352441Protein of unknown function (DUF3810)
SlyXPF04102670.000005713.200482522469535SlyX
CREPTPF165661470.000059.700531611527628Cell-cycle alteration and expression-elevated protein in tumour
HTH_40PF14493880.00002111.300582638567642Helix-turn-helix domain
interactor150.54925.539Ndc80_HEC (PF03801): HEC/Ndc80p family
ADIP (PF11559): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325): TATA element modulatory factor 1 TATA binding
DUF3810 (PF12725): Protein of unknown function (DUF3810)
SlyX (PF04102): SlyX
CREPT (PF16566): Cell-cycle alteration and expression-elevated protein in tumour
HTH_40 (PF14493): Helix-turn-helix domain
Neu2

Domain structure obtained by HMM

Protein ID: XP_008836328.1 - sialidase-2
KEEG Ortholog ID: K12357
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
BNR_2PF130882783.7e-49153.6003334232345BNR repeat-like domain
interactor100BNR_2 (PF13088): BNR repeat-like domain
Nfs1

Domain structure obtained by HMM

Protein ID: XP_008838982.1 - cysteine desulfurase, mitochondrial
KEEG Ortholog ID: K04487
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Aminotran_5PF002663716.4e-97310.8006242361424Aminotransferase class-V
interactor21.0000Aminotran_5 (PF00266): Aminotransferase class-V
Nsl1

Domain structure obtained by HMM

Protein ID: XP_008823063.1 - kinetochore-associated protein NSL1 homolog isoform X1
KEEG Ortholog ID: K11545
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Mis14PF086411330.00000000000001940.3008315082177Kinetochore protein Mis14 like
interactor90.9440.472Mis14 (PF08641): Kinetochore protein Mis14 like
Nuf2

Domain structure obtained by HMM

Protein ID: XP_008846443.1 - kinetochore protein Nuf2
KEEG Ortholog ID: K11548
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Nuf2PF038001398.6e-40122.30041443146Nuf2 family
DUF3106PF113041040.00002910.800151226142230Protein of unknown function (DUF3106)
ApoLp-IIIPF074641460.000007312.300234283227285Apolipophorin-III precursor (apoLp-III)
Spc7PF083173100.0000279.200296433287440Spc7 kinetochore protein
SyntaxinPF008042000.0000001817.200387455384463Syntaxin
interactor120.68210.206Nuf2 (PF03800): Nuf2 family
DUF3106 (PF11304): Protein of unknown function (DUF3106)
ApoLp-III (PF07464): Apolipophorin-III precursor (apoLp-III)
Spc7 (PF08317): Spc7 kinetochore protein
Syntaxin (PF00804): Syntaxin
Pcolce2

Domain structure obtained by HMM

Protein ID: XP_017650657.1 - procollagen C-endopeptidase enhancer 2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
CUBPF004311101.9e-3194.90051135113CUB domain
CUBPF004311102e-34104.600126234126237CUB domain
NTRPF017591076.7e-2160.400282383281384UNC-6/NTR/C345C module
interactor100CUB (PF00431): CUB domain
NTR (PF01759): UNC-6/NTR/C345C module
Phax

Domain structure obtained by HMM

Protein ID: XP_008839216.1 - phosphorylated adapter RNA export protein
KEEG Ortholog ID: K14291
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
RNA_GG_bindPF10258841.4e-37113.900230312230313PHAX RNA-binding domain
interactor100RNA_GG_bind (PF10258): PHAX RNA-binding domain
Ppa2

Domain structure obtained by HMM

Protein ID: XP_008839496.1 - inorganic pyrophosphatase 2, mitochondrial
KEEG Ortholog ID: K01507
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PyrophosphatasePF007191603.7e-62195.0009828098280Inorganic pyrophosphatase
interactor100Pyrophosphatase (PF00719): Inorganic pyrophosphatase
Ppp1cc

Domain structure obtained by HMM

Protein ID: XP_008837623.1 - serine/threonine-protein phosphatase PP1-gamma catalytic subunit
KEEG Ortholog ID: K06269
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
STPPase_NPF16891482.5e-2781.400956956Serine-threonine protein phosphatase N-terminal domain
MetallophosPF001492046.7e-45140.2006024957252Calcineurin-like phosphoesterase
oncogene90.44418.333STPPase_N (PF16891): Serine-threonine protein phosphatase N-terminal domain
Metallophos (PF00149): Calcineurin-like phosphoesterase
Rabl6

Domain structure obtained by HMM

Protein ID: XP_008840142.1 - rab-like protein 6
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
RocPF084771200.0000000000329.9004510245112Ras of Complex, Roc, domain of DAPkinase
Eapp_CPF102381490.0280.70011215981161E2F-associated phosphoprotein
RasPF000711620.00000006118.600136218132228Ras family
RP-C_CPF118002060.012.000237314233339Replication protein C C-terminal region
HistonePF001251320.00633.100458507450513Core histone H2A/H2B/H3/H4
CDC27PF095074270.00821.600475586444620DNA polymerase subunit Cdc27
eIF3_subunitPF085972420.000001414.500612708598713Translation initiation factor eIF3 subunit
oncogene40.5003.000Roc (PF08477): Ras of Complex, Roc, domain of DAPkinase
Eapp_C (PF10238): E2F-associated phosphoprotein
Ras (PF00071): Ras family
RP-C_C (PF11800): Replication protein C C-terminal region
Histone (PF00125): Core histone H2A/H2B/H3/H4
CDC27 (PF09507): DNA polymerase subunit Cdc27
eIF3_subunit (PF08597): Translation initiation factor eIF3 subunit
Rasip1

Domain structure obtained by HMM

Protein ID: XP_008843224.1 - ras-interacting protein 1
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DILPF018431041.5e-2782.300426531426533DIL domain
interactor100DIL (PF01843): DIL domain
Rbm25

Domain structure obtained by HMM

Protein ID: XP_008848013.1 - RNA-binding protein 25 isoform X1
KEEG Ortholog ID: K12822
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
RRM_1PF00076700.0000000000004935.1008915789158RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
VID27PF085538030.00153.10011223998249VID27 cytoplasmic protein
SMNPF060032640.0180.400211256177268Survival motor neuron protein (SMN)
PRP38_assocPF12871990.00001811.600270353261355Pre-mRNA-splicing factor 38-associated hydrophilic C-term
U1snRNP70_NPF12220930.0271.500453505452505U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF3441PF119231160.0171.400488545486553Domain of unknown function (DUF3441)
DUF4778PF160082990.000316.900524740493746Domain of unknown function (DUF4778)
Vfa1PF084321810.0530.000717755669775AAA-ATPase Vps4-associated protein 1
PWIPF01480699.6e-1850.600768832766835PWI domain
interactor100RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
VID27 (PF08553): VID27 cytoplasmic protein
SMN (PF06003): Survival motor neuron protein (SMN)
PRP38_assoc (PF12871): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
U1snRNP70_N (PF12220): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF3441 (PF11923): Domain of unknown function (DUF3441)
DUF4778 (PF16008): Domain of unknown function (DUF4778)
Vfa1 (PF08432): AAA-ATPase Vps4-associated protein 1
PWI (PF01480): PWI domain
Rcn1

Domain structure obtained by HMM

Protein ID: XP_008849642.1 - reticulocalbin-1
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
EF-hand_7PF13499710.00000000001930.6008314077141EF-hand domain pair
EF-hand_7PF13499710.00000002120.900169226165229EF-hand domain pair
EF-hand_6PF13405310.0000006215.600245269244274EF-hand domain
EF-hand_7PF13499710.000002514.300253302245305EF-hand domain pair
EF-hand_4PF127631040.0360.400295315285324Cytoskeletal-regulatory complex EF hand
interactor100EF-hand_7 (PF13499): EF-hand domain pair
EF-hand_6 (PF13405): EF-hand domain
EF-hand_4 (PF12763): Cytoskeletal-regulatory complex EF hand
Rin1

Domain structure obtained by HMM

Protein ID: XP_008820481.1 - LOW QUALITY PROTEIN: ras and Rab interactor 1
KEEG Ortholog ID: K17638
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SH2PF00017770.00000008818.50010117092170SH2 domain
PRIMA1PF161011210.0033.800261300256312Proline-rich membrane anchor 1
VPS9PF022041041.2e-2679.300514612513615Vacuolar sorting protein 9 (VPS9) domain
RAPF00788930.00000004520.000646729645735Ras association (RalGDS/AF-6) domain
interactor100SH2 (PF00017): SH2 domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
VPS9 (PF02204): Vacuolar sorting protein 9 (VPS9) domain
RA (PF00788): Ras association (RalGDS/AF-6) domain
Scmh1

Domain structure obtained by HMM

Protein ID: XP_008833645.1 - polycomb protein SCMH1 isoform X2
KEEG Ortholog ID: K11461
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
MBTPF02820693e-2471.5006212962130mbt repeat
MBTPF02820695.6e-3089.900171236171238mbt repeat
RBRPF17208576.4e-1645.200271324271324RNA binding Region
SLEDPF121401121.7e-40124.300358466358466SLED domain
SAM_1PF00536642.9e-2058.800596661596661SAM domain (Sterile alpha motif)
interactor200MBT (PF02820): mbt repeat
RBR (PF17208): RNA binding Region
SLED (PF12140): SLED domain
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
Slc25a19

Domain structure obtained by HMM

Protein ID: XP_008829636.1 - mitochondrial thiamine pyrophosphate carrier isoform X1
KEEG Ortholog ID: K15108
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Mito_carrPF00153977.3e-2263.5002711821119Mitochondrial carrier protein
Mito_carrPF00153971.4e-2575.300125209122212Mitochondrial carrier protein
Mito_carrPF00153975.4e-2676.700221318220320Mitochondrial carrier protein
interactor100Mito_carr (PF00153): Mitochondrial carrier protein
Smg5

Domain structure obtained by HMM

Protein ID: XP_008851847.1 - protein SMG5
KEEG Ortholog ID: K11125
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
EST1PF103741361.5e-2886.4007718877189Telomerase activating protein Est1
EST1_DNA_bindPF103732836.9e-36110.200197400197426Est1 DNA/RNA binding domain
EST1_DNA_bindPF103732830.000000001124.300650743573745Est1 DNA/RNA binding domain
PIN_4PF136381310.0000000007725.400859941858966PIN domain
interactor30.6670.500EST1 (PF10374): Telomerase activating protein Est1
EST1_DNA_bind (PF10373): Est1 DNA/RNA binding domain
PIN_4 (PF13638): PIN domain
Smtn

Domain structure obtained by HMM

Protein ID: XP_017655598.1 - smoothelin isoform X4
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SmoothelinPF12510500.000000000000003642.100141141Smoothelin cytoskeleton protein
SmoothelinPF12510502.3e-1955.5007412273122Smoothelin cytoskeleton protein
SmoothelinPF12510501.6e-2472.000572619570619Smoothelin cytoskeleton protein
Nop25PF098051370.0015.800609688598709Nucleolar protein 12 (25kDa)
CHPF003071098.6e-2057.300802870800878Calponin homology (CH) domain
interactor100Smoothelin (PF12510): Smoothelin cytoskeleton protein
Nop25 (PF09805): Nucleolar protein 12 (25kDa)
CH (PF00307): Calponin homology (CH) domain
Snap29

Domain structure obtained by HMM

Protein ID: XP_008840461.1 - synaptosomal-associated protein 29
KEEG Ortholog ID: K08509
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
V-SNARE_CPF12352660.000000000825.2005811049111Snare region anchored in the vesicle membrane C-terminus
DUF1664PF078891240.0000778.900192254180255Protein of unknown function (DUF1664)
interactor70.3339.500V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus
DUF1664 (PF07889): Protein of unknown function (DUF1664)
Spc25

Domain structure obtained by HMM

Protein ID: XP_008836037.1 - kinetochore protein Spc25
KEEG Ortholog ID: K11550
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF3800PF126862390.000008611.70023801594Protein of unknown function (DUF3800)
Spc7PF083173100.00000001220.3006216028162Spc7 kinetochore protein
Spindle_Spc25PF08234734e-2677.400150219149220Chromosome segregation protein Spc25
interactor90.7786.556DUF3800 (PF12686): Protein of unknown function (DUF3800)
Spc7 (PF08317): Spc7 kinetochore protein
Spindle_Spc25 (PF08234): Chromosome segregation protein Spc25
Sqor

Domain structure obtained by HMM

Protein ID: XP_008847513.1 - sulfide:quinone oxidoreductase, mitochondrial
KEEG Ortholog ID: K17218
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Spermine_synthPF015642470.00001310.40038593276Spermine/spermidine synthase
Pyr_redox_2PF079922920.00000000000009237.4004516145193Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_2PF079922920.0000001517.000241348215355Pyridine nucleotide-disulphide oxidoreductase
interactor100Spermine_synth (PF01564): Spermine/spermidine synthase
Pyr_redox_2 (PF07992): Pyridine nucleotide-disulphide oxidoreductase
Ssr3

Domain structure obtained by HMM

Protein ID: XP_008835669.1 - translocon-associated protein subunit gamma
KEEG Ortholog ID: K13251
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
TRAP-gammaPF070741702.6e-88280.1001218312183Translocon-associated protein, gamma subunit (TRAP-gamma)
interactor100TRAP-gamma (PF07074): Translocon-associated protein, gamma subunit (TRAP-gamma)
Stx11

Domain structure obtained by HMM

Protein ID: XP_008828031.1 - syntaxin-11
KEEG Ortholog ID: K08487
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SyntaxinPF008042003.5e-68215.4004123841239Syntaxin
SNAREPF05739530.0000000006925.200242283240286SNARE domain
interactor40.6670.500Syntaxin (PF00804): Syntaxin
SNARE (PF05739): SNARE domain
Stx18

Domain structure obtained by HMM

Protein ID: XP_008831338.1 - syntaxin-18
KEEG Ortholog ID: K08492
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Syntaxin-18_NPF10496843.3e-2574.500496396SNARE-complex protein Syntaxin-18 N-terminus
Phage_Integr_2PF130093240.0000006714.8009116356191Putative phage integrase
interactor40.5002.667Syntaxin-18_N (PF10496): SNARE-complex protein Syntaxin-18 N-terminus
Phage_Integr_2 (PF13009): Putative phage integrase
Stx19

Domain structure obtained by HMM

Protein ID: XP_008830463.1 - syntaxin-19
KEEG Ortholog ID: K08487
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SyntaxinPF008042002.3e-61193.1004824447244Syntaxin
SNAREPF05739530.000002713.600247288245291SNARE domain
interactor100Syntaxin (PF00804): Syntaxin
SNARE (PF05739): SNARE domain
Stx3

Domain structure obtained by HMM

Protein ID: XP_008840236.1 - syntaxin-3 isoform X1
KEEG Ortholog ID: K08486
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF4162PF13732810.000756.600951254Domain of unknown function (DUF4162)
SyntaxinPF008042008.5e-65204.3003222632226Syntaxin
SNAREPF05739537.4e-1747.500227265227267SNARE domain
interactor21.0000DUF4162 (PF13732): Domain of unknown function (DUF4162)
Syntaxin (PF00804): Syntaxin
SNARE (PF05739): SNARE domain
Sugp1

Domain structure obtained by HMM

Protein ID: XP_008822703.2 - SURP and G-patch domain-containing protein 1
KEEG Ortholog ID: K13096
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
ATP-synt_EPF05680960.000267.60022611080ATP synthase E chain
SurpPF01805535.8e-2057.400185236185237Surp module
SurpPF01805530.000000000000001843.100262312260312Surp module
G-patch_2PF12656610.0310.800416429416448G-patch domain
ATP-synt_EPF05680960.0640.000435471427497ATP synthase E chain
RtcBPF011394120.00001110.800448523420527tRNA-splicing ligase RtcB
G-patchPF01585453.3e-1954.900561604560605G-patch domain
interactor100ATP-synt_E (PF05680): ATP synthase E chain
Surp (PF01805): Surp module
G-patch_2 (PF12656): G-patch domain
RtcB (PF01139): tRNA-splicing ligase RtcB
G-patch (PF01585): G-patch domain
Syce3

Domain structure obtained by HMM

Protein ID: XP_008833003.1 - synaptonemal complex central element protein 3
KEEG Ortholog ID: K19536
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Synaptonemal_3PF15191925e-43131.20010941094Synaptonemal complex central element protein 3
interactor21.0000Synaptonemal_3 (PF15191): Synaptonemal complex central element protein 3
Taf12

Domain structure obtained by HMM

Protein ID: XP_008846165.1 - transcription initiation factor TFIID subunit 12 isoform X1
KEEG Ortholog ID: K03126
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
TFIID_20kDaPF03847683e-40122.9005912659126Transcription initiation factor TFIID subunit A
interactor100TFIID_20kDa (PF03847): Transcription initiation factor TFIID subunit A
Tcf12

Domain structure obtained by HMM

Protein ID: XP_008845765.1 - transcription factor 12 isoform X13
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
HLHPF00010550.0390.300257271225288Helix-loop-helix DNA-binding domain
CDC45PF027246270.000384.900375445339505CDC45-like protein
HLHPF00010550.00000000000001639.900432485432485Helix-loop-helix DNA-binding domain
oncogene200HLH (PF00010): Helix-loop-helix DNA-binding domain
CDC45 (PF02724): CDC45-like protein
Thbs2

Domain structure obtained by HMM

Protein ID: XP_008841609.1 - thrombospondin-2
KEEG Ortholog ID: K04659
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Laminin_G_3PF133851520.000003813.30010721170213Concanavalin A-like lectin/glucanases superfamily
VWCPF00093571.8e-1646.600320374320374von Willebrand factor type C domain
TSP_1PF00090492.9e-1645.800384429384429Thrombospondin type 1 domain
TSP_1PF00090495.3e-1954.600440490440490Thrombospondin type 1 domain
TSP_1PF00090491.1e-1956.700497547497547Thrombospondin type 1 domain
EGF_3PF12947360.00018.800556587552587EGF domain
cEGFPF12662240.0000001217.900572592570592Complement Clr-like EGF-like
EGF_CAPF07645420.0000000001127.900589626589645Calcium-binding EGF domain
EGF_3PF12947360.000000000003632.700651690651690EGF domain
TSP_3PF02412360.000005712.300689711684713Thrombospondin type 3 repeat
TSP_3PF02412360.00174.400716727715727Thrombospondin type 3 repeat
TSP_3PF02412360.0000000000001536.500728763728763Thrombospondin type 3 repeat
TSP_3PF02412360.00000003719.300764786762786Thrombospondin type 3 repeat
TSP_3PF02412360.000000000005531.500788822787822Thrombospondin type 3 repeat
TSP_3PF02412360.00000002320.000823845822845Thrombospondin type 3 repeat
TSP_3PF02412360.00000000000006637.700846883846883Thrombospondin type 3 repeat
TSP_3PF02412360.000000000000734.400885919884919Thrombospondin type 3 repeat
TSP_3PF02412360.000000000001833.100920951920955Thrombospondin type 3 repeat
TSP_CPF057351986.3e-100319.20097311709731170Thrombospondin C-terminal region
oncogene100Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
VWC (PF00093): von Willebrand factor type C domain
TSP_1 (PF00090): Thrombospondin type 1 domain
EGF_3 (PF12947): EGF domain
cEGF (PF12662): Complement Clr-like EGF-like
EGF_CA (PF07645): Calcium-binding EGF domain
TSP_3 (PF02412): Thrombospondin type 3 repeat
TSP_C (PF05735): Thrombospondin C-terminal region
Tjap1

Domain structure obtained by HMM

Protein ID: XP_008827294.1 - tight junction-associated protein 1 isoform X1
KEEG Ortholog ID: K06105
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
HMMR_NPF159053350.00000003219.4004918045224Hyaluronan mediated motility receptor N-terminal
DUF342PF039614540.00431.700146194134213Protein of unknown function (DUF342)
PiltPF154533656.5e-58182.900295457284473Protein incorporated later into Tight Junctions
PiltPF154533654.1e-2471.700486562468562Protein incorporated later into Tight Junctions
interactor21.0000HMMR_N (PF15905): Hyaluronan mediated motility receptor N-terminal
DUF342 (PF03961): Protein of unknown function (DUF342)
Pilt (PF15453): Protein incorporated later into Tight Junctions
Tmem126a

Domain structure obtained by HMM

Protein ID: XP_008842394.1 - transmembrane protein 126A isoform X1
KEEG Ortholog ID: K18157
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
TMEM126PF071141807.4e-46141.9005217051174Transmembrane protein 126
TMEM126PF071141801.7e-83264.600186362184363Transmembrane protein 126
interactor100TMEM126 (PF07114): Transmembrane protein 126
Tmpo

Domain structure obtained by HMM

Protein ID: XP_017653378.1 - thymopoietin isoform X4
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
ThymopoietinPF08198485.2e-3398.800249249Thymopoietin protein
LEMPF03020405.8e-2366.500110149110149LEM domain
OPTPF031696180.000005511.300287326249336OPT oligopeptide transporter protein
interactor21.0000Thymopoietin (PF08198): Thymopoietin protein
LEM (PF03020): LEM domain
OPT (PF03169): OPT oligopeptide transporter protein
Tp53

Domain structure obtained by HMM

Protein ID: NP_001306217.1 - tumor protein p53
KEEG Ortholog ID: K04451
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
P53_TADPF08563257.9e-1746.700529529P53 transactivation motif
P53PF008701961.9e-119382.5009328793287P53 DNA-binding domain
P53_tetramerPF07710422.2e-2161.300317355317356P53 tetramerisation motif
tumor suppressor120.30937.000P53_TAD (PF08563): P53 transactivation motif
P53 (PF00870): P53 DNA-binding domain
P53_tetramer (PF07710): P53 tetramerisation motif
Trim28

Domain structure obtained by HMM

Protein ID: XP_008821046.1 - transcription intermediary factor 1-beta
KEEG Ortholog ID: K08882
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
zf-RING_5PF14634440.00000000000002339.4004810648106zinc-RING finger domain
DUF1178PF066761500.00244.5009715186179Protein of unknown function (DUF1178)
zf-B_boxPF00643420.000000000128.000134177132179B-box zinc finger
zf-B_boxPF00643420.000000000001533.800191227188229B-box zinc finger
FYVE_2PF023181180.000436.800204239193245FYVE-type zinc finger
SKA2PF167401100.00194.300230287217289Spindle and kinetochore-associated protein 2
SKA2PF167401100.0024.200281330269346Spindle and kinetochore-associated protein 2
K_channel_TIDPF07941740.00284.400506526499533Potassium channel Kv1.4 tandem inactivation domain
PHDPF00628520.000000000006431.600609652609654PHD-finger
interactor41.0000zf-RING_5 (PF14634): zinc-RING finger domain
DUF1178 (PF06676): Protein of unknown function (DUF1178)
zf-B_box (PF00643): B-box zinc finger
FYVE_2 (PF02318): FYVE-type zinc finger
SKA2 (PF16740): Spindle and kinetochore-associated protein 2
K_channel_TID (PF07941): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628): PHD-finger
Tyw3

Domain structure obtained by HMM

Protein ID: XP_008851860.2 - tRNA wybutosine-synthesizing protein 3 homolog
KEEG Ortholog ID: K15450
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
TYW3PF026762143.2e-59185.9007725469255Methyltransferase TYW3
interactor21.0000TYW3 (PF02676): Methyltransferase TYW3
Zw10

Domain structure obtained by HMM

Protein ID: XP_008830971.1 - centromere/kinetochore protein zw10 homolog isoform X3
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Zw10PF062485952.6e-68216.90091939195Centromere/kinetochore Zw10
Zw10PF062485952.4e-39121.200194313193323Centromere/kinetochore Zw10
Zw10PF062485957.9e-129416.700353612347613Centromere/kinetochore Zw10
DUF4363PF142761200.000327.000593627589631Domain of unknown function (DUF4363)
RSTPF12174670.0000858.800710727706730RCD1-SRO-TAF4 (RST) plant domain
interactor30.6670.667Zw10 (PF06248): Centromere/kinetochore Zw10
DUF4363 (PF14276): Domain of unknown function (DUF4363)
RST (PF12174): RCD1-SRO-TAF4 (RST) plant domain

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