Find Protein-Protein Interactions (PPI) Network

Choose & Enter
Choose animal: Visualization driver:
Protein/NCBI_ID(s):
Refseq_ID(s):
KEGG_KO(s):


Level of PPIs:
or Upload text file: 		Update repository

Visible interactions: Visible interactors: Size of node:

Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Znrf4 (from a repository: Mon Apr 16 21:34:22 2018)
Examples

Layout Breadthfirst

Circle

Concentric

Cose

Grid

Random
Export graph PNG file
JPG file
JSON file

Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)30
The number (and %) of the onco-proteins3 (10.00 %)
The number (and %) of the tumor suppressors1 (3.33 %)
Total number of binary PPIs (saturation %)48 (11.03 %)
The number (and %) of affected PPIs29 (60.42 %)
PPI diameter2
PPI radius1
The average degree of PPI2.533
Assortativity coefficient-0.6221
The network average Clustering coefficient0.284
The number (and %) of a zero Clustering coefficients19 (63.33 %)
The number (and %) of a zero Betweenness Centrality25 (83.33 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure		 Type Number
of PPI (degree)		 Clustering
Coefficient		 Betweenness
Centrality		 Domains (Pfam ID): description
Znrf4

Domain structure obtained by HMM

Protein ID: XP_008835464.1 - E3 ubiquitin-protein ligase ZNRF4
KEEG Ortholog ID: K15715
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
zf-RING_2PF13639443.1e-1645.700142186141186Ring finger domain
Prok-RING_1PF14446540.0390.300181190176194Prokaryotic RING finger family 1
user protein290.022788.000zf-RING_2 (PF13639): Ring finger domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
Arel1

Domain structure obtained by HMM

Protein ID: XP_008847960.1 - apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
FilaminPF006301030.0000001918.2007614453145Filamin/ABP280 repeat
FilaminPF006301030.000527.100170260152262Filamin/ABP280 repeat
FilaminPF006301030.0311.400280301269539Filamin/ABP280 repeat
HECTPF006323074.6e-83265.300503812502813HECT-domain (ubiquitin-transferase)
interactor41.0000Filamin (PF00630): Filamin/ABP280 repeat
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Atp13a2

Domain structure obtained by HMM

Protein ID: XP_017650973.1 - probable cation-transporting ATPase 13A2 isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
P5-ATPasePF124091256.8e-2986.8003817435175P5-type ATPase cation transporter
Cation_ATPase_NPF00690690.0000006115.400194246187250Cation transporter/ATPase, N-terminus
E1-E2_ATPasePF001222211e-41128.800262496260501E1-E2 ATPase
HydrolasePF007022104.5e-2058.900507850506850haloacid dehalogenase-like hydrolase
MARVELPF012841440.030.500884939855976Membrane-associating domain
MARVELPF012841440.0111.9001033109310061099Membrane-associating domain
interactor100P5-ATPase (PF12409): P5-type ATPase cation transporter
Cation_ATPase_N (PF00690): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122): E1-E2 ATPase
Hydrolase (PF00702): haloacid dehalogenase-like hydrolase
MARVEL (PF01284): Membrane-associating domain
C2cd2l

Domain structure obtained by HMM

Protein ID: XP_008824193.1 - C2 domain-containing protein 2-like isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
C2PF001681030.0000004216.500290374286387C2 domain
DUF2880PF11082790.00003510.400549607548620Protein of unknown function (DUF2880)
interactor100C2 (PF00168): C2 domain
DUF2880 (PF11082): Protein of unknown function (DUF2880)
Canx

Domain structure obtained by HMM

Protein ID: XP_008850479.1 - calnexin
KEEG Ortholog ID: K08054
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
TRAP_alphaPF038962850.00771.5001650572Translocon-associated protein (TRAP), alpha subunit
CalreticulinPF002623663.3e-172558.4007244172441Calreticulin family
DUF1510PF074232170.0000000009324.400487578480590Protein of unknown function (DUF1510)
interactor100TRAP_alpha (PF03896): Translocon-associated protein (TRAP), alpha subunit
Calreticulin (PF00262): Calreticulin family
DUF1510 (PF07423): Protein of unknown function (DUF1510)
Cgrrf1

Domain structure obtained by HMM

Protein ID: XP_008837769.1 - cell growth regulator with RING finger domain protein 1
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF4205PF138983510.000007111.20010214891154Domain of unknown function (DUF4205)
zf-C3HC4_3PF13920500.000000000000001243.500272314270315Zinc finger, C3HC4 type (RING finger)
interactor30.6671.000DUF4205 (PF13898): Domain of unknown function (DUF4205)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
Fbxo11

Domain structure obtained by HMM

Protein ID: XP_008821269.1 - F-box only protein 11
KEEG Ortholog ID: K10297
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
F-box-likePF12937487e-2057.0007411773118F-box-like
Beta_helixPF132291582.4e-1852.600247407245410Right handed beta helix region
Beta_helixPF132291581.3e-2989.300406543400546Right handed beta helix region
Beta_helixPF132291581.4e-2163.200500610500611Right handed beta helix region
Beta_helixPF132291583.2e-3297.700580735580739Right handed beta helix region
Beta_helixPF132291580.00263.800727742721796Right handed beta helix region
zf-UBRPF02207700.0000000000002236.500764810750817Putative zinc finger in N-recognin (UBR box)
oncogene100F-box-like (PF12937): F-box-like
Beta_helix (PF13229): Right handed beta helix region
zf-UBR (PF02207): Putative zinc finger in N-recognin (UBR box)
Fzd6

Domain structure obtained by HMM

Protein ID: XP_008849770.1 - frizzled-6 isoform X1
KEEG Ortholog ID: K02376
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
FzPF013921112.4e-3195.0002412824131Fz domain
FrizzledPF015343241.2e-125404.900188508188509Frizzled/Smoothened family membrane region
Integrin_alphaPF00357150.00001311.500504512503514Integrin alpha cytoplasmic region
interactor100Fz (PF01392): Fz domain
Frizzled (PF01534): Frizzled/Smoothened family membrane region
Integrin_alpha (PF00357): Integrin alpha cytoplasmic region
Itpr2

Domain structure obtained by HMM

Protein ID: XP_008847228.2 - inositol 1,4,5-trisphosphate receptor type 2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
IncAPF041561900.0340.100131162116182IncA protein
RIH_assocPF084541019.6e-37111.200252358249359RyR and IP3R Homology associated
SUR7PF066872070.0000848.400552617517617SUR7/PalI family
Ion_transPF005202456.4e-2264.100605888598889Ion transport protein
Sec2pPF06428920.00002210.70097710199681021GDP/GTP exchange factor Sec2p
interactor100IncA (PF04156): IncA protein
RIH_assoc (PF08454): RyR and IP3R Homology associated
SUR7 (PF06687): SUR7/PalI family
Ion_trans (PF00520): Ion transport protein
Sec2p (PF06428): GDP/GTP exchange factor Sec2p
Kcng1

Domain structure obtained by HMM

Protein ID: XP_008833373.1 - potassium voltage-gated channel subfamily G member 1
KEEG Ortholog ID: K04900
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
BTB_2PF02214944.6e-3193.4006516465164BTB/POZ domain
Ion_transPF005202458.6e-44135.700227467226471Ion transport protein
interactor100BTB_2 (PF02214): BTB/POZ domain
Ion_trans (PF00520): Ion transport protein
LOC103738938

Domain structure obtained by HMM

Protein ID: XP_008837361.1 - S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
KEEG Ortholog ID: K15449
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Flavodoxin_1PF002581434.6e-2987.7007921579230Flavodoxin
DUF4769PF159922570.000008311.800229327219353Domain of unknown function (DUF4769)
Radical_SAMPF040551671.6e-3299.400399580398580Radical SAM superfamily
Wyosine_formPF08608631.6e-3194.800583645582645Wyosine base formation
interactor100Flavodoxin_1 (PF00258): Flavodoxin
DUF4769 (PF15992): Domain of unknown function (DUF4769)
Radical_SAM (PF04055): Radical SAM superfamily
Wyosine_form (PF08608): Wyosine base formation
LOC103742369

Domain structure obtained by HMM

Protein ID: XP_017656220.1 - butyrophilin-like protein 1
KEEG Ortholog ID: K06712
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
V-setPF076861090.0000000000001437.300381182Immunoglobulin V-set domain
C2-set_2PF08205900.00000002820.10010016286169CD80-like C2-set immunoglobulin domain
BatDPF135844830.00001110.500186241155244Oxygen tolerance
SPRYPF006221200.0000000003426.400323436323441SPRY domain
interactor50.5003.000V-set (PF07686): Immunoglobulin V-set domain
C2-set_2 (PF08205): CD80-like C2-set immunoglobulin domain
BatD (PF13584): Oxygen tolerance
SPRY (PF00622): SPRY domain
Lemd3

Domain structure obtained by HMM

Protein ID: XP_008827285.1 - inner nuclear membrane protein Man1
KEEG Ortholog ID: K19410
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
LEMPF03020409e-2159.50013501150LEM domain
CENP-B_dimerisPF090261000.00593.300211237202244Centromere protein B dimerisation domain
CENP-B_dimerisPF090261000.00254.500259293250297Centromere protein B dimerisation domain
MSCPF094023279.5e-2573.800532745517747Man1-Src1p-C-terminal domain
RBM39linkerPF15519890.000001115.900773799745799linker between RRM2 and RRM3 domains in RBM39 protein
interactor100LEM (PF03020): LEM domain
CENP-B_dimeris (PF09026): Centromere protein B dimerisation domain
MSC (PF09402): Man1-Src1p-C-terminal domain
RBM39linker (PF15519): linker between RRM2 and RRM3 domains in RBM39 protein
Ndc1

Domain structure obtained by HMM

Protein ID: XP_008831241.1 - nucleoporin NDC1
KEEG Ortholog ID: K14315
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Ndc1_NupPF095316134e-137444.5006771366713Nucleoporin protein Ndc1-Nup
interactor100Ndc1_Nup (PF09531): Nucleoporin protein Ndc1-Nup
Osbp

Domain structure obtained by HMM

Protein ID: XP_008840229.1 - oxysterol-binding protein 1
KEEG Ortholog ID: K20456
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PH_8PF15409890.00000004119.800554255Pleckstrin homology domain
Syntaxin-6_NPF09177990.000006812.9006611925135Syntaxin 6, N-terminal
HlyD_D23PF165762140.00001110.900128181123207Barrel-sandwich domain of CusB or HlyD membrane-fusion
betaPIX_CCPF16523880.000005712.400150192127197betaPIX coiled coil
Oxysterol_BPPF012373714.7e-151488.800293668293668Oxysterol-binding protein
interactor21.0000PH_8 (PF15409): Pleckstrin homology domain
Syntaxin-6_N (PF09177): Syntaxin 6, N-terminal
HlyD_D23 (PF16576): Barrel-sandwich domain of CusB or HlyD membrane-fusion
betaPIX_CC (PF16523): betaPIX coiled coil
Oxysterol_BP (PF01237): Oxysterol-binding protein
Osbpl8

Domain structure obtained by HMM

Protein ID: XP_008850153.1 - oxysterol-binding protein-related protein 8 isoform X1
KEEG Ortholog ID: K20464
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF1980PF093231800.00124.9009414254157Domain of unknown function (DUF1980)
PHPF001691050.00000000000001640.600163277162278PH domain
CDC45PF027246270.000364.900325376310466CDC45-like protein
Oxysterol_BPPF012373718e-94300.500423759419765Oxysterol-binding protein
interactor100DUF1980 (PF09323): Domain of unknown function (DUF1980)
PH (PF00169): PH domain
CDC45 (PF02724): CDC45-like protein
Oxysterol_BP (PF01237): Oxysterol-binding protein
Pdzd8

Domain structure obtained by HMM

Protein ID: XP_008825550.1 - PDZ domain-containing protein 8
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PDZPF00595820.000000000005432.300367441366445PDZ domain (Also known as DHR or GLGF)
IncAPF041561900.0230.600489514466529IncA protein
RICTOR_phosphoPF146651090.00002211.100542588534608Rapamycin-insensitive companion of mTOR, phosphorylation-site
C1_1PF00130530.000000000006531.500837882837886Phorbol esters/diacylglycerol binding domain (C1 domain)
IncAPF041561900.0000399.6001024111210061132IncA protein
interactor21.0000PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
IncA (PF04156): IncA protein
RICTOR_phospho (PF14665): Rapamycin-insensitive companion of mTOR, phosphorylation-site
C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
Scap

Domain structure obtained by HMM

Protein ID: XP_008828888.1 - sterol regulatory element-binding protein cleavage-activating protein
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Sterol-sensingPF123491538.5e-57177.500308451308457Sterol-sensing domain of SREBP cleavage-activation
WD40PF00400380.00004610.600771801767801WD domain, G-beta repeat
ANAPC4_WD40PF12894920.012.500783811776816Anaphase-promoting complex subunit 4 WD40 domain
ANAPC4_WD40PF12894920.0181.7009709979641013Anaphase-promoting complex subunit 4 WD40 domain
WD40PF00400380.000139.2001066109810611099WD domain, G-beta repeat
WD40PF00400380.0000001318.7001104114011031140WD domain, G-beta repeat
WD40PF00400380.000946.5001149118011441180WD domain, G-beta repeat
WD40PF00400380.0192.4001206122011991220WD domain, G-beta repeat
interactor30.6671.000Sterol-sensing (PF12349): Sterol-sensing domain of SREBP cleavage-activation
WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Srebf2

Domain structure obtained by HMM

Protein ID: XP_008843011.1 - sterol regulatory element-binding protein 2 isoform X1
KEEG Ortholog ID: K09107
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
TFIIAPF031534150.000635.80010924173428Transcription factor IIA, alpha/beta subunit
HLHPF00010552.7e-2058.500325375325375Helix-loop-helix DNA-binding domain
interactor40.6671.000TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
HLH (PF00010): Helix-loop-helix DNA-binding domain
Tmx2

Domain structure obtained by HMM

Protein ID: XP_008834385.1 - thioredoxin-related transmembrane protein 2 isoform X3
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PAP2_3PF143781900.00055.900346192PAP2 superfamily
PAP2_3PF143781900.00592.40011414092174PAP2 superfamily
ThioredoxinPF000851046.8e-1644.400140230137244Thioredoxin
interactor100PAP2_3 (PF14378): PAP2 superfamily
Thioredoxin (PF00085): Thioredoxin
Ube2d1

Domain structure obtained by HMM

Protein ID: XP_008827231.1 - ubiquitin-conjugating enzyme E2 D1
KEEG Ortholog ID: K06689
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
UQ_conPF001791403.7e-48149.00011041105Ubiquitin-conjugating enzyme
interactor41.0000UQ_con (PF00179): Ubiquitin-conjugating enzyme
Ube2d2

Domain structure obtained by HMM

Protein ID: XP_008842509.1 - ubiquitin-conjugating enzyme E2 D2
KEEG Ortholog ID: K06689
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
UQ_conPF001791404.1e-58181.20051415142Ubiquitin-conjugating enzyme
oncogene41.0000UQ_con (PF00179): Ubiquitin-conjugating enzyme
Ube2d4

Domain structure obtained by HMM

Protein ID: XP_008832265.1 - ubiquitin-conjugating enzyme E2 D4 isoform X1
KEEG Ortholog ID: K06689
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
UQ_conPF001791404.4e-57177.90051365140Ubiquitin-conjugating enzyme
interactor200UQ_con (PF00179): Ubiquitin-conjugating enzyme
Ube2e1

Domain structure obtained by HMM

Protein ID: XP_008831376.1 - ubiquitin-conjugating enzyme E2 E1
KEEG Ortholog ID: K20217
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SR-25PF105002270.000007611.800654182Nuclear RNA-splicing-associated protein
UQ_conPF001791403.7e-51158.7005118751188Ubiquitin-conjugating enzyme
interactor200SR-25 (PF10500): Nuclear RNA-splicing-associated protein
UQ_con (PF00179): Ubiquitin-conjugating enzyme
Ube2e3

Domain structure obtained by HMM

Protein ID: XP_008826180.1 - ubiquitin-conjugating enzyme E2 E3
KEEG Ortholog ID: K20217
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
UQ_conPF001791404.9e-50155.0006520165202Ubiquitin-conjugating enzyme
interactor100UQ_con (PF00179): Ubiquitin-conjugating enzyme
Ube2g2

Domain structure obtained by HMM

Protein ID: XP_008838643.1 - ubiquitin-conjugating enzyme E2 G2
KEEG Ortholog ID: K04555
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
UQ_conPF001791408.4e-53164.00081588159Ubiquitin-conjugating enzyme
interactor200UQ_con (PF00179): Ubiquitin-conjugating enzyme
Ube2n

Domain structure obtained by HMM

Protein ID: XP_017651379.1 - ubiquitin-conjugating enzyme E2 N
KEEG Ortholog ID: K10580
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
UQ_conPF001791404.6e-52161.60071427144Ubiquitin-conjugating enzyme
interactor200UQ_con (PF00179): Ubiquitin-conjugating enzyme
Ube2w

Domain structure obtained by HMM

Protein ID: XP_008847117.1 - ubiquitin-conjugating enzyme E2 W isoform X1
KEEG Ortholog ID: K10688
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
UQ_conPF001791404.2e-38116.4003616936176Ubiquitin-conjugating enzyme
interactor200UQ_con (PF00179): Ubiquitin-conjugating enzyme
Usp33

Domain structure obtained by HMM

Protein ID: XP_008846867.1 - ubiquitin carboxyl-terminal hydrolase 33 isoform X1
KEEG Ortholog ID: K11848
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
zf-UBPPF02148641.3e-2059.90030913095Zn-finger in ubiquitin-hydrolases and other protein
UCHPF004432573.1e-67212.800153680153680Ubiquitin carboxyl-terminal hydrolase
DUSPPF06337920.00000000001131.500708777705778DUSP domain
DUSPPF06337923.3e-1852.500815884813887DUSP domain
tumor suppressor21.0000zf-UBP (PF02148): Zn-finger in ubiquitin-hydrolases and other protein
UCH (PF00443): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337): DUSP domain
Zdhhc18

Domain structure obtained by HMM

Protein ID: XP_017654558.1 - palmitoyltransferase ZDHHC18
KEEG Ortholog ID: K16675
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Phage_holin_3_6PF073321130.000596.1005610652131Putative Actinobacterial Holin-X, holin superfamily III
zf-DHHCPF015291342.8e-40123.700161285158287DHHC palmitoyltransferase
oncogene100Phage_holin_3_6 (PF07332): Putative Actinobacterial Holin-X, holin superfamily III
zf-DHHC (PF01529): DHHC palmitoyltransferase

B a c k    t o    T o p ⇑