Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Znrf4 (from a repository: Mon Apr 16 21:34:22 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)30
The number (and %) of the onco-proteins3 (10.00 %)
The number (and %) of the tumor suppressors1 (3.33 %)
Total number of binary PPIs (saturation %)48 (11.03 %)
The number (and %) of affected PPIs29 (60.42 %)
PPI diameter2
PPI radius1
The average degree of PPI2.533
Assortativity coefficient-0.6221
The network average Clustering coefficient0.284
The number (and %) of a zero Clustering coefficients19 (63.33 %)
The number (and %) of a zero Betweenness Centrality25 (83.33 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Znrf4
user protein290.022788.000zf-RING_2 (PF13639): Ring finger domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
Arel1
interactor41.0000Filamin (PF00630): Filamin/ABP280 repeat
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Atp13a2
interactor100P5-ATPase (PF12409): P5-type ATPase cation transporter
Cation_ATPase_N (PF00690): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122): E1-E2 ATPase
Hydrolase (PF00702): haloacid dehalogenase-like hydrolase
MARVEL (PF01284): Membrane-associating domain
C2cd2l
interactor100C2 (PF00168): C2 domain
DUF2880 (PF11082): Protein of unknown function (DUF2880)
Canx
interactor100TRAP_alpha (PF03896): Translocon-associated protein (TRAP), alpha subunit
Calreticulin (PF00262): Calreticulin family
DUF1510 (PF07423): Protein of unknown function (DUF1510)
Cgrrf1
interactor30.6671.000DUF4205 (PF13898): Domain of unknown function (DUF4205)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
Fbxo11
oncogene100F-box-like (PF12937): F-box-like
Beta_helix (PF13229): Right handed beta helix region
zf-UBR (PF02207): Putative zinc finger in N-recognin (UBR box)
Fzd6
interactor100Fz (PF01392): Fz domain
Frizzled (PF01534): Frizzled/Smoothened family membrane region
Integrin_alpha (PF00357): Integrin alpha cytoplasmic region
Itpr2
interactor100IncA (PF04156): IncA protein
RIH_assoc (PF08454): RyR and IP3R Homology associated
SUR7 (PF06687): SUR7/PalI family
Ion_trans (PF00520): Ion transport protein
Sec2p (PF06428): GDP/GTP exchange factor Sec2p
Kcng1
interactor100BTB_2 (PF02214): BTB/POZ domain
Ion_trans (PF00520): Ion transport protein
LOC103738938
interactor100Flavodoxin_1 (PF00258): Flavodoxin
DUF4769 (PF15992): Domain of unknown function (DUF4769)
Radical_SAM (PF04055): Radical SAM superfamily
Wyosine_form (PF08608): Wyosine base formation
LOC103742369
interactor50.5003.000V-set (PF07686): Immunoglobulin V-set domain
C2-set_2 (PF08205): CD80-like C2-set immunoglobulin domain
BatD (PF13584): Oxygen tolerance
SPRY (PF00622): SPRY domain
Lemd3
interactor100LEM (PF03020): LEM domain
CENP-B_dimeris (PF09026): Centromere protein B dimerisation domain
MSC (PF09402): Man1-Src1p-C-terminal domain
RBM39linker (PF15519): linker between RRM2 and RRM3 domains in RBM39 protein
Ndc1
interactor100Ndc1_Nup (PF09531): Nucleoporin protein Ndc1-Nup
Osbp
interactor21.0000PH_8 (PF15409): Pleckstrin homology domain
Syntaxin-6_N (PF09177): Syntaxin 6, N-terminal
HlyD_D23 (PF16576): Barrel-sandwich domain of CusB or HlyD membrane-fusion
betaPIX_CC (PF16523): betaPIX coiled coil
Oxysterol_BP (PF01237): Oxysterol-binding protein
Osbpl8
interactor100DUF1980 (PF09323): Domain of unknown function (DUF1980)
PH (PF00169): PH domain
CDC45 (PF02724): CDC45-like protein
Oxysterol_BP (PF01237): Oxysterol-binding protein
Pdzd8
interactor21.0000PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
IncA (PF04156): IncA protein
RICTOR_phospho (PF14665): Rapamycin-insensitive companion of mTOR, phosphorylation-site
C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
Scap
interactor30.6671.000Sterol-sensing (PF12349): Sterol-sensing domain of SREBP cleavage-activation
WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Srebf2
interactor40.6671.000TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
HLH (PF00010): Helix-loop-helix DNA-binding domain
Tmx2
interactor100PAP2_3 (PF14378): PAP2 superfamily
Thioredoxin (PF00085): Thioredoxin
Ube2d1
interactor41.0000UQ_con (PF00179): Ubiquitin-conjugating enzyme
Ube2d2
oncogene41.0000UQ_con (PF00179): Ubiquitin-conjugating enzyme
Ube2d4
interactor200UQ_con (PF00179): Ubiquitin-conjugating enzyme
Ube2e1
interactor200SR-25 (PF10500): Nuclear RNA-splicing-associated protein
UQ_con (PF00179): Ubiquitin-conjugating enzyme
Ube2e3
interactor100UQ_con (PF00179): Ubiquitin-conjugating enzyme
Ube2g2
interactor200UQ_con (PF00179): Ubiquitin-conjugating enzyme
Ube2n
interactor200UQ_con (PF00179): Ubiquitin-conjugating enzyme
Ube2w
interactor200UQ_con (PF00179): Ubiquitin-conjugating enzyme
Usp33
tumor suppressor21.0000zf-UBP (PF02148): Zn-finger in ubiquitin-hydrolases and other protein
UCH (PF00443): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337): DUSP domain
Zdhhc18
oncogene100Phage_holin_3_6 (PF07332): Putative Actinobacterial Holin-X, holin superfamily III
zf-DHHC (PF01529): DHHC palmitoyltransferase

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