Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Znrf3 (from a repository: Wed Apr 11 04:13:28 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)10
The number (and %) of the onco-proteins5 (50.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)17 (37.78 %)
The number (and %) of affected PPIs9 (52.94 %)
PPI diameter2
PPI radius1
The average degree of PPI2.600
Assortativity coefficient-0.5309
The network average Clustering coefficient0.561
The number (and %) of a zero Clustering coefficients3 (30.00 %)
The number (and %) of a zero Betweenness Centrality8 (80.00 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure		 Type Number
of PPI (degree)		 Clustering
Coefficient		 Betweenness
Centrality		 Domains (Pfam ID): description
Znrf3

Domain structure obtained by HMM

Protein ID: XP_008839343.1 - E3 ubiquitin-protein ligase ZNRF3
KEEG Ortholog ID: K16273
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PAPF02225930.00002210.90040881691PA domain
Cadherin_C_2PF16492850.00001112.500123173120192Cadherin cytoplasmic C-terminal
zf-RING_2PF13639441.1e-1647.100192234191234Ring finger domain
zf-C3H2C3PF17122350.00553.100421443419445Zinc-finger
user protein90.11161.000PA (PF02225): PA domain
Cadherin_C_2 (PF16492): Cadherin cytoplasmic C-terminal
zf-RING_2 (PF13639): Ring finger domain
zf-C3H2C3 (PF17122): Zinc-finger
Dvl2

Domain structure obtained by HMM

Protein ID: XP_008854073.1 - segment polarity protein dishevelled homolog DVL-2 isoform X2
KEEG Ortholog ID: K02353
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DIXPF00778811e-36111.00013901291DIX domain
Mito_fiss_regPF053082440.000128.4009416275181Mitochondrial fission regulator
DishevelledPF023771593.6e-58182.700119257107257Dishevelled specific domain
PDZPF00595824.7e-2264.500262336261346PDZ domain (Also known as DHR or GLGF)
DEPPF00610728.9e-2160.100430499430499Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dsh_CPF123162079.1e-77244.300509722509722Segment polarity protein dishevelled (Dsh) C terminal
interactor200DIX (PF00778): DIX domain
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
Dishevelled (PF02377): Dishevelled specific domain
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
DEP (PF00610): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dsh_C (PF12316): Segment polarity protein dishevelled (Dsh) C terminal
Fzd4

Domain structure obtained by HMM

Protein ID: XP_008842354.1 - frizzled-4
KEEG Ortholog ID: K02354
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
FzPF013921114e-34104.0004515245153Fz domain
FrizzledPF015343244.7e-130419.400211510210511Frizzled/Smoothened family membrane region
interactor100Fz (PF01392): Fz domain
Frizzled (PF01534): Frizzled/Smoothened family membrane region
Gfi1b

Domain structure obtained by HMM

Protein ID: XP_008842169.1 - zinc finger protein Gfi-1b
KEEG Ortholog ID: K09223
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
UBZ_FAAP20PF15750350.0380.30068726876Ubiquitin-binding zinc-finger
SPR1PF153561140.000001215.2007712358130Psoriasis susceptibility locus 2
zf-C2H2PF00096230.000000006222.400161184161184Zinc finger, C2H2 type
zf-H2C2_2PF13465260.000000001124.800176201175201Zinc-finger double domain
zf-H2C2_2PF13465260.0000000121.800204229204229Zinc-finger double domain
zf-C2H2PF00096230.0000000009425.000218240218240Zinc finger, C2H2 type
zf-H2C2_2PF13465260.0000002217.600233256232257Zinc-finger double domain
zf-H2C2_2PF13465260.000000000004232.500261284260285Zinc-finger double domain
zf-C2H2PF00096230.000000001124.800274296274296Zinc finger, C2H2 type
zf-H2C2_2PF13465260.000000001224.800288311288313Zinc-finger double domain
zf-C2H2_4PF13894240.00000009519.000302325302325C2H2-type zinc finger
oncogene100UBZ_FAAP20 (PF15750): Ubiquitin-binding zinc-finger
SPR1 (PF15356): Psoriasis susceptibility locus 2
zf-C2H2 (PF00096): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Hspb1

Domain structure obtained by HMM

Protein ID: XP_008830488.1 - heat shock protein beta-1
KEEG Ortholog ID: K04455
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
HSP20PF000111014.4e-2987.0009218791188Hsp20/alpha crystallin family
heat shock, oncogene31.0000HSP20 (PF00011): Hsp20/alpha crystallin family
Lgr4

Domain structure obtained by HMM

Protein ID: XP_008849334.1 - leucine-rich repeat-containing G-protein coupled receptor 4
KEEG Ortholog ID: K04309
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
LRRNTPF01462280.00000000002229.60029552956Leucine rich repeat N-terminal domain
LRR_8PF13855617e-1850.5006011759117Leucine rich repeat
LRR_8PF13855611.2e-1646.600106165105165Leucine rich repeat
LRR_8PF13855610.0000000000001336.800130184129185Leucine rich repeat
LRR_8PF13855611.3e-1956.100177237177237Leucine rich repeat
LRR_8PF13855610.0000000000003235.600248305248307Leucine rich repeat
LRR_8PF13855610.00000000000004438.400320377319377Leucine rich repeat
LRR_8PF13855616e-1747.500367425365425Leucine rich repeat
LRR_4PF12799430.000009612.300416448415464Leucine Rich repeats (2 copies)
7tm_1PF000012680.000000000001133.8005568015558017 transmembrane receptor (rhodopsin family)
interactor50.5003.000LRRNT (PF01462): Leucine rich repeat N-terminal domain
LRR_8 (PF13855): Leucine rich repeat
LRR_4 (PF12799): Leucine Rich repeats (2 copies)
7tm_1 (PF00001): 7 transmembrane receptor (rhodopsin family)
Rspo1

Domain structure obtained by HMM

Protein ID: XP_008848429.1 - R-spondin-1 isoform X2
KEEG Ortholog ID: K19471
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Furin-like_2PF159131074.1e-51158.0004214940149Furin-like repeat, cysteine-rich
TSP_1PF00090490.000000002423.600151201151206Thrombospondin type 1 domain
TSP_1PF00090490.0221.300236253234258Thrombospondin type 1 domain
oncogene21.0000Furin-like_2 (PF15913): Furin-like repeat, cysteine-rich
TSP_1 (PF00090): Thrombospondin type 1 domain
Rspo2

Domain structure obtained by HMM

Protein ID: XP_008849730.1 - R-spondin-2 isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Furin-like_2PF159131073.7e-52161.3004014640146Furin-like repeat, cysteine-rich
VSPPF033023970.00232.900127204122219Giardia variant-specific surface protein
CDT1PF088391760.000009812.100207239156242DNA replication factor CDT1 like
oncogene21.0000Furin-like_2 (PF15913): Furin-like repeat, cysteine-rich
VSP (PF03302): Giardia variant-specific surface protein
CDT1 (PF08839): DNA replication factor CDT1 like
Rspo3

Domain structure obtained by HMM

Protein ID: XP_008831854.1 - R-spondin-3
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Furin-like_2PF159131071e-50156.7004214841149Furin-like repeat, cysteine-rich
TSP_1PF00090490.0000000002626.700151202151206Thrombospondin type 1 domain
RR_TM4-6PF064592800.00452.900193267159274Ryanodine Receptor TM 4-6
oncogene21.0000Furin-like_2 (PF15913): Furin-like repeat, cysteine-rich
TSP_1 (PF00090): Thrombospondin type 1 domain
RR_TM4-6 (PF06459): Ryanodine Receptor TM 4-6
Ube2n

Domain structure obtained by HMM

Protein ID: XP_017651379.1 - ubiquitin-conjugating enzyme E2 N
KEEG Ortholog ID: K10580
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
UQ_conPF001791404.6e-52161.60071427144Ubiquitin-conjugating enzyme
interactor31.0000UQ_con (PF00179): Ubiquitin-conjugating enzyme

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