Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Znrf2
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Visible interactors:

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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Znrf2 (from a repository: Sat Apr 14 00:07:57 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	6
The number (and %) of the onco-proteins	1 (16.67 %)
The number (and %) of the tumor suppressors	0 (0.00 %)
Total number of binary PPIs (saturation %)	9 (60.00 %)
The number (and %) of affected PPIs	5 (55.56 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	2.333
Assortativity coefficient	-0.2582
The network average Clustering coefficient	0.700
The number (and %) of a zero Clustering coefficients	1 (16.67 %)
The number (and %) of a zero Betweenness Centrality	5 (83.33 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Znrf2

XP_008839761.1

Domain structure obtained by HMM

Protein ID: XP_008839761.1 - E3 ubiquitin-protein ligase ZNRF2
KEEG Ortholog ID: K10694

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PRP21_like_P	PF12230	217	0.00000023	17.000	158	192	147	216	Pre-mRNA splicing factor PRP21 like protein
zf-RING_2	PF13639	44	0.000000000000098	37.700	202	241	201	242	Ring finger domain

user protein

0.200

16.000

PRP21_like_P (PF12230): Pre-mRNA splicing factor PRP21 like protein
zf-RING_2 (PF13639): Ring finger domain

Atp1a1

XP_008832247.1

Domain structure obtained by HMM

Protein ID: XP_008832247.1 - sodium/potassium-transporting ATPase subunit alpha-1 isoform X1
KEEG Ortholog ID: K01539

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Cation_ATPase_N	PF00690	69	5.2e-22	63.700	44	111	43	111	Cation transporter/ATPase, N-terminus
E1-E2_ATPase	PF00122	221	3.4e-62	195.700	135	365	134	365	E1-E2 ATPase
Cation_ATPase	PF13246	91	1e-27	82.400	427	521	426	521	Cation transport ATPase (P-type)
Hydrolase_3	PF08282	255	0.0012	4.700	601	633	595	646	haloacid dehalogenase-like hydrolase
Hydrolase_3	PF08282	255	0.00000023	16.900	712	757	701	761	haloacid dehalogenase-like hydrolase
Cation_ATPase_C	PF00689	182	4.8e-49	152.700	799	1008	799	1008	Cation transporting ATPase, C-terminus

interactor

1.000

Cation_ATPase_N (PF00690): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122): E1-E2 ATPase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
Hydrolase_3 (PF08282): haloacid dehalogenase-like hydrolase
Cation_ATPase_C (PF00689): Cation transporting ATPase, C-terminus

Elavl1

XP_008822366.1

Domain structure obtained by HMM

Protein ID: XP_008822366.1 - ELAV-like protein 1
KEEG Ortholog ID: K13088

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
RRM_1	PF00076	70	6.8e-24	69.800	22	92	22	92	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_1	PF00076	70	5.6e-22	63.700	108	174	108	176	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_1	PF00076	70	8e-24	69.600	246	315	246	316	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

oncogene

1.000

RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

Ubc

XP_008837468.1

Domain structure obtained by HMM

Protein ID: XP_008837468.1 - polyubiquitin-C
KEEG Ortholog ID: K08770

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
ubiquitin	PF00240	72	2e-33	100.300	3	74	3	74	Ubiquitin family
ubiquitin	PF00240	72	3.4e-32	96.400	79	150	79	150	Ubiquitin family
ubiquitin	PF00240	72	3.4e-32	96.400	155	226	155	226	Ubiquitin family
ubiquitin	PF00240	72	3.4e-32	96.400	231	302	231	302	Ubiquitin family
ubiquitin	PF00240	72	3.4e-32	96.400	307	378	307	378	Ubiquitin family
ubiquitin	PF00240	72	2.9e-35	106.200	383	454	383	454	Ubiquitin family
ubiquitin	PF00240	72	0.0000031	13.200	459	483	459	486	Ubiquitin family

interactor

1.000

ubiquitin (PF00240): Ubiquitin family

Wdr5b

XP_008841161.1

Domain structure obtained by HMM

Protein ID: XP_008841161.1 - WD repeat-containing protein 5B
KEEG Ortholog ID: K14963

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
WD40	PF00400	38	0.0000000000086	31.900	33	66	29	66	WD domain, G-beta repeat
Kelch_6	PF13964	50	0.036	0.900	57	71	54	81	Kelch motif
WD40	PF00400	38	0.000000000002	33.900	72	109	71	109	WD domain, G-beta repeat
WD40	PF00400	38	0.00000000000027	36.700	113	150	113	151	WD domain, G-beta repeat
WD40	PF00400	38	0.000000000002	33.900	155	193	155	193	WD domain, G-beta repeat
WD40	PF00400	38	0.00000000056	26.200	197	236	197	236	WD domain, G-beta repeat
WD40	PF00400	38	0.00000000033	26.900	240	281	240	281	WD domain, G-beta repeat
WD40	PF00400	38	0.000001	15.900	287	324	285	325	WD domain, G-beta repeat

interactor

WD40 (PF00400): WD domain, G-beta repeat
Kelch_6 (PF13964): Kelch motif

Xpo1

XP_008842706.1

Domain structure obtained by HMM

Protein ID: XP_008842706.1 - exportin-1
KEEG Ortholog ID: K14290

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
IBN_N	PF03810	74	5.1e-16	44.700	46	111	46	112	Importin-beta N-terminal domain
Xpo1	PF08389	149	1.9e-45	140.800	124	268	123	268	Exportin 1-like protein
Vac14_Fab1_bd	PF12755	97	0.00024	8.000	560	626	553	638	Vacuolar 14 Fab1-binding region
Hydrolase_3	PF08282	255	0.033	0.000	618	695	610	697	haloacid dehalogenase-like hydrolase
CRM1_C	PF08767	321	2e-139	450.300	709	1027	709	1027	CRM1 C terminal

interactor

1.000

IBN_N (PF03810): Importin-beta N-terminal domain
Xpo1 (PF08389): Exportin 1-like protein
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
Hydrolase_3 (PF08282): haloacid dehalogenase-like hydrolase
CRM1_C (PF08767): CRM1 C terminal

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