Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Znrd1
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Visible interactors:

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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Znrd1 (from a repository: Fri Apr 13 14:08:43 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	14
The number (and %) of the onco-proteins	2 (14.29 %)
The number (and %) of the tumor suppressors	1 (7.14 %)
Total number of binary PPIs (saturation %)	24 (26.37 %)
The number (and %) of affected PPIs	13 (54.17 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	2.429
Assortativity coefficient	-0.5230
The network average Clustering coefficient	0.361
The number (and %) of a zero Clustering coefficients	8 (57.14 %)
The number (and %) of a zero Betweenness Centrality	13 (92.86 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Znrd1

XP_008826083.1

Domain structure obtained by HMM

Protein ID: XP_008826083.1 - DNA-directed RNA polymerase I subunit RPA12 isoform X2
KEEG Ortholog ID: K03000

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DZR	PF12773	49	0.00000012	18.000	13	43	6	47	Double zinc ribbon
zf-ISL3	PF14690	47	0.0006	6.800	33	47	31	55	zinc-finger of transposase IS204/IS1001/IS1096/IS1165
TFIIS_C	PF01096	39	4.9e-19	54.300	83	118	82	120	Transcription factor S-II (TFIIS)

user protein

0.051

148.000

DZR (PF12773): Double zinc ribbon
zf-ISL3 (PF14690): zinc-finger of transposase IS204/IS1001/IS1096/IS1165
TFIIS_C (PF01096): Transcription factor S-II (TFIIS)

Atxn2

XP_017657246.1

Domain structure obtained by HMM

Protein ID: XP_017657246.1 - ataxin-2 isoform X5

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SM-ATX	PF14438	81	2.1e-25	75.100	2	76	1	76	Ataxin 2 SM domain
LsmAD	PF06741	70	3.2e-20	58.900	144	211	144	211	LsmAD domain
PAM2	PF07145	18	0.00000000019	26.300	643	659	643	660	Ataxin-2 C-terminal region
DUF3446	PF11928	88	0.014	2.000	743	772	708	778	Domain of unknown function (DUF3446)
DUF3446	PF11928	88	0.015	2.000	935	978	927	990	Domain of unknown function (DUF3446)

interactor

SM-ATX (PF14438): Ataxin 2 SM domain
LsmAD (PF06741): LsmAD domain
PAM2 (PF07145): Ataxin-2 C-terminal region
DUF3446 (PF11928): Domain of unknown function (DUF3446)

Dusp1

XP_008848991.1

Domain structure obtained by HMM

Protein ID: XP_008848991.1 - dual specificity protein phosphatase 1
KEEG Ortholog ID: K21278

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Rhodanese	PF00581	107	0.00000000000027	36.700	19	130	10	131	Rhodanese-like domain
DSPc	PF00782	133	2e-52	162.800	181	310	181	311	Dual specificity phosphatase, catalytic domain

tumor suppressor

Rhodanese (PF00581): Rhodanese-like domain
DSPc (PF00782): Dual specificity phosphatase, catalytic domain

Gpr20

XP_008849304.1

Domain structure obtained by HMM

Protein ID: XP_008849304.1 - G-protein coupled receptor 20
KEEG Ortholog ID: K04317

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
7tm_1	PF00001	268	3.9e-34	104.200	69	296	68	296	7 transmembrane receptor (rhodopsin family)

interactor

7tm_1 (PF00001): 7 transmembrane receptor (rhodopsin family)

Ivns1abp

XP_008822496.1

Domain structure obtained by HMM

Protein ID: XP_008822496.1 - influenza virus NS1A-binding protein isoform X1
KEEG Ortholog ID: K15046

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
BTB	PF00651	111	4.9e-31	93.500	22	126	22	128	BTB/POZ domain
BACK	PF07707	103	1.2e-16	47.000	134	221	134	228	BTB And C-terminal Kelch
Kelch_1	PF01344	46	4.7e-17	47.700	357	402	357	402	Kelch motif
Kelch_1	PF01344	46	0.0000000000011	33.700	404	450	404	450	Kelch motif
Kelch_1	PF01344	46	8.8e-18	50.000	453	499	452	499	Kelch motif
Kelch_1	PF01344	46	2.4e-18	51.800	501	546	501	546	Kelch motif
Kelch_1	PF01344	46	1.8e-16	45.800	548	592	548	593	Kelch motif
Kelch_1	PF01344	46	2e-19	55.300	595	635	595	638	Kelch motif

interactor

BTB (PF00651): BTB/POZ domain
BACK (PF07707): BTB And C-terminal Kelch
Kelch_1 (PF01344): Kelch motif

Mapk8ip2

XP_008833007.1

Domain structure obtained by HMM

Protein ID: XP_008833007.1 - C-Jun-amino-terminal kinase-interacting protein 2 isoform X2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PBP_sp32	PF07222	243	0.00046	5.800	58	109	47	114	Proacrosin binding protein sp32
RXT2_N	PF08595	156	0.000049	9.600	86	138	58	145	RXT2-like, N-terminal
TonB_N	PF16031	134	0.000092	9.200	300	327	292	335	TonB N-terminal region
TonB_N	PF16031	134	0.0045	3.700	406	438	401	452	TonB N-terminal region
CENP-B_dimeris	PF09026	100	0.000054	9.900	477	496	467	523	Centromere protein B dimerisation domain
S-antigen	PF05756	93	0.016	1.800	542	564	533	567	S-antigen protein
SH3_9	PF14604	49	8.7e-18	50.300	619	668	619	669	Variant SH3 domain
PID	PF00640	140	1.2e-36	112.000	691	820	691	822	Phosphotyrosine interaction domain (PTB/PID)

interactor

PBP_sp32 (PF07222): Proacrosin binding protein sp32
RXT2_N (PF08595): RXT2-like, N-terminal
TonB_N (PF16031): TonB N-terminal region
CENP-B_dimeris (PF09026): Centromere protein B dimerisation domain
S-antigen (PF05756): S-antigen protein
SH3_9 (PF14604): Variant SH3 domain
PID (PF00640): Phosphotyrosine interaction domain (PTB/PID)

Nono

XP_008853791.1

Domain structure obtained by HMM

Protein ID: XP_008853791.1 - non-POU domain-containing octamer-binding protein
KEEG Ortholog ID: K13214

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SUIM_assoc	PF16619	64	0.0081	2.600	18	44	7	53	Unstructured region C-term to UIM in Ataxin3
RRM_1	PF00076	70	4.1e-20	57.800	71	135	71	135	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_1	PF00076	70	2.4e-17	48.900	145	205	145	212	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
NOPS	PF08075	52	6.1e-31	92.700	216	267	216	267	NOPS (NUC059) domain
PAS_7	PF12860	115	0.00001	11.900	233	312	231	315	PAS fold
GvpL_GvpF	PF06386	244	0.00016	7.800	266	386	261	393	Gas vesicle synthesis protein GvpL/GvpF

oncogene

1.000

SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
NOPS (PF08075): NOPS (NUC059) domain
PAS_7 (PF12860): PAS fold
GvpL_GvpF (PF06386): Gas vesicle synthesis protein GvpL/GvpF

Pms2

XP_008822235.1

Domain structure obtained by HMM

Protein ID: XP_008822235.1 - mismatch repair endonuclease PMS2 isoform X1
KEEG Ortholog ID: K10858

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
HATPase_c_3	PF13589	137	6.5e-16	44.600	35	138	33	159	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
DNA_mis_repair	PF01119	119	4.8e-27	80.300	266	359	252	363	DNA mismatch repair protein, C-terminal domain
MutL_C	PF08676	147	2.1e-36	111.100	675	819	673	819	MutL C terminal dimerisation domain

oncogene

HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
DNA_mis_repair (PF01119): DNA mismatch repair protein, C-terminal domain
MutL_C (PF08676): MutL C terminal dimerisation domain

Polr1a

XP_008834971.1

Domain structure obtained by HMM

Protein ID: XP_008834971.1 - DNA-directed RNA polymerase I subunit RPA1 isoform X1
KEEG Ortholog ID: K02999

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
RNA_pol_Rpb1_1	PF04997	312	5.4e-23	67.800	11	356	9	365	RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_1	PF04997	312	0.00063	5.200	394	437	383	439	RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2	PF00623	166	8.6e-75	236.700	441	620	441	621	RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3	PF04983	158	9.6e-41	125.500	624	809	624	809	RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4	PF05000	108	6.3e-28	83.200	850	958	845	958	RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5	PF04998	267	4.4e-107	343.500	965	1666	965	1668	RNA polymerase Rpb1, domain 5

interactor

1.000

RNA_pol_Rpb1_1 (PF04997): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998): RNA polymerase Rpb1, domain 5

Polr2e

XP_008835404.1

Domain structure obtained by HMM

Protein ID: XP_008835404.1 - DNA-directed RNA polymerases I, II, and III subunit RPABC1
KEEG Ortholog ID: K03013

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
RNA_pol_Rpb5_N	PF03871	89	1e-39	121.300	4	94	4	94	RNA polymerase Rpb5, N-terminal domain
RNA_pol_Rpb5_C	PF01191	73	8.5e-40	120.800	137	209	137	209	RNA polymerase Rpb5, C-terminal domain

interactor

1.000

RNA_pol_Rpb5_N (PF03871): RNA polymerase Rpb5, N-terminal domain
RNA_pol_Rpb5_C (PF01191): RNA polymerase Rpb5, C-terminal domain

Polr2f

XP_008849500.1

Domain structure obtained by HMM

Protein ID: XP_008849500.1 - DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1
KEEG Ortholog ID: K03014

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
BDHCT_assoc	PF16204	223	0.000053	9.100	3	24	1	55	BDHCT-box associated domain on Bloom syndrome protein
RNA_pol_Rpb6	PF01192	49	4.5e-20	57.700	51	104	51	104	RNA polymerase Rpb6

interactor

1.000

BDHCT_assoc (PF16204): BDHCT-box associated domain on Bloom syndrome protein
RNA_pol_Rpb6 (PF01192): RNA polymerase Rpb6

Sacs

XP_008823226.1

Domain structure obtained by HMM

Protein ID: XP_008823226.1 - sacsin
KEEG Ortholog ID: K17592

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF4368	PF14287	67	0.000031	10.600	1168	1214	1163	1219	Domain of unknown function (DUF4368)
HATPase_c_3	PF13589	137	0.0063	2.600	1336	1368	1330	1455	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HATPase_c_3	PF13589	137	0.0023	4.000	2400	2429	2396	2491	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
DnaJ	PF00226	63	0.00000011	18.300	4182	4219	4172	4224	DnaJ domain
HEPN	PF05168	118	0.0000000000013	34.200	4305	4426	4305	4432	HEPN domain

interactor

DUF4368 (PF14287): Domain of unknown function (DUF4368)
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
DnaJ (PF00226): DnaJ domain
HEPN (PF05168): HEPN domain

Tns2

XP_008836627.1

Domain structure obtained by HMM

Protein ID: XP_008836627.1 - tensin-2 isoform X2
KEEG Ortholog ID: K18080

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
C1_1	PF00130	53	0.0000000012	24.200	32	80	32	82	Phorbol esters/diacylglycerol binding domain (C1 domain)
PTEN_C2	PF10409	135	5.3e-29	86.900	298	423	297	424	C2 domain of PTEN tumour-suppressor protein
cEGF	PF12662	24	0.00015	8.000	591	599	589	608	Complement Clr-like EGF-like
SH2	PF00017	77	0.000000000001	34.300	1138	1239	1138	1239	SH2 domain
PTB	PF08416	131	2.4e-43	133.700	1282	1415	1282	1416	Phosphotyrosine-binding domain

interactor

C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
PTEN_C2 (PF10409): C2 domain of PTEN tumour-suppressor protein
cEGF (PF12662): Complement Clr-like EGF-like
SH2 (PF00017): SH2 domain
PTB (PF08416): Phosphotyrosine-binding domain

Ube2i

XP_008854385.1

Domain structure obtained by HMM

Protein ID: XP_008854385.1 - SUMO-conjugating enzyme UBC9 isoform X2
KEEG Ortholog ID: K10577

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
UQ_con	PF00179	140	1.2e-53	166.700	8	150	8	152	Ubiquitin-conjugating enzyme

interactor

1.000

UQ_con (PF00179): Ubiquitin-conjugating enzyme

B a c k t o T o p ⇑