Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Znf592 (from a repository: Fri May 11 01:59:25 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins4 (22.22 %)
The number (and %) of the tumor suppressors2 (11.11 %)
Total number of binary PPIs (saturation %)52 (33.99 %)
The number (and %) of affected PPIs17 (32.69 %)
PPI diameter2
PPI radius1
The average degree of PPI5.111
Assortativity coefficient-0.3149
The network average Clustering coefficient0.795
The number (and %) of a zero Clustering coefficients1 (5.56 %)
The number (and %) of a zero Betweenness Centrality12 (66.67 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure		 Type Number
of PPI (degree)		 Clustering
Coefficient		 Betweenness
Centrality		 Domains (Pfam ID): description
Znf592

Domain structure obtained by HMM

Protein ID: XP_008826392.1 - zinc finger protein 592
KEEG Ortholog ID: K19325
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
zf-H2C2_2PF13465260.00364.200583599580599Zinc-finger double domain
zf-C2H2_11PF16622290.0000798.700590607586614zinc-finger C2H2-type
zf-C2H2_4PF13894240.0035.000619641617642C2H2-type zinc finger
zf-H2C2_2PF13465260.0231.700634650633652Zinc-finger double domain
zf-C2H2_9PF16293590.000955.300715739713742C2H2 type zinc-finger (1 copy)
zf-C2H2PF00096230.00175.300744765743765Zinc finger, C2H2 type
zf-H2C2_2PF13465260.000337.500761777760782Zinc-finger double domain
zf-C2H2_4PF13894240.00514.300771790771791C2H2-type zinc finger
zf-C2H2_4PF13894240.00384.700802825802825C2H2-type zinc finger
zf-H2C2_2PF13465260.000337.500818841811841Zinc-finger double domain
zf-C2H2_4PF13894240.00001512.100895918895918C2H2-type zinc finger
Zf_RINGPF16744730.000357.000982993968995KIAA1045 RING finger
zf-C2H2_4PF13894240.00003910.90098710099861009C2H2-type zinc finger
zf-C2H2PF00096230.00000004419.8001016103910161039Zinc finger, C2H2 type
zf-H2C2_2PF13465260.000007612.7001030105210301054Zinc-finger double domain
zf-C2H2PF00096230.00000001621.2001046107210461072Zinc finger, C2H2 type
PHDPF00628520.0121.8001119113311141135PHD-finger
zf-C2H2_4PF13894240.00683.9001127114911271150C2H2-type zinc finger
zf-C2H2_11PF16622294.7e-2057.4001152118011521180zinc-finger C2H2-type
user protein170.213149.333zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2_11 (PF16622): zinc-finger C2H2-type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_9 (PF16293): C2H2 type zinc-finger (1 copy)
zf-C2H2 (PF00096): Zinc finger, C2H2 type
Zf_RING (PF16744): KIAA1045 RING finger
PHD (PF00628): PHD-finger
Brd4

Domain structure obtained by HMM

Protein ID: XP_008828214.1 - LOW QUALITY PROTEIN: bromodomain-containing protein 4
KEEG Ortholog ID: K11722
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
BromodomainPF00439842e-2471.8007015067152Bromodomain
DUF2360PF101521550.0112.300153222144236Predicted coiled-coil domain-containing protein (DUF2360)
NAM-associatedPF143031560.0211.700322370283445No apical meristem-associated C-terminal domain
BromodomainPF00439845.1e-2573.700357444357445Bromodomain
SRP-alpha_NPF040862920.0000928.500420582416622Signal recognition particle, alpha subunit, N-terminal
BETPF17035641.9e-33100.800609672609673Bromodomain extra-terminal - transcription regulation
SR-25PF105002270.000001614.000676740646773Nuclear RNA-splicing-associated protein
SelP_NPF045922330.00114.500700767690777Selenoprotein P, N terminal region
DDHDPF028622400.000356.9001133125810811294DDHD domain
BRD4_CDTPF17105444.3e-2986.2001254129712541297C-terminal domain of bromodomain protein 4
oncogene21.0000Bromodomain (PF00439): Bromodomain
DUF2360 (PF10152): Predicted coiled-coil domain-containing protein (DUF2360)
NAM-associated (PF14303): No apical meristem-associated C-terminal domain
SRP-alpha_N (PF04086): Signal recognition particle, alpha subunit, N-terminal
BET (PF17035): Bromodomain extra-terminal - transcription regulation
SR-25 (PF10500): Nuclear RNA-splicing-associated protein
SelP_N (PF04592): Selenoprotein P, N terminal region
DDHD (PF02862): DDHD domain
BRD4_CDT (PF17105): C-terminal domain of bromodomain protein 4
Csnk2a2

Domain structure obtained by HMM

Protein ID: XP_008833084.1 - casein kinase II subunit alpha'
KEEG Ortholog ID: K03097
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PkinasePF000692641.7e-75239.9002430924309Protein kinase domain
interactor40.8330.667Pkinase (PF00069): Protein kinase domain
Gatad2a

Domain structure obtained by HMM

Protein ID: XP_017651470.1 - transcriptional repressor p66-alpha isoform X4
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF4140PF13600980.00003210.60010216397171N-terminal domain of unknown function (DUF4140)
P66_CCPF16563445.8e-2469.800133175132175Coiled-coil and interaction region of P66A and P66B with MBD2
DUF3729PF125261130.0232.600169231160238Protein of unknown function (DUF3729)
DUF3729PF125261130.0173.000259335252339Protein of unknown function (DUF3729)
GATAPF00320360.00000000005428.300373406373407GATA zinc finger
DUF3729PF125261130.120.200471524469574Protein of unknown function (DUF3729)
interactor31.0000DUF4140 (PF13600): N-terminal domain of unknown function (DUF4140)
P66_CC (PF16563): Coiled-coil and interaction region of P66A and P66B with MBD2
DUF3729 (PF12526): Protein of unknown function (DUF3729)
GATA (PF00320): GATA zinc finger
Hdac1

Domain structure obtained by HMM

Protein ID: XP_008846179.1 - histone deacetylase 1
KEEG Ortholog ID: K06067
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Hist_deacetylPF008503065.2e-87278.2002831728319Histone deacetylase domain
FSAP_sig_propepPF03032460.021.300416431404442Frog skin active peptide family signal and propeptide
tumor suppressor60.8001.333Hist_deacetyl (PF00850): Histone deacetylase domain
FSAP_sig_propep (PF03032): Frog skin active peptide family signal and propeptide
Ints3

Domain structure obtained by HMM

Protein ID: XP_008853521.1 - integrator complex subunit 3 isoform X1
KEEG Ortholog ID: K13140
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SKA1PF071602400.0161.100113134112152Spindle and kinetochore-associated protein 1
Ints3PF101892256.2e-111355.100268492268492Integrator complex subunit 3
Fn_bindPF02986380.0000688.9001009102410051027Fibronectin binding repeat
interactor51.0000SKA1 (PF07160): Spindle and kinetochore-associated protein 1
Ints3 (PF10189): Integrator complex subunit 3
Fn_bind (PF02986): Fibronectin binding repeat
Ints5

Domain structure obtained by HMM

Protein ID: XP_008835747.1 - integrator complex subunit 5
KEEG Ortholog ID: K13142
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
INTS5_NPF148372101.9e-82262.1002925129252Integrator complex subunit 5 N-terminus
INTS5_CPF148386981.2e-248813.300290999290999Integrator complex subunit 5 C-terminus
interactor51.0000INTS5_N (PF14837): Integrator complex subunit 5 N-terminus
INTS5_C (PF14838): Integrator complex subunit 5 C-terminus
Ints6

Domain structure obtained by HMM

Protein ID: XP_008823177.1 - integrator complex subunit 6 isoform X1
KEEG Ortholog ID: K13143
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
VWA_2PF135191071.5e-2679.40041314132von Willebrand factor type A domain
INT_SG_DDX_CT_CPF15300636.3e-3192.400804865804866INTS6/SAGE1/DDX26B/CT45 C-terminus
oncogene, tumor suppressor51.0000VWA_2 (PF13519): von Willebrand factor type A domain
INT_SG_DDX_CT_C (PF15300): INTS6/SAGE1/DDX26B/CT45 C-terminus
Kdm5c

Domain structure obtained by HMM

Protein ID: XP_008847923.1 - lysine-specific demethylase 5C isoform X5
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
JmjNPF02375345.3e-2057.50015481548jmjN domain
ARIDPF01388892.9e-2162.3008216581165ARID/BRIGHT DNA binding domain
FYVE_2PF023181180.0000459.900291348252353FYVE-type zinc finger
PHDPF00628522.8e-1645.500326372326374PHD-finger
JmjCPF023731141.5e-47147.000501617501617JmjC domain, hydroxylase
FYVE_2PF023181180.00862.600665735659750FYVE-type zinc finger
zf-C5HC2PF02928534.9e-2058.000707759707759C5HC2 zinc finger
PLU-1PF084293347.7e-92294.00077210997721099PLU-1-like protein
PHDPF00628520.0000000002226.7001187124911871250PHD-finger
PLU-1PF084293340.000005411.8001250130012461316PLU-1-like protein
PHD_4PF16866680.0122.0001335135013251350PHD-finger
oncogene60.7003.000JmjN (PF02375): jmjN domain
ARID (PF01388): ARID/BRIGHT DNA binding domain
FYVE_2 (PF02318): FYVE-type zinc finger
PHD (PF00628): PHD-finger
JmjC (PF02373): JmjC domain, hydroxylase
zf-C5HC2 (PF02928): C5HC2 zinc finger
PLU-1 (PF08429): PLU-1-like protein
PHD_4 (PF16866): PHD-finger
Llgl2

Domain structure obtained by HMM

Protein ID: XP_008829620.2 - lethal(2) giant larvae protein homolog 2 isoform X1
KEEG Ortholog ID: K06094
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
ANAPC4_WD40PF12894920.00443.6004010136116Anaphase-promoting complex subunit 4 WD40 domain
RAB3GAP2_NPF146554140.000196.800196237138255Rab3 GTPase-activating protein regulatory subunit N-terminus
ANAPC4_WD40PF12894920.000158.400228253204290Anaphase-promoting complex subunit 4 WD40 domain
LLGLPF083661045.3e-44135.200272372271372LLGL2
WD40PF00400380.0000009915.900427451414451WD domain, G-beta repeat
Lgl_CPF085963930.0000179.700811924794953Lethal giant larvae(Lgl) like, C-terminal
interactor41.0000ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
RAB3GAP2_N (PF14655): Rab3 GTPase-activating protein regulatory subunit N-terminus
LLGL (PF08366): LLGL2
WD40 (PF00400): WD domain, G-beta repeat
Lgl_C (PF08596): Lethal giant larvae(Lgl) like, C-terminal
Med23

Domain structure obtained by HMM

Protein ID: XP_008820340.1 - mediator of RNA polymerase II transcription subunit 23 isoform X1
KEEG Ortholog ID: K15166
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Med23PF11573130202036.0002131311313Mediator complex subunit 23
interactor31.0000Med23 (PF11573): Mediator complex subunit 23
P4ha3

Domain structure obtained by HMM

Protein ID: XP_008850927.1 - prolyl 4-hydroxylase subunit alpha-3
KEEG Ortholog ID: K00472
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
P4Ha_NPF083361358.6e-3399.4003415932160Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
SPO22PF086312760.0000001417.300154286149296Meiosis protein SPO22/ZIP4 like
2OG-FeII_Oxy_3PF13640961.4e-1957.1004255274255272OG-Fe(II) oxygenase superfamily
interactor31.0000P4Ha_N (PF08336): Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
SPO22 (PF08631): Meiosis protein SPO22/ZIP4 like
2OG-FeII_Oxy_3 (PF13640): 2OG-Fe(II) oxygenase superfamily
Smad9

Domain structure obtained by HMM

Protein ID: XP_008845345.1 - mothers against decapentaplegic homolog 9
KEEG Ortholog ID: K16791
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
MH1PF031651032.1e-46142.7003513534135MH1 domain
MH2PF031661861.4e-79252.800234406234406MH2 domain
interactor200MH1 (PF03165): MH1 domain
MH2 (PF03166): MH2 domain
Srpk2

Domain structure obtained by HMM

Protein ID: XP_017653039.1 - SRSF protein kinase 2 isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
YrzOPF14142460.000138.20024372244YrzO-like protein
Mito_fiss_regPF053082440.000526.20042752298Mitochondrial fission regulator
PkinasePF000692642.5e-2678.700118260118268Protein kinase domain
CAP_NPF012133170.0190.500277313260344Adenylate cyclase associated (CAP) N terminal
CNDH2_CPF168582760.0000379.900297435275470Condensin II complex subunit CAP-H2 or CNDH2, C-term
S-antigenPF05756930.0142.000430456418460S-antigen protein
PkinasePF000692648.7e-2263.800560753548753Protein kinase domain
oncogene31.0000YrzO (PF14142): YrzO-like protein
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
Pkinase (PF00069): Protein kinase domain
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
CNDH2_C (PF16858): Condensin II complex subunit CAP-H2 or CNDH2, C-term
S-antigen (PF05756): S-antigen protein
Srsf11

Domain structure obtained by HMM

Protein ID: XP_017656835.1 - serine/arginine-rich splicing factor 11 isoform X3
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
RRM_1PF00076700.0000000001127.50028942697RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TransformerPF064951820.0290.600216295206300Fruit fly transformer protein
TP2PF012541370.00932.800237325231334Nuclear transition protein 2
MRIPF153251050.0590.900350412335421Modulator of retrovirus infection
DUF4746PF159282970.00991.400374441349458Domain of unknown function (DUF4746)
MRIPF153251050.0810.500425450415475Modulator of retrovirus infection
interactor21.0000RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495): Fruit fly transformer protein
TP2 (PF01254): Nuclear transition protein 2
MRI (PF15325): Modulator of retrovirus infection
DUF4746 (PF15928): Domain of unknown function (DUF4746)
Zmynd8

Domain structure obtained by HMM

Protein ID: XP_008825650.1 - protein kinase C-binding protein 1 isoform X3
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF2360PF101521550.0191.500279724114Predicted coiled-coil domain-containing protein (DUF2360)
Prim_Zn_RibbonPF08273390.00175.100104122100124Zinc-binding domain of primase-helicase
PHDPF00628520.00000000006628.300113154113155PHD-finger
BromodomainPF00439846.2e-2057.400186262180263Bromodomain
PWWPPF00855960.00000000007728.700300372298374PWWP domain
DUF3544PF120642072.8e-100320.900436645436646Domain of unknown function (DUF3544)
PresenilinPF010803990.00641.300617724555726Presenilin
Neur_chan_membPF029322380.000596.000829902745961Neurotransmitter-gated ion-channel transmembrane region
CAMLPF149632700.000925.500856987828990Calcium signal-modulating cyclophilin ligand
DUF1640PF077981750.0000001717.60097610479401052Protein of unknown function (DUF1640)
zf-MYNDPF01753380.000000118.3001051108510511085MYND finger
Kei1PF085521820.00432.9001094113110531158Inositolphosphorylceramide synthase subunit Kei1
interactor, oncogene120.37929.667DUF2360 (PF10152): Predicted coiled-coil domain-containing protein (DUF2360)
Prim_Zn_Ribbon (PF08273): Zinc-binding domain of primase-helicase
PHD (PF00628): PHD-finger
Bromodomain (PF00439): Bromodomain
PWWP (PF00855): PWWP domain
DUF3544 (PF12064): Domain of unknown function (DUF3544)
Presenilin (PF01080): Presenilin
Neur_chan_memb (PF02932): Neurotransmitter-gated ion-channel transmembrane region
CAML (PF14963): Calcium signal-modulating cyclophilin ligand
DUF1640 (PF07798): Protein of unknown function (DUF1640)
zf-MYND (PF01753): MYND finger
Kei1 (PF08552): Inositolphosphorylceramide synthase subunit Kei1
Znf408

Domain structure obtained by HMM

Protein ID: XP_008841775.1 - zinc finger protein 408
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
zf-H2C2_2PF13465260.000002314.300358383358383Zinc-finger double domain
zf-C2H2PF00096230.0000001118.500373394372394Zinc finger, C2H2 type
zf-H2C2_2PF13465260.0000001917.700387411386411Zinc-finger double domain
zf-H2C2_2PF13465260.00000001221.600414438414439Zinc-finger double domain
zf-C2H2PF00096230.00000000622.500428450428450Zinc finger, C2H2 type
zf-C2H2PF00096230.000000007822.100460481459481Zinc finger, C2H2 type
zf-H2C2_2PF13465260.000000000002833.000473498473498Zinc-finger double domain
zf-H2C2_2PF13465260.00000000007928.400501524501526Zinc-finger double domain
zf-H2C2_2PF13465260.00000005219.500530550529552Zinc-finger double domain
zf-C2H2PF00096230.0000006316.100544564542564Zinc finger, C2H2 type
zf-H2C2_2PF13465260.00000000008328.400557580556580Zinc-finger double domain
zf-C2H2_11PF16622290.00000005418.900570589567591zinc-finger C2H2-type
zf-H2C2_2PF13465260.00000008318.900585607584608Zinc-finger double domain
zf-C2H2PF00096230.0000004916.500598620598620Zinc finger, C2H2 type
interactor41.0000zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2 (PF00096): Zinc finger, C2H2 type
zf-C2H2_11 (PF16622): zinc-finger C2H2-type
Znf687

Domain structure obtained by HMM

Protein ID: XP_008826455.1 - zinc finger protein 687
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
zf-C2H2_11PF16622290.000001314.400530548528550zinc-finger C2H2-type
zinc_ribbon_9PF14369350.0530.200552564528568zinc-ribbon
Fer4_8PF13183650.00004810.1005606795586824Fe-4S dicluster domain
zf-C2H2_2PF127561010.0034.200667690662694C2H2 type zinc-finger (2 copies)
zinc_ribbon_9PF14369350.050.300698706692707zinc-ribbon
zf-C2H2PF00096230.000138.800702723702723Zinc finger, C2H2 type
zf-H2C2_2PF13465260.000003713.700716739715740Zinc-finger double domain
TF_Zn_RibbonPF08271430.0000758.500730768729770TFIIB zinc-binding
zf-C2H2_4PF13894240.000149.100760783760783C2H2-type zinc finger
zf-C2H2PF00096230.000069.900788811788811Zinc finger, C2H2 type
PyrI_CPF02748480.000546.200815835810836Aspartate carbamoyltransferase regulatory chain, metal binding domain
zf-C2H2PF00096230.000009412.400823845823845Zinc finger, C2H2 type
zf-H2C2_2PF13465260.00115.900838860838865Zinc-finger double domain
zf-C2H2_4PF13894240.00002611.400854877854877C2H2-type zinc finger
zf-C2H2_4PF13894240.00001412.300960982959982C2H2-type zinc finger
zf-C2H2_11PF16622290.0000000319.70099110129891013zinc-finger C2H2-type
zf-H2C2_2PF13465260.000001814.7001003102510031033Zinc-finger double domain
zf-C2H2_11PF16622290.0000758.8001024104510211045zinc-finger C2H2-type
zf-C2H2_11PF16622292.1e-1955.3001128115611281156zinc-finger C2H2-type
zf-C2H2PF00096230.0000005916.2001198121911971219Zinc finger, C2H2 type
interactor120.37930.000zf-C2H2_11 (PF16622): zinc-finger C2H2-type
zinc_ribbon_9 (PF14369): zinc-ribbon
Fer4_8 (PF13183): 4Fe-4S dicluster domain
zf-C2H2_2 (PF12756): C2H2 type zinc-finger (2 copies)
zf-C2H2 (PF00096): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465): Zinc-finger double domain
TF_Zn_Ribbon (PF08271): TFIIB zinc-binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
PyrI_C (PF02748): Aspartate carbamoyltransferase regulatory chain, metal binding domain

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