Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Znf592 (from a repository: Fri May 11 01:59:25 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins4 (22.22 %)
The number (and %) of the tumor suppressors2 (11.11 %)
Total number of binary PPIs (saturation %)52 (33.99 %)
The number (and %) of affected PPIs17 (32.69 %)
PPI diameter2
PPI radius1
The average degree of PPI5.111
Assortativity coefficient-0.3149
The network average Clustering coefficient0.795
The number (and %) of a zero Clustering coefficients1 (5.56 %)
The number (and %) of a zero Betweenness Centrality12 (66.67 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Znf592
user protein170.213149.333zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2_11 (PF16622): zinc-finger C2H2-type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_9 (PF16293): C2H2 type zinc-finger (1 copy)
zf-C2H2 (PF00096): Zinc finger, C2H2 type
Zf_RING (PF16744): KIAA1045 RING finger
PHD (PF00628): PHD-finger
Brd4
oncogene21.0000Bromodomain (PF00439): Bromodomain
DUF2360 (PF10152): Predicted coiled-coil domain-containing protein (DUF2360)
NAM-associated (PF14303): No apical meristem-associated C-terminal domain
SRP-alpha_N (PF04086): Signal recognition particle, alpha subunit, N-terminal
BET (PF17035): Bromodomain extra-terminal - transcription regulation
SR-25 (PF10500): Nuclear RNA-splicing-associated protein
SelP_N (PF04592): Selenoprotein P, N terminal region
DDHD (PF02862): DDHD domain
BRD4_CDT (PF17105): C-terminal domain of bromodomain protein 4
Csnk2a2
interactor40.8330.667Pkinase (PF00069): Protein kinase domain
Gatad2a
interactor31.0000DUF4140 (PF13600): N-terminal domain of unknown function (DUF4140)
P66_CC (PF16563): Coiled-coil and interaction region of P66A and P66B with MBD2
DUF3729 (PF12526): Protein of unknown function (DUF3729)
GATA (PF00320): GATA zinc finger
Hdac1
tumor suppressor60.8001.333Hist_deacetyl (PF00850): Histone deacetylase domain
FSAP_sig_propep (PF03032): Frog skin active peptide family signal and propeptide
Ints3
interactor51.0000SKA1 (PF07160): Spindle and kinetochore-associated protein 1
Ints3 (PF10189): Integrator complex subunit 3
Fn_bind (PF02986): Fibronectin binding repeat
Ints5
interactor51.0000INTS5_N (PF14837): Integrator complex subunit 5 N-terminus
INTS5_C (PF14838): Integrator complex subunit 5 C-terminus
Ints6
oncogene, tumor suppressor51.0000VWA_2 (PF13519): von Willebrand factor type A domain
INT_SG_DDX_CT_C (PF15300): INTS6/SAGE1/DDX26B/CT45 C-terminus
Kdm5c
oncogene60.7003.000JmjN (PF02375): jmjN domain
ARID (PF01388): ARID/BRIGHT DNA binding domain
FYVE_2 (PF02318): FYVE-type zinc finger
PHD (PF00628): PHD-finger
JmjC (PF02373): JmjC domain, hydroxylase
zf-C5HC2 (PF02928): C5HC2 zinc finger
PLU-1 (PF08429): PLU-1-like protein
PHD_4 (PF16866): PHD-finger
Llgl2
interactor41.0000ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
RAB3GAP2_N (PF14655): Rab3 GTPase-activating protein regulatory subunit N-terminus
LLGL (PF08366): LLGL2
WD40 (PF00400): WD domain, G-beta repeat
Lgl_C (PF08596): Lethal giant larvae(Lgl) like, C-terminal
Med23
interactor31.0000Med23 (PF11573): Mediator complex subunit 23
P4ha3
interactor31.0000P4Ha_N (PF08336): Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
SPO22 (PF08631): Meiosis protein SPO22/ZIP4 like
2OG-FeII_Oxy_3 (PF13640): 2OG-Fe(II) oxygenase superfamily
Smad9
interactor200MH1 (PF03165): MH1 domain
MH2 (PF03166): MH2 domain
Srpk2
oncogene31.0000YrzO (PF14142): YrzO-like protein
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
Pkinase (PF00069): Protein kinase domain
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
CNDH2_C (PF16858): Condensin II complex subunit CAP-H2 or CNDH2, C-term
S-antigen (PF05756): S-antigen protein
Srsf11
interactor21.0000RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495): Fruit fly transformer protein
TP2 (PF01254): Nuclear transition protein 2
MRI (PF15325): Modulator of retrovirus infection
DUF4746 (PF15928): Domain of unknown function (DUF4746)
Zmynd8
interactor, oncogene120.37929.667DUF2360 (PF10152): Predicted coiled-coil domain-containing protein (DUF2360)
Prim_Zn_Ribbon (PF08273): Zinc-binding domain of primase-helicase
PHD (PF00628): PHD-finger
Bromodomain (PF00439): Bromodomain
PWWP (PF00855): PWWP domain
DUF3544 (PF12064): Domain of unknown function (DUF3544)
Presenilin (PF01080): Presenilin
Neur_chan_memb (PF02932): Neurotransmitter-gated ion-channel transmembrane region
CAML (PF14963): Calcium signal-modulating cyclophilin ligand
DUF1640 (PF07798): Protein of unknown function (DUF1640)
zf-MYND (PF01753): MYND finger
Kei1 (PF08552): Inositolphosphorylceramide synthase subunit Kei1
Znf408
interactor41.0000zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2 (PF00096): Zinc finger, C2H2 type
zf-C2H2_11 (PF16622): zinc-finger C2H2-type
Znf687
interactor120.37930.000zf-C2H2_11 (PF16622): zinc-finger C2H2-type
zinc_ribbon_9 (PF14369): zinc-ribbon
Fer4_8 (PF13183): 4Fe-4S dicluster domain
zf-C2H2_2 (PF12756): C2H2 type zinc-finger (2 copies)
zf-C2H2 (PF00096): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465): Zinc-finger double domain
TF_Zn_Ribbon (PF08271): TFIIB zinc-binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
PyrI_C (PF02748): Aspartate carbamoyltransferase regulatory chain, metal binding domain

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