Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Znf581 (from a repository: Fri May 11 01:58:22 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)36
The number (and %) of the onco-proteins8 (22.22 %)
The number (and %) of the tumor suppressors6 (16.67 %)
Total number of binary PPIs (saturation %)77 (12.22 %)
The number (and %) of affected PPIs35 (45.45 %)
PPI diameter2
PPI radius1
The average degree of PPI3.056
Assortativity coefficient-0.5502
The network average Clustering coefficient0.389
The number (and %) of a zero Clustering coefficients16 (44.44 %)
The number (and %) of a zero Betweenness Centrality24 (66.67 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Znf581
user protein350.0341114.000PBP_N (PF17093): Penicillin-binding protein N-terminus
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2 (PF00096): Zinc finger, C2H2 type
Adnp
interactor100zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-Di19 (PF05605): Drought induced 19 protein (Di19), zinc-binding
Rpr2 (PF04032): RNAse P Rpr2/Rpp21/SNM1 subunit domain
zf-C2H2_2 (PF12756): C2H2 type zinc-finger (2 copies)
zf-BED (PF02892): BED zinc finger
Homeobox (PF00046): Homeobox domain
App
interactor70.33310.000APP_N (PF02177): Amyloid A4 N-terminal heparin-binding
APP_Cu_bd (PF12924): Copper-binding of amyloid precursor, CuBD
SDA1 (PF05285): SDA1
YtxH (PF12732): YtxH-like protein
Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2 (PF12925): E2 domain of amyloid precursor protein
Beta-APP (PF03494): Beta-amyloid peptide (beta-APP)
APP_amyloid (PF10515): beta-amyloid precursor protein C-terminus
Banp
tumor suppressor40.6671.000DUF1845 (PF08900): Domain of unknown function (DUF1845)
BEN (PF10523): BEN domain
Calcoco2
interactor40.6671.000CALCOCO1 (PF07888): Calcium binding and coiled-coil domain (CALCOCO1) like
bZIP_1 (PF00170): bZIP transcription factor
DUF641 (PF04859): Plant protein of unknown function (DUF641)
YlqD (PF11068): YlqD protein
HALZ (PF02183): Homeobox associated leucine zipper
Ccdc136
tumor suppressor100Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
Baculo_PEP_C (PF04513): Baculovirus polyhedron envelope protein, PEP, C terminus
HIP1_clath_bdg (PF16515): Clathrin-binding domain of Huntingtin-interacting protein 1
HAP1_N (PF04849): HAP1 N-terminal conserved region
ERM (PF00769): Ezrin/radixin/moesin family
FliD_N (PF02465): Flagellar hook-associated protein 2 N-terminus
Sec34 (PF04136): Sec34-like family
Macoilin (PF09726): Transmembrane protein
FlxA (PF14282): FlxA-like protein
DUF2924 (PF11149): Protein of unknown function (DUF2924)
AIF_C (PF14721): Apoptosis-inducing factor, mitochondrion-associated, C-term
Ccndbp1
tumor suppressor100GCIP (PF13324): Grap2 and cyclin-D-interacting
Chd4
oncogene60.4006.000DTHCT (PF08070): DTHCT (NUC029) region
FAM176 (PF14851): FAM176 family
CHDNT (PF08073): CHDNT (NUC034) domain
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
Coilin_N (PF15862): Coilin N-terminus
zf-RING_9 (PF13901): Putative zinc-RING and/or ribbon
PHD (PF00628): PHD-finger
Chromo (PF00385): Chromo (CHRromatin Organisation MOdifier) domain
SNF2_N (PF00176): SNF2 family N-terminal domain
Helicase_C (PF00271): Helicase conserved C-terminal domain
DUF1087 (PF06465): Domain of Unknown Function (DUF1087)
DUF1086 (PF06461): Domain of Unknown Function (DUF1086)
CDC27 (PF09507): DNA polymerase subunit Cdc27
CHDCT2 (PF08074): CHDCT2 (NUC038) domain
Dazap2
interactor50.5003.000DAZAP2 (PF11029): DAZ associated protein 2 (DAZAP2)
Diras2
interactor100Ras (PF00071): Ras family
ArgK (PF03308): ArgK protein
Dmwd
interactor100ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
WD40 (PF00400): WD domain, G-beta repeat
Dock8
interactor200DOCK-C2 (PF14429): C2 domain in Dock180 and Zizimin proteins
DHR-2 (PF06920): Dock homology region 2
Erbin
oncogene200LRR_8 (PF13855): Leucine rich repeat
LRR_4 (PF12799): Leucine Rich repeats (2 copies)
Neur_chan_memb (PF02932): Neurotransmitter-gated ion-channel transmembrane region
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Fsd2
interactor100DUF4994 (PF16385): Domain of unknown function
Fumerase_C (PF05683): Fumarase C-terminus
DUF3552 (PF12072): Domain of unknown function (DUF3552)
fn3 (PF00041): Fibronectin type III domain
PRY (PF13765): SPRY-associated domain
SPRY (PF00622): SPRY domain
Gopc
oncogene200DUF3209 (PF11483): Protein of unknown function (DUF3209)
NPV_P10 (PF05531): Nucleopolyhedrovirus P10 protein
DivIC (PF04977): Septum formation initiator
bZIP_2 (PF07716): Basic region leucine zipper
CENP-H (PF05837): Centromere protein H (CENP-H)
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
DUF903 (PF06004): Bacterial protein of unknown function (DUF903)
Hikeshi
interactor21.0000DUF775 (PF05603): Protein of unknown function (DUF775)
Hmbox1
interactor31.0000DUF494 (PF04361): Protein of unknown function (DUF494)
HNF-1_N (PF04814): Hepatocyte nuclear factor 1 (HNF-1), N terminus
Homeobox (PF00046): Homeobox domain
DSBA (PF01323): DSBA-like thioredoxin domain
Ikzf1
oncogene, tumor suppressor31.0000ADK_lid (PF05191): Adenylate kinase, active site lid
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2 (PF00096): Zinc finger, C2H2 type
Desulfoferrod_N (PF06397): Desulfoferrodoxin, N-terminal domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Kdm1a
interactor60.4006.000DUF4298 (PF14131): Domain of unknown function (DUF4298)
ZapB (PF06005): Cell division protein ZapB
SWIRM (PF04433): SWIRM domain
Amino_oxidase (PF01593): Flavin containing amine oxidoreductase
LOC103727574
interactor21.0000Atg14 (PF10186): Vacuolar sorting 38 and autophagy-related subunit 14
CENP-Q (PF13094): CENP-Q, a CENPA-CAD centromere complex subunit
DUF2046 (PF09755): Uncharacterized conserved protein H4 (DUF2046)
BRE1 (PF08647): BRE1 E3 ubiquitin ligase
FliJ (PF02050): Flagellar FliJ protein
GOLGA2L5 (PF15070): Putative golgin subfamily A member 2-like protein 5
LOC103735136
interactor31.0000RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RP-C_C (PF11800): Replication protein C C-terminal region
Stm1_N (PF09598): Stm1
Lzts2
tumor suppressor30.6671.000CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
DUF4250 (PF14056): Domain of unknown function (DUF4250)
ATG16 (PF08614): Autophagy protein 16 (ATG16)
DUF3287 (PF11690): Protein of unknown function (DUF3287)
CENP-F_leu_zip (PF10473): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Fez1 (PF06818): Fez1
DUF1127 (PF06568): Domain of unknown function (DUF1127)
Mdfi
interactor200Herpes_LMP1 (PF05297): Herpesvirus latent membrane protein 1 (LMP1)
Herpes_UL56 (PF04534): Herpesvirus UL56 protein
MDFI (PF15316): MyoD family inhibitor
Mtus2
tumor suppressor100DivIC (PF04977): Septum formation initiator
DUF148 (PF02520): Domain of unknown function DUF148
Jnk-SapK_ap_N (PF09744): JNK_SAPK-associated protein-1
RNA_pol_Rpb1_R (PF05001): RNA polymerase Rpb1 C-terminal repeat
Nt5c
interactor100NT5C (PF06941): 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
Plscr1
interactor30.6671.000Scramblase (PF03803): Scramblase
Pnma1
oncogene100PNMA (PF14893): PNMA
Rbpms
interactor50.5003.000RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Sdcbp2
interactor200PadR (PF03551): Transcriptional regulator PadR-like family
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Sox5
oncogene31.0000MPS2 (PF17060): Monopolar spindle protein 2
SOAR (PF16533): STIM1 Orai1-activating region
HMG_box (PF00505): HMG (high mobility group) box
Spert
interactor200Chibby (PF14645): Chibby family
ZapB (PF06005): Cell division protein ZapB
Latarcin (PF10279): Latarcin precursor
TPR_MLP1_2 (PF07926): TPR/MLP1/MLP2-like protein
Suv39h1
interactor40.6671.000Chromo (PF00385): Chromo (CHRromatin Organisation MOdifier) domain
Pre-SET (PF05033): Pre-SET motif
SET (PF00856): SET domain
Tmcc2
interactor31.0000IncA (PF04156): IncA protein
DUF1690 (PF07956): Protein of Unknown function (DUF1690)
Tmemb_cc2 (PF10267): Predicted transmembrane and coiled-coil 2 protein
HbrB (PF08539): HbrB-like
Traf1
oncogene200zf-C4H2 (PF10146): Zinc finger-containing protein
TRAF_BIRC3_bd (PF16673): TNF receptor-associated factor BIRC3 binding domain
SlyX (PF04102): SlyX
Traf4
oncogene50.5003.000zf-C3HC4 (PF00097): Zinc finger, C3HC4 type (RING finger)
Sina (PF03145): Seven in absentia protein family
zf-TRAF (PF02176): TRAF-type zinc finger
MATH (PF00917): MATH domain
Trim27
oncogene31.0000Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
zf-AN1 (PF01428): AN1-like Zinc finger
zf-B_box (PF00643): B-box zinc finger
Lebercilin (PF15619): Ciliary protein causing Leber congenital amaurosis disease
IncA (PF04156): IncA protein
PRY (PF13765): SPRY-associated domain
SPRY (PF00622): SPRY domain

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