Find Protein-Protein Interactions (PPI) Network

Choose & Enter

Choose animal:			Visualization driver:
Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Znf580
Level of PPIs:		or Upload text file:	Update repository

Visible interactions:

Visible interactors:

Size of node:

Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Znf580 (from a repository: Fri May 11 01:57:19 2018)

	Examples
	Layout Breadthfirst Circle Concentric Cose Grid Random
	Export graph PNG file JPG file JSON file

Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	7
The number (and %) of the onco-proteins	3 (42.86 %)
The number (and %) of the tumor suppressors	0 (0.00 %)
Total number of binary PPIs (saturation %)	9 (42.86 %)
The number (and %) of affected PPIs	6 (66.67 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	1.714
Assortativity coefficient	0
The network average Clustering coefficient	0.000
The number (and %) of a zero Clustering coefficients	7 (100.00 %)
The number (and %) of a zero Betweenness Centrality	6 (85.71 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Znf580

XP_017657044.1

Domain structure obtained by HMM

Protein ID: XP_017657044.1 - zinc finger protein 580 isoform X2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
zf-H2C2_2	PF13465	26	0.000046	10.200	87	103	83	103	Zinc-finger double domain
zf-C2H2_4	PF13894	24	0.00000015	18.400	92	114	92	115	C2H2-type zinc finger
zf-H2C2_2	PF13465	26	0.000000018	21.000	107	131	106	131	Zinc-finger double domain
zf-C2H2	PF00096	23	0.00000000016	27.400	120	142	120	142	Zinc finger, C2H2 type
zf-H2C2_2	PF13465	26	0.00000015	18.100	134	159	134	160	Zinc-finger double domain
zf-C2H2	PF00096	23	0.000000054	19.500	150	172	150	172	Zinc finger, C2H2 type

user protein

30.000

zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2 (PF00096): Zinc finger, C2H2 type

Arhgef6

XP_008838927.1

Domain structure obtained by HMM

Protein ID: XP_008838927.1 - LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 6
KEEG Ortholog ID: K05729

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
CH	PF00307	109	3.9e-21	61.600	27	132	26	137	Calponin homology (CH) domain
RhoGEF67_u1	PF16615	48	2.6e-20	59.200	140	185	139	185	Unstructured region one on RhoGEF 6 and 7
SH3_9	PF14604	49	2.7e-21	61.500	192	239	192	240	Variant SH3 domain
RhoGEF	PF00621	181	6.6e-34	103.900	270	443	270	444	RhoGEF domain
PH	PF00169	105	0.00000000000046	35.900	491	572	469	573	PH domain
RhoGEF67_u2	PF16614	109	2.2e-66	207.100	594	699	594	702	Unstructured region two on RhoGEF 6 and 7
betaPIX_CC	PF16523	88	2.6e-40	122.500	701	788	701	789	betaPIX coiled coil

oncogene

CH (PF00307): Calponin homology (CH) domain
RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7
SH3_9 (PF14604): Variant SH3 domain
RhoGEF (PF00621): RhoGEF domain
PH (PF00169): PH domain
RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7
betaPIX_CC (PF16523): betaPIX coiled coil

Pax9

XP_008829043.1

Domain structure obtained by HMM

Protein ID: XP_008829043.1 - paired box protein Pax-9
KEEG Ortholog ID: K09382

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PAX	PF00292	125	9.7e-76	238.000	5	128	4	128	'Paired box' domain

oncogene

PAX (PF00292): 'Paired box' domain

Ppp2r3a

XP_008839859.1

Domain structure obtained by HMM

Protein ID: XP_008839859.1 - serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1
KEEG Ortholog ID: K11583

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF4116	PF13475	49	0.000019	10.600	209	257	208	264	Domain of unknown function (DUF4116)
EF-hand_1	PF00036	29	0.0023	4.000	764	788	764	788	EF hand
DUF4187	PF13821	54	0.000016	11.000	878	905	874	916	Domain of unknown function (DUF4187)
EF-hand_7	PF13499	71	2.1e-26	78.600	898	1000	898	1000	EF-hand domain pair
EF-hand_7	PF13499	71	0.014	2.200	1022	1057	1018	1097	EF-hand domain pair

interactor

DUF4116 (PF13475): Domain of unknown function (DUF4116)
EF-hand_1 (PF00036): EF hand
DUF4187 (PF13821): Domain of unknown function (DUF4187)
EF-hand_7 (PF13499): EF-hand domain pair

Rad54b

XP_008846057.1

Domain structure obtained by HMM

Protein ID: XP_008846057.1 - DNA repair and recombination protein RAD54B
KEEG Ortholog ID: K10877

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SNF2_N	PF00176	350	1.4e-62	197.500	302	582	292	583	SNF2 family N-terminal domain
HDA2-3	PF11496	289	0.0037	2.500	566	591	518	603	Class II histone deacetylase complex subunits 2 and 3
Helicase_C	PF00271	111	2.4e-21	62.500	629	742	627	743	Helicase conserved C-terminal domain

interactor

SNF2_N (PF00176): SNF2 family N-terminal domain
HDA2-3 (PF11496): Class II histone deacetylase complex subunits 2 and 3
Helicase_C (PF00271): Helicase conserved C-terminal domain

Sh3gl2

XP_008836962.1

Domain structure obtained by HMM

Protein ID: XP_008836962.1 - endophilin-A1 isoform X1
KEEG Ortholog ID: K11247

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
BAR	PF03114	239	8.3e-85	270.300	6	241	6	242	BAR domain
SH3_1	PF00018	48	1.3e-18	52.700	296	340	296	341	SH3 domain

oncogene

BAR (PF03114): BAR domain
SH3_1 (PF00018): SH3 domain

Xbp1

XP_008832262.1

Domain structure obtained by HMM

Protein ID: XP_008832262.1 - LOW QUALITY PROTEIN: X-box-binding protein 1
KEEG Ortholog ID: K09027

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
bZIP_2	PF07716	54	6.5e-16	44.500	69	120	68	123	Basic region leucine zipper

interactor

bZIP_2 (PF07716): Basic region leucine zipper

B a c k t o T o p ⇑