Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Znf579 (from a repository: Fri May 11 01:56:15 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins6 (23.08 %)
The number (and %) of the tumor suppressors3 (11.54 %)
Total number of binary PPIs (saturation %)34 (10.46 %)
The number (and %) of affected PPIs25 (73.53 %)
PPI diameter2
PPI radius1
The average degree of PPI2.308
Assortativity coefficient-0.4425
The network average Clustering coefficient0.283
The number (and %) of a zero Clustering coefficients17 (65.38 %)
The number (and %) of a zero Betweenness Centrality23 (88.46 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Znf579
user protein250.017588.000FoP_duplication (PF13865): C-terminal duplication domain of Friend of PRMT1
Anti-TRAP (PF15777): Tryptophan RNA-binding attenuator protein inhibitory protein
zf-C2H2 (PF00096): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2HE (PF16278): C2HE / C2H2 / C2HC zinc-binding finger
zf-C2H2_6 (PF13912): C2H2-type zinc finger
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Asna1
interactor100ArsA_ATPase (PF02374): Anion-transporting ATPase
Bhlha15
interactor21.0000OrfB_IS605 (PF01385): Probable transposase
HLH (PF00010): Helix-loop-helix DNA-binding domain
FliD_N (PF02465): Flagellar hook-associated protein 2 N-terminus
Clec3a
interactor30.6671.000DUF3545 (PF12065): Protein of unknown function (DUF3545)
Lectin_C (PF00059): Lectin C-type domain
Gtf3c2
interactor21.0000WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Hecw2
interactor200HECW_N (PF16562): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
C2 (PF00168): C2 domain
Cep57_CLD (PF14073): Centrosome localisation domain of Cep57
WW (PF00397): WW domain
RFXA_RFXANK_bdg (PF15289): Regulatory factor X-associated C-terminal binding domain
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Ilk
tumor suppressor200Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Lbr
interactor30.6671.000LBR_tudor (PF09465): Lamin-B receptor of TUDOR domain
ERG4_ERG24 (PF01222): Ergosterol biosynthesis ERG4/ERG24 family
Mapk6
oncogene200Pkinase (PF00069): Protein kinase domain
Mest
interactor100REV (PF00424): REV protein (anti-repression trans-activator protein)
Abhydrolase_1 (PF00561): alpha/beta hydrolase fold
Mrps15
interactor100Ribosomal_S15 (PF00312): Ribosomal protein S15
DUF2284 (PF10050): Predicted metal-binding protein (DUF2284)
TSC22 (PF01166): TSC-22/dip/bun family
Nr4a1
tumor suppressor100SR-25 (PF10500): Nuclear RNA-splicing-associated protein
zf-C4 (PF00105): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104): Ligand-binding domain of nuclear hormone receptor
Osgep
interactor31.0000Peptidase_M22 (PF00814): Glycoprotease family
Osm
interactor100Apolipo_F (PF15148): Apolipoprotein F
LIF_OSM (PF01291): LIF / OSM family
P4ha3
interactor21.0000P4Ha_N (PF08336): Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
SPO22 (PF08631): Meiosis protein SPO22/ZIP4 like
2OG-FeII_Oxy_3 (PF13640): 2OG-Fe(II) oxygenase superfamily
Rasa1
oncogene100SH2 (PF00017): SH2 domain
SH3_1 (PF00018): SH3 domain
PH (PF00169): PH domain
C2 (PF00168): C2 domain
RasGAP (PF00616): GTPase-activator protein for Ras-like GTPase
Rgs2
oncogene100RGS (PF00615): Regulator of G protein signaling domain
Rspo1
oncogene100Furin-like_2 (PF15913): Furin-like repeat, cysteine-rich
TSP_1 (PF00090): Thrombospondin type 1 domain
Rsrp1
oncogene100RSRP (PF17069): Arginine/Serine-Rich protein 1
Sf3b3
interactor21.0000MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
CPSF_A (PF03178): CPSF A subunit region
Sparc
tumor suppressor100FOLN (PF09289): Follistatin/Osteonectin-like EGF domain
Kazal_1 (PF00050): Kazal-type serine protease inhibitor domain
SPARC_Ca_bdg (PF10591): Secreted protein acidic and rich in cysteine Ca binding region
Tinag
interactor100Somatomedin_B (PF01033): Somatomedin B domain
Pacifastin_I (PF05375): Pacifastin inhibitor (LCMII)
Propeptide_C1 (PF08127): Peptidase family C1 propeptide
Peptidase_C1 (PF00112): Papain family cysteine protease
Tnfrsf13b
oncogene100TACI-CRD2 (PF09305): TACI, cysteine-rich domain
BaffR-Tall_bind (PF09256): BAFF-R, TALL-1 binding
Yae1d1
interactor100Yae1_N (PF09811): Essential protein Yae1, N terminal
Znf444
interactor21.0000SCAN (PF02023): SCAN domain
zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2 (PF00096): Zinc finger, C2H2 type
Znf707
interactor100KRAB (PF01352): KRAB box
zinc_ribbon_15 (PF17032): zinc-ribbon family
zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2 (PF00096): Zinc finger, C2H2 type

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