Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Adgrl3
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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Adgrl3 (from a repository: Mon Apr 16 19:55:43 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	7
The number (and %) of the onco-proteins	2 (28.57 %)
The number (and %) of the tumor suppressors	0 (0.00 %)
Total number of binary PPIs (saturation %)	8 (38.10 %)
The number (and %) of affected PPIs	6 (75.00 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	2.286
Assortativity coefficient	-0.5082
The network average Clustering coefficient	0.400
The number (and %) of a zero Clustering coefficients	3 (42.86 %)
The number (and %) of a zero Betweenness Centrality	5 (71.43 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Adgrl3

XP_008831485.1

Domain structure obtained by HMM

Protein ID: XP_008831485.1 - adhesion G protein-coupled receptor L3 isoform X1
KEEG Ortholog ID: K04594

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Gal_Lectin	PF02140	80	1.1e-27	82.700	117	197	117	197	Galactose binding lectin domain
OLF	PF02191	247	4.1e-88	281.200	215	465	213	465	Olfactomedin-like domain
HRM	PF02793	65	0.00000000098	25.000	571	627	570	628	Hormone receptor domain
GAIN	PF16489	210	9.6e-59	184.400	643	863	642	863	GPCR-Autoproteolysis INducing (GAIN) domain
GPS	PF01825	42	7.7e-19	54.500	891	935	891	935	GPCR proteolysis site, GPS, motif
7tm_2	PF00002	245	8e-74	234.100	951	1194	949	1194	7 transmembrane receptor (Secretin family)
MpPF26	PF07666	130	0.0013	5.100	1174	1212	1167	1217	M penetrans paralogue family 26
Latrophilin	PF02354	375	4.7e-154	499.000	1215	1592	1214	1592	Latrophilin Cytoplasmic C-terminal region

user protein

0.133

25.000

Gal_Lectin (PF02140): Galactose binding lectin domain
OLF (PF02191): Olfactomedin-like domain
HRM (PF02793): Hormone receptor domain
GAIN (PF16489): GPCR-Autoproteolysis INducing (GAIN) domain
GPS (PF01825): GPCR proteolysis site, GPS, motif
7tm_2 (PF00002): 7 transmembrane receptor (Secretin family)
MpPF26 (PF07666): M penetrans paralogue family 26
Latrophilin (PF02354): Latrophilin Cytoplasmic C-terminal region

Asgr2

XP_008854085.1

Domain structure obtained by HMM

Protein ID: XP_008854085.1 - asialoglycoprotein receptor 2
KEEG Ortholog ID: K10064

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Lectin_N	PF03954	131	8.5e-62	192.900	31	162	29	162	Hepatic lectin, N-terminal domain
UL45	PF05473	200	0.00000084	14.900	166	206	155	241	UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_C	PF00059	108	7e-26	77.400	188	297	187	297	Lectin C-type domain

interactor

Lectin_N (PF03954): Hepatic lectin, N-terminal domain
UL45 (PF05473): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_C (PF00059): Lectin C-type domain

C3ar1

XP_008823555.1

Domain structure obtained by HMM

Protein ID: XP_008823555.1 - C3a anaphylatoxin chemotactic receptor
KEEG Ortholog ID: K04009

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
7tm_1	PF00001	268	6.3e-29	87.100	40	176	40	189	7 transmembrane receptor (rhodopsin family)
7TM_GPCR_Srw	PF10324	319	0.000025	9.800	108	200	88	207	Serpentine type 7TM GPCR chemoreceptor Srw
7tm_1	PF00001	268	2.2e-19	55.800	321	422	308	422	7 transmembrane receptor (rhodopsin family)
DUF4199	PF13858	168	0.016	1.800	410	433	382	445	Protein of unknown function (DUF4199)

oncogene

1.000

7tm_1 (PF00001): 7 transmembrane receptor (rhodopsin family)
7TM_GPCR_Srw (PF10324): Serpentine type 7TM GPCR chemoreceptor Srw
DUF4199 (PF13858): Protein of unknown function (DUF4199)

Flrt1

XP_008837187.1

Domain structure obtained by HMM

Protein ID: XP_008837187.1 - leucine-rich repeat transmembrane protein FLRT1
KEEG Ortholog ID: K16362

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
LRRNT	PF01462	28	0.000000000053	28.300	54	80	53	80	Leucine rich repeat N-terminal domain
LRR_4	PF12799	43	0.00016	8.400	84	121	84	127	Leucine Rich repeats (2 copies)
LRR_8	PF13855	61	0.00000000000057	34.800	128	189	127	189	Leucine rich repeat
LRR_8	PF13855	61	0.0000000000000093	40.500	199	260	198	260	Leucine rich repeat
LRR_4	PF12799	43	0.0000022	14.300	248	285	248	292	Leucine Rich repeats (2 copies)
LRR_8	PF13855	61	6.7e-17	47.400	271	329	270	329	Leucine rich repeat
TPKR_C2	PF16920	45	0.00000013	18.100	332	361	331	372	Tyrosine-protein kinase receptor C2 Ig-like domain
LRRCT	PF01463	26	0.00000086	15.800	355	378	354	378	Leucine rich repeat C-terminal domain
fn3	PF00041	85	0.00000011	18.400	443	512	441	517	Fibronectin type III domain

interactor

LRRNT (PF01462): Leucine rich repeat N-terminal domain
LRR_4 (PF12799): Leucine Rich repeats (2 copies)
LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
LRRCT (PF01463): Leucine rich repeat C-terminal domain
fn3 (PF00041): Fibronectin type III domain

Ippk

XP_008851096.1

Domain structure obtained by HMM

Protein ID: XP_008851096.1 - inositol-pentakisphosphate 2-kinase isoform X1
KEEG Ortholog ID: K10572

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Ins_P5_2-kin	PF06090	333	9.1e-98	313.800	13	454	13	455	Inositol-pentakisphosphate 2-kinase

interactor

1.000

Ins_P5_2-kin (PF06090): Inositol-pentakisphosphate 2-kinase

LOC103732400

XP_017653093.1

Domain structure obtained by HMM

Protein ID: XP_017653093.1 - C-type lectin domain family 2 member D11-like
KEEG Ortholog ID: K10072

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
UL45	PF05473	200	0.000000044	19.100	44	122	29	148	UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_C	PF00059	108	3.8e-16	46.100	100	170	99	209	Lectin C-type domain

interactor

UL45 (PF05473): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_C (PF00059): Lectin C-type domain

Lpar1

XP_008829336.1

Domain structure obtained by HMM

Protein ID: XP_008829336.1 - lysophosphatidic acid receptor 1 isoform X1
KEEG Ortholog ID: K04289

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
7tm_1	PF00001	268	4.2e-42	130.300	67	311	66	311	7 transmembrane receptor (rhodopsin family)

oncogene

0.667

1.000

7tm_1 (PF00001): 7 transmembrane receptor (rhodopsin family)

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