Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Adgrl2
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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Adgrl2 (from a repository: Sat Apr 21 11:01:18 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	10
The number (and %) of the onco-proteins	2 (20.00 %)
The number (and %) of the tumor suppressors	2 (20.00 %)
Total number of binary PPIs (saturation %)	12 (26.67 %)
The number (and %) of affected PPIs	9 (75.00 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	1.800
Assortativity coefficient	0
The network average Clustering coefficient	0.000
The number (and %) of a zero Clustering coefficients	10 (100.00 %)
The number (and %) of a zero Betweenness Centrality	9 (90.00 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Adgrl2

XP_008824439.1

Domain structure obtained by HMM

Protein ID: XP_008824439.1 - adhesion G protein-coupled receptor L2 isoform X1
KEEG Ortholog ID: K04593

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Gal_Lectin	PF02140	80	8.6e-28	83.000	49	129	49	129	Galactose binding lectin domain
OLF	PF02191	247	2.4e-87	278.700	149	397	145	397	Olfactomedin-like domain
HRM	PF02793	65	0.0000000000013	34.200	472	528	471	529	Hormone receptor domain
GAIN	PF16489	210	1.1e-58	184.200	544	765	543	765	GPCR-Autoproteolysis INducing (GAIN) domain
GPS	PF01825	42	0.0000000000000019	43.600	792	835	791	835	GPCR proteolysis site, GPS, motif
7tm_2	PF00002	245	1.2e-72	230.300	851	1085	849	1085	7 transmembrane receptor (Secretin family)
zf-C2HCIx2C	PF10782	58	0.00014	8.100	1089	1109	1085	1111	Zinc-finger
Latrophilin	PF02354	375	6.9e-179	580.700	1105	1462	1105	1462	Latrophilin Cytoplasmic C-terminal region

user protein, oncogene

72.000

Gal_Lectin (PF02140): Galactose binding lectin domain
OLF (PF02191): Olfactomedin-like domain
HRM (PF02793): Hormone receptor domain
GAIN (PF16489): GPCR-Autoproteolysis INducing (GAIN) domain
GPS (PF01825): GPCR proteolysis site, GPS, motif
7tm_2 (PF00002): 7 transmembrane receptor (Secretin family)
zf-C2HCIx2C (PF10782): Zinc-finger
Latrophilin (PF02354): Latrophilin Cytoplasmic C-terminal region

Cln3

XP_008822154.1

Domain structure obtained by HMM

Protein ID: XP_008822154.1 - battenin isoform X1
KEEG Ortholog ID: K12389

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
CLN3	PF02487	397	3.2e-144	466.900	38	434	37	435	CLN3 protein

interactor

CLN3 (PF02487): CLN3 protein

Ctdspl

XP_008853323.2

Domain structure obtained by HMM

Protein ID: XP_008853323.2 - CTD small phosphatase-like protein isoform X1
KEEG Ortholog ID: K15731

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
NIF	PF03031	156	4.4e-58	181.700	107	266	107	267	NLI interacting factor-like phosphatase

tumor suppressor

NIF (PF03031): NLI interacting factor-like phosphatase

Flrt1

XP_008837187.1

Domain structure obtained by HMM

Protein ID: XP_008837187.1 - leucine-rich repeat transmembrane protein FLRT1
KEEG Ortholog ID: K16362

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
LRRNT	PF01462	28	0.000000000053	28.300	54	80	53	80	Leucine rich repeat N-terminal domain
LRR_4	PF12799	43	0.00016	8.400	84	121	84	127	Leucine Rich repeats (2 copies)
LRR_8	PF13855	61	0.00000000000057	34.800	128	189	127	189	Leucine rich repeat
LRR_8	PF13855	61	0.0000000000000093	40.500	199	260	198	260	Leucine rich repeat
LRR_4	PF12799	43	0.0000022	14.300	248	285	248	292	Leucine Rich repeats (2 copies)
LRR_8	PF13855	61	6.7e-17	47.400	271	329	270	329	Leucine rich repeat
TPKR_C2	PF16920	45	0.00000013	18.100	332	361	331	372	Tyrosine-protein kinase receptor C2 Ig-like domain
LRRCT	PF01463	26	0.00000086	15.800	355	378	354	378	Leucine rich repeat C-terminal domain
fn3	PF00041	85	0.00000011	18.400	443	512	441	517	Fibronectin type III domain

interactor

LRRNT (PF01462): Leucine rich repeat N-terminal domain
LRR_4 (PF12799): Leucine Rich repeats (2 copies)
LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
LRRCT (PF01463): Leucine rich repeat C-terminal domain
fn3 (PF00041): Fibronectin type III domain

Irf3

XP_008843304.1

Domain structure obtained by HMM

Protein ID: XP_008843304.1 - interferon regulatory factor 3 isoform X1
KEEG Ortholog ID: K05411

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
IRF	PF00605	105	1e-38	118.100	7	109	7	110	Interferon regulatory factor transcription factor
IRF-3	PF10401	180	1.9e-53	167.100	196	373	195	374	Interferon-regulatory factor 3

tumor suppressor

IRF (PF00605): Interferon regulatory factor transcription factor
IRF-3 (PF10401): Interferon-regulatory factor 3

Nck1

XP_008839871.1

Domain structure obtained by HMM

Protein ID: XP_008839871.1 - cytoplasmic protein NCK1 isoform X1
KEEG Ortholog ID: K07365

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SH3_1	PF00018	48	1e-17	49.800	8	53	8	53	SH3 domain
SH3_9	PF14604	49	2.2e-16	45.800	113	161	113	161	Variant SH3 domain
SH3_1	PF00018	48	1.7e-19	55.600	196	244	196	244	SH3 domain
SH2	PF00017	77	1.6e-27	81.800	282	356	282	356	SH2 domain

oncogene

SH3_1 (PF00018): SH3 domain
SH3_9 (PF14604): Variant SH3 domain
SH2 (PF00017): SH2 domain

Ntrk1

XP_008851531.1

Domain structure obtained by HMM

Protein ID: XP_008851531.1 - high affinity nerve growth factor receptor isoform X1
KEEG Ortholog ID: K03176

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
LRR_8	PF13855	61	0.0011	5.000	65	98	62	102	Leucine rich repeat
LRR_8	PF13855	61	7.9e-17	47.100	92	150	91	150	Leucine rich repeat
TPKR_C2	PF16920	45	0.0000000000000013	43.700	151	194	151	194	Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3	PF13927	79	0.0000000041	23.300	196	271	196	271	Immunoglobulin domain
I-set	PF07679	90	0.0000000087	21.700	305	379	292	381	Immunoglobulin I-set domain
Pkinase_Tyr	PF07714	260	4.9e-97	310.300	514	783	512	783	Protein tyrosine kinase

oncogene

LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase

Shank1

XP_008843381.1

Domain structure obtained by HMM

Protein ID: XP_008843381.1 - SH3 and multiple ankyrin repeat domains protein 1 isoform X1
KEEG Ortholog ID: K15009

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
FERM_f0	PF16511	82	3e-18	52.300	74	152	73	156	N-terminal or F0 domain of Talin-head FERM
Ank_2	PF12796	84	0.00000000000039	36.200	190	277	184	277	Ankyrin repeats (3 copies)
Ank_4	PF13637	55	0.000000019	21.100	283	328	281	334	Ankyrin repeats (many copies)
Ank_2	PF12796	84	0.000000000000013	40.900	318	399	318	408	Ankyrin repeats (3 copies)
RSRP	PF17069	299	0.0034	3.000	453	516	445	525	Arginine/Serine-Rich protein 1
SH3_2	PF07653	55	3.9e-17	48.000	561	611	559	611	Variant SH3 domain
PDZ	PF00595	82	0.00000000000072	35.100	666	753	663	754	PDZ domain (Also known as DHR or GLGF)
RSRP	PF17069	299	0.0056	2.300	1165	1180	1147	1185	Arginine/Serine-Rich protein 1
Mito_fiss_reg	PF05308	244	0.027	0.600	1833	1864	1810	1884	Mitochondrial fission regulator
CAP_N	PF01213	317	0.01	1.400	1844	1890	1821	1892	Adenylate cyclase associated (CAP) N terminal
SAM_1	PF00536	64	7.4e-23	67.200	2098	2158	2097	2160	SAM domain (Sterile alpha motif)

interactor

FERM_f0 (PF16511): N-terminal or F0 domain of Talin-head FERM
Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RSRP (PF17069): Arginine/Serine-Rich protein 1
SH3_2 (PF07653): Variant SH3 domain
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
SAM_1 (PF00536): SAM domain (Sterile alpha motif)

Tmem17

XP_008833399.1

Domain structure obtained by HMM

Protein ID: XP_008833399.1 - transmembrane protein 17
KEEG Ortholog ID: K19384

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Transmemb_17	PF09799	107	2e-34	104.700	45	151	45	151	Predicted membrane protein
DUF3043	PF11241	171	0.000078	8.900	118	174	111	184	Protein of unknown function (DUF3043)

interactor

Transmemb_17 (PF09799): Predicted membrane protein
DUF3043 (PF11241): Protein of unknown function (DUF3043)

Tmem216

XP_008825309.1

Domain structure obtained by HMM

Protein ID: XP_008825309.1 - transmembrane protein 216 isoform X1
KEEG Ortholog ID: K19385

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Transmemb_17	PF09799	107	6.4e-37	112.700	15	121	15	121	Predicted membrane protein

interactor

Transmemb_17 (PF09799): Predicted membrane protein

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