Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Adgrl1 (from a repository: Thu Apr 19 20:59:48 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)20
The number (and %) of the onco-proteins1 (5.00 %)
The number (and %) of the tumor suppressors1 (5.00 %)
Total number of binary PPIs (saturation %)26 (13.68 %)
The number (and %) of affected PPIs19 (73.08 %)
PPI diameter2
PPI radius1
The average degree of PPI2.100
Assortativity coefficient-0.5966
The network average Clustering coefficient0.134
The number (and %) of a zero Clustering coefficients16 (80.00 %)
The number (and %) of a zero Betweenness Centrality18 (90.00 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure		 Type Number
of PPI (degree)		 Clustering
Coefficient		 Betweenness
Centrality		 Domains (Pfam ID): description
Adgrl1

Domain structure obtained by HMM

Protein ID: XP_008853630.1 - adhesion G protein-coupled receptor L1 isoform X1
KEEG Ortholog ID: K04592
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Gal_LectinPF02140807.4e-2780.0004812848128Galactose binding lectin domain
OLFPF021912478.2e-89283.500145397145397Olfactomedin-like domain
HRMPF02793650.000000000001933.600485541484542Hormone receptor domain
GAINPF164892108.7e-58181.300557780556780GPCR-Autoproteolysis INducing (GAIN) domain
GPSPF01825427.5e-1851.300807850806850GPCR proteolysis site, GPS, motif
7tm_2PF000022451.9e-70223.000865109986310997 transmembrane receptor (Secretin family)
LatrophilinPF023543751.9e-148480.6001119148011191480Latrophilin Cytoplasmic C-terminal region
user protein190.012337.000Gal_Lectin (PF02140): Galactose binding lectin domain
OLF (PF02191): Olfactomedin-like domain
HRM (PF02793): Hormone receptor domain
GAIN (PF16489): GPCR-Autoproteolysis INducing (GAIN) domain
GPS (PF01825): GPCR proteolysis site, GPS, motif
7tm_2 (PF00002): 7 transmembrane receptor (Secretin family)
Latrophilin (PF02354): Latrophilin Cytoplasmic C-terminal region
Apc

Domain structure obtained by HMM

Protein ID: XP_008832538.1 - adenomatous polyposis coli protein isoform X4
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
APC_N_CCPF16689521e-3298.300455455Coiled-coil N-terminus of APC, dimerisation domain
SAS4PF15460990.000626.20022741682Something about silencing, SAS, complex subunit 4
Suppressor_APCPF11414828.6e-2573.000131206127207Adenomatous polyposis coli tumour suppressor protein
DUF972PF061561020.0361.000184252184272Protein of unknown function (DUF972)
ArmPF00514410.000009312.000344369340370Armadillo/beta-catenin-like repeat
ArmPF00514410.0161.700460484459489Armadillo/beta-catenin-like repeat
ArmPF00514410.00000001121.300518552512553Armadillo/beta-catenin-like repeat
ArmPF00514410.000007312.300560597556597Armadillo/beta-catenin-like repeat
ArmPF00514410.0000000000130.900649689649689Armadillo/beta-catenin-like repeat
ArmPF00514410.00000008618.500691730691731Armadillo/beta-catenin-like repeat
Arm_APC_u3PF166292934.1e-171554.20073210197321019Armadillo-associated region on APC
APC_15aaPF05972150.000000003822.9001020103410201034APC 15 residue motif
APC_u5PF166301002.4e-56175.3001036113510361135Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_15aaPF05972150.00000004819.4001136115011361150APC 15 residue motif
APC_15aaPF05972150.000003813.4001155116911551169APC 15 residue motif
APC_15aaPF05972150.0000000006325.3001172118611721186APC 15 residue motif
APC_rPF05923249.6e-1643.5001258127912561279APC repeat
APC_u9PF16633881.1e-39121.8001281136712811367Unstructured region on APC between 1st two creatine-rich regions
APC_rPF05923240.00000000005328.4001371139213701392APC repeat
APC_rPF05923240.0000000007224.8001485150814851508APC repeat
SAMPPF05924220.0000000000006933.9001565158615651586SAMP Motif
APC_rPF05923240.000000000000001742.7001635165816351658APC repeat
APC_u13PF16634542.6e-2987.3001660171316601713Unstructured region on APC between APC_crr and SAMP
SAMPPF05924220.000000000007530.6001717173517141735SAMP Motif
APC_u14PF16635944.6e-44135.3001744183717441837Unstructured region on APC between SAMP and APC_crr
APC_rPF05923240.000000000000004541.4001839186318391863APC repeat
APC_u15PF16636811.6e-39120.5001865194518651945Unstructured region on APC between APC_crr regions 5 and 6
APC_rPF05923240.00000000000002139.3001948197019471970APC repeat
APC_rPF05923240.00000000000001140.1002007202920072029APC repeat
SAMPPF05924220.00000000000001239.5002030205120302051SAMP Motif
APC_basicPF059563424.1e-113364.3002223257422222574APC basic domain
EB1_bindingPF059371741.1e-92295.5002669284126692841EB-1 Binding Domain
oncogene, tumor suppressor200APC_N_CC (PF16689): Coiled-coil N-terminus of APC, dimerisation domain
SAS4 (PF15460): Something about silencing, SAS, complex subunit 4
Suppressor_APC (PF11414): Adenomatous polyposis coli tumour suppressor protein
DUF972 (PF06156): Protein of unknown function (DUF972)
Arm (PF00514): Armadillo/beta-catenin-like repeat
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_15aa (PF05972): APC 15 residue motif
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_r (PF05923): APC repeat
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
SAMP (PF05924): SAMP Motif
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_basic (PF05956): APC basic domain
EB1_binding (PF05937): EB-1 Binding Domain
Atp6v0d1

Domain structure obtained by HMM

Protein ID: XP_008837307.1 - V-type proton ATPase subunit d 1 isoform X1
KEEG Ortholog ID: K02146
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
vATP-synt_AC39PF019923336.5e-116373.5001636416364ATP synthase (C/AC39) subunit
interactor100vATP-synt_AC39 (PF01992): ATP synthase (C/AC39) subunit
B4gat1

Domain structure obtained by HMM

Protein ID: XP_008820483.1 - beta-1,4-glucuronyltransferase 1
KEEG Ortholog ID: K21032
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
GspL_CPF126931580.000008111.9001468678GspL periplasmic domain
Glyco_transf_49PF138963306.6e-108347.0009440994409Glycosyl-transferase for dystroglycan
interactor100GspL_C (PF12693): GspL periplasmic domain
Glyco_transf_49 (PF13896): Glycosyl-transferase for dystroglycan
Cacna1a

Domain structure obtained by HMM

Protein ID: XP_008853739.1 - voltage-dependent P/Q-type calcium channel subunit alpha-1A
KEEG Ortholog ID: K04344
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Fungus-inducedPF10917500.0171.8001330631Fungus-induced protein
Ion_transPF005202452.9e-72228.9009937198372Ion transport protein
Ion_transPF005202452e-57180.300488724487726Ion transport protein
PNK3PPF086451610.00001710.700738802714843Polynucleotide kinase 3 phosphatase
Ion_transPF005202453.4e-66209.0001151142511501428Ion transport protein
Ion_transPF005202455.2e-68215.0001473173014721731Ion transport protein
GPHHPF16905711.6e-40123.1001732180217321802Voltage-dependent L-type calcium channel, IQ-associated
Ca_chan_IQPF08763781.1e-34104.9001803187918031880Voltage gated calcium channel IQ domain
SelP_NPF045922330.0014.6002105213420832162Selenoprotein P, N terminal region
interactor100Fungus-induced (PF10917): Fungus-induced protein
Ion_trans (PF00520): Ion transport protein
PNK3P (PF08645): Polynucleotide kinase 3 phosphatase
GPHH (PF16905): Voltage-dependent L-type calcium channel, IQ-associated
Ca_chan_IQ (PF08763): Voltage gated calcium channel IQ domain
SelP_N (PF04592): Selenoprotein P, N terminal region
Cd1b

Domain structure obtained by HMM

Protein ID: XP_008851569.1 - T-cell surface glycoprotein CD1b
KEEG Ortholog ID: K06448
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
MHC_I_3PF164971985.2e-67211.3001519212192MHC-I family domain
Ig_3PF13927790.000005213.300198243198267Immunoglobulin domain
C1-setPF07654890.000000000000008141.400213280199280Immunoglobulin C1-set domain
interactor100MHC_I_3 (PF16497): MHC-I family domain
Ig_3 (PF13927): Immunoglobulin domain
C1-set (PF07654): Immunoglobulin C1-set domain
Edil3

Domain structure obtained by HMM

Protein ID: XP_008851507.1 - EGF-like repeat and discoidin I-like domain-containing protein 3
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
EGFPF00008320.0000000000009634.60026572658EGF-like domain
EGFPF00008320.0000000004126.2006810568105EGF-like domain
EGFPF00008320.000000009321.800113136113143EGF-like domain
F5_F8_type_CPF007541273.6e-33100.600163301163301F5/8 type C domain
F5_F8_type_CPF007541275.3e-36109.800324463324463F5/8 type C domain
interactor100EGF (PF00008): EGF-like domain
F5_F8_type_C (PF00754): F5/8 type C domain
Elavl1

Domain structure obtained by HMM

Protein ID: XP_008822366.1 - ELAV-like protein 1
KEEG Ortholog ID: K13088
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
RRM_1PF00076706.8e-2469.80022922292RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_1PF00076705.6e-2263.700108174108176RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_1PF00076708e-2469.600246315246316RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
oncogene31.0000RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fam189a2

Domain structure obtained by HMM

Protein ID: XP_008840961.1 - protein FAM189A2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
CD20PF041031560.00000000000001340.70031071109CD20-like family
interactor100CD20 (PF04103): CD20-like family
Flrt1

Domain structure obtained by HMM

Protein ID: XP_008837187.1 - leucine-rich repeat transmembrane protein FLRT1
KEEG Ortholog ID: K16362
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
LRRNTPF01462280.00000000005328.30054805380Leucine rich repeat N-terminal domain
LRR_4PF12799430.000168.4008412184127Leucine Rich repeats (2 copies)
LRR_8PF13855610.0000000000005734.800128189127189Leucine rich repeat
LRR_8PF13855610.000000000000009340.500199260198260Leucine rich repeat
LRR_4PF12799430.000002214.300248285248292Leucine Rich repeats (2 copies)
LRR_8PF13855616.7e-1747.400271329270329Leucine rich repeat
TPKR_C2PF16920450.0000001318.100332361331372Tyrosine-protein kinase receptor C2 Ig-like domain
LRRCTPF01463260.0000008615.800355378354378Leucine rich repeat C-terminal domain
fn3PF00041850.0000001118.400443512441517Fibronectin type III domain
interactor100LRRNT (PF01462): Leucine rich repeat N-terminal domain
LRR_4 (PF12799): Leucine Rich repeats (2 copies)
LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
LRRCT (PF01463): Leucine rich repeat C-terminal domain
fn3 (PF00041): Fibronectin type III domain
Gpr21

Domain structure obtained by HMM

Protein ID: XP_008822632.1 - probable G-protein coupled receptor 21
KEEG Ortholog ID: K04318
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
7tm_1PF000012681.8e-41128.20045304453047 transmembrane receptor (rhodopsin family)
interactor1007tm_1 (PF00001): 7 transmembrane receptor (rhodopsin family)
LOC103732400

Domain structure obtained by HMM

Protein ID: XP_017653093.1 - C-type lectin domain family 2 member D11-like
KEEG Ortholog ID: K10072
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
UL45PF054732000.00000004419.1004412229148UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_CPF000591083.8e-1646.10010017099209Lectin C-type domain
interactor100UL45 (PF05473): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_C (PF00059): Lectin C-type domain
LOC103736087

Domain structure obtained by HMM

Protein ID: XP_008833755.1 - protocadherin alpha-10-like
KEEG Ortholog ID: K16493
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Cadherin_2PF08266831.7e-33100.6002610726108Cadherin-like
Cadherin_3PF161841110.00224.300112163109185Cadherin-like
CadherinPF00028930.000000000000137.900138229134229Cadherin domain
CadherinPF00028931.1e-2163.400243337243337Cadherin domain
Cadherin_3PF161841110.000004912.800330384328391Cadherin-like
CadherinPF00028931.7e-1646.800353441351442Cadherin domain
Cadherin_3PF161841110.000177.900435489433511Cadherin-like
CadherinPF00028931.6e-1750.100456552456552Cadherin domain
CadherinPF00028930.00000000000001240.800581665575666Cadherin domain
Cadherin_C_2PF16492850.0000000003726.800692758691786Cadherin cytoplasmic C-terminal
interactor200Cadherin_2 (PF08266): Cadherin-like
Cadherin_3 (PF16184): Cadherin-like
Cadherin (PF00028): Cadherin domain
Cadherin_C_2 (PF16492): Cadherin cytoplasmic C-terminal
LOC103736112

Domain structure obtained by HMM

Protein ID: XP_017654256.1 - LOW QUALITY PROTEIN: protocadherin gamma-B7-like
KEEG Ortholog ID: K16496
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Cadherin_2PF08266832.7e-3090.4003311232112Cadherin-like
CadherinPF00028930.00000000000004639.000140232138233Cadherin domain
CadherinPF00028931.9e-2162.700247338247338Cadherin domain
CadherinPF00028938.9e-1954.100356443353443Cadherin domain
CadherinPF00028935.5e-1954.800457552457553Cadherin domain
CadherinPF00028930.000000000001434.200582661577663Cadherin domain
Cadherin_C_2PF16492859.7e-2470.300687768687769Cadherin cytoplasmic C-terminal
interactor200Cadherin_2 (PF08266): Cadherin-like
Cadherin (PF00028): Cadherin domain
Cadherin_C_2 (PF16492): Cadherin cytoplasmic C-terminal
Nrg1

Domain structure obtained by HMM

Protein ID: XP_008843150.1 - pro-neuregulin-1, membrane-bound isoform isoform X4
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
I-setPF07679901.1e-1750.2004813644136Immunoglobulin I-set domain
EGFPF00008320.000000118.500160193155193EGF-like domain
NeuregulinPF021584001.4e-193629.800213607213607Neuregulin family
interactor100I-set (PF07679): Immunoglobulin I-set domain
EGF (PF00008): EGF-like domain
Neuregulin (PF02158): Neuregulin family
Nrn1

Domain structure obtained by HMM

Protein ID: XP_008829877.1 - neuritin
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
NRN1PF15056883.4e-43132.0003111531117Neuritin protein family
interactor100NRN1 (PF15056): Neuritin protein family
Psma3

Domain structure obtained by HMM

Protein ID: XP_008837735.1 - proteasome subunit alpha type-3
KEEG Ortholog ID: K02727
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Proteasome_A_NPF10584232.9e-1851.600830830Proteasome subunit A N-terminal signature
ProteasomePF002271901.3e-55174.0003121731217Proteasome subunit
interactor200Proteasome_A_N (PF10584): Proteasome subunit A N-terminal signature
Proteasome (PF00227): Proteasome subunit
Tmem30a

Domain structure obtained by HMM

Protein ID: XP_008825282.1 - cell cycle control protein 50A
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
CDC50PF033812731.5e-98315.8006935268355LEM3 (ligand-effect modulator 3) family / CDC50 family
interactor30.6671.000CDC50 (PF03381): LEM3 (ligand-effect modulator 3) family / CDC50 family
Tmem30b

Domain structure obtained by HMM

Protein ID: XP_008848730.1 - cell cycle control protein 50B
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
CDC50PF033812731.8e-93299.1005334253345LEM3 (ligand-effect modulator 3) family / CDC50 family
interactor21.0000CDC50 (PF03381): LEM3 (ligand-effect modulator 3) family / CDC50 family
Upk1a

Domain structure obtained by HMM

Protein ID: XP_008826257.1 - uroplakin-1a
KEEG Ortholog ID: K17347
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
TetraspanninPF003352081.8e-3092.4001925516258Tetraspanin family
interactor100Tetraspannin (PF00335): Tetraspanin family

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