Find Protein-Protein Interactions (PPI) Network

Choose & Enter

Choose animal:			Visualization driver:
Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Adcyap1
Level of PPIs:		or Upload text file:	Update repository

Visible interactions:

Visible interactors:

Size of node:

Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Adcyap1 (from a repository: Thu Apr 19 16:00:55 2018)

	Examples
	Layout Breadthfirst Circle Concentric Cose Grid Random
	Export graph PNG file JPG file JSON file

Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	21
The number (and %) of the onco-proteins	2 (9.52 %)
The number (and %) of the tumor suppressors	0 (0.00 %)
Total number of binary PPIs (saturation %)	28 (13.33 %)
The number (and %) of affected PPIs	20 (71.43 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	2.095
Assortativity coefficient	-0.5164
The network average Clustering coefficient	0.191
The number (and %) of a zero Clustering coefficients	16 (76.19 %)
The number (and %) of a zero Betweenness Centrality	20 (95.24 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Adcyap1

XP_008825168.1

Domain structure obtained by HMM

Protein ID: XP_008825168.1 - pituitary adenylate cyclase-activating polypeptide
KEEG Ortholog ID: K05262

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Hormone_2	PF00123	28	0.0000000057	22.200	84	106	84	107	Peptide hormone
Hormone_2	PF00123	28	1.6e-16	46.300	128	154	128	155	Peptide hormone

user protein

0.011

376.000

Hormone_2 (PF00123): Peptide hormone

Amd1

XP_008850631.1

Domain structure obtained by HMM

Protein ID: XP_008850631.1 - S-adenosylmethionine decarboxylase proenzyme
KEEG Ortholog ID: K01611

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SAM_decarbox	PF01536	355	2.1e-125	404.500	5	325	4	326	Adenosylmethionine decarboxylase

interactor

SAM_decarbox (PF01536): Adenosylmethionine decarboxylase

Apbb2

XP_008825451.1

Domain structure obtained by HMM

Protein ID: XP_008825451.1 - amyloid beta A4 precursor protein-binding family B member 2 isoform X1
KEEG Ortholog ID: K04530

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
WW	PF00397	31	0.0000000005	25.500	293	321	293	321	WW domain
PID	PF00640	140	1.4e-42	131.300	420	557	420	558	Phosphotyrosine interaction domain (PTB/PID)
PID	PF00640	140	0.000000000000041	39.000	593	713	593	715	Phosphotyrosine interaction domain (PTB/PID)

interactor

WW (PF00397): WW domain
PID (PF00640): Phosphotyrosine interaction domain (PTB/PID)

Armc8

XP_008835661.1

Domain structure obtained by HMM

Protein ID: XP_008835661.1 - armadillo repeat-containing protein 8 isoform X2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Arm	PF00514	41	0.000000025	20.200	8	49	8	50	Armadillo/beta-catenin-like repeat
Arm	PF00514	41	0.0000082	12.200	54	90	52	92	Armadillo/beta-catenin-like repeat
UNC45-central	PF11701	152	0.00024	7.300	83	133	51	139	Myosin-binding striated muscle assembly central
HEAT	PF02985	31	0.00000074	15.600	150	174	147	175	HEAT repeat
IFRD	PF05004	305	0.000049	8.600	196	362	187	366	Interferon-related developmental regulator (IFRD)
HEAT	PF02985	31	0.0000038	13.400	344	371	343	373	HEAT repeat
Uso1_p115_head	PF04869	310	0.000086	7.900	351	385	340	412	Uso1 / p115 like vesicle tethering protein, head region
Arm	PF00514	41	0.0000067	12.500	418	454	415	455	Armadillo/beta-catenin-like repeat
HEAT_EZ	PF13513	55	0.00000018	17.900	440	496	440	496	HEAT-like repeat
DUF383	PF04063	175	0.000011	11.400	492	610	417	614	Domain of unknown function (DUF383)
V-ATPase_H_C	PF11698	116	0.0087	2.500	556	628	545	631	V-ATPase subunit H

interactor

Arm (PF00514): Armadillo/beta-catenin-like repeat
UNC45-central (PF11701): Myosin-binding striated muscle assembly central
HEAT (PF02985): HEAT repeat
IFRD (PF05004): Interferon-related developmental regulator (IFRD)
Uso1_p115_head (PF04869): Uso1 / p115 like vesicle tethering protein, head region
HEAT_EZ (PF13513): HEAT-like repeat
DUF383 (PF04063): Domain of unknown function (DUF383)
V-ATPase_H_C (PF11698): V-ATPase subunit H

Coprs

XP_008827117.1

Domain structure obtained by HMM

Protein ID: XP_008827117.1 - coordinator of PRMT5 and differentiation stimulator

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
COPR5	PF15340	151	1.4e-86	275.000	24	174	24	174	Cooperator of PRMT5 family

interactor

COPR5 (PF15340): Cooperator of PRMT5 family

Cops8

XP_008821882.1

Domain structure obtained by HMM

Protein ID: XP_008821882.1 - COP9 signalosome complex subunit 8 isoform X1
KEEG Ortholog ID: K12181

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
CSN8_PSD8_EIF3K	PF10075	144	1.3e-42	131.400	34	165	31	171	CSN8/PSMD8/EIF3K family

interactor

CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family

Ggps1

XP_008845250.1

Domain structure obtained by HMM

Protein ID: XP_008845250.1 - geranylgeranyl pyrophosphate synthase
KEEG Ortholog ID: K00804

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
polyprenyl_synt	PF00348	257	1.2e-68	217.100	10	250	9	251	Polyprenyl synthetase
EBA-175_VI	PF11556	80	0.0000004	16.600	242	273	226	275	Erythrocyte binding antigen 175

interactor

polyprenyl_synt (PF00348): Polyprenyl synthetase
EBA-175_VI (PF11556): Erythrocyte binding antigen 175

Gid4

XP_008820192.2

Domain structure obtained by HMM

Protein ID: XP_008820192.2 - LOW QUALITY PROTEIN: glucose-induced degradation protein 4 homolog

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Vac_ImportDeg	PF09783	162	3.2e-66	208.300	118	285	117	285	Vacuolar import and degradation protein

interactor

Vac_ImportDeg (PF09783): Vacuolar import and degradation protein

Gid8

XP_017656166.1

Domain structure obtained by HMM

Protein ID: XP_017656166.1 - glucose-induced degradation protein 8 homolog

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
LisH	PF08513	27	0.0000000000000036	41.800	28	53	27	53	LisH
CLTH	PF10607	147	4.8e-38	116.500	65	206	63	207	CTLH/CRA C-terminal to LisH motif domain

interactor

1.000

LisH (PF08513): LisH
CLTH (PF10607): CTLH/CRA C-terminal to LisH motif domain

Mkln1

XP_008849083.1

Domain structure obtained by HMM

Protein ID: XP_008849083.1 - muskelin isoform X1

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Muskelin_N	PF06588	199	7.6e-106	338.500	12	207	12	207	Muskelin N-terminus
Kelch_3	PF13415	49	0.000000000000011	40.700	283	332	282	334	Galactose oxidase, central domain
Kelch_6	PF13964	50	0.0000035	13.600	326	371	325	377	Kelch motif
Kelch_5	PF13854	42	0.00019	7.700	388	409	387	418	Kelch motif
Kelch_1	PF01344	46	0.003	3.500	400	441	398	443	Kelch motif
Kelch_1	PF01344	46	0.000000011	20.900	467	493	459	498	Kelch motif
Kelch_1	PF01344	46	0.000079	8.500	542	561	533	561	Kelch motif
Kelch_5	PF13854	42	0.00039	6.800	581	604	580	619	Kelch motif

interactor

1.000

Muskelin_N (PF06588): Muskelin N-terminus
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
Kelch_5 (PF13854): Kelch motif
Kelch_1 (PF01344): Kelch motif

Nucb1

XP_008843238.1

Domain structure obtained by HMM

Protein ID: XP_008843238.1 - nucleobindin-1
KEEG Ortholog ID: K20371

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF1104	PF06518	92	0.067	0.000	65	106	53	109	Protein of unknown function (DUF1104)
DUF1104	PF06518	92	0.00035	7.300	152	213	146	228	Protein of unknown function (DUF1104)
EF-hand_7	PF13499	71	0.00000000000032	36.300	245	316	243	320	EF-hand domain pair
DUF16	PF01519	104	0.00002	11.300	318	393	296	405	Protein of unknown function DUF16
Spc24	PF08286	105	0.00032	7.200	359	404	341	422	Spc24 subunit of Ndc80

interactor

DUF1104 (PF06518): Protein of unknown function (DUF1104)
EF-hand_7 (PF13499): EF-hand domain pair
DUF16 (PF01519): Protein of unknown function DUF16
Spc24 (PF08286): Spc24 subunit of Ndc80

Osbpl3

XP_008839769.1

Domain structure obtained by HMM

Protein ID: XP_008839769.1 - oxysterol-binding protein-related protein 3
KEEG Ortholog ID: K20463

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PH_8	PF15409	89	0.0000000000033	32.900	56	128	56	138	Pleckstrin homology domain
Oxysterol_BP	PF01237	371	5.3e-137	442.600	439	782	439	783	Oxysterol-binding protein

oncogene

PH_8 (PF15409): Pleckstrin homology domain
Oxysterol_BP (PF01237): Oxysterol-binding protein

Pcsk1n

XP_008840781.1

Domain structure obtained by HMM

Protein ID: XP_008840781.1 - proSAAS

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
ProSAAS	PF07259	188	2.1e-108	346.600	1	189	1	189	ProSAAS precursor
ProSAAS	PF07259	188	0.0099	2.000	211	223	199	259	ProSAAS precursor

interactor

ProSAAS (PF07259): ProSAAS precursor

Ppp4r3a

XP_008819957.1

Domain structure obtained by HMM

Protein ID: XP_008819957.1 - serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1
KEEG Ortholog ID: K17491

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
WH1	PF00568	111	0.00000032	16.600	7	97	1	101	WH1 domain
SMK-1	PF04802	191	2.9e-85	271.100	166	357	166	357	Component of IIS longevity pathway SMK-1
Collagen	PF01391	60	0.0000027	13.400	766	783	760	792	Collagen triple helix repeat (20 copies)
PBP1_TM	PF14812	85	0.0029	4.400	805	830	802	833	Transmembrane domain of transglycosylase PBP1 at N-terminal

interactor

WH1 (PF00568): WH1 domain
SMK-1 (PF04802): Component of IIS longevity pathway SMK-1
Collagen (PF01391): Collagen triple helix repeat (20 copies)
PBP1_TM (PF14812): Transmembrane domain of transglycosylase PBP1 at N-terminal

Pxdn

XP_008848403.1

Domain structure obtained by HMM

Protein ID: XP_008848403.1 - peroxidasin homolog isoform X1
KEEG Ortholog ID: K19511

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
TILa	PF12714	55	0.024	0.900	31	47	27	49	TILa domain
LRR_8	PF13855	61	9.5e-18	50.100	61	114	59	114	Leucine rich repeat
LRR_8	PF13855	61	2.8e-22	64.600	83	143	83	143	Leucine rich repeat
LRR_8	PF13855	61	1.9e-18	52.400	136	191	136	191	Leucine rich repeat
I-set	PF07679	90	6.3e-23	67.000	243	325	243	331	Immunoglobulin I-set domain
I-set	PF07679	90	1.5e-22	65.800	339	425	339	426	Immunoglobulin I-set domain
I-set	PF07679	90	1.5e-26	78.600	430	516	430	516	Immunoglobulin I-set domain
I-set	PF07679	90	1.2e-23	69.400	522	608	522	608	Immunoglobulin I-set domain
An_peroxidase	PF03098	530	1e-199	650.500	738	1286	738	1286	Animal haem peroxidase
VWC	PF00093	57	0.0000000000042	32.600	1411	1463	1408	1463	von Willebrand factor type C domain

interactor

TILa (PF12714): TILa domain
LRR_8 (PF13855): Leucine rich repeat
I-set (PF07679): Immunoglobulin I-set domain
An_peroxidase (PF03098): Animal haem peroxidase
VWC (PF00093): von Willebrand factor type C domain

Sav1

XP_008828065.1

Domain structure obtained by HMM

Protein ID: XP_008828065.1 - protein salvador homolog 1 isoform X1
KEEG Ortholog ID: K16686

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
WW	PF00397	31	0.000000000000033	38.900	203	232	203	232	WW domain
WW	PF00397	31	0.0000000012	24.400	238	267	238	267	WW domain

oncogene

1.000

WW (PF00397): WW domain

Sctr

XP_017657228.1

Domain structure obtained by HMM

Protein ID: XP_017657228.1 - secretin receptor
KEEG Ortholog ID: K04588

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
bcl-2I13	PF12201	155	0.00023	7.300	2	30	1	32	Bcl2-interacting killer, BH3-domain containing
HRM	PF02793	65	6.4e-24	70.400	71	132	70	133	Hormone receptor domain
7tm_2	PF00002	245	6e-96	306.500	148	391	146	391	7 transmembrane receptor (Secretin family)

interactor

bcl-2I13 (PF12201): Bcl2-interacting killer, BH3-domain containing
HRM (PF02793): Hormone receptor domain
7tm_2 (PF00002): 7 transmembrane receptor (Secretin family)

Stk3

XP_008829767.1

Domain structure obtained by HMM

Protein ID: XP_008829767.1 - serine/threonine-protein kinase 3 isoform X1
KEEG Ortholog ID: K04412

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pkinase	PF00069	264	1.1e-75	240.500	28	278	27	278	Protein kinase domain
Selenoprotein_S	PF06936	192	0.000029	10.100	272	340	252	356	Selenoprotein S (SelS)
Mst1_SARAH	PF11629	48	2.1e-29	87.700	436	483	436	483	C terminal SARAH domain of Mst1

interactor

1.000

Pkinase (PF00069): Protein kinase domain
Selenoprotein_S (PF06936): Selenoprotein S (SelS)
Mst1_SARAH (PF11629): C terminal SARAH domain of Mst1

Timm10

XP_008834368.1

Domain structure obtained by HMM

Protein ID: XP_008834368.1 - mitochondrial import inner membrane translocase subunit Tim10
KEEG Ortholog ID: K17778

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
zf-Tim10_DDP	PF02953	64	7.5e-28	82.400	7	70	7	71	Tim10/DDP family zinc finger

interactor

zf-Tim10_DDP (PF02953): Tim10/DDP family zinc finger

Timm10b

XP_008835614.1

Domain structure obtained by HMM

Protein ID: XP_008835614.1 - mitochondrial import inner membrane translocase subunit Tim10 B
KEEG Ortholog ID: K17779

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
zf-Tim10_DDP	PF02953	64	1.5e-19	55.800	4	65	4	67	Tim10/DDP family zinc finger

interactor

zf-Tim10_DDP (PF02953): Tim10/DDP family zinc finger

Ypel5

XP_008844704.1

Domain structure obtained by HMM

Protein ID: XP_008844704.1 - protein yippee-like 5

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Yippee-Mis18	PF03226	105	1.5e-18	53.200	14	108	13	118	Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

interactor

Yippee-Mis18 (PF03226): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly

B a c k t o T o p ⇑