Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Adcy9
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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Adcy9 (from a repository: Tue Apr 24 08:21:44 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	15
The number (and %) of the onco-proteins	3 (20.00 %)
The number (and %) of the tumor suppressors	1 (6.67 %)
Total number of binary PPIs (saturation %)	20 (19.05 %)
The number (and %) of affected PPIs	14 (70.00 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	2.133
Assortativity coefficient	-0.5812
The network average Clustering coefficient	0.179
The number (and %) of a zero Clustering coefficients	11 (73.33 %)
The number (and %) of a zero Betweenness Centrality	13 (86.67 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Adcy9

XP_008844447.1

Domain structure obtained by HMM

Protein ID: XP_008844447.1 - adenylate cyclase type 9 isoform X1
KEEG Ortholog ID: K08049

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF2207	PF09972	493	0.00015	6.700	114	170	74	259	Predicted membrane protein (DUF2207)
Promethin	PF16015	106	0.00016	7.900	140	190	131	199	Promethin
DUF202	PF02656	68	0.00023	7.900	173	234	171	310	Domain of unknown function (DUF202)
AC_N	PF16214	415	0.00000032	15.800	230	347	218	358	Adenylyl cyclase N-terminal extracellular and transmembrane region
Guanylate_cyc	PF00211	183	7.7e-67	210.600	386	571	385	573	Adenylate and Guanylate cyclase catalytic domain
zf-C2HC_2	PF13913	25	0.0000077	12.100	627	641	626	641	zinc-finger of a C2HC-type
DUF1053	PF06327	103	0.0000073	12.800	737	785	722	788	Domain of Unknown Function (DUF1053)
AC_N	PF16214	415	0.004	2.300	815	866	785	896	Adenylyl cyclase N-terminal extracellular and transmembrane region
DUF2157	PF09925	147	0.0042	3.100	886	1021	884	1025	Predicted membrane protein (DUF2157)
AC_N	PF16214	415	0.021	0.000	1019	1064	994	1073	Adenylyl cyclase N-terminal extracellular and transmembrane region
Guanylate_cyc	PF00211	183	6.7e-55	171.700	1068	1259	1067	1261	Adenylate and Guanylate cyclase catalytic domain

user protein

0.022

177.000

DUF2207 (PF09972): Predicted membrane protein (DUF2207)
Promethin (PF16015): Promethin
DUF202 (PF02656): Domain of unknown function (DUF202)
AC_N (PF16214): Adenylyl cyclase N-terminal extracellular and transmembrane region
Guanylate_cyc (PF00211): Adenylate and Guanylate cyclase catalytic domain
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
DUF1053 (PF06327): Domain of Unknown Function (DUF1053)
DUF2157 (PF09925): Predicted membrane protein (DUF2157)

Areg

XP_008841702.1

Domain structure obtained by HMM

Protein ID: XP_008841702.1 - amphiregulin
KEEG Ortholog ID: K09782

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PHC2_SAM_assoc	PF16616	120	0.027	1.600	50	76	28	95	Unstructured region on Polyhomeotic-like protein 1 and 2
Pestivirus_E2	PF16329	372	0.00000051	14.900	117	180	100	184	Pestivirus envelope glycoprotein E2
FtsL	PF04999	97	0.00000021	17.200	197	250	190	252	Cell division protein FtsL

oncogene

PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
Pestivirus_E2 (PF16329): Pestivirus envelope glycoprotein E2
FtsL (PF04999): Cell division protein FtsL

Cd27

XP_008823733.1

Domain structure obtained by HMM

Protein ID: XP_008823733.1 - CD27 antigen
KEEG Ortholog ID: K05144

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
TNFR_c6	PF00020	39	0.00000057	16.200	27	61	27	61	TNFR/NGFR cysteine-rich region
TNFR_c6	PF00020	39	0.00000000044	26.200	64	103	64	103	TNFR/NGFR cysteine-rich region

interactor

TNFR_c6 (PF00020): TNFR/NGFR cysteine-rich region

Cdh1

XP_017653858.1

Domain structure obtained by HMM

Protein ID: XP_017653858.1 - LOW QUALITY PROTEIN: cadherin-1
KEEG Ortholog ID: K05689

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Cadherin	PF00028	93	2e-17	49.800	33	124	31	125	Cadherin domain
Cadherin	PF00028	93	5.4e-27	80.400	140	238	139	238	Cadherin domain
Cadherin	PF00028	93	3.6e-18	52.200	252	349	252	350	Cadherin domain
Cadherin	PF00028	93	5.7e-17	48.300	364	453	363	457	Cadherin domain
Cadherin	PF00028	93	0.000000000031	29.900	476	558	470	558	Cadherin domain
Cadherin_C	PF01049	132	1.7e-50	157.000	610	750	605	751	Cadherin cytoplasmic region

oncogene, tumor suppressor

Cadherin (PF00028): Cadherin domain
Cadherin_C (PF01049): Cadherin cytoplasmic region

Gpr21

XP_008822632.1

Domain structure obtained by HMM

Protein ID: XP_008822632.1 - probable G-protein coupled receptor 21
KEEG Ortholog ID: K04318

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
7tm_1	PF00001	268	1.8e-41	128.200	45	304	45	304	7 transmembrane receptor (rhodopsin family)

interactor

7tm_1 (PF00001): 7 transmembrane receptor (rhodopsin family)

Hspb1

XP_008830488.1

Domain structure obtained by HMM

Protein ID: XP_008830488.1 - heat shock protein beta-1
KEEG Ortholog ID: K04455

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
HSP20	PF00011	101	4.4e-29	87.000	92	187	91	188	Hsp20/alpha crystallin family

heat shock, oncogene

HSP20 (PF00011): Hsp20/alpha crystallin family

Ier3ip1

XP_008824120.1

Domain structure obtained by HMM

Protein ID: XP_008824120.1 - immediate early response 3-interacting protein 1

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Yos1	PF08571	80	1.9e-35	107.300	5	82	5	82	Yos1-like

interactor

Yos1 (PF08571): Yos1-like

LOC103746864

XP_008847367.1

Domain structure obtained by HMM

Protein ID: XP_008847367.1 - phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like
KEEG Ortholog ID: K18079

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PKD_channel	PF08016	426	0.00000066	14.300	66	118	50	126	Polycystin cation channel
PTPlike_phytase	PF14566	156	0.00000000032	26.500	229	293	192	294	Inositol hexakisphosphate
PTEN_C2	PF10409	135	0.000000049	19.000	349	424	348	429	C2 domain of PTEN tumour-suppressor protein
PTEN_C2	PF10409	135	0.000000013	20.900	426	461	423	462	C2 domain of PTEN tumour-suppressor protein

interactor

PKD_channel (PF08016): Polycystin cation channel
PTPlike_phytase (PF14566): Inositol hexakisphosphate
PTEN_C2 (PF10409): C2 domain of PTEN tumour-suppressor protein

Lgals3

XP_008837759.1

Domain structure obtained by HMM

Protein ID: XP_008837759.1 - galectin-3
KEEG Ortholog ID: K06831

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Gal-bind_lectin	PF00337	134	4.2e-42	129.100	138	265	137	267	Galactoside-binding lectin

oncogene

Gal-bind_lectin (PF00337): Galactoside-binding lectin

Lgals8

XP_017657700.1

Domain structure obtained by HMM

Protein ID: XP_017657700.1 - galectin-8 isoform X1
KEEG Ortholog ID: K06832

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Gal-bind_lectin	PF00337	134	7.1e-44	134.800	17	149	17	150	Galactoside-binding lectin
Gal-bind_lectin	PF00337	134	1.2e-39	121.100	180	308	180	310	Galactoside-binding lectin

interactor

Gal-bind_lectin (PF00337): Galactoside-binding lectin

Pianp

XP_017651657.1

Domain structure obtained by HMM

Protein ID: XP_017651657.1 - PILR alpha-associated neural protein

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
AJAP1_PANP_C	PF15298	193	0.0000000000027	33.400	176	233	132	241	AJAP1/PANP C-terminus

interactor

AJAP1_PANP_C (PF15298): AJAP1/PANP C-terminus

Popdc2

XP_008841121.1

Domain structure obtained by HMM

Protein ID: XP_008841121.1 - popeye domain-containing protein 2 isoform X2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Popeye	PF04831	140	1.3e-52	164.000	26	251	25	251	Popeye protein conserved region

interactor

Popeye (PF04831): Popeye protein conserved region

Slc20a1

XP_008838589.1

Domain structure obtained by HMM

Protein ID: XP_008838589.1 - sodium-dependent phosphate transporter 1 isoform X1
KEEG Ortholog ID: K14640

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF4229	PF14012	68	0.00054	6.400	12	42	3	46	Protein of unknown function (DUF4229)
PHO4	PF01384	333	7.1e-142	458.400	43	669	43	669	Phosphate transporter family

interactor

1.000

DUF4229 (PF14012): Protein of unknown function (DUF4229)
PHO4 (PF01384): Phosphate transporter family

Stx7

XP_008820337.1

Domain structure obtained by HMM

Protein ID: XP_008820337.1 - syntaxin-7
KEEG Ortholog ID: K08488

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Syntaxin_2	PF14523	101	1.1e-31	95.500	18	119	18	119	Syntaxin-like protein
Cep57_CLD_2	PF14197	67	0.000062	9.400	154	187	147	194	Centrosome localisation domain of PPC89
SNARE	PF05739	53	3.7e-22	64.500	202	252	201	253	SNARE domain

interactor

1.000

Syntaxin_2 (PF14523): Syntaxin-like protein
Cep57_CLD_2 (PF14197): Centrosome localisation domain of PPC89
SNARE (PF05739): SNARE domain

Tmem17

XP_008833399.1

Domain structure obtained by HMM

Protein ID: XP_008833399.1 - transmembrane protein 17
KEEG Ortholog ID: K19384

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Transmemb_17	PF09799	107	2e-34	104.700	45	151	45	151	Predicted membrane protein
DUF3043	PF11241	171	0.000078	8.900	118	174	111	184	Protein of unknown function (DUF3043)

interactor

0.667

1.000

Transmemb_17 (PF09799): Predicted membrane protein
DUF3043 (PF11241): Protein of unknown function (DUF3043)

B a c k t o T o p ⇑