Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Adck5
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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Adck5 (from a repository: Thu Apr 19 22:16:57 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	11
The number (and %) of the onco-proteins	1 (9.09 %)
The number (and %) of the tumor suppressors	1 (9.09 %)
Total number of binary PPIs (saturation %)	18 (32.73 %)
The number (and %) of affected PPIs	11 (61.11 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	2.364
Assortativity coefficient	-0.6419
The network average Clustering coefficient	0.309
The number (and %) of a zero Clustering coefficients	6 (54.55 %)
The number (and %) of a zero Betweenness Centrality	8 (72.73 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Adck5

XP_008832641.1

Domain structure obtained by HMM

Protein ID: XP_008832641.1 - uncharacterized aarF domain-containing protein kinase 5 isoform X1
KEEG Ortholog ID: K08869

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
ABC1	PF03109	119	2.1e-39	120.600	219	332	216	332	ABC1 family
Pkinase	PF00069	264	0.0000005	15.400	319	421	302	431	Protein kinase domain

user protein

0.067

82.000

ABC1 (PF03109): ABC1 family
Pkinase (PF00069): Protein kinase domain

C1qbp

XP_008854173.1

Domain structure obtained by HMM

Protein ID: XP_008854173.1 - complement component 1 Q subcomponent-binding protein, mitochondrial
KEEG Ortholog ID: K15414

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
MAM33	PF02330	200	3.6e-47	147.100	81	273	81	273	Mitochondrial glycoprotein

interactor

0.667

1.000

MAM33 (PF02330): Mitochondrial glycoprotein

Chchd2

XP_008837379.1

Domain structure obtained by HMM

Protein ID: XP_008837379.1 - coiled-coil-helix-coiled-coil-helix domain-containing protein 2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF2076	PF09849	259	0.00000002	20.700	12	99	2	133	Uncharacterized protein conserved in bacteria (DUF2076)
CHCH	PF06747	35	0.0000000006	25.400	116	148	116	149	CHCH domain

interactor

0.667

1.000

DUF2076 (PF09849): Uncharacterized protein conserved in bacteria (DUF2076)
CHCH (PF06747): CHCH domain

Fus

XP_008822020.1

Domain structure obtained by HMM

Protein ID: XP_008822020.1 - RNA-binding protein FUS isoform X2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Chorion_3	PF05387	277	0.0028	3.400	47	93	41	96	Chorion family 3
SVS_QK	PF10578	12	0.11	0.000	88	97	87	97	Seminal vesicle protein repeat
SVS_QK	PF10578	12	0.04	1.300	117	124	117	127	Seminal vesicle protein repeat
SVS_QK	PF10578	12	0.042	1.200	131	137	131	137	Seminal vesicle protein repeat
SVS_QK	PF10578	12	0.031	1.600	138	149	138	149	Seminal vesicle protein repeat
SVS_QK	PF10578	12	0.039	1.300	174	181	174	181	Seminal vesicle protein repeat
RRM_1	PF00076	70	0.0000000000000062	41.100	276	354	276	354	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1	PF11608	88	0.000019	11.000	324	365	317	368	Limkain b1
Keratin_2_head	PF16208	161	0.01	2.200	363	405	335	420	Keratin type II head
zf-RanBP	PF00641	30	1.9e-16	45.500	411	442	411	442	Zn-finger in Ran binding protein and others

oncogene, tumor suppressor

Chorion_3 (PF05387): Chorion family 3
SVS_QK (PF10578): Seminal vesicle protein repeat
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608): Limkain b1
Keratin_2_head (PF16208): Keratin type II head
zf-RanBP (PF00641): Zn-finger in Ran binding protein and others

Hoga1

XP_008830192.1

Domain structure obtained by HMM

Protein ID: XP_008830192.1 - 4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X1
KEEG Ortholog ID: K18123

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DHDPS	PF00701	289	1.6e-49	154.200	29	271	28	283	Dihydrodipicolinate synthetase family

interactor

1.000

DHDPS (PF00701): Dihydrodipicolinate synthetase family

Hspa6

XP_008847280.1

Domain structure obtained by HMM

Protein ID: XP_008847280.1 - heat shock 70 kDa protein 6
KEEG Ortholog ID: K03283

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
HSP70	PF00012	599	1.4e-264	864.800	8	613	8	614	Hsp70 protein

heat shock

HSP70 (PF00012): Hsp70 protein

Immt

XP_008834962.1

Domain structure obtained by HMM

Protein ID: XP_008834962.1 - MICOS complex subunit MIC60 isoform X1
KEEG Ortholog ID: K17785

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Mitofilin	PF09731	623	1.9e-208	680.200	43	745	40	745	Mitochondrial inner membrane protein

interactor

Mitofilin (PF09731): Mitochondrial inner membrane protein

Pmpcb

XP_008828982.1

Domain structure obtained by HMM

Protein ID: XP_008828982.1 - mitochondrial-processing peptidase subunit beta
KEEG Ortholog ID: K17732

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Peptidase_M16	PF00675	149	6.3e-61	190.900	68	214	68	215	Insulinase (Peptidase family M16)
Peptidase_M16_C	PF05193	183	5.2e-43	133.300	220	404	220	404	Peptidase M16 inactive domain

interactor

1.000

Peptidase_M16 (PF00675): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193): Peptidase M16 inactive domain

Rhod

XP_008821093.1

Domain structure obtained by HMM

Protein ID: XP_008821093.1 - rho-related GTP-binding protein RhoD
KEEG Ortholog ID: K07530

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Ras	PF00071	162	1.2e-56	177.000	19	190	19	192	Ras family

interactor

Ras (PF00071): Ras family

Stoml2

XP_008840624.1

Domain structure obtained by HMM

Protein ID: XP_008840624.1 - stomatin-like protein 2, mitochondrial

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Band_7	PF01145	178	6.6e-35	106.900	37	205	35	218	SPFH domain / Band 7 family
DUF4769	PF15992	257	0.0000016	14.200	144	242	139	293	Domain of unknown function (DUF4769)
Band_7_C	PF16200	63	3e-29	87.200	256	316	255	317	C-terminal region of band_7

oncogene

Band_7 (PF01145): SPFH domain / Band 7 family
DUF4769 (PF15992): Domain of unknown function (DUF4769)
Band_7_C (PF16200): C-terminal region of band_7

Tns2

XP_008836627.1

Domain structure obtained by HMM

Protein ID: XP_008836627.1 - tensin-2 isoform X2
KEEG Ortholog ID: K18080

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
C1_1	PF00130	53	0.0000000012	24.200	32	80	32	82	Phorbol esters/diacylglycerol binding domain (C1 domain)
PTEN_C2	PF10409	135	5.3e-29	86.900	298	423	297	424	C2 domain of PTEN tumour-suppressor protein
cEGF	PF12662	24	0.00015	8.000	591	599	589	608	Complement Clr-like EGF-like
SH2	PF00017	77	0.000000000001	34.300	1138	1239	1138	1239	SH2 domain
PTB	PF08416	131	2.4e-43	133.700	1282	1415	1282	1416	Phosphotyrosine-binding domain

interactor

C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
PTEN_C2 (PF10409): C2 domain of PTEN tumour-suppressor protein
cEGF (PF12662): Complement Clr-like EGF-like
SH2 (PF00017): SH2 domain
PTB (PF08416): Phosphotyrosine-binding domain

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