Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Adar (from a repository: Thu Apr 19 21:42:34 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)55
The number (and %) of the onco-proteins11 (20.00 %)
The number (and %) of the tumor suppressors5 (9.09 %)
Total number of binary PPIs (saturation %)316 (21.28 %)
The number (and %) of affected PPIs54 (17.09 %)
PPI diameter2
PPI radius1
The average degree of PPI10.473
Assortativity coefficient-0.3345
The network average Clustering coefficient0.549
The number (and %) of a zero Clustering coefficients6 (10.91 %)
The number (and %) of a zero Betweenness Centrality12 (21.82 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Adar
user protein540.1641559.523z-alpha (PF02295): Adenosine deaminase z-alpha domain
dsrm (PF00035): Double-stranded RNA binding motif
A_deamin (PF02137): Adenosine-deaminase (editase) domain
Bmi1
oncogene120.50915.287zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207): RAWUL domain RING finger- and WD40-associated ubiquitin-like
Cand1
interactor150.64810.502HEAT_2 (PF13646): HEAT repeats
Cnd1 (PF12717): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
DUF3385 (PF11865): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
HEAT (PF02985): HEAT repeat
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
MMS19_C (PF12460): RNAPII transcription regulator C-terminal
Adaptin_N (PF01602): Adaptin N terminal region
TIP120 (PF08623): TATA-binding protein interacting (TIP20)
Cry2
interactor90.5714.667DNA_photolyase (PF00875): DNA photolyase
FAD_binding_7 (PF03441): FAD binding domain of DNA photolyase
Cul3
interactor170.65013.891Cullin (PF00888): Cullin family
WAC_Acf1_DNA_bd (PF10537): ATP-utilising chromatin assembly and remodelling N-terminal
Cullin_Nedd8 (PF10557): Cullin protein neddylation domain
Cul7
interactor140.53816.124Cul7 (PF11515): Mouse development and cellular proliferation protein Cullin-7
ANAPC10 (PF03256): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888): Cullin family
Cullin_Nedd8 (PF10557): Cullin protein neddylation domain
Ddx17
interactor220.47146.365Flavi_DEAD (PF07652): Flavivirus DEAD domain
DEAD (PF00270): DEAD/DEAH box helicase
Ferritin (PF00210): Ferritin-like domain
Helicase_C (PF00271): Helicase conserved C-terminal domain
Eed
tumor suppressor150.47319.963WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Nup160 (PF11715): Nucleoporin Nup120/160
Elavl1
oncogene270.326128.670RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Erg
oncogene60.8670.271Pex14_N (PF04695): Peroxisomal membrane anchor protein (Pex14p) conserved region
SAM_PNT (PF02198): Sterile alpha motif (SAM)/Pointed domain
Ets (PF00178): Ets-domain
SAM_2 (PF07647): SAM domain (Sterile alpha motif)
Exosc4
interactor60.8000.444RNase_PH (PF01138): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725): 3' exoribonuclease family, domain 2
Ezh2
oncogene, tumor suppressor90.6434.498EZH2_WD-Binding (PF11616): WD repeat binding protein EZH2
CDC45 (PF02724): CDC45-like protein
CENP-B_dimeris (PF09026): Centromere protein B dimerisation domain
FAM176 (PF14851): FAM176 family
TCR (PF03638): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856): SET domain
Fbxw11
interactor110.53312.410Beta-TrCP_D (PF12125): D domain of beta-TrCP
F-box-like (PF12937): F-box-like
WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Nucleoporin_N (PF08801): Nup133 N terminal like
Foxa2
oncogene, tumor suppressor100Forkhead_N (PF08430): Forkhead N-terminal region
Forkhead (PF00250): Forkhead domain
DHHA1 (PF02272): DHHA1 domain
HNF_C (PF09354): HNF3 C-terminal domain
Foxa3
interactor31.0000Forkhead_N (PF08430): Forkhead N-terminal region
Forkhead (PF00250): Forkhead domain
MSA-2c (PF12238): Merozoite surface antigen 2c
HNF_C (PF09354): HNF3 C-terminal domain
Foxb1
interactor31.0000Forkhead (PF00250): Forkhead domain
Foxg1
oncogene30.6671.000Forkhead (PF00250): Forkhead domain
Foxh1
interactor21.0000Forkhead (PF00250): Forkhead domain
Foxi2
interactor100Forkhead (PF00250): Forkhead domain
Foxl1
oncogene100Forkhead (PF00250): Forkhead domain
Foxs1
interactor21.0000Forkhead (PF00250): Forkhead domain
Hdac5
interactor90.6792.783HDAC4_Gln (PF12203): Glutamine rich N terminal domain of histone deacetylase 4
TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
PTPRCAP (PF15713): Protein tyrosine phosphatase receptor type C-associated
Hist_deacetyl (PF00850): Histone deacetylase domain
Hdac9
interactor200HDAC4_Gln (PF12203): Glutamine rich N terminal domain of histone deacetylase 4
Gastrin (PF00918): Gastrin/cholecystokinin family
CDC37_N (PF03234): Cdc37 N terminal kinase binding
Hdlbp
oncogene40.6670.650KH_1 (PF00013): KH domain
BMC (PF00936): BMC domain
KH_4 (PF13083): KH domain
KH_5 (PF13184): NusA-like KH domain
DUF4530 (PF15039): Domain of unknown function (DUF4530)
Hnrnpa1
interactor260.45066.941RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627): Nuclear factor hnRNPA1
Hnrnpm
interactor170.51523.029HnRNP_M (PF11532): Heterogeneous nuclear ribonucleoprotein M
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Collagen_mid (PF15984): Bacterial collagen, middle region
LOC103728480
interactor200Transglut_N (PF00868): Transglutaminase family
LOC103732819
interactor70.7621.169F-box-like (PF12937): F-box-like
FBA (PF04300): F-box associated region
LOC103748852
interactor90.6072.976Recep_L_domain (PF01030): Receptor L domain
Furin-like (PF00757): Furin-like cysteine rich region
GF_recep_IV (PF14843): Growth factor receptor domain IV
Matr3
interactor220.44349.061zf-C2H2_jaz (PF12171): Zinc-finger double-stranded RNA-binding
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
NPR3 (PF03666): Nitrogen Permease regulator of amino acid transport activity 3
FGF-BP1 (PF06473): FGF binding protein 1 (FGF-BP1)
Tim54 (PF11711): Inner membrane protein import complex subunit Tim54
zf-U1 (PF06220): U1 zinc finger
Mex3c
interactor31.0000KH_1 (PF00013): KH domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
Mmgt1
interactor21.0000MMgT (PF10270): Membrane magnesium transporter
Myc
oncogene80.7142.567Myc_N (PF01056): Myc amino-terminal region
TFIIE-A_C (PF11521): C-terminal general transcription factor TFIIE alpha
HLH (PF00010): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344): Myc leucine zipper domain
Ntrk1
oncogene210.42664.349LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Obsl1
interactor120.45512.980I-set (PF07679): Immunoglobulin I-set domain
Herpes_gE (PF02480): Alphaherpesvirus glycoprotein E
fn3 (PF00041): Fibronectin type III domain
Ig_3 (PF13927): Immunoglobulin domain
BiPBP_C (PF06832): Penicillin-Binding Protein C-terminus Family
Ig_4 (PF16680): T-cell surface glycoprotein CD3 delta chain
Rbpj
interactor50.8000.786LAG1-DNAbind (PF09271): LAG1, DNA binding
BTD (PF09270): Beta-trefoil DNA-binding domain
TIG (PF01833): IPT/TIG domain
Rnf2
interactor140.51316.572zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-C4_Topoisom (PF01396): Topoisomerase DNA binding C4 zinc finger
RAWUL (PF16207): RAWUL domain RING finger- and WD40-associated ubiquitin-like
Rpa1
tumor suppressor190.52927.994Rep-A_N (PF04057): Replication factor-A protein 1, N-terminal domain
tRNA_anti-codon (PF01336): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900): Replication protein A OB domain
Rep_fac-A_C (PF08646): Replication factor-A C terminal domain
Rpa2
oncogene180.43846.290tRNA_anti-codon (PF01336): OB-fold nucleic acid binding domain
RMI2 (PF16100): RecQ-mediated genome instability protein 2
RPA_C (PF08784): Replication protein A C terminal
Rpa3
interactor170.50027.390Rep_fac-A_3 (PF08661): Replication factor A protein 3
Snrpb
interactor90.5004.973LSM (PF01423): LSM domain
Snrpn
interactor60.7331.456LSM (PF01423): LSM domain
Stau1
interactor170.61715.100dsrm (PF00035): Double-stranded RNA binding motif
Staufen_C (PF16482): Staufen C-terminal domain
Stau2
interactor60.7330.768dsrm (PF00035): Double-stranded RNA binding motif
LPP20 (PF02169): LPP20 lipoprotein
Staufen_C (PF16482): Staufen C-terminal domain
Suz12
oncogene, tumor suppressor110.5569.747Cloacin (PF03515): Colicin-like bacteriocin tRNase domain
VEFS-Box (PF09733): VEFS-Box of polycomb protein
DUF2070 (PF09843): Predicted membrane protein (DUF2070)
Tacc3
oncogene30.6670.667DUF2072 (PF09845): Zn-ribbon containing protein
TACC (PF05010): Transforming acidic coiled-coil-containing protein (TACC)
Tardbp
interactor200.60220.880RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Thoc1
interactor100.5568.627efThoc1 (PF11957): THO complex subunit 1 transcription elongation factor
Death (PF00531): Death domain
Thoc2
interactor130.41018.526THOC2_N (PF16134): THO complex subunit 2 N-terminus
Thoc2 (PF11732): Transcription- and export-related complex subunit
Sec62 (PF03839): Translocation protein Sec62
Tho2 (PF11262): Transcription factor/nuclear export subunit protein 2
Usp (PF00582): Universal stress protein family
Thoc7
interactor60.8670.533THOC7 (PF05615): Tho complex subunit 7
UPF0193 (PF05250): Uncharacterised protein family (UPF0193)
Terpene_synth_C (PF03936): Terpene synthase family, metal binding domain
Com_YlbF (PF06133): Control of competence regulator ComK, YlbF/YmcA
Ube2i
interactor100.4448.794UQ_con (PF00179): Ubiquitin-conjugating enzyme
Upf1
interactor200.33277.477UPF1_Zn_bind (PF09416): RNA helicase (UPF2 interacting domain)
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
Usp38
oncogene100UCH (PF00443): Ubiquitin carboxyl-terminal hydrolase
Xpo1
interactor170.39743.282IBN_N (PF03810): Importin-beta N-terminal domain
Xpo1 (PF08389): Exportin 1-like protein
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
Hydrolase_3 (PF08282): haloacid dehalogenase-like hydrolase
CRM1_C (PF08767): CRM1 C terminal
Zfc3h1
interactor50.4004.019Gly_rich (PF12810): Glycine rich protein
DUF2570 (PF10828): Protein of unknown function (DUF2570)
Bap31 (PF05529): B-cell receptor-associated protein 31-like
DUF4398 (PF14346): Domain of unknown function (DUF4398)
DUF572 (PF04502): Family of unknown function (DUF572)
zf-C3H1 (PF10650): Putative zinc-finger domain
DUF2277 (PF10041): Uncharacterized conserved protein (DUF2277)
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_2 (PF07719): Tetratricopeptide repeat
FAM176 (PF14851): FAM176 family

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