Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Adap2
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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Adap2 (from a repository: Sat Apr 14 03:28:33 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	10
The number (and %) of the onco-proteins	0 (0.00 %)
The number (and %) of the tumor suppressors	2 (20.00 %)
Total number of binary PPIs (saturation %)	19 (42.22 %)
The number (and %) of affected PPIs	9 (47.37 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	2.400
Assortativity coefficient	-0.5122
The network average Clustering coefficient	0.342
The number (and %) of a zero Clustering coefficients	5 (50.00 %)
The number (and %) of a zero Betweenness Centrality	7 (70.00 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Adap2

XP_008819842.1

Domain structure obtained by HMM

Protein ID: XP_008819842.1 - arf-GAP with dual PH domain-containing protein 2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
ArfGap	PF01412	117	3.1e-36	110.200	15	124	8	126	Putative GTPase activating protein for Arf
PH	PF00169	105	0.0000000000026	33.500	135	231	133	232	PH domain
PH	PF00169	105	0.000000000000048	39.100	258	360	256	361	PH domain

user protein

0.083

64.000

ArfGap (PF01412): Putative GTPase activating protein for Arf
PH (PF00169): PH domain

App

XP_017657176.1

Domain structure obtained by HMM

Protein ID: XP_017657176.1 - amyloid beta A4 protein
KEEG Ortholog ID: K04520

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
APP_N	PF02177	100	8.1e-49	150.500	31	131	31	131	Amyloid A4 N-terminal heparin-binding
APP_Cu_bd	PF12924	57	1.8e-29	88.600	132	188	132	188	Copper-binding of amyloid precursor, CuBD
SDA1	PF05285	347	0.0000059	12.000	193	270	155	307	SDA1
YtxH	PF12732	75	0.0048	3.800	251	291	245	298	YtxH-like protein
Kunitz_BPTI	PF00014	53	1.4e-23	69.200	291	342	291	343	Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2	PF12925	190	1e-78	249.500	365	547	365	547	E2 domain of amyloid precursor protein
YtxH	PF12732	75	0.029	1.300	520	565	516	576	YtxH-like protein
Beta-APP	PF03494	39	3.3e-28	83.600	676	712	674	712	Beta-amyloid peptide (beta-APP)
APP_amyloid	PF10515	52	3.7e-29	87.400	715	765	715	765	beta-amyloid precursor protein C-terminus

interactor

0.667

1.000

APP_N (PF02177): Amyloid A4 N-terminal heparin-binding
APP_Cu_bd (PF12924): Copper-binding of amyloid precursor, CuBD
SDA1 (PF05285): SDA1
YtxH (PF12732): YtxH-like protein
Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2 (PF12925): E2 domain of amyloid precursor protein
Beta-APP (PF03494): Beta-amyloid peptide (beta-APP)
APP_amyloid (PF10515): beta-amyloid precursor protein C-terminus

Eef1g

XP_008835762.1

Domain structure obtained by HMM

Protein ID: XP_008835762.1 - elongation factor 1-gamma isoform X1
KEEG Ortholog ID: K03233

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
GST_N	PF02798	76	1.1e-26	79.400	3	80	2	81	Glutathione S-transferase, N-terminal domain
GST_C	PF00043	93	4.2e-23	67.800	108	198	106	198	Glutathione S-transferase, C-terminal domain
EF1G	PF00647	107	6.2e-57	176.600	275	381	275	381	Elongation factor 1 gamma, conserved domain

interactor

GST_N (PF02798): Glutathione S-transferase, N-terminal domain
GST_C (PF00043): Glutathione S-transferase, C-terminal domain
EF1G (PF00647): Elongation factor 1 gamma, conserved domain

Ikbkg

XP_017652770.1

Domain structure obtained by HMM

Protein ID: XP_017652770.1 - NF-kappa-B essential modulator isoform X2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
NEMO	PF11577	68	6.8e-32	95.700	44	111	44	111	NF-kappa-B essential modulator NEMO
APC_u15	PF16636	81	0.0000085	12.500	107	146	105	161	Unstructured region on APC between APC_crr regions 5 and 6
Golgin_A5	PF09787	306	0.0000014	14.100	152	285	139	289	Golgin subfamily A member 5
CC2-LZ	PF16516	104	2.6e-33	100.800	248	343	239	343	Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
LLC1	PF14945	119	0.00002	11.400	302	360	300	386	Normal lung function maintenance, Low in Lung Cancer 1 protein

interactor

NEMO (PF11577): NF-kappa-B essential modulator NEMO
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
Golgin_A5 (PF09787): Golgin subfamily A member 5
CC2-LZ (PF16516): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
LLC1 (PF14945): Normal lung function maintenance, Low in Lung Cancer 1 protein

Kctd10

XP_008847190.1

Domain structure obtained by HMM

Protein ID: XP_008847190.1 - BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform X1
KEEG Ortholog ID: K15074

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
BTB_2	PF02214	94	3.6e-25	74.500	34	124	34	124	BTB/POZ domain

interactor

BTB_2 (PF02214): BTB/POZ domain

Ncl

XP_008836296.1

Domain structure obtained by HMM

Protein ID: XP_008836296.1 - nucleolin
KEEG Ortholog ID: K11294

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PBP1_TM	PF14812	85	0.0000038	13.600	8	62	4	68	Transmembrane domain of transglycosylase PBP1 at N-terminal
YL1	PF05764	242	0.000027	10.500	24	96	7	135	YL1 nuclear protein
Myc_N	PF01056	332	0.000063	9.000	77	177	45	190	Myc amino-terminal region
ANAPC15	PF15243	90	0.0012	5.600	194	221	176	225	Anaphase-promoting complex subunit 15
Sigma70_ner	PF04546	204	0.000064	9.000	246	297	240	343	Sigma-70, non-essential region
RRM_1	PF00076	70	0.00000000000012	37.000	316	384	316	384	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1	PF11608	88	0.0058	3.100	358	392	316	398	Limkain b1
RRM_1	PF00076	70	1.4e-16	46.400	405	466	402	467	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_1	PF00076	70	6e-20	57.200	494	560	494	560	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_1	PF00076	70	1.1e-21	62.800	580	646	580	647	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

interactor

PBP1_TM (PF14812): Transmembrane domain of transglycosylase PBP1 at N-terminal
YL1 (PF05764): YL1 nuclear protein
Myc_N (PF01056): Myc amino-terminal region
ANAPC15 (PF15243): Anaphase-promoting complex subunit 15
Sigma70_ner (PF04546): Sigma-70, non-essential region
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608): Limkain b1

Nedd4l

XP_008853586.1

Domain structure obtained by HMM

Protein ID: XP_008853586.1 - E3 ubiquitin-protein ligase NEDD4-like isoform X1
KEEG Ortholog ID: K13305

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
C2	PF00168	103	8.9e-30	89.400	21	119	20	127	C2 domain
WW	PF00397	31	3.6e-16	45.200	195	224	195	224	WW domain
WW	PF00397	31	2.5e-17	48.900	388	417	388	417	WW domain
WW	PF00397	31	2.4e-17	48.900	500	529	500	529	WW domain
WW	PF00397	31	0.0000000000000018	42.900	551	580	551	580	WW domain
HECT	PF00632	307	5.8e-106	340.500	671	973	670	975	HECT-domain (ubiquitin-transferase)

oncogene, tumor suppressor

1.000

C2 (PF00168): C2 domain
WW (PF00397): WW domain
HECT (PF00632): HECT-domain (ubiquitin-transferase)

Prnp

XP_008834115.1

Domain structure obtained by HMM

Protein ID: XP_008834115.1 - major prion protein
KEEG Ortholog ID: K05634

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Prion_bPrPp	PF11587	30	3e-19	54.900	1	28	1	28	Major prion protein bPrPp - N terminal
Prion_octapep	PF03991	8	0.13	0.000	54	59	53	59	Copper binding octapeptide repeat
Prion_octapep	PF03991	8	0.044	1.500	60	68	60	68	Copper binding octapeptide repeat
Prion_octapep	PF03991	8	0.044	1.500	69	77	69	77	Copper binding octapeptide repeat
Prion_octapep	PF03991	8	0.044	1.500	78	86	78	86	Copper binding octapeptide repeat
Prion_octapep	PF03991	8	0.044	1.500	87	95	87	95	Copper binding octapeptide repeat
Glt_symporter	PF03616	368	0.000011	10.300	94	185	89	217	Sodium/glutamate symporter
Prion	PF00377	117	1.2e-39	121.000	136	254	136	255	Prion/Doppel alpha-helical domain

interactor

Prion_bPrPp (PF11587): Major prion protein bPrPp - N terminal
Prion_octapep (PF03991): Copper binding octapeptide repeat
Glt_symporter (PF03616): Sodium/glutamate symporter
Prion (PF00377): Prion/Doppel alpha-helical domain

Ranbp9

XP_008829900.1

Domain structure obtained by HMM

Protein ID: XP_008829900.1 - ran-binding protein 9

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SPRY	PF00622	120	1.8e-29	88.600	115	232	115	233	SPRY domain
LisH	PF08513	27	0.00000000037	25.900	270	293	268	294	LisH
CLTH	PF10607	147	2.7e-53	166.000	304	608	304	611	CTLH/CRA C-terminal to LisH motif domain

tumor suppressor

1.000

SPRY (PF00622): SPRY domain
LisH (PF08513): LisH
CLTH (PF10607): CTLH/CRA C-terminal to LisH motif domain

Snca

XP_008842850.1

Domain structure obtained by HMM

Protein ID: XP_008842850.1 - alpha-synuclein isoform X2
KEEG Ortholog ID: K04528

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Synuclein	PF01387	134	2.3e-57	179.100	1	127	1	132	Synuclein

interactor

0.667

1.000

Synuclein (PF01387): Synuclein

B a c k t o T o p ⇑