Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Adap1
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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Adap1 (from a repository: Fri Apr 20 03:46:57 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	15
The number (and %) of the onco-proteins	2 (13.33 %)
The number (and %) of the tumor suppressors	5 (33.33 %)
Total number of binary PPIs (saturation %)	27 (25.71 %)
The number (and %) of affected PPIs	14 (51.85 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	2.267
Assortativity coefficient	-0.7963
The network average Clustering coefficient	0.236
The number (and %) of a zero Clustering coefficients	10 (66.67 %)
The number (and %) of a zero Betweenness Centrality	13 (86.67 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Adap1

XP_008849659.1

Domain structure obtained by HMM

Protein ID: XP_008849659.1 - arf-GAP with dual PH domain-containing protein 1

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
ArfGap	PF01412	117	0.00000097	15.100	1	48	1	50	Putative GTPase activating protein for Arf
PH	PF00169	105	0.000000000058	29.200	59	156	58	157	PH domain
PH	PF00169	105	4.9e-17	48.700	182	283	181	284	PH domain

user protein

0.033

173.000

ArfGap (PF01412): Putative GTPase activating protein for Arf
PH (PF00169): PH domain

Anp32a

XP_008834595.1

Domain structure obtained by HMM

Protein ID: XP_008834595.1 - acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X1
KEEG Ortholog ID: K18646

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
LRR_4	PF12799	43	0.011	2.600	58	99	56	101	Leucine Rich repeats (2 copies)
LRR_9	PF14580	175	5.2e-23	67.600	91	186	56	209	Leucine-rich repeat
SDA1	PF05285	347	0.000046	9.000	189	276	128	286	SDA1

oncogene, tumor suppressor

LRR_4 (PF12799): Leucine Rich repeats (2 copies)
LRR_9 (PF14580): Leucine-rich repeat
SDA1 (PF05285): SDA1

Csnk1a1

XP_008836126.1

Domain structure obtained by HMM

Protein ID: XP_008836126.1 - casein kinase I isoform X3
KEEG Ortholog ID: K08957

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pkinase	PF00069	264	1.8e-28	85.700	17	263	17	280	Protein kinase domain

oncogene, tumor suppressor

Pkinase (PF00069): Protein kinase domain

Dvl3

XP_008829491.1

Domain structure obtained by HMM

Protein ID: XP_008829491.1 - segment polarity protein dishevelled homolog DVL-3 isoform X1
KEEG Ortholog ID: K02353

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DIX	PF00778	81	2.9e-34	103.100	3	79	2	80	DIX domain
Dishevelled	PF02377	159	1.2e-65	207.000	90	245	87	245	Dishevelled specific domain
PDZ	PF00595	82	1.5e-22	66.100	250	333	249	334	PDZ domain (Also known as DHR or GLGF)
DEP	PF00610	72	3.6e-22	64.600	425	494	425	494	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dsh_C	PF12316	207	1.1e-81	260.300	500	709	500	709	Segment polarity protein dishevelled (Dsh) C terminal

interactor

DIX (PF00778): DIX domain
Dishevelled (PF02377): Dishevelled specific domain
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
DEP (PF00610): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dsh_C (PF12316): Segment polarity protein dishevelled (Dsh) C terminal

Gsk3b

XP_008841124.1

Domain structure obtained by HMM

Protein ID: XP_008841124.1 - glycogen synthase kinase-3 beta isoform X1
KEEG Ortholog ID: K03083

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pkinase	PF00069	264	1.9e-72	229.900	56	353	56	353	Protein kinase domain

oncogene, tumor suppressor

1.000

Pkinase (PF00069): Protein kinase domain

LOC103727574

XP_008823743.1

Domain structure obtained by HMM

Protein ID: XP_008823743.1 - golgin subfamily A member 2 isoform X7

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Atg14	PF10186	324	0.0077	1.400	17	53	10	65	Vacuolar sorting 38 and autophagy-related subunit 14
CENP-Q	PF13094	155	0.033	0.600	56	140	15	143	CENP-Q, a CENPA-CAD centromere complex subunit
DUF2046	PF09755	304	0.000013	10.600	179	246	149	256	Uncharacterized conserved protein H4 (DUF2046)
BRE1	PF08647	95	0.000056	9.500	238	328	238	336	BRE1 E3 ubiquitin ligase
FliJ	PF02050	123	0.000024	10.800	335	406	330	410	Flagellar FliJ protein
GOLGA2L5	PF15070	622	3.4e-303	993.000	386	1004	386	1004	Putative golgin subfamily A member 2-like protein 5

interactor

Atg14 (PF10186): Vacuolar sorting 38 and autophagy-related subunit 14
CENP-Q (PF13094): CENP-Q, a CENPA-CAD centromere complex subunit
DUF2046 (PF09755): Uncharacterized conserved protein H4 (DUF2046)
BRE1 (PF08647): BRE1 E3 ubiquitin ligase
FliJ (PF02050): Flagellar FliJ protein
GOLGA2L5 (PF15070): Putative golgin subfamily A member 2-like protein 5

Ncl

XP_008836296.1

Domain structure obtained by HMM

Protein ID: XP_008836296.1 - nucleolin
KEEG Ortholog ID: K11294

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PBP1_TM	PF14812	85	0.0000038	13.600	8	62	4	68	Transmembrane domain of transglycosylase PBP1 at N-terminal
YL1	PF05764	242	0.000027	10.500	24	96	7	135	YL1 nuclear protein
Myc_N	PF01056	332	0.000063	9.000	77	177	45	190	Myc amino-terminal region
ANAPC15	PF15243	90	0.0012	5.600	194	221	176	225	Anaphase-promoting complex subunit 15
Sigma70_ner	PF04546	204	0.000064	9.000	246	297	240	343	Sigma-70, non-essential region
RRM_1	PF00076	70	0.00000000000012	37.000	316	384	316	384	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1	PF11608	88	0.0058	3.100	358	392	316	398	Limkain b1
RRM_1	PF00076	70	1.4e-16	46.400	405	466	402	467	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_1	PF00076	70	6e-20	57.200	494	560	494	560	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_1	PF00076	70	1.1e-21	62.800	580	646	580	647	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)

interactor

1.000

PBP1_TM (PF14812): Transmembrane domain of transglycosylase PBP1 at N-terminal
YL1 (PF05764): YL1 nuclear protein
Myc_N (PF01056): Myc amino-terminal region
ANAPC15 (PF15243): Anaphase-promoting complex subunit 15
Sigma70_ner (PF04546): Sigma-70, non-essential region
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608): Limkain b1

Pik3ca

XP_008836896.1

Domain structure obtained by HMM

Protein ID: XP_008836896.1 - phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
KEEG Ortholog ID: K00922

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PI3K_p85B	PF02192	76	2.6e-33	99.900	32	107	32	107	PI3-kinase family, p85-binding domain
PI3K_rbd	PF00794	107	8.6e-41	124.800	174	291	173	292	PI3-kinase family, ras-binding domain
PI3K_C2	PF00792	136	2e-37	114.500	352	483	350	485	Phosphoinositide 3-kinase C2
PI3Ka	PF00613	185	4.4e-73	230.800	521	703	519	704	Phosphoinositide 3-kinase family, accessory domain (PIK domain)
DUF2321	PF10083	156	0.000003	13.200	688	738	674	742	Uncharacterized protein conserved in bacteria (DUF2321)
PI3_PI4_kinase	PF00454	250	4.3e-61	193.000	798	1014	796	1015	Phosphatidylinositol 3- and 4-kinase

oncogene

PI3K_p85B (PF02192): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794): PI3-kinase family, ras-binding domain
PI3K_C2 (PF00792): Phosphoinositide 3-kinase C2
PI3Ka (PF00613): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
DUF2321 (PF10083): Uncharacterized protein conserved in bacteria (DUF2321)
PI3_PI4_kinase (PF00454): Phosphatidylinositol 3- and 4-kinase

Prkce

XP_008821291.1

Domain structure obtained by HMM

Protein ID: XP_008821291.1 - protein kinase C epsilon type isoform X1
KEEG Ortholog ID: K18050

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
C2	PF00168	103	7.5e-17	47.800	7	116	6	119	C2 domain
PP_M1	PF03012	296	0.000013	10.900	79	168	43	183	Phosphoprotein
C1_1	PF00130	53	6e-20	57.300	170	221	170	223	Phorbol esters/diacylglycerol binding domain (C1 domain)
C1_1	PF00130	53	8e-21	60.100	243	294	243	295	Phorbol esters/diacylglycerol binding domain (C1 domain)
Pkinase	PF00069	264	1.1e-69	220.800	409	667	408	668	Protein kinase domain
Pkinase_C	PF00433	46	0.00000000000074	35.400	690	730	689	730	Protein kinase C terminal domain

tumor suppressor

C2 (PF00168): C2 domain
PP_M1 (PF03012): Phosphoprotein
C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
Pkinase (PF00069): Protein kinase domain
Pkinase_C (PF00433): Protein kinase C terminal domain

Prkci

XP_008828336.1

Domain structure obtained by HMM

Protein ID: XP_008828336.1 - protein kinase C iota type isoform X1
KEEG Ortholog ID: K06069

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PB1	PF00564	84	3e-19	55.100	27	108	26	108	PB1 domain
C1_1	PF00130	53	6.6e-19	53.900	142	193	142	194	Phorbol esters/diacylglycerol binding domain (C1 domain)
Pkinase	PF00069	264	6.9e-72	228.000	257	523	255	523	Protein kinase domain
Pkinase_C	PF00433	46	0.0000000036	23.500	552	585	546	585	Protein kinase C terminal domain

interactor

1.000

PB1 (PF00564): PB1 domain
C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
Pkinase (PF00069): Protein kinase domain
Pkinase_C (PF00433): Protein kinase C terminal domain

Prkcz

XP_008850855.1

Domain structure obtained by HMM

Protein ID: XP_008850855.1 - protein kinase C zeta type isoform X1
KEEG Ortholog ID: K18952

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PB1	PF00564	84	3e-16	45.500	11	80	5	81	PB1 domain
C1_1	PF00130	53	2.8e-18	51.900	114	165	114	166	Phorbol esters/diacylglycerol binding domain (C1 domain)
Pkinase	PF00069	264	1.8e-68	216.900	236	500	234	500	Protein kinase domain
Pkinase_C	PF00433	46	0.00000000086	25.500	528	562	521	562	Protein kinase C terminal domain

interactor

0.500

3.000

PB1 (PF00564): PB1 domain
C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
Pkinase (PF00069): Protein kinase domain
Pkinase_C (PF00433): Protein kinase C terminal domain

Prkd1

XP_008827472.2

Domain structure obtained by HMM

Protein ID: XP_008827472.2 - serine/threonine-protein kinase D1
KEEG Ortholog ID: K06070

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
C1_1	PF00130	53	3.2e-18	51.700	71	118	68	119	Phorbol esters/diacylglycerol binding domain (C1 domain)
C1_1	PF00130	53	1.3e-18	53.000	199	248	199	251	Phorbol esters/diacylglycerol binding domain (C1 domain)
PH	PF00169	105	0.00000000000011	37.900	351	467	351	469	PH domain
PH	PF00169	105	0.053	0.400	483	504	473	536	PH domain
Pkinase	PF00069	264	3.5e-75	238.800	515	767	512	767	Protein kinase domain

oncogene

C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
PH (PF00169): PH domain
Pkinase (PF00069): Protein kinase domain

Psme3

XP_008833566.1

Domain structure obtained by HMM

Protein ID: XP_008833566.1 - proteasome activator complex subunit 3
KEEG Ortholog ID: K06698

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PA28_alpha	PF02251	61	9e-29	85.800	10	69	9	69	Proteasome activator pa28 alpha subunit
PA28_beta	PF02252	145	1.3e-69	218.700	109	251	108	252	Proteasome activator pa28 beta subunit

interactor

PA28_alpha (PF02251): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252): Proteasome activator pa28 beta subunit

Ranbp9

XP_008829900.1

Domain structure obtained by HMM

Protein ID: XP_008829900.1 - ran-binding protein 9

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SPRY	PF00622	120	1.8e-29	88.600	115	232	115	233	SPRY domain
LisH	PF08513	27	0.00000000037	25.900	270	293	268	294	LisH
CLTH	PF10607	147	2.7e-53	166.000	304	608	304	611	CTLH/CRA C-terminal to LisH motif domain

tumor suppressor

SPRY (PF00622): SPRY domain
LisH (PF08513): LisH
CLTH (PF10607): CTLH/CRA C-terminal to LisH motif domain

Sdcbp2

XP_008832536.2

Domain structure obtained by HMM

Protein ID: XP_008832536.2 - syntenin-2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PadR	PF03551	75	0.000026	10.500	31	57	26	64	Transcriptional regulator PadR-like family
PadR	PF03551	75	0.0082	2.500	74	86	60	101	Transcriptional regulator PadR-like family
PDZ	PF00595	82	0.00000000000011	37.700	142	217	141	218	PDZ domain (Also known as DHR or GLGF)
PDZ	PF00595	82	0.0000000013	24.600	226	296	225	297	PDZ domain (Also known as DHR or GLGF)

interactor

PadR (PF03551): Transcriptional regulator PadR-like family
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)

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