Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Adamtsl4 (from a repository: Sat Apr 21 20:10:43 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)65
The number (and %) of the onco-proteins6 (9.23 %)
The number (and %) of the tumor suppressors7 (10.77 %)
Total number of binary PPIs (saturation %)125 (6.01 %)
The number (and %) of affected PPIs64 (51.20 %)
PPI diameter2
PPI radius1
The average degree of PPI3.231
Assortativity coefficient-0.6217
The network average Clustering coefficient0.397
The number (and %) of a zero Clustering coefficients32 (49.23 %)
The number (and %) of a zero Betweenness Centrality50 (76.92 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Adamtsl4
user protein640.0203819.833TSP_1 (PF00090): Thrombospondin type 1 domain
ADAM_spacer1 (PF05986): ADAM-TS Spacer 1
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
PLAC (PF08686): PLAC (protease and lacunin) domain
Adamtsl5
interactor100TSP_1 (PF00090): Thrombospondin type 1 domain
ADAM_spacer1 (PF05986): ADAM-TS Spacer 1
NTR (PF01759): UNC-6/NTR/C345C module
Ammecr1
interactor100DUF3678 (PF12435): Protein of unknown function (DUF3678)
AMMECR1 (PF01871): AMMECR1
Aqp1
interactor31.0000MIP (PF00230): Major intrinsic protein
Arnt2
interactor30.6671.000HLH (PF00010): Helix-loop-helix DNA-binding domain
PAS (PF00989): PAS fold
PAS_11 (PF14598): PAS domain
Aspscr1
oncogene100TUG-UBL1 (PF11470): TUG ubiquitin-like domain
UBX (PF00789): UBX domain
Cfap206
interactor200DUF3508 (PF12018): Domain of unknown function (DUF3508)
Chchd2
interactor31.0000DUF2076 (PF09849): Uncharacterized protein conserved in bacteria (DUF2076)
CHCH (PF06747): CHCH domain
Dip2a
interactor21.0000DMAP_binding (PF06464): DMAP1-binding Domain
AMP-binding (PF00501): AMP-binding enzyme
Dlk2
interactor21.0000Laminin_EGF (PF00053): Laminin EGF domain
EGF (PF00008): EGF-like domain
cEGF (PF12662): Complement Clr-like EGF-like
Dnpep
interactor200Peptidase_M18 (PF02127): Aminopeptidase I zinc metalloprotease (M18)
Eif4e2
interactor100IF4E (PF01652): Eukaryotic initiation factor 4E
Fah
interactor100FAA_hydrolase_N (PF09298): Fumarylacetoacetase N-terminal
FAA_hydrolase (PF01557): Fumarylacetoacetate (FAA) hydrolase family
Fam124b
interactor100FAM124 (PF15067): FAM124 family
Fars2
interactor30.6671.000tRNA-synt_2d (PF01409): tRNA synthetases class II core domain (F)
FDX-ACB (PF03147): Ferredoxin-fold anticodon binding domain
Fbln1
oncogene, tumor suppressor41.0000stn_TNFRSF12A (PF12191): Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain
ANATO (PF01821): Anaphylotoxin-like domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
cEGF (PF12662): Complement Clr-like EGF-like
EGF_CA (PF07645): Calcium-binding EGF domain
EGF (PF00008): EGF-like domain
Fbxw5
interactor100F-box-like (PF12937): F-box-like
WD40 (PF00400): WD domain, G-beta repeat
Fhl3
interactor41.0000LIM (PF00412): LIM domain
Med27 (PF11571): Mediator complex subunit 27
Fkbp1b
interactor21.0000FKBP_C (PF00254): FKBP-type peptidyl-prolyl cis-trans isomerase
Flna
tumor suppressor100CH (PF00307): Calponin homology (CH) domain
Filamin (PF00630): Filamin/ABP280 repeat
Frs3
tumor suppressor31.0000IRS (PF02174): PTB domain (IRS-1 type)
DUF566 (PF04484): Family of unknown function (DUF566)
Gip
oncogene100Hormone_2 (PF00123): Peptide hormone
Glrx3
interactor60.5005.000Thioredoxin (PF00085): Thioredoxin
Glutaredoxin (PF00462): Glutaredoxin
Gne
interactor200Epimerase_2 (PF02350): UDP-N-acetylglucosamine 2-epimerase
ROK (PF00480): ROK family
Hgf
oncogene200PAN_1 (PF00024): PAN domain
Kringle (PF00051): Kringle domain
Trypsin (PF00089): Trypsin
Hoxa1
interactor50.6671.667SelP_N (PF04592): Selenoprotein P, N terminal region
Homeobox (PF00046): Homeobox domain
Kif1a
interactor40.5002.167Kinesin (PF00225): Kinesin motor domain
Kinesin_assoc (PF16183): Kinesin-associated
FHA (PF00498): FHA domain
IncA (PF04156): IncA protein
KIF1B (PF12423): Kinesin protein 1B
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
DUF3694 (PF12473): Kinesin protein
PH (PF00169): PH domain
LOC103732819
interactor100F-box-like (PF12937): F-box-like
FBA (PF04300): F-box associated region
LOC103742152
interactor100DUF1708 (PF08101): Domain of unknown function (DUF1708)
ApoL (PF05461): Apolipoprotein L
LOC103751510
interactor100p450 (PF00067): Cytochrome P450
Lmo1
oncogene100Vps39_2 (PF10367): Vacuolar sorting protein 39 domain 2
LIM (PF00412): LIM domain
Lmo2
oncogene31.0000CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
LIM (PF00412): LIM domain
Lonrf1
interactor41.0000TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
zf-P11 (PF03854): P-11 zinc finger
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_2 (PF07719): Tetratricopeptide repeat
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
DZR (PF12773): Double zinc ribbon
LON_substr_bdg (PF02190): ATP-dependent protease La (LON) substrate-binding domain
Mapkbp1
interactor30.6671.000eIF2A (PF08662): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005): WD40-like domain
Mid2
interactor90.28619.333BIR (PF00653): Inhibitor of Apoptosis domain
zf-RING_UBOX (PF13445): RING-type zinc-finger
CEBP_ZZ (PF16366): Cytoplasmic polyadenylation element-binding protein ZZ domain
zf-B_box (PF00643): B-box zinc finger
zf-4CXXC_R1 (PF10497): Zinc-finger domain of monoamine-oxidase A repressor R1
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
fn3 (PF00041): Fibronectin type III domain
PRY (PF13765): SPRY-associated domain
SPRY (PF00622): SPRY domain
Mvp
oncogene50.8330.500Vault (PF01505): Major Vault Protein repeat
DUF3601 (PF12208): Domain of unknown function (DUF3601)
MVP_shoulder (PF11978): Shoulder domain
DUF2543 (PF10820): Protein of unknown function (DUF2543)
Natd1
interactor100Acetyltransf_CG (PF14542): GCN5-related N-acetyl-transferase
Nmur2
interactor1007tm_1 (PF00001): 7 transmembrane receptor (rhodopsin family)
Ntf4
interactor100NGF (PF00243): Nerve growth factor family
Ntn4
interactor21.0000Laminin_N (PF00055): Laminin N-terminal (Domain VI)
Laminin_EGF (PF00053): Laminin EGF domain
EGF_2 (PF07974): EGF-like domain
NTR (PF01759): UNC-6/NTR/C345C module
Olfm3
interactor21.0000Noelin-1 (PF12308): Neurogenesis glycoprotein
Dynactin_p22 (PF07426): Dynactin subunit p22
DUF1664 (PF07889): Protein of unknown function (DUF1664)
OLF (PF02191): Olfactomedin-like domain
Otx1
interactor21.0000Homeobox (PF00046): Homeobox domain
SR-25 (PF10500): Nuclear RNA-splicing-associated protein
TF_Otx (PF03529): Otx1 transcription factor
NicO (PF03824): High-affinity nickel-transport protein
Pid1
interactor100PID_2 (PF14719): Phosphotyrosine interaction domain (PTB/PID)
Pin1
tumor suppressor21.0000WW (PF00397): WW domain
Rotamase (PF00639): PPIC-type PPIASE domain
Plscr1
interactor140.20967.667Scramblase (PF03803): Scramblase
Prkab2
interactor200AMPK1_CBM (PF16561): Glycogen recognition site of AMP-activated protein kinase
AMPKBI (PF04739): 5'-AMP-activated protein kinase beta subunit, interaction domain
Rchy1
oncogene, tumor suppressor31.0000zf-CHY (PF05495): CHY zinc finger
C1_2 (PF03107): C1 domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_2 (PF13639): Ring finger domain
zinc_ribbon_6 (PF14599): Zinc-ribbon
Rhoj
interactor100Ras (PF00071): Ras family
P12 (PF12669): Virus attachment protein p12 family
Sall2
tumor suppressor100Zn-ribbon_8 (PF09723): Zinc ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2_jaz (PF12171): Zinc-finger double-stranded RNA-binding
zf-C2H2 (PF00096): Zinc finger, C2H2 type
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
Nop14 (PF04147): Nop14-like family
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
zf-C2H2_6 (PF13912): C2H2-type zinc finger
Slc23a1
interactor100Xan_ur_permease (PF00860): Permease family
Slc6a15
interactor100SNF (PF00209): Sodium:neurotransmitter symporter family
Smarcc1
tumor suppressor40.6671.000SWIRM-assoc_2 (PF16496): SWIRM-associated domain at the N-terminal
DUF2618 (PF10940): Protein of unknown function (DUF2618)
SWIRM (PF04433): SWIRM domain
Myb_DNA-binding (PF00249): Myb-like DNA-binding domain
SWIRM-assoc_3 (PF16498): SWIRM-associated domain at the C-terminal
SWIRM-assoc_1 (PF16495): SWIRM-associated region 1
CYSTM (PF12734): Cysteine-rich TM module stress tolerance
Sorbs3
interactor40.6671.000Sorb (PF02208): Sorbin homologous domain
SH3_9 (PF14604): Variant SH3 domain
SH3_1 (PF00018): SH3 domain
Spink2
interactor100Kazal_1 (PF00050): Kazal-type serine protease inhibitor domain
Stk16
interactor41.0000Pkinase (PF00069): Protein kinase domain
Susd6
interactor100Sushi (PF00084): Sushi repeat (SCR repeat)
MASE2 (PF05230): MASE2 domain
Tapbpl
interactor100V-set (PF07686): Immunoglobulin V-set domain
C1-set (PF07654): Immunoglobulin C1-set domain
Tcea2
interactor21.0000Med26 (PF08711): TFIIS helical bundle-like domain
TFIIS_M (PF07500): Transcription factor S-II (TFIIS), central domain
TFIIS_C (PF01096): Transcription factor S-II (TFIIS)
Tmem150a
interactor100Frag1 (PF10277): Frag1/DRAM/Sfk1 family
Top3b
interactor21.0000Toprim (PF01751): Toprim domain
Topoisom_bac (PF01131): DNA topoisomerase
Zn_Tnp_IS1595 (PF12760): Transposase zinc-ribbon domain
Tnp_zf-ribbon_2 (PF13842): DDE_Tnp_1-like zinc-ribbon
Trim42
interactor100.38918.167zf-B_box (PF00643): B-box zinc finger
CHDCT2 (PF08074): CHDCT2 (NUC038) domain
fn3 (PF00041): Fibronectin type III domain
Trip6
interactor60.4008.667zf-dskA_traR (PF01258): Prokaryotic dksA/traR C4-type zinc finger
LIM (PF00412): LIM domain
Tssk3
interactor100Pkinase (PF00069): Protein kinase domain
Tubgcp4
interactor100Spc97_Spc98 (PF04130): Spc97 / Spc98 family
Zfp69
interactor40.6672.000KRAB (PF01352): KRAB box
zf-C2H2 (PF00096): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465): Zinc-finger double domain

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