Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Adamtsl1
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Visible interactions:

Visible interactors:

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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Adamtsl1 (from a repository: Fri Apr 20 16:53:54 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	8
The number (and %) of the onco-proteins	3 (37.50 %)
The number (and %) of the tumor suppressors	0 (0.00 %)
Total number of binary PPIs (saturation %)	8 (28.57 %)
The number (and %) of affected PPIs	7 (87.50 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	1.750
Assortativity coefficient	0
The network average Clustering coefficient	0.000
The number (and %) of a zero Clustering coefficients	8 (100.00 %)
The number (and %) of a zero Betweenness Centrality	7 (87.50 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Adamtsl1

XP_008843766.1

Domain structure obtained by HMM

Protein ID: XP_008843766.1 - ADAMTS-like protein 1

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
TSP_1	PF00090	49	0.00000000096	24.900	38	81	37	81	Thrombospondin type 1 domain
ADAM_spacer1	PF05986	114	0.000000091	18.400	188	293	186	296	ADAM-TS Spacer 1
TSP_1	PF00090	49	0.0011	5.500	308	322	303	359	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.000000012	21.400	383	407	381	437	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.0000000013	24.500	443	483	441	492	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.00000000024	26.900	530	575	528	583	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.00018	8.000	616	666	612	666	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.0000000012	24.600	673	698	671	728	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.00000000098	24.900	736	788	734	788	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.0000000046	22.700	795	821	790	849	Thrombospondin type 1 domain
Ig_3	PF13927	79	0.000000000069	29.000	892	949	887	950	Immunoglobulin domain
I-set	PF07679	90	0.0000000000000071	41.200	1196	1265	1179	1266	Immunoglobulin I-set domain
Ig_3	PF13927	79	7.9e-17	48.000	1284	1356	1284	1356	Immunoglobulin domain
V-set	PF07686	109	0.00000054	16.100	1333	1369	1324	1370	Immunoglobulin V-set domain
I-set	PF07679	90	0.0000000000000045	41.800	1404	1485	1396	1485	Immunoglobulin I-set domain
TSP_1	PF00090	49	0.012	2.100	1497	1544	1494	1544	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.0000000041	22.900	1551	1606	1546	1606	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.0049	3.400	1611	1665	1610	1665	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.00013	8.500	1672	1703	1670	1729	Thrombospondin type 1 domain
PLAC	PF08686	32	0.000000000087	28.700	1729	1758	1729	1759	PLAC (protease and lacunin) domain

user protein

42.000

TSP_1 (PF00090): Thrombospondin type 1 domain
ADAM_spacer1 (PF05986): ADAM-TS Spacer 1
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
V-set (PF07686): Immunoglobulin V-set domain
PLAC (PF08686): PLAC (protease and lacunin) domain

Acox1

XP_008829582.1

Domain structure obtained by HMM

Protein ID: XP_008829582.1 - peroxisomal acyl-coenzyme A oxidase 1 isoform X1
KEEG Ortholog ID: K00232

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Acyl-CoA_ox_N	PF14749	125	3.4e-39	120.500	15	132	15	133	Acyl-coenzyme A oxidase N-terminal
Acyl-CoA_dh_M	PF02770	97	0.0000000000000091	41.000	136	244	135	245	Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_1	PF00441	150	0.00000025	17.200	321	435	276	436	Acyl-CoA dehydrogenase, C-terminal domain
ACOX	PF01756	180	3.2e-71	224.800	480	657	479	659	Acyl-CoA oxidase

interactor

Acyl-CoA_ox_N (PF14749): Acyl-coenzyme A oxidase N-terminal
Acyl-CoA_dh_M (PF02770): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_1 (PF00441): Acyl-CoA dehydrogenase, C-terminal domain
ACOX (PF01756): Acyl-CoA oxidase

B3glct

XP_017651579.1

Domain structure obtained by HMM

Protein ID: XP_017651579.1 - beta-1,3-glucosyltransferase
KEEG Ortholog ID: K13675

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Fringe	PF02434	252	0.0000000018	23.500	111	200	94	217	Fringe-like
Fringe	PF02434	252	6.9e-56	175.500	254	447	253	456	Fringe-like

interactor

Fringe (PF02434): Fringe-like

Fbn2

XP_008839304.1

Domain structure obtained by HMM

Protein ID: XP_008839304.1 - fibrillin-2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
EGF_2	PF07974	32	0.0055	3.400	106	132	106	132	EGF-like domain
EGF	PF00008	32	0.000059	9.700	143	164	138	165	EGF-like domain
EGF_2	PF07974	32	0.00011	8.900	171	198	171	198	EGF-like domain
TB	PF00683	41	0.0000000000036	32.100	215	251	215	254	TB domain
cEGF	PF12662	24	0.00013	8.200	252	270	242	270	Complement Clr-like EGF-like
EGF_CA	PF07645	42	0.00000000000037	35.800	267	307	267	307	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.00000000000036	35.900	309	349	309	349	Calcium-binding EGF domain
TB	PF00683	41	8.9e-16	43.700	365	407	365	407	TB domain
hEGF	PF12661	22	0.00000011	18.700	494	514	494	514	Human growth factor-like EGF
cEGF	PF12662	24	0.0000000013	24.200	505	527	505	527	Complement Clr-like EGF-like
EGF_CA	PF07645	42	0.00000000003	29.700	524	562	524	562	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.0000000000002	36.700	564	604	564	604	Calcium-binding EGF domain
cEGF	PF12662	24	0.00000000000047	35.200	627	650	627	650	Complement Clr-like EGF-like
EGF_CA	PF07645	42	0.0000000000031	32.900	647	686	647	686	Calcium-binding EGF domain
TB	PF00683	41	8.4e-16	43.800	704	742	703	744	TB domain
EGF_CA	PF07645	42	0.00000000000027	36.300	757	797	757	797	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.0000000000034	32.800	799	839	799	839	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.0000000021	23.800	841	871	841	879	Calcium-binding EGF domain
cEGF	PF12662	24	0.000053	9.500	861	881	861	881	Complement Clr-like EGF-like
TB	PF00683	41	0.00000000018	26.700	895	926	895	931	TB domain
cEGF	PF12662	24	0.0000055	12.600	924	947	923	947	Complement Clr-like EGF-like
EGF_CA	PF07645	42	0.000000000003	32.900	944	982	944	984	Calcium-binding EGF domain
cEGF	PF12662	24	0.0000000056	22.200	966	987	966	987	Complement Clr-like EGF-like
TB	PF00683	41	2.4e-17	48.700	1000	1040	1000	1040	TB domain
EGF_CA	PF07645	42	0.0000000000014	34.000	1062	1102	1062	1102	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.0000000000034	32.700	1104	1137	1104	1145	Calcium-binding EGF domain
cEGF	PF12662	24	0.0000011	14.800	1126	1150	1126	1150	Complement Clr-like EGF-like
EGF_CA	PF07645	42	0.0000000000029	33.000	1147	1187	1147	1187	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.0000000000004	35.700	1189	1229	1189	1229	Calcium-binding EGF domain
cEGF	PF12662	24	0.0000000000034	32.400	1212	1234	1211	1234	Complement Clr-like EGF-like
cEGF	PF12662	24	0.000000000000045	38.500	1252	1275	1252	1275	Complement Clr-like EGF-like
EGF_CA	PF07645	42	0.00000000011	27.900	1272	1312	1272	1312	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.00000000004	29.300	1314	1354	1314	1354	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.0000000000000051	41.800	1356	1391	1356	1395	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.000000000000078	38.000	1397	1436	1397	1436	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.0000000000098	31.300	1438	1478	1438	1478	Calcium-binding EGF domain
cEGF	PF12662	24	0.000000000025	29.700	1461	1483	1460	1483	Complement Clr-like EGF-like
EGF_CA	PF07645	42	0.000000005	22.600	1480	1519	1480	1519	Calcium-binding EGF domain
cEGF	PF12662	24	0.0000000017	23.900	1502	1524	1502	1524	Complement Clr-like EGF-like
EGF_CA	PF07645	42	0.00000000027	26.700	1521	1560	1521	1561	Calcium-binding EGF domain
TB	PF00683	41	1.7e-16	46.000	1582	1621	1581	1621	TB domain
EGF_CA	PF07645	42	0.00000000000066	35.000	1639	1676	1639	1679	Calcium-binding EGF domain
cEGF	PF12662	24	0.00000000011	27.700	1661	1684	1661	1684	Complement Clr-like EGF-like
EGF_CA	PF07645	42	0.0000000032	23.200	1681	1721	1681	1734	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.000000000000085	37.900	1746	1781	1746	1786	Calcium-binding EGF domain
cEGF	PF12662	24	0.000000012	21.100	1768	1791	1768	1791	Complement Clr-like EGF-like
EGF_CA	PF07645	42	0.000000000000096	37.700	1788	1825	1788	1828	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.000000000066	28.600	1830	1870	1830	1870	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.00000000015	27.500	1872	1908	1872	1909	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.00000000000054	35.300	1911	1952	1911	1952	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.0000000000029	32.900	1954	1992	1954	1992	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.0000000000047	32.300	1994	2034	1994	2034	Calcium-binding EGF domain
hEGF	PF12661	22	0.089	0.000	2030	2042	2029	2043	Human growth factor-like EGF
TB	PF00683	41	2.9e-16	45.200	2050	2092	2050	2092	TB domain
Dickkopf_N	PF04706	52	0.038	0.900	2092	2126	2080	2129	Dickkopf N-terminal cysteine-rich region
EGF_CA	PF07645	42	0.0000000000011	34.300	2109	2144	2109	2149	Calcium-binding EGF domain
cEGF	PF12662	24	0.00000000056	25.400	2131	2154	2131	2154	Complement Clr-like EGF-like
EGF_CA	PF07645	42	0.00000000018	27.200	2151	2185	2151	2189	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.0000000000014	34.000	2191	2230	2191	2230	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.0000000000004	35.700	2232	2274	2232	2274	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.000000000021	30.200	2276	2316	2276	2316	Calcium-binding EGF domain
TB	PF00683	41	1.2e-17	49.700	2336	2373	2332	2374	TB domain
cEGF	PF12662	24	0.021	1.100	2379	2390	2374	2392	Complement Clr-like EGF-like
EGF_CA	PF07645	42	0.00000000000019	36.700	2387	2427	2387	2427	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.00000000000013	37.300	2429	2468	2429	2468	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.00000000000012	37.400	2470	2507	2470	2507	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.000000000014	30.700	2509	2550	2509	2550	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.0000000012	24.600	2552	2590	2552	2590	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.0000000039	22.900	2592	2631	2592	2631	Calcium-binding EGF domain
EGF_CA	PF07645	42	0.0000000014	24.400	2633	2667	2633	2671	Calcium-binding EGF domain
cEGF	PF12662	24	0.004	3.500	2654	2671	2654	2672	Complement Clr-like EGF-like
Cadherin	PF00028	93	0.000006	13.000	2766	2803	2760	2813	Cadherin domain

oncogene

EGF_2 (PF07974): EGF-like domain
EGF (PF00008): EGF-like domain
TB (PF00683): TB domain
cEGF (PF12662): Complement Clr-like EGF-like
EGF_CA (PF07645): Calcium-binding EGF domain
hEGF (PF12661): Human growth factor-like EGF
Dickkopf_N (PF04706): Dickkopf N-terminal cysteine-rich region
Cadherin (PF00028): Cadherin domain

Fhl2

XP_008838533.1

Domain structure obtained by HMM

Protein ID: XP_008838533.1 - four and a half LIM domains protein 2
KEEG Ortholog ID: K14380

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF1272	PF06906	57	0.0000093	12.000	4	44	1	48	Protein of unknown function (DUF1272)
LIM	PF00412	58	0.00000000000032	36.100	40	96	40	97	LIM domain
LIM	PF00412	58	2.5e-17	49.200	101	157	101	158	LIM domain
LIM	PF00412	58	7.5e-16	44.500	162	216	162	217	LIM domain
LIM	PF00412	58	0.000000000000074	38.100	221	275	221	278	LIM domain
zf-ribbon_3	PF13248	26	0.000003	12.900	266	279	262	279	zinc-ribbon domain

oncogene

DUF1272 (PF06906): Protein of unknown function (DUF1272)
LIM (PF00412): LIM domain
zf-ribbon_3 (PF13248): zinc-ribbon domain

Grn

XP_008836409.2

Domain structure obtained by HMM

Protein ID: XP_008836409.2 - granulins

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Granulin	PF00396	42	0.062	0.000	31	39	27	41	Granulin
Granulin	PF00396	42	0.01	2.500	43	56	42	58	Granulin
Lustrin_cystein	PF14625	44	0.00016	8.400	73	98	63	98	Lustrin, cysteine-rich repeated domain
Granulin	PF00396	42	2.1e-17	49.600	85	125	85	126	Granulin
Lustrin_cystein	PF14625	44	0.04	0.700	132	163	120	163	Lustrin, cysteine-rich repeated domain
Granulin	PF00396	42	1.4e-18	53.300	150	191	150	191	Granulin
Granulin	PF00396	42	0.00044	6.900	213	233	204	233	Granulin
Granulin	PF00396	42	8.2e-20	57.300	232	273	232	273	Granulin
Lustrin_cystein	PF14625	44	0.00000013	18.300	289	319	280	319	Lustrin, cysteine-rich repeated domain
Granulin	PF00396	42	1.8e-20	59.400	306	346	306	347	Granulin
Lustrin_cystein	PF14625	44	0.0019	4.900	375	401	361	401	Lustrin, cysteine-rich repeated domain
Granulin	PF00396	42	5.2e-19	54.700	388	427	388	428	Granulin
Lustrin_cystein	PF14625	44	0.000032	10.600	450	479	437	479	Lustrin, cysteine-rich repeated domain
Granulin	PF00396	42	1.7e-19	56.200	466	506	466	507	Granulin
Granulin	PF00396	42	5.9e-18	51.300	541	582	541	582	Granulin

oncogene

Granulin (PF00396): Granulin
Lustrin_cystein (PF14625): Lustrin, cysteine-rich repeated domain

Rspry1

XP_008833126.1

Domain structure obtained by HMM

Protein ID: XP_008833126.1 - RING finger and SPRY domain-containing protein 1

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SPRY	PF00622	120	1.2e-23	69.800	361	480	360	481	SPRY domain
zf-C3HC4_3	PF13920	50	0.0000000000049	31.900	524	566	523	568	Zinc finger, C3HC4 type (RING finger)

interactor

SPRY (PF00622): SPRY domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)

Wdcp

XP_008847048.1

Domain structure obtained by HMM

Protein ID: XP_008847048.1 - WD repeat and coiled-coil-containing protein

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF4613	PF15390	682	0	1069.700	2	672	2	672	Domain of unknown function (DUF4613)

interactor

DUF4613 (PF15390): Domain of unknown function (DUF4613)

B a c k t o T o p ⇑