Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Adamts2
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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Adamts2 (from a repository: Wed Apr 11 18:56:44 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	16
The number (and %) of the onco-proteins	1 (6.25 %)
The number (and %) of the tumor suppressors	0 (0.00 %)
Total number of binary PPIs (saturation %)	18 (15.00 %)
The number (and %) of affected PPIs	15 (83.33 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	2.000
Assortativity coefficient	-0.5375
The network average Clustering coefficient	0.126
The number (and %) of a zero Clustering coefficients	13 (81.25 %)
The number (and %) of a zero Betweenness Centrality	15 (93.75 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Adamts2

XP_017658447.1

Domain structure obtained by HMM

Protein ID: XP_017658447.1 - A disintegrin and metalloproteinase with thrombospondin motifs 2
KEEG Ortholog ID: K08618

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pep_M12B_propep	PF01562	140	2.9e-38	117.500	82	234	80	234	Reprolysin family propeptide
Reprolysin	PF01421	199	1.2e-22	67.000	297	494	291	494	Reprolysin (M12B) family zinc metalloprotease
Dickkopf_N	PF04706	52	0.00024	7.900	540	575	534	575	Dickkopf N-terminal cysteine-rich region
TSP_1	PF00090	49	0.000000000000075	38.100	590	639	588	639	Thrombospondin type 1 domain
ADAM_spacer1	PF05986	114	4.7e-35	106.400	747	861	747	861	ADAM-TS Spacer 1
TSP_1	PF00090	49	0.0000003	16.900	886	937	882	937	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.000000029	20.200	944	985	943	999	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.00000000000065	35.100	1006	1052	1004	1052	Thrombospondin type 1 domain
PLAC	PF08686	32	0.00000036	17.200	1087	1117	1087	1118	PLAC (protease and lacunin) domain

user protein

0.010

208.000

Pep_M12B_propep (PF01562): Reprolysin family propeptide
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
Dickkopf_N (PF04706): Dickkopf N-terminal cysteine-rich region
TSP_1 (PF00090): Thrombospondin type 1 domain
ADAM_spacer1 (PF05986): ADAM-TS Spacer 1
PLAC (PF08686): PLAC (protease and lacunin) domain

Adam30

XP_008828756.1

Domain structure obtained by HMM

Protein ID: XP_008828756.1 - disintegrin and metalloproteinase domain-containing protein 30
KEEG Ortholog ID: K08615

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pep_M12B_propep	PF01562	140	6.6e-24	70.900	51	157	35	157	Reprolysin family propeptide
Reprolysin	PF01421	199	2.6e-37	114.800	200	391	200	391	Reprolysin (M12B) family zinc metalloprotease
Disintegrin	PF00200	76	4.9e-23	68.100	406	478	406	478	Disintegrin
ADAM_CR	PF08516	113	2.4e-35	107.700	483	592	483	602	ADAM cysteine-rich

interactor

Pep_M12B_propep (PF01562): Reprolysin family propeptide
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
Disintegrin (PF00200): Disintegrin
ADAM_CR (PF08516): ADAM cysteine-rich

Adamts4

XP_008846211.1

Domain structure obtained by HMM

Protein ID: XP_008846211.1 - A disintegrin and metalloproteinase with thrombospondin motifs 4
KEEG Ortholog ID: K07764

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pep_M12B_propep	PF01562	140	0.000000000006	32.200	91	182	70	195	Reprolysin family propeptide
Reprolysin	PF01421	199	4.5e-19	55.300	232	442	232	442	Reprolysin (M12B) family zinc metalloprotease
TSP_1	PF00090	49	0.0000000000013	34.100	538	588	538	588	Thrombospondin type 1 domain
ADAM_spacer1	PF05986	114	1.5e-34	104.700	701	817	700	817	ADAM-TS Spacer 1

interactor

Pep_M12B_propep (PF01562): Reprolysin family propeptide
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
TSP_1 (PF00090): Thrombospondin type 1 domain
ADAM_spacer1 (PF05986): ADAM-TS Spacer 1

B3gnt2

XP_008842714.1

Domain structure obtained by HMM

Protein ID: XP_008842714.1 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
KEEG Ortholog ID: K00741

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Galactosyl_T	PF01762	195	1.7e-44	138.100	156	348	156	351	Galactosyltransferase

interactor

Galactosyl_T (PF01762): Galactosyltransferase

Cd1b

XP_008851569.1

Domain structure obtained by HMM

Protein ID: XP_008851569.1 - T-cell surface glycoprotein CD1b
KEEG Ortholog ID: K06448

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
MHC_I_3	PF16497	198	5.2e-67	211.300	15	192	12	192	MHC-I family domain
Ig_3	PF13927	79	0.0000052	13.300	198	243	198	267	Immunoglobulin domain
C1-set	PF07654	89	0.0000000000000081	41.400	213	280	199	280	Immunoglobulin C1-set domain

interactor

MHC_I_3 (PF16497): MHC-I family domain
Ig_3 (PF13927): Immunoglobulin domain
C1-set (PF07654): Immunoglobulin C1-set domain

Clec12a

XP_008845635.1

Domain structure obtained by HMM

Protein ID: XP_008845635.1 - C-type lectin domain family 12 member A
KEEG Ortholog ID: K17516

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Lectin_N	PF03954	131	0.00000059	15.500	42	117	16	122	Hepatic lectin, N-terminal domain
Lectin_C	PF00059	108	0.054	0.500	122	146	63	149	Lectin C-type domain
Lectin_C	PF00059	108	0.000000000002	34.100	152	249	151	249	Lectin C-type domain

interactor

Lectin_N (PF03954): Hepatic lectin, N-terminal domain
Lectin_C (PF00059): Lectin C-type domain

Ids

XP_008835497.1

Domain structure obtained by HMM

Protein ID: XP_008835497.1 - iduronate 2-sulfatase isoform X1
KEEG Ortholog ID: K01136

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Sulfatase	PF00884	309	9.1e-57	178.800	39	416	38	417	Sulfatase
DUF4976	PF16347	103	0.0000091	12.200	515	550	491	551	Domain of unknown function (DUF4976)

interactor

Sulfatase (PF00884): Sulfatase
DUF4976 (PF16347): Domain of unknown function (DUF4976)

LOC103730001

XP_008826366.1

Domain structure obtained by HMM

Protein ID: XP_008826366.1 - disintegrin and metalloproteinase domain-containing protein 2
KEEG Ortholog ID: K06833

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pep_M12B_propep	PF01562	140	5.9e-27	80.800	35	144	16	144	Reprolysin family propeptide
Reprolysin	PF01421	199	1.7e-73	232.900	181	378	181	378	Reprolysin (M12B) family zinc metalloprotease
Disintegrin	PF00200	76	1e-20	60.600	395	469	395	469	Disintegrin
ADAM_CR	PF08516	113	2.2e-28	85.300	474	580	474	588	ADAM cysteine-rich
ADAM_CR	PF08516	113	0.0081	2.900	592	609	592	618	ADAM cysteine-rich
EGF_2	PF07974	32	0.00000052	16.300	620	645	617	645	EGF-like domain
ECSCR	PF15820	103	0.000027	10.300	687	724	677	730	Endothelial cell-specific chemotaxis regulator

interactor

Pep_M12B_propep (PF01562): Reprolysin family propeptide
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
Disintegrin (PF00200): Disintegrin
ADAM_CR (PF08516): ADAM cysteine-rich
EGF_2 (PF07974): EGF-like domain
ECSCR (PF15820): Endothelial cell-specific chemotaxis regulator

LOC103750665

XP_008852054.1

Domain structure obtained by HMM

Protein ID: XP_008852054.1 - LOW QUALITY PROTEIN: transmembrane protease serine 11B-like
KEEG Ortholog ID: K09751

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Trypsin	PF00089	221	4.2e-65	205.700	84	309	84	309	Trypsin

interactor

Trypsin (PF00089): Trypsin

Liph

XP_008829555.1

Domain structure obtained by HMM

Protein ID: XP_008829555.1 - lipase member H
KEEG Ortholog ID: K19404

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Lipase	PF00151	336	2.9e-83	266.000	117	407	91	407	Lipase

interactor

Lipase (PF00151): Lipase

Lypd4

XP_008844672.1

Domain structure obtained by HMM

Protein ID: XP_008844672.1 - ly6/PLAUR domain-containing protein 4

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
UPAR_LY6	PF00021	77	0.0035	4.400	54	115	45	115	u-PAR/Ly-6 domain
UPAR_LY6	PF00021	77	1.9e-22	66.100	141	211	141	233	u-PAR/Ly-6 domain

interactor

UPAR_LY6 (PF00021): u-PAR/Ly-6 domain

Pik3r1

XP_008837055.1

Domain structure obtained by HMM

Protein ID: XP_008837055.1 - phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
KEEG Ortholog ID: K02649

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SH3_2	PF07653	55	0.000000019	20.300	8	75	7	77	Variant SH3 domain
PRIMA1	PF16101	121	0.0053	3.000	77	98	69	118	Proline-rich membrane anchor 1
Dscam_C	PF12355	118	0.041	1.100	84	109	64	114	Down syndrome cell adhesion molecule C terminal
RhoGAP	PF00620	152	2.5e-33	101.300	129	278	129	282	RhoGAP domain
Dscam_C	PF12355	118	0.00011	9.400	300	327	287	351	Down syndrome cell adhesion molecule C terminal
SH2	PF00017	77	4.5e-22	64.300	333	408	333	408	SH2 domain
PI3K_P85_iSH2	PF16454	161	1.3e-65	206.100	431	598	431	599	Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
SH2	PF00017	77	1.5e-24	72.200	624	698	624	698	SH2 domain

oncogene

SH3_2 (PF07653): Variant SH3 domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Dscam_C (PF12355): Down syndrome cell adhesion molecule C terminal
RhoGAP (PF00620): RhoGAP domain
SH2 (PF00017): SH2 domain
PI3K_P85_iSH2 (PF16454): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

Slamf1

XP_008839022.1

Domain structure obtained by HMM

Protein ID: XP_008839022.1 - signaling lymphocytic activation molecule
KEEG Ortholog ID: K06536

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SLAM	PF06214	125	7.3e-64	199.700	1	125	1	125	Signaling lymphocytic activation molecule (SLAM) protein
Ig_2	PF13895	79	0.0000000053	22.700	158	224	148	226	Immunoglobulin domain

interactor

SLAM (PF06214): Signaling lymphocytic activation molecule (SLAM) protein
Ig_2 (PF13895): Immunoglobulin domain

St8sia4

XP_008832821.1

Domain structure obtained by HMM

Protein ID: XP_008832821.1 - CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
KEEG Ortholog ID: K06614

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF5037	PF16440	242	0.000034	9.500	109	168	99	172	Domain of unknown function (DUF5037)
Glyco_transf_29	PF00777	271	4e-80	255.100	191	448	189	448	Glycosyltransferase family 29 (sialyltransferase)

interactor

1.000

DUF5037 (PF16440): Domain of unknown function (DUF5037)
Glyco_transf_29 (PF00777): Glycosyltransferase family 29 (sialyltransferase)

Susd4

XP_008821967.1

Domain structure obtained by HMM

Protein ID: XP_008821967.1 - sushi domain-containing protein 4 isoform X1

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Sushi	PF00084	56	0.00000003	20.600	57	112	57	117	Sushi repeat (SCR repeat)
Sushi	PF00084	56	0.00000000017	27.800	122	177	122	177	Sushi repeat (SCR repeat)
Sushi	PF00084	56	0.00000000000007	38.600	180	237	180	237	Sushi repeat (SCR repeat)
Sushi	PF00084	56	0.0000000000032	33.300	245	299	245	304	Sushi repeat (SCR repeat)

interactor

Sushi (PF00084): Sushi repeat (SCR repeat)

Tctn2

XP_008837499.1

Domain structure obtained by HMM

Protein ID: XP_008837499.1 - tectonic-2 isoform X1
KEEG Ortholog ID: K19361

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF1619	PF07773	316	1.2e-73	234.900	171	441	171	441	Protein of unknown function (DUF1619)
DUF1619	PF07773	316	0.000026	10.400	452	578	442	621	Protein of unknown function (DUF1619)

interactor

1.000

DUF1619 (PF07773): Protein of unknown function (DUF1619)

B a c k t o T o p ⇑