Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Adamts10
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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Adamts10 (from a repository: Sat Apr 21 16:31:19 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	7
The number (and %) of the onco-proteins	1 (14.29 %)
The number (and %) of the tumor suppressors	2 (28.57 %)
Total number of binary PPIs (saturation %)	9 (42.86 %)
The number (and %) of affected PPIs	6 (66.67 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	2.000
Assortativity coefficient	-0.4714
The network average Clustering coefficient	0.295
The number (and %) of a zero Clustering coefficients	4 (57.14 %)
The number (and %) of a zero Betweenness Centrality	6 (85.71 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Adamts10

XP_008842803.1

Domain structure obtained by HMM

Protein ID: XP_008842803.1 - A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X1
KEEG Ortholog ID: K08625

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pep_M12B_propep	PF01562	140	1.5e-36	111.900	40	180	40	180	Reprolysin family propeptide
Reprolysin	PF01421	199	7.6e-28	83.900	239	457	239	457	Reprolysin (M12B) family zinc metalloprotease
TSP_1	PF00090	49	0.0000000000052	32.200	551	601	551	601	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.042	0.400	637	677	634	677	Thrombospondin type 1 domain
ADAM_spacer1	PF05986	114	2.7e-29	87.800	707	818	706	818	ADAM-TS Spacer 1
TSP_1	PF00090	49	0.000004	13.300	832	884	830	884	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.000000038	19.800	891	944	889	944	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.0000021	14.200	952	974	948	1002	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.00000011	18.300	1010	1056	1008	1057	Thrombospondin type 1 domain
PLAC	PF08686	32	0.0000000000004	36.200	1069	1101	1069	1101	PLAC (protease and lacunin) domain

user protein

0.067

28.000

Pep_M12B_propep (PF01562): Reprolysin family propeptide
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
TSP_1 (PF00090): Thrombospondin type 1 domain
ADAM_spacer1 (PF05986): ADAM-TS Spacer 1
PLAC (PF08686): PLAC (protease and lacunin) domain

Anxa7

XP_008834821.1

Domain structure obtained by HMM

Protein ID: XP_008834821.1 - annexin A7 isoform X1
KEEG Ortholog ID: K17095

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Annexin	PF00191	66	8.4e-31	92.200	186	251	186	251	Annexin
Annexin	PF00191	66	1.5e-29	88.300	258	322	258	323	Annexin
Annexin	PF00191	66	4.1e-22	64.400	342	407	341	407	Annexin
Annexin	PF00191	66	1.3e-27	82.000	417	482	417	482	Annexin

tumor suppressor

Annexin (PF00191): Annexin

Cdkn1a

XP_008838294.1

Domain structure obtained by HMM

Protein ID: XP_008838294.1 - cyclin-dependent kinase inhibitor 1
KEEG Ortholog ID: K06625

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
CDI	PF02234	49	1.5e-23	69.100	20	67	19	67	Cyclin-dependent kinase inhibitor

oncogene, tumor suppressor

1.000

CDI (PF02234): Cyclin-dependent kinase inhibitor

Hmgcl

XP_008846824.1

Domain structure obtained by HMM

Protein ID: XP_008846824.1 - hydroxymethylglutaryl-CoA lyase, mitochondrial isoform X2
KEEG Ortholog ID: K01640

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
HMGL-like	PF00682	264	1.1e-77	247.200	33	306	32	306	HMGL-like

interactor

HMGL-like (PF00682): HMGL-like

Lamtor3

XP_008824390.1

Domain structure obtained by HMM

Protein ID: XP_008824390.1 - ragulator complex protein LAMTOR3
KEEG Ortholog ID: K04370

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
MAPKK1_Int	PF08923	119	1.3e-53	166.200	3	120	3	121	Mitogen-activated protein kinase kinase 1 interacting

interactor

MAPKK1_Int (PF08923): Mitogen-activated protein kinase kinase 1 interacting

Smn1

XP_008836707.1

Domain structure obtained by HMM

Protein ID: XP_008836707.1 - survival motor neuron protein
KEEG Ortholog ID: K13129

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SMN	PF06003	264	2e-108	347.700	23	284	23	288	Survival motor neuron protein (SMN)

interactor

SMN (PF06003): Survival motor neuron protein (SMN)

Tk1

XP_008846297.1

Domain structure obtained by HMM

Protein ID: XP_008846297.1 - thymidine kinase, cytosolic
KEEG Ortholog ID: K00857

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
TK	PF00265	177	8.8e-75	236.600	19	189	19	189	Thymidine kinase

oncogene

1.000

TK (PF00265): Thymidine kinase

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