Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Adamts1
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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Adamts1 (from a repository: Fri May 11 04:01:28 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	14
The number (and %) of the onco-proteins	1 (7.14 %)
The number (and %) of the tumor suppressors	1 (7.14 %)
Total number of binary PPIs (saturation %)	16 (17.58 %)
The number (and %) of affected PPIs	13 (81.25 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	1.857
Assortativity coefficient	0
The network average Clustering coefficient	0.000
The number (and %) of a zero Clustering coefficients	14 (100.00 %)
The number (and %) of a zero Betweenness Centrality	13 (92.86 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Adamts1

XP_008854317.1

Domain structure obtained by HMM

Protein ID: XP_008854317.1 - A disintegrin and metalloproteinase with thrombospondin motifs 1
KEEG Ortholog ID: K08617

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pep_M12B_propep	PF01562	140	1.2e-27	83.100	72	168	30	178	Reprolysin family propeptide
Reprolysin	PF01421	199	2.9e-24	72.200	258	467	258	467	Reprolysin (M12B) family zinc metalloprotease
TSP_1	PF00090	49	0.0000000000023	33.300	564	613	563	613	Thrombospondin type 1 domain
ADAM_spacer1	PF05986	114	2.3e-37	113.800	725	842	725	843	ADAM-TS Spacer 1
TSP_1	PF00090	49	0.00000013	18.100	861	909	856	909	Thrombospondin type 1 domain
TSP_1	PF00090	49	0.000000000091	28.200	915	943	913	966	Thrombospondin type 1 domain

user protein, oncogene

156.000

Pep_M12B_propep (PF01562): Reprolysin family propeptide
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
TSP_1 (PF00090): Thrombospondin type 1 domain
ADAM_spacer1 (PF05986): ADAM-TS Spacer 1

Adam32

XP_008841591.1

Domain structure obtained by HMM

Protein ID: XP_008841591.1 - disintegrin and metalloproteinase domain-containing protein 32
KEEG Ortholog ID: K16070

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pep_M12B_propep	PF01562	140	1.4e-26	79.600	141	245	124	245	Reprolysin family propeptide
Reprolysin	PF01421	199	5.8e-67	211.600	290	486	289	486	Reprolysin (M12B) family zinc metalloprotease
Disintegrin	PF00200	76	3.1e-21	62.300	502	580	502	580	Disintegrin
ADAM_CR	PF08516	113	2.4e-32	98.100	585	695	585	700	ADAM cysteine-rich
EGF_2	PF07974	32	0.000000034	20.100	732	759	732	759	EGF-like domain

interactor

Pep_M12B_propep (PF01562): Reprolysin family propeptide
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
Disintegrin (PF00200): Disintegrin
ADAM_CR (PF08516): ADAM cysteine-rich
EGF_2 (PF07974): EGF-like domain

Cep250

XP_017655535.1

Domain structure obtained by HMM

Protein ID: XP_017655535.1 - centrosome-associated protein CEP250
KEEG Ortholog ID: K16464

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
AATF-Che1	PF13339	138	0.0087	3.000	21	80	9	91	Apoptosis antagonizing transcription factor
Rootletin	PF15035	186	2.7e-61	193.100	41	214	40	216	Ciliary rootlet component, centrosome cohesion
FlaC_arch	PF05377	55	0.000092	9.100	281	317	280	318	Flagella accessory protein C (FlaC)
Alanine_zipper	PF11839	97	0.054	0.100	295	326	286	357	Alanine-zipper, major outer membrane lipoprotein
DUF4404	PF14357	84	0.062	0.400	336	365	323	385	Domain of unknown function (DUF4404)
APG6	PF04111	312	0.000033	9.500	405	533	394	537	Autophagy protein Apg6
DUF724	PF05266	188	0.000095	8.400	563	643	554	650	Protein of unknown function (DUF724)
CENP-F_leu_zip	PF10473	140	0.000086	8.800	620	703	615	707	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
CENP-F_leu_zip	PF10473	140	0.001	5.300	697	824	696	828	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
DUF3584	PF12128	1200	0.00004	7.300	741	915	732	933	Protein of unknown function (DUF3584)
Cnn_1N	PF07989	73	0.028	0.900	876	958	874	959	Centrosomin N-terminal motif 1
HIP1_clath_bdg	PF16515	99	0.0029	4.500	966	1061	963	1061	Clathrin-binding domain of Huntingtin-interacting protein 1
Fib_alpha	PF08702	143	0.00063	6.200	1007	1097	997	1099	Fibrinogen alpha/beta chain family
DUF4472	PF14739	107	0.0000081	12.800	1050	1127	1045	1135	Domain of unknown function (DUF4472)
Med9	PF07544	80	0.013	2.000	1149	1188	1126	1194	RNA polymerase II transcription mediator complex subunit 9
ATG16	PF08614	203	0.000018	11.200	1174	1350	1167	1358	Autophagy protein 16 (ATG16)
HAUS-augmin3	PF14932	258	0.000077	8.400	1308	1375	1304	1377	HAUS augmin-like complex subunit 3
DUF1664	PF07889	124	0.024	0.900	1340	1409	1318	1417	Protein of unknown function (DUF1664)
Pox_A_type_inc	PF04508	23	0.00061	6.100	1438	1452	1437	1452	Viral A-type inclusion protein repeat
TPR_MLP1_2	PF07926	129	0.000062	9.300	1471	1543	1467	1545	TPR/MLP1/MLP2-like protein
CENP-F_leu_zip	PF10473	140	0.0022	4.300	1503	1558	1497	1560	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
CENP-F_leu_zip	PF10473	140	0.0002	7.600	1557	1637	1555	1640	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
SlyX	PF04102	67	0.000011	12.400	1611	1659	1609	1667	SlyX
Spc7	PF08317	310	0.00012	7.200	1669	1775	1661	1783	Spc7 kinetochore protein
Reo_sigmaC	PF04582	326	0.000075	8.300	1836	1911	1811	1950	Reovirus sigma C capsid protein
DUF2407_C	PF13373	140	0.0014	5.100	1892	1955	1886	1989	DUF2407 C-terminal domain
CP12	PF02672	70	0.01	3.000	1938	1988	1934	1989	CP12 domain
DUF641	PF04859	127	0.0003	7.400	1989	2034	1965	2049	Plant protein of unknown function (DUF641)
Bacillus_HBL	PF05791	178	0.026	0.400	2071	2106	2063	2110	Bacillus haemolytic enterotoxin (HBL)
PKcGMP_CC	PF16808	35	0.000017	11.000	2092	2112	2092	2113	Coiled-coil N-terminus of cGMP-dependent protein kinase
CENP-F_leu_zip	PF10473	140	0.00082	5.600	2134	2212	2124	2215	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Fez1	PF06818	198	0.000037	10.400	2246	2360	2236	2371	Fez1
DUF630	PF04783	59	0.000099	8.900	2356	2389	2348	2391	Protein of unknown function (DUF630)

interactor

AATF-Che1 (PF13339): Apoptosis antagonizing transcription factor
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
FlaC_arch (PF05377): Flagella accessory protein C (FlaC)
Alanine_zipper (PF11839): Alanine-zipper, major outer membrane lipoprotein
DUF4404 (PF14357): Domain of unknown function (DUF4404)
APG6 (PF04111): Autophagy protein Apg6
DUF724 (PF05266): Protein of unknown function (DUF724)
CENP-F_leu_zip (PF10473): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
DUF3584 (PF12128): Protein of unknown function (DUF3584)
Cnn_1N (PF07989): Centrosomin N-terminal motif 1
HIP1_clath_bdg (PF16515): Clathrin-binding domain of Huntingtin-interacting protein 1
Fib_alpha (PF08702): Fibrinogen alpha/beta chain family
DUF4472 (PF14739): Domain of unknown function (DUF4472)
Med9 (PF07544): RNA polymerase II transcription mediator complex subunit 9
ATG16 (PF08614): Autophagy protein 16 (ATG16)
HAUS-augmin3 (PF14932): HAUS augmin-like complex subunit 3
DUF1664 (PF07889): Protein of unknown function (DUF1664)
Pox_A_type_inc (PF04508): Viral A-type inclusion protein repeat
TPR_MLP1_2 (PF07926): TPR/MLP1/MLP2-like protein
SlyX (PF04102): SlyX
Spc7 (PF08317): Spc7 kinetochore protein
Reo_sigmaC (PF04582): Reovirus sigma C capsid protein
DUF2407_C (PF13373): DUF2407 C-terminal domain
CP12 (PF02672): CP12 domain
DUF641 (PF04859): Plant protein of unknown function (DUF641)
Bacillus_HBL (PF05791): Bacillus haemolytic enterotoxin (HBL)
PKcGMP_CC (PF16808): Coiled-coil N-terminus of cGMP-dependent protein kinase
Fez1 (PF06818): Fez1
DUF630 (PF04783): Protein of unknown function (DUF630)

Cer1

XP_008847060.1

Domain structure obtained by HMM

Protein ID: XP_008847060.1 - cerberus
KEEG Ortholog ID: K01645

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DAN	PF03045	114	2e-32	97.800	146	243	135	244	DAN domain

interactor

DAN (PF03045): DAN domain

Hpx

XP_008835610.1

Domain structure obtained by HMM

Protein ID: XP_008835610.1 - hemopexin
KEEG Ortholog ID: K18977

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Hemopexin	PF00045	45	0.00000003	19.900	56	81	56	91	Hemopexin
Hemopexin	PF00045	45	0.0000000000000048	41.600	97	140	97	141	Hemopexin
Hemopexin	PF00045	45	0.01	2.200	144	168	143	183	Hemopexin
Hemopexin	PF00045	45	0.000000000007	31.500	190	229	188	232	Hemopexin
Hemopexin	PF00045	45	0.00000000015	27.200	265	305	262	305	Hemopexin
Hemopexin	PF00045	45	0.000000000061	28.500	307	345	307	350	Hemopexin
Hemopexin	PF00045	45	0.039	0.300	359	384	359	389	Hemopexin

interactor

Hemopexin (PF00045): Hemopexin

Igfbp1

XP_008840409.1

Domain structure obtained by HMM

Protein ID: XP_008840409.1 - insulin-like growth factor-binding protein 1

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
IGFBP	PF00219	55	0.000000000003	33.400	32	86	32	86	Insulin-like growth factor binding protein
Thyroglobulin_1	PF00086	67	2.3e-28	84.000	189	264	189	264	Thyroglobulin type-1 repeat

oncogene

IGFBP (PF00219): Insulin-like growth factor binding protein
Thyroglobulin_1 (PF00086): Thyroglobulin type-1 repeat

Klk1

XP_017656577.1

Domain structure obtained by HMM

Protein ID: XP_017656577.1 - kallikrein-1
KEEG Ortholog ID: K01325

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Trypsin	PF00089	221	8.2e-44	136.100	1	132	1	132	Trypsin

interactor

Trypsin (PF00089): Trypsin

LOC103736148

XP_008833827.1

Domain structure obtained by HMM

Protein ID: XP_008833827.1 - interferon alpha-12-like
KEEG Ortholog ID: K05414

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Interferon	PF00143	160	9e-63	197.400	27	185	26	185	Interferon alpha/beta domain
DIRP	PF06584	106	0.023	1.200	180	190	140	191	DIRP

interactor

Interferon (PF00143): Interferon alpha/beta domain
DIRP (PF06584): DIRP

LOC103745223

XP_008845367.1

Domain structure obtained by HMM

Protein ID: XP_008845367.1 - alpha-2-macroglobulin-like
KEEG Ortholog ID: K03910

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
A2M_N	PF01835	96	1.5e-23	69.400	128	220	127	220	MG2 domain
Big_3_5	PF16640	90	0.0000017	14.500	373	429	354	434	Bacterial Ig-like domain (group 3)
A2M_N_2	PF07703	139	1.9e-30	92.200	459	606	458	606	Alpha-2-macroglobulin family N-terminal region
A2M	PF00207	92	2.2e-33	100.300	740	830	740	830	Alpha-2-macroglobulin family
SVA	PF05326	124	0.0000000059	22.200	792	887	771	888	Seminal vesicle autoantigen (SVA)
Thiol-ester_cl	PF10569	30	1.6e-20	58.900	965	992	963	992	Alpha-macro-globulin thiol-ester bond-forming region
A2M_comp	PF07678	249	4.1e-100	320.400	1013	1267	1012	1268	A-macroglobulin complement component
A2M_recep	PF07677	92	8.3e-31	93.000	1378	1465	1378	1465	A-macroglobulin receptor

interactor

A2M_N (PF01835): MG2 domain
Big_3_5 (PF16640): Bacterial Ig-like domain (group 3)
A2M_N_2 (PF07703): Alpha-2-macroglobulin family N-terminal region
A2M (PF00207): Alpha-2-macroglobulin family
SVA (PF05326): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569): Alpha-macro-globulin thiol-ester bond-forming region
A2M_comp (PF07678): A-macroglobulin complement component
A2M_recep (PF07677): A-macroglobulin receptor

Napsa

XP_008843359.1

Domain structure obtained by HMM

Protein ID: XP_008843359.1 - napsin-A
KEEG Ortholog ID: K08565

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Asp	PF00026	315	1.2e-107	346.000	79	395	79	403	Eukaryotic aspartyl protease

interactor

Asp (PF00026): Eukaryotic aspartyl protease

Pla2g12b

XP_008834841.1

Domain structure obtained by HMM

Protein ID: XP_008834841.1 - group XIIB secretory phospholipase A2-like protein isoform X1
KEEG Ortholog ID: K01047

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PLA2G12	PF06951	182	1.4e-92	294.800	18	194	12	194	Group XII secretory phospholipase A2 precursor (PLA2G12)

interactor

PLA2G12 (PF06951): Group XII secretory phospholipase A2 precursor (PLA2G12)

Pla2g1b

XP_008838991.1

Domain structure obtained by HMM

Protein ID: XP_008838991.1 - phospholipase A2
KEEG Ortholog ID: K01047

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Phospholip_A2_1	PF00068	111	6.3e-42	128.800	24	137	24	138	Phospholipase A2

interactor

Phospholip_A2_1 (PF00068): Phospholipase A2

Prss50

XP_008829087.1

Domain structure obtained by HMM

Protein ID: XP_008829087.1 - probable threonine protease PRSS50

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Trypsin	PF00089	221	3.4e-53	166.800	135	369	131	369	Trypsin

interactor

Trypsin (PF00089): Trypsin

Vegfa

XP_008827276.1

Domain structure obtained by HMM

Protein ID: XP_008827276.1 - vascular endothelial growth factor A isoform X1
KEEG Ortholog ID: K05448

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
CXCXC	PF03128	13	0.02	2.000	48	52	47	53	CXCXC repeat
VEGF_C	PF14554	58	2.1e-33	100.600	88	137	84	137	VEGF heparin-binding domain

oncogene, tumor suppressor

CXCXC (PF03128): CXCXC repeat
VEGF_C (PF14554): VEGF heparin-binding domain

B a c k t o T o p ⇑