Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Adam9
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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Adam9 (from a repository: Thu Apr 19 20:15:23 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	12
The number (and %) of the onco-proteins	1 (8.33 %)
The number (and %) of the tumor suppressors	2 (16.67 %)
Total number of binary PPIs (saturation %)	18 (27.27 %)
The number (and %) of affected PPIs	11 (61.11 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	2.167
Assortativity coefficient	-0.5654
The network average Clustering coefficient	0.225
The number (and %) of a zero Clustering coefficients	8 (66.67 %)
The number (and %) of a zero Betweenness Centrality	10 (83.33 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Adam9

XP_008841585.1

Domain structure obtained by HMM

Protein ID: XP_008841585.1 - disintegrin and metalloproteinase domain-containing protein 9
KEEG Ortholog ID: K06834

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pep_M12B_propep	PF01562	140	7.9e-32	96.600	32	151	23	151	Reprolysin family propeptide
Reprolysin	PF01421	199	2.9e-75	238.700	200	394	200	394	Reprolysin (M12B) family zinc metalloprotease
Disintegrin	PF00200	76	1.3e-23	70.000	411	484	411	484	Disintegrin
ADAM_CR	PF08516	113	9.4e-38	115.400	489	603	489	603	ADAM cysteine-rich
EGF_2	PF07974	32	0.000000081	18.900	635	661	632	661	EGF-like domain

user protein, oncogene

0.036

105.000

Pep_M12B_propep (PF01562): Reprolysin family propeptide
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
Disintegrin (PF00200): Disintegrin
ADAM_CR (PF08516): ADAM cysteine-rich
EGF_2 (PF07974): EGF-like domain

Adam32

XP_008841591.1

Domain structure obtained by HMM

Protein ID: XP_008841591.1 - disintegrin and metalloproteinase domain-containing protein 32
KEEG Ortholog ID: K16070

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pep_M12B_propep	PF01562	140	1.4e-26	79.600	141	245	124	245	Reprolysin family propeptide
Reprolysin	PF01421	199	5.8e-67	211.600	290	486	289	486	Reprolysin (M12B) family zinc metalloprotease
Disintegrin	PF00200	76	3.1e-21	62.300	502	580	502	580	Disintegrin
ADAM_CR	PF08516	113	2.4e-32	98.100	585	695	585	700	ADAM cysteine-rich
EGF_2	PF07974	32	0.000000034	20.100	732	759	732	759	EGF-like domain

interactor

Cd1b

XP_008851569.1

Domain structure obtained by HMM

Protein ID: XP_008851569.1 - T-cell surface glycoprotein CD1b
KEEG Ortholog ID: K06448

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
MHC_I_3	PF16497	198	5.2e-67	211.300	15	192	12	192	MHC-I family domain
Ig_3	PF13927	79	0.0000052	13.300	198	243	198	267	Immunoglobulin domain
C1-set	PF07654	89	0.0000000000000081	41.400	213	280	199	280	Immunoglobulin C1-set domain

interactor

MHC_I_3 (PF16497): MHC-I family domain
Ig_3 (PF13927): Immunoglobulin domain
C1-set (PF07654): Immunoglobulin C1-set domain

Insl5

XP_008829310.1

Domain structure obtained by HMM

Protein ID: XP_008829310.1 - LOW QUALITY PROTEIN: insulin-like peptide INSL5
KEEG Ortholog ID: K05255

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Insulin	PF00049	85	0.00000000024	27.600	27	132	26	132	Insulin/IGF/Relaxin family

interactor

0.667

1.000

Insulin (PF00049): Insulin/IGF/Relaxin family

Itgav

XP_008824997.1

Domain structure obtained by HMM

Protein ID: XP_008824997.1 - integrin alpha-V isoform X1
KEEG Ortholog ID: K06487

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
VCBS	PF13517	61	0.000000038	20.200	224	266	211	267	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP	PF01839	37	0.0000000000077	31.500	249	282	248	282	FG-GAP repeat
VCBS	PF13517	61	0.00000086	15.800	279	321	271	321	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP	PF01839	37	0.0000000000042	32.300	302	343	302	344	FG-GAP repeat
VCBS	PF13517	61	0.000005	13.400	339	385	328	386	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP	PF01839	37	0.00000000019	27.000	366	402	366	402	FG-GAP repeat
VCBS	PF13517	61	0.0000000012	25.000	375	450	375	450	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
Integrin_alpha2	PF08441	467	7.6e-129	416.600	463	911	463	911	Integrin alpha
Integrin_alpha	PF00357	15	0.00000001	21.200	1014	1028	1014	1028	Integrin alpha cytoplasmic region

tumor suppressor

1.000

VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP (PF01839): FG-GAP repeat
Integrin_alpha2 (PF08441): Integrin alpha
Integrin_alpha (PF00357): Integrin alpha cytoplasmic region

Itgb5

XP_008841196.1

Domain structure obtained by HMM

Protein ID: XP_008841196.1 - integrin beta-5 isoform X1
KEEG Ortholog ID: K06588

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PSI_integrin	PF17205	48	8.4e-18	50.300	26	75	26	76	Integrin plexin domain
Integrin_beta	PF00362	248	2.8e-111	357.200	134	382	133	382	Integrin beta chain VWA domain
EGF_2	PF07974	32	0.0000052	13.100	473	498	465	498	EGF-like domain
EGF_2	PF07974	32	0.0000042	13.400	513	548	513	552	EGF-like domain
EGF_2	PF07974	32	0.00000018	17.800	555	585	555	585	EGF-like domain
EGF_2	PF07974	32	0.000000014	21.300	594	625	594	625	EGF-like domain
Integrin_B_tail	PF07965	85	4.2e-22	64.800	635	719	635	719	Integrin beta tail domain
DUF2975	PF11188	131	0.0000029	13.400	701	755	691	763	Protein of unknown function (DUF2975)
Integrin_b_cyt	PF08725	45	8.2e-22	63.000	743	788	743	788	Integrin beta cytoplasmic domain

interactor

1.000

PSI_integrin (PF17205): Integrin plexin domain
Integrin_beta (PF00362): Integrin beta chain VWA domain
EGF_2 (PF07974): EGF-like domain
Integrin_B_tail (PF07965): Integrin beta tail domain
DUF2975 (PF11188): Protein of unknown function (DUF2975)
Integrin_b_cyt (PF08725): Integrin beta cytoplasmic domain

Mad2l2

XP_008829754.1

Domain structure obtained by HMM

Protein ID: XP_008829754.1 - mitotic spindle assembly checkpoint protein MAD2B
KEEG Ortholog ID: K13728

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
HORMA	PF02301	212	0.00000000000049	35.300	20	103	16	114	HORMA domain

interactor

HORMA (PF02301): HORMA domain

Prkcd

XP_008850041.1

Domain structure obtained by HMM

Protein ID: XP_008850041.1 - protein kinase C delta type
KEEG Ortholog ID: K06068

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
C1_1	PF00130	53	1.3e-18	53.000	159	209	159	211	Phorbol esters/diacylglycerol binding domain (C1 domain)
Prok-RING_1	PF14446	54	0.00011	8.400	187	216	168	221	Prokaryotic RING finger family 1
C1_1	PF00130	53	3.7e-21	61.100	231	282	231	283	Phorbol esters/diacylglycerol binding domain (C1 domain)
Pkinase	PF00069	264	2.9e-65	206.300	350	603	349	603	Protein kinase domain
Pkinase_C	PF00433	46	0.00000000000045	36.100	624	665	624	665	Protein kinase C terminal domain

oncogene, tumor suppressor

C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
Pkinase (PF00069): Protein kinase domain
Pkinase_C (PF00433): Protein kinase C terminal domain

Rnf2

XP_008822501.1

Domain structure obtained by HMM

Protein ID: XP_008822501.1 - E3 ubiquitin-protein ligase RING2
KEEG Ortholog ID: K10695

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
zf-C3HC4_2	PF13923	40	4.5e-20	57.600	50	90	50	90	Zinc finger, C3HC4 type (RING finger)
zf-C4_Topoisom	PF01396	39	0.000015	11.100	85	99	84	101	Topoisomerase DNA binding C4 zinc finger
RAWUL	PF16207	72	1.3e-32	98.600	246	330	246	330	RAWUL domain RING finger- and WD40-associated ubiquitin-like

interactor

zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-C4_Topoisom (PF01396): Topoisomerase DNA binding C4 zinc finger
RAWUL (PF16207): RAWUL domain RING finger- and WD40-associated ubiquitin-like

Sh3gl2

XP_008836962.1

Domain structure obtained by HMM

Protein ID: XP_008836962.1 - endophilin-A1 isoform X1
KEEG Ortholog ID: K11247

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
BAR	PF03114	239	8.3e-85	270.300	6	241	6	242	BAR domain
SH3_1	PF00018	48	1.3e-18	52.700	296	340	296	341	SH3 domain

oncogene

BAR (PF03114): BAR domain
SH3_1 (PF00018): SH3 domain

Snx9

XP_008837665.1

Domain structure obtained by HMM

Protein ID: XP_008837665.1 - sorting nexin-9
KEEG Ortholog ID: K17923

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SH3_1	PF00018	48	0.00000000000074	34.300	1	47	1	47	SH3 domain
PX	PF00787	113	1.8e-26	78.700	241	348	239	349	PX domain
BAR_3_WASP_bdg	PF10456	236	2.3e-121	389.700	350	584	350	585	WASP-binding domain of Sorting nexin protein

interactor

SH3_1 (PF00018): SH3 domain
PX (PF00787): PX domain
BAR_3_WASP_bdg (PF10456): WASP-binding domain of Sorting nexin protein

Vegfd

XP_008839102.1

Domain structure obtained by HMM

Protein ID: XP_008839102.1 - vascular endothelial growth factor D isoform X1
KEEG Ortholog ID: K05449

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PDGF	PF00341	82	1.7e-27	81.900	111	191	111	191	PDGF/VEGF domain
CXCXC	PF03128	13	0.0012	5.800	228	236	226	236	CXCXC repeat
CXCXC	PF03128	13	0.0000039	13.600	263	273	262	273	CXCXC repeat
CXCXC	PF03128	13	0.023	1.800	285	290	285	291	CXCXC repeat
CXCXC	PF03128	13	0.00012	8.900	305	315	305	315	CXCXC repeat

interactor

PDGF (PF00341): PDGF/VEGF domain
CXCXC (PF03128): CXCXC repeat

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