Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Adam33 (from a repository: Tue Apr 17 09:33:57 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins1 (2.86 %)
The number (and %) of the tumor suppressors1 (2.86 %)
Total number of binary PPIs (saturation %)39 (6.55 %)
The number (and %) of affected PPIs34 (87.18 %)
PPI diameter2
PPI radius1
The average degree of PPI2.000
Assortativity coefficient-0.5601
The network average Clustering coefficient0.057
The number (and %) of a zero Clustering coefficients32 (91.43 %)
The number (and %) of a zero Betweenness Centrality34 (97.14 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Adam33
user protein340.0021120.000Pep_M12B_propep (PF01562): Reprolysin family propeptide
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
Adam15
interactor100Pep_M12B_propep (PF01562): Reprolysin family propeptide
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
Disintegrin (PF00200): Disintegrin
ADAM_CR (PF08516): ADAM cysteine-rich
CD20 (PF04103): CD20-like family
Amigo1
interactor200LRRNT (PF01462): Leucine rich repeat N-terminal domain
LRR_8 (PF13855): Leucine rich repeat
LRR_4 (PF12799): Leucine Rich repeats (2 copies)
LRR_1 (PF00560): Leucine Rich Repeat
I-set (PF07679): Immunoglobulin I-set domain
Ankrd46
interactor100Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Asb7
interactor100Ank_5 (PF13857): Ankyrin repeats (many copies)
Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ank (PF00023): Ankyrin repeat
SOCS_box (PF07525): SOCS box
Atxn7
interactor100SCA7 (PF08313): SCA7, zinc-binding domain
Clec7a
interactor200Ly49 (PF08391): Ly49-like protein, N-terminal region
Lectin_C (PF00059): Lectin C-type domain
Clstn1
interactor100Cadherin (PF00028): Cadherin domain
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
Laminin_G_2 (PF02210): Laminin G domain
CDC45 (PF02724): CDC45-like protein
Pox_Ag35 (PF03286): Pox virus Ag35 surface protein
Dgcr2
interactor100Ldl_recept_a (PF00057): Low-density lipoprotein receptor domain class A
UL45 (PF05473): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_C (PF00059): Lectin C-type domain
Dhfr
interactor100DHFR_1 (PF00186): Dihydrofolate reductase
Egfl7
interactor21.0000EMI (PF07546): EMI domain
EGF_2 (PF07974): EGF-like domain
EGF_CA (PF07645): Calcium-binding EGF domain
SlyX (PF04102): SlyX
Fbxo2
interactor100F-box (PF00646): F-box domain
FBA (PF04300): F-box associated region
Fstl1
interactor100FOLN (PF09289): Follistatin/Osteonectin-like EGF domain
Kazal_2 (PF07648): Kazal-type serine protease inhibitor domain
EF-hand_7 (PF13499): EF-hand domain pair
Pacifastin_I (PF05375): Pacifastin inhibitor (LCMII)
Galnt14
interactor100DUF4519 (PF15012): Domain of unknown function (DUF4519)
Glycos_transf_2 (PF00535): Glycosyl transferase family 2
Glyco_transf_7C (PF02709): N-terminal domain of galactosyltransferase
Ricin_B_lectin (PF00652): Ricin-type beta-trefoil lectin domain
Hmox1
interactor200Heme_oxygenase (PF01126): Heme oxygenase
Itgb5
interactor100PSI_integrin (PF17205): Integrin plexin domain
Integrin_beta (PF00362): Integrin beta chain VWA domain
EGF_2 (PF07974): EGF-like domain
Integrin_B_tail (PF07965): Integrin beta tail domain
DUF2975 (PF11188): Protein of unknown function (DUF2975)
Integrin_b_cyt (PF08725): Integrin beta cytoplasmic domain
Kcnj8
interactor100IRK (PF01007): Inward rectifier potassium channel
LOC103738938
interactor100Flavodoxin_1 (PF00258): Flavodoxin
DUF4769 (PF15992): Domain of unknown function (DUF4769)
Radical_SAM (PF04055): Radical SAM superfamily
Wyosine_form (PF08608): Wyosine base formation
Lrp12
interactor100CUB (PF00431): CUB domain
Ldl_recept_a (PF00057): Low-density lipoprotein receptor domain class A
Lrp5
oncogene100Ldl_recept_b (PF00058): Low-density lipoprotein receptor repeat class B
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
Ldl_recept_a (PF00057): Low-density lipoprotein receptor domain class A
Lrp6
interactor100Ldl_recept_b (PF00058): Low-density lipoprotein receptor repeat class B
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
SGL (PF08450): SMP-30/Gluconolaconase/LRE-like region
Ldl_recept_a (PF00057): Low-density lipoprotein receptor domain class A
Lsr
interactor100V-set (PF07686): Immunoglobulin V-set domain
LSR (PF05624): Lipolysis stimulated receptor (LSR)
Maneal
interactor100Glyco_hydro_99 (PF16317): Glycosyl hydrolase family 99
Neto2
interactor100CUB (PF00431): CUB domain
Ldl_recept_a (PF00057): Low-density lipoprotein receptor domain class A
Notch3
oncogene, tumor suppressor21.0000EGF (PF00008): EGF-like domain
EGF_CA (PF07645): Calcium-binding EGF domain
cEGF (PF12662): Complement Clr-like EGF-like
hEGF (PF12661): Human growth factor-like EGF
EGF_alliinase (PF04863): Alliinase EGF-like domain
Notch (PF00066): LNR domain
NOD (PF06816): NOTCH protein
NODP (PF07684): NOTCH protein
Ank_5 (PF13857): Ankyrin repeats (many copies)
Ank (PF00023): Ankyrin repeat
Ank_2 (PF12796): Ankyrin repeats (3 copies)
DUF3454 (PF11936): Domain of unknown function (DUF3454)
Pdf
interactor100Pep_deformylase (PF01327): Polypeptide deformylase
Sdf2l1
interactor100MIR (PF02815): MIR domain
Slc27a3
interactor100AMP-binding (PF00501): AMP-binding enzyme
AMP-binding_C (PF13193): AMP-binding enzyme C-terminal domain
Slc30a2
interactor100Cation_efflux (PF01545): Cation efflux family
Tmbim6
interactor100Bax1-I (PF01027): Inhibitor of apoptosis-promoting Bax1
Tmem39b
interactor100Tmp39 (PF10271): Putative transmembrane protein
Tmem67
interactor100Ephrin_rec_like (PF07699): Putative ephrin-receptor like
NCD3G (PF07562): Nine Cysteines Domain of family 3 GPCR
Tme5_EGF_like (PF09064): Thrombomodulin like fifth domain, EGF-like
C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
Meckelin (PF09773): Meckelin (Transmembrane protein 67)
Ttc17
interactor100TPR_17 (PF13431): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_8 (PF13181): Tetratricopeptide repeat
TPR_2 (PF07719): Tetratricopeptide repeat
TPR_1 (PF00515): Tetratricopeptide repeat
TPR_7 (PF13176): Tetratricopeptide repeat
ChAPs (PF09295): ChAPs (Chs5p-Arf1p-binding proteins)
Ubqln4
interactor200ubiquitin (PF00240): Ubiquitin family
DUF1180 (PF06679): Protein of unknown function (DUF1180)
Fur_reg_FbpB (PF13040): Fur-regulated basic protein B
partial_CstF (PF15861): Partial cleavage stimulation factor domain
XPC-binding (PF09280): XPC-binding domain
CRF (PF00473): Corticotropin-releasing factor family
Arm_2 (PF04826): Armadillo-like
UBA (PF00627): UBA/TS-N domain
Zdhhc6
interactor100zf-DHHC (PF01529): DHHC palmitoyltransferase
SH3_2 (PF07653): Variant SH3 domain

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