Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Adam32 (from a repository: Sun Apr 15 22:19:17 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins6 (31.58 %)
The number (and %) of the tumor suppressors3 (15.79 %)
Total number of binary PPIs (saturation %)20 (11.70 %)
The number (and %) of affected PPIs18 (90.00 %)
PPI diameter2
PPI radius1
The average degree of PPI2.000
Assortativity coefficient-0.5443
The network average Clustering coefficient0.106
The number (and %) of a zero Clustering coefficients16 (84.21 %)
The number (and %) of a zero Betweenness Centrality18 (94.74 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Adam32
user protein180.007304.000Pep_M12B_propep (PF01562): Reprolysin family propeptide
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
Disintegrin (PF00200): Disintegrin
ADAM_CR (PF08516): ADAM cysteine-rich
EGF_2 (PF07974): EGF-like domain
Adam9
oncogene100Pep_M12B_propep (PF01562): Reprolysin family propeptide
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
Disintegrin (PF00200): Disintegrin
ADAM_CR (PF08516): ADAM cysteine-rich
EGF_2 (PF07974): EGF-like domain
Adamts1
oncogene100Pep_M12B_propep (PF01562): Reprolysin family propeptide
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
TSP_1 (PF00090): Thrombospondin type 1 domain
ADAM_spacer1 (PF05986): ADAM-TS Spacer 1
Asphd2
interactor100Asp_Arg_Hydrox (PF05118): Aspartyl/Asparaginyl beta-hydroxylase
Bcl2l11
oncogene, tumor suppressor100Bim_N (PF06773): Bim protein N-terminus
Bclx_interact (PF08945): Bcl-x interacting, BH3 domain
Gas6
oncogene100Gla (PF00594): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
EGF (PF00008): EGF-like domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
EGF_CA (PF07645): Calcium-binding EGF domain
Laminin_G_1 (PF00054): Laminin G domain
Laminin_G_2 (PF02210): Laminin G domain
Ints4
interactor100Adaptin_N (PF01602): Adaptin N terminal region
HEAT_2 (PF13646): HEAT repeats
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
Itga5
tumor suppressor100FG-GAP (PF01839): FG-GAP repeat
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
Integrin_alpha2 (PF08441): Integrin alpha
Integrin_alpha (PF00357): Integrin alpha cytoplasmic region
Jag2
oncogene21.0000MNNL (PF07657): N terminus of Notch ligand
DSL (PF01414): Delta serrate ligand
EGF_2 (PF07974): EGF-like domain
EGF (PF00008): EGF-like domain
EGF_CA (PF07645): Calcium-binding EGF domain
hEGF (PF12661): Human growth factor-like EGF
cEGF (PF12662): Complement Clr-like EGF-like
NTP_transf_3 (PF12804): MobA-like NTP transferase domain
MFS_2 (PF13347): MFS/sugar transport protein
Kiaa0391
interactor100PPR_2 (PF13041): PPR repeat family
PRORP (PF16953): Protein-only RNase P
Ktn1
oncogene100Rib_recp_KP_reg (PF05104): Ribosome receptor lysine/proline rich region
Golgin_A5 (PF09787): Golgin subfamily A member 5
DUF1664 (PF07889): Protein of unknown function (DUF1664)
Fimbrial_PilY2 (PF14481): Type 4 fimbrial biogenesis protein PilY2
TBPIP (PF07106): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
MCPsignal (PF00015): Methyl-accepting chemotaxis protein (MCP) signalling domain
FAD-SLDH (PF12318): Membrane bound FAD containing D-sorbitol dehydrogenase
HALZ (PF02183): Homeobox associated leucine zipper
Fez1 (PF06818): Fez1
ZapB (PF06005): Cell division protein ZapB
FlgN (PF05130): FlgN protein
Fib_alpha (PF08702): Fibrinogen alpha/beta chain family
Fzo_mitofusin (PF04799): fzo-like conserved region
DUF724 (PF05266): Protein of unknown function (DUF724)
PRKG1_interact (PF15898): cGMP-dependent protein kinase interacting domain
Lclat1
interactor100Peptidase_U4 (PF03419): Sporulation factor SpoIIGA
Acyltransferase (PF01553): Acyltransferase
Acyltransf_C (PF16076): Acyltransferase C-terminus
Man1a2
interactor100Apolipoprotein (PF01442): Apolipoprotein A1/A4/E domain
Glyco_hydro_47 (PF01532): Glycosyl hydrolase family 47
Map2k7
interactor100Pkinase (PF00069): Protein kinase domain
Mettl9
interactor100DREV (PF05219): DREV methyltransferase
Notch3
oncogene, tumor suppressor21.0000EGF (PF00008): EGF-like domain
EGF_CA (PF07645): Calcium-binding EGF domain
cEGF (PF12662): Complement Clr-like EGF-like
hEGF (PF12661): Human growth factor-like EGF
EGF_alliinase (PF04863): Alliinase EGF-like domain
Notch (PF00066): LNR domain
NOD (PF06816): NOTCH protein
NODP (PF07684): NOTCH protein
Ank_5 (PF13857): Ankyrin repeats (many copies)
Ank (PF00023): Ankyrin repeat
Ank_2 (PF12796): Ankyrin repeats (3 copies)
DUF3454 (PF11936): Domain of unknown function (DUF3454)
Plxna2
interactor100Sema (PF01403): Sema domain
PSI (PF01437): Plexin repeat
TIG (PF01833): IPT/TIG domain
IncA (PF04156): IncA protein
Plexin_cytopl (PF08337): Plexin cytoplasmic RasGAP domain
Pomgnt1
interactor100ILEI (PF15711): Interleukin-like EMT inducer
GNT-I (PF03071): GNT-I family
Stat5b
oncogene200STAT_int (PF02865): STAT protein, protein interaction domain
STAT_alpha (PF01017): STAT protein, all-alpha domain
STAT_bind (PF02864): STAT protein, DNA binding domain
SH2 (PF00017): SH2 domain

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