Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Adam28
Level of PPIs:		or Upload text file:	Update repository

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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Adam28 (from a repository: Sat Apr 21 01:24:32 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	2
The number (and %) of the onco-proteins	0 (0.00 %)
The number (and %) of the tumor suppressors	1 (50.00 %)
Total number of binary PPIs (saturation %)	2 (200.00 %)
The number (and %) of affected PPIs	1 (50.00 %)
PPI diameter	1
PPI radius	1
The average degree of PPI	1.000
Assortativity coefficient	0
The network average Clustering coefficient	0.000
The number (and %) of a zero Clustering coefficients	2 (100.00 %)
The number (and %) of a zero Betweenness Centrality	2 (100.00 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Adam28

XP_017658052.1

Domain structure obtained by HMM

Protein ID: XP_017658052.1 - disintegrin and metalloproteinase domain-containing protein 28
KEEG Ortholog ID: K08614

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Pep_M12B_propep	PF01562	140	1.1e-34	105.800	31	158	31	158	Reprolysin family propeptide
DUF16	PF01519	104	0.000028	10.900	144	206	129	249	Protein of unknown function DUF16
Reprolysin	PF01421	199	3.1e-72	228.800	207	402	206	402	Reprolysin (M12B) family zinc metalloprotease
Disintegrin	PF00200	76	7.5e-25	73.900	419	491	419	491	Disintegrin
ADAM_CR	PF08516	113	1.5e-24	72.900	496	573	496	590	ADAM cysteine-rich
hEGF	PF12661	22	0.000015	12.000	636	654	636	654	Human growth factor-like EGF
PRIMA1	PF16101	121	0.0000095	11.900	670	703	656	732	Proline-rich membrane anchor 1

user protein

Pep_M12B_propep (PF01562): Reprolysin family propeptide
DUF16 (PF01519): Protein of unknown function DUF16
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
Disintegrin (PF00200): Disintegrin
ADAM_CR (PF08516): ADAM cysteine-rich
hEGF (PF12661): Human growth factor-like EGF
PRIMA1 (PF16101): Proline-rich membrane anchor 1

Tp53

NP_001306217.1

Domain structure obtained by HMM

Protein ID: NP_001306217.1 - tumor protein p53
KEEG Ortholog ID: K04451

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
P53_TAD	PF08563	25	7.9e-17	46.700	5	29	5	29	P53 transactivation motif
P53	PF00870	196	1.9e-119	382.500	93	287	93	287	P53 DNA-binding domain
P53_tetramer	PF07710	42	2.2e-21	61.300	317	355	317	356	P53 tetramerisation motif

tumor suppressor

P53_TAD (PF08563): P53 transactivation motif
P53 (PF00870): P53 DNA-binding domain
P53_tetramer (PF07710): P53 tetramerisation motif

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