Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Adam22 (from a repository: Tue Apr 17 15:08:49 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)9
The number (and %) of the onco-proteins4 (44.44 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)16 (44.44 %)
The number (and %) of affected PPIs8 (50.00 %)
PPI diameter2
PPI radius1
The average degree of PPI2.222
Assortativity coefficient-0.4082
The network average Clustering coefficient0.452
The number (and %) of a zero Clustering coefficients4 (44.44 %)
The number (and %) of a zero Betweenness Centrality8 (88.89 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Adam22
user protein80.07152.000Pep_M12B_propep (PF01562): Reprolysin family propeptide
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
Disintegrin (PF00200): Disintegrin
ADAM_CR (PF08516): ADAM cysteine-rich
EGF_2 (PF07974): EGF-like domain
App
interactor31.0000APP_N (PF02177): Amyloid A4 N-terminal heparin-binding
APP_Cu_bd (PF12924): Copper-binding of amyloid precursor, CuBD
SDA1 (PF05285): SDA1
YtxH (PF12732): YtxH-like protein
Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2 (PF12925): E2 domain of amyloid precursor protein
Beta-APP (PF03494): Beta-amyloid peptide (beta-APP)
APP_amyloid (PF10515): beta-amyloid precursor protein C-terminus
Csnk1e
interactor31.0000Pkinase (PF00069): Protein kinase domain
APH (PF01636): Phosphotransferase enzyme family
Dlg4
interactor31.0000MAGUK_N_PEST (PF10608): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
PDZ_assoc (PF10600): PDZ-associated domain of NMDA receptors
SH3_1 (PF00018): SH3 domain
Guanylate_kin (PF00625): Guanylate kinase
Eps8
oncogene200PTB (PF08416): Phosphotyrosine-binding domain
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
Med2 (PF11214): Mediator complex subunit 2
SH3_3 (PF08239): Bacterial SH3 domain
SH3_1 (PF00018): SH3 domain
DEC-1_N (PF04625): DEC-1 protein, N-terminal region
Lgi1
oncogene21.0000LRR_8 (PF13855): Leucine rich repeat
LRR_1 (PF00560): Leucine Rich Repeat
LRRCT (PF01463): Leucine rich repeat C-terminal domain
EPTP (PF03736): EPTP domain
Lyn
oncogene200SH3_1 (PF00018): SH3 domain
SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Nxf1
interactor200Tap-RNA_bind (PF09162): Tap, RNA-binding
LRR_8 (PF13855): Leucine rich repeat
NTF2 (PF02136): Nuclear transport factor 2 (NTF2) domain
TAP_C (PF03943): TAP C-terminal domain
Rac2
oncogene100Ras (PF00071): Ras family

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