Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Adam21 (from a repository: Sat Apr 14 08:20:30 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins3 (11.54 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)30 (9.23 %)
The number (and %) of affected PPIs25 (83.33 %)
PPI diameter2
PPI radius1
The average degree of PPI2.154
Assortativity coefficient-0.4367
The network average Clustering coefficient0.180
The number (and %) of a zero Clustering coefficients20 (76.92 %)
The number (and %) of a zero Betweenness Centrality24 (92.31 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Adam21
user protein250.010593.000Pep_M12B_propep (PF01562): Reprolysin family propeptide
Reprolysin (PF01421): Reprolysin (M12B) family zinc metalloprotease
Disintegrin (PF00200): Disintegrin
ADAM_CR (PF08516): ADAM cysteine-rich
Acta2
interactor100Actin (PF00022): Actin
Amigo1
interactor200LRRNT (PF01462): Leucine rich repeat N-terminal domain
LRR_8 (PF13855): Leucine rich repeat
LRR_4 (PF12799): Leucine Rich repeats (2 copies)
LRR_1 (PF00560): Leucine Rich Repeat
I-set (PF07679): Immunoglobulin I-set domain
Ankrd46
interactor100Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Asphd2
interactor100Asp_Arg_Hydrox (PF05118): Aspartyl/Asparaginyl beta-hydroxylase
Canx
interactor100TRAP_alpha (PF03896): Translocon-associated protein (TRAP), alpha subunit
Calreticulin (PF00262): Calreticulin family
DUF1510 (PF07423): Protein of unknown function (DUF1510)
Ccpg1
interactor21.0000Pap_E4 (PF02711): E4 protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
DUF1049 (PF06305): Protein of unknown function (DUF1049)
YtxH (PF12732): YtxH-like protein
PRESAN (PF09687): Plasmodium RESA N-terminal
Chsy3
interactor21.0000Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
Fringe (PF02434): Fringe-like
CHGN (PF05679): Chondroitin N-acetylgalactosaminyltransferase
Dhfr
interactor100DHFR_1 (PF00186): Dihydrofolate reductase
Egfl7
interactor100EMI (PF07546): EMI domain
EGF_2 (PF07974): EGF-like domain
EGF_CA (PF07645): Calcium-binding EGF domain
SlyX (PF04102): SlyX
Gnb2
interactor100CALM_bind (PF16025): Calcium-dependent calmodulin binding
WD40 (PF00400): WD domain, G-beta repeat
WD40_like (PF17005): WD40-like domain
Golga5
oncogene100ADIP (PF11559): Afadin- and alpha -actinin-Binding
HIP1_clath_bdg (PF16515): Clathrin-binding domain of Huntingtin-interacting protein 1
Spc7 (PF08317): Spc7 kinetochore protein
Golgin_A5 (PF09787): Golgin subfamily A member 5
Gpc4
interactor100Glypican (PF01153): Glypican
Hspa5
heat shock, oncogene200HSP70 (PF00012): Hsp70 protein
Itgb5
interactor100PSI_integrin (PF17205): Integrin plexin domain
Integrin_beta (PF00362): Integrin beta chain VWA domain
EGF_2 (PF07974): EGF-like domain
Integrin_B_tail (PF07965): Integrin beta tail domain
DUF2975 (PF11188): Protein of unknown function (DUF2975)
Integrin_b_cyt (PF08725): Integrin beta cytoplasmic domain
LOC103752329
interactor21.0000MHC_I (PF00129): Class I Histocompatibility antigen, domains alpha 1 and 2
C1-set (PF07654): Immunoglobulin C1-set domain
Lclat1
interactor100Peptidase_U4 (PF03419): Sporulation factor SpoIIGA
Acyltransferase (PF01553): Acyltransferase
Acyltransf_C (PF16076): Acyltransferase C-terminus
Lrfn3
interactor30.6671.000LRRNT (PF01462): Leucine rich repeat N-terminal domain
LRR_8 (PF13855): Leucine rich repeat
I-set (PF07679): Immunoglobulin I-set domain
fn3 (PF00041): Fibronectin type III domain
Peptidase_MA_2 (PF13485): Peptidase MA superfamily
Lrp10
interactor100CUB (PF00431): CUB domain
Ldl_recept_a (PF00057): Low-density lipoprotein receptor domain class A
Syndecan (PF01034): Syndecan domain
Lrrc3
interactor100LRRNT (PF01462): Leucine rich repeat N-terminal domain
LRR_8 (PF13855): Leucine rich repeat
LRR_1 (PF00560): Leucine Rich Repeat
Manf
oncogene100Armet (PF10208): Degradation arginine-rich protein for mis-folding
Pcsk1n
interactor100ProSAAS (PF07259): ProSAAS precursor
Pdf
interactor100Pep_deformylase (PF01327): Polypeptide deformylase
Plxna2
interactor100Sema (PF01403): Sema domain
PSI (PF01437): Plexin repeat
TIG (PF01833): IPT/TIG domain
IncA (PF04156): IncA protein
Plexin_cytopl (PF08337): Plexin cytoplasmic RasGAP domain
Plxnb2
interactor100Sema (PF01403): Sema domain
PSI (PF01437): Plexin repeat
TIG (PF01833): IPT/TIG domain
Plexin_cytopl (PF08337): Plexin cytoplasmic RasGAP domain
Vegfb
interactor21.0000PDGF (PF00341): PDGF/VEGF domain
VEGF_C (PF14554): VEGF heparin-binding domain

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