Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Acvrl1 (from a repository: Fri Apr 13 06:55:57 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins3 (21.43 %)
The number (and %) of the tumor suppressors1 (7.14 %)
Total number of binary PPIs (saturation %)31 (34.07 %)
The number (and %) of affected PPIs13 (41.94 %)
PPI diameter2
PPI radius1
The average degree of PPI3.571
Assortativity coefficient-0.6369
The network average Clustering coefficient0.579
The number (and %) of a zero Clustering coefficients3 (21.43 %)
The number (and %) of a zero Betweenness Centrality8 (57.14 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Acvrl1
user protein130.154111.000TGF_beta_GS (PF08515): Transforming growth factor beta type I GS-motif
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Acvr1
interactor60.4005.667Activin_recp (PF01064): Activin types I and II receptor domain
TGF_beta_GS (PF08515): Transforming growth factor beta type I GS-motif
Pkinase (PF00069): Protein kinase domain
Bambi
interactor30.6670.667BAMBI (PF06211): BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain
JIP_LZII (PF16471): JNK-interacting protein leucine zipper II
DUF1049 (PF06305): Protein of unknown function (DUF1049)
Csnk2b
interactor200CK_II_beta (PF01214): Casein kinase II regulatory subunit
Eng
interactor50.6671.667Zona_pellucida (PF00100): Zona pellucida-like domain
Fkbp1a
interactor41.0000FKBP_C (PF00254): FKBP-type peptidyl-prolyl cis-trans isomerase
Hsp90aa1
oncogene31.0000HATPase_c (PF02518): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183): Hsp90 protein
Inhba
interactor21.0000TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Nr1h2
oncogene100zf-C4 (PF00105): Zinc finger, C4 type (two domains)
DUF1180 (PF06679): Protein of unknown function (DUF1180)
Hormone_recep (PF00104): Ligand-binding domain of nuclear hormone receptor
Slc25a24
interactor100Mito_carr (PF00153): Mitochondrial carrier protein
Smad1
interactor31.0000MH1 (PF03165): MH1 domain
MH2 (PF03166): MH2 domain
Snx6
interactor21.0000PX (PF00787): PX domain
Vps5 (PF09325): Vps5 C terminal like
Tgfb1
oncogene, tumor suppressor40.8330.667TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Tgfbr1
oncogene70.38112.333Activin_recp (PF01064): Activin types I and II receptor domain
DUF4448 (PF14610): Protein of unknown function (DUF4448)
TGF_beta_GS (PF08515): Transforming growth factor beta type I GS-motif
Pkinase (PF00069): Protein kinase domain

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