Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Acvr2b (from a repository: Mon Apr 16 19:50:30 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins9 (25.71 %)
The number (and %) of the tumor suppressors4 (11.43 %)
Total number of binary PPIs (saturation %)70 (11.76 %)
The number (and %) of affected PPIs34 (48.57 %)
PPI diameter2
PPI radius1
The average degree of PPI3.486
Assortativity coefficient-0.5725
The network average Clustering coefficient0.410
The number (and %) of a zero Clustering coefficients16 (45.71 %)
The number (and %) of a zero Betweenness Centrality24 (68.57 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Acvr2b
user protein340.0481010.667Activin_recp (PF01064): Activin types I and II receptor domain
Pkinase (PF00069): Protein kinase domain
Acvr1b
oncogene110.29136.667Activin_recp (PF01064): Activin types I and II receptor domain
TGF_beta_GS (PF08515): Transforming growth factor beta type I GS-motif
Pkinase (PF00069): Protein kinase domain
Bmp10
tumor suppressor100TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Bmp6
interactor100TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Bmp7
interactor31.0000TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Cd79b
oncogene100V-set (PF07686): Immunoglobulin V-set domain
Sigma_reg_N (PF13800): Sigma factor regulator N-terminal
ITAM (PF02189): Immunoreceptor tyrosine-based activation motif
Cnga3
interactor100Ion_trans (PF00520): Ion transport protein
cNMP_binding (PF00027): Cyclic nucleotide-binding domain
CLZ (PF16526): C-terminal leucine zipper domain of cyclic nucleotide-gated channels
Dlk1
tumor suppressor100hEGF (PF12661): Human growth factor-like EGF
EGF_2 (PF07974): EGF-like domain
EGF (PF00008): EGF-like domain
cEGF (PF12662): Complement Clr-like EGF-like
Eng
interactor40.6671.000Zona_pellucida (PF00100): Zona pellucida-like domain
Erbin
oncogene41.0000LRR_8 (PF13855): Leucine rich repeat
LRR_4 (PF12799): Leucine Rich repeats (2 copies)
Neur_chan_memb (PF02932): Neurotransmitter-gated ion-channel transmembrane region
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Gdf2
interactor100TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Gdf5
interactor100TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Grpr
oncogene1007tm_1 (PF00001): 7 transmembrane receptor (rhodopsin family)
Hsp90aa1
oncogene50.6671.500HATPase_c (PF02518): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183): Hsp90 protein
Il17rb
oncogene100IL17R_fnIII_D1 (PF16556): Interleukin-17 receptor, fibronectin-III-like domain 1
IL17R_fnIII_D2 (PF16578): Interleukin 17 receptor D
SEFIR (PF08357): SEFIR domain
Il17rc
interactor100IL17_R_N (PF15037): Interleukin-17 receptor extracellular region
SEFIR (PF08357): SEFIR domain
Il4r
oncogene100IL4Ra_N (PF09238): Interleukin-4 receptor alpha chain, N-terminal
Inhba
interactor21.0000TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Inhbb
interactor21.0000TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Izumo1
interactor100IZUMO (PF15005): Izumo sperm-egg fusion, Ig domain-associated
Izumo-Ig (PF16706): Izumo-like Immunoglobulin domain
Peptidase_M56 (PF05569): BlaR1 peptidase M56
SIT (PF15330): SHP2-interacting transmembrane adaptor protein, SIT
LOC103736106
interactor31.0000Cadherin_2 (PF08266): Cadherin-like
Cadherin_3 (PF16184): Cadherin-like
Cadherin (PF00028): Cadherin domain
Cadherin_C_2 (PF16492): Cadherin cytoplasmic C-terminal
LOC103736112
interactor31.0000Cadherin_2 (PF08266): Cadherin-like
Cadherin (PF00028): Cadherin domain
Cadherin_C_2 (PF16492): Cadherin cytoplasmic C-terminal
Mas1
oncogene1007tm_1 (PF00001): 7 transmembrane receptor (rhodopsin family)
7TM_GPCR_Srbc (PF10316): Serpentine type 7TM GPCR chemoreceptor Srbc
Mrap2
interactor21.0000MRAP (PF15183): Melanocortin-2 receptor accessory protein family
Mstn
interactor100TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Pdgfrb
oncogene50.6671.333ig (PF00047): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
V-set (PF07686): Immunoglobulin V-set domain
I-set (PF07679): Immunoglobulin I-set domain
C1-set (PF07654): Immunoglobulin C1-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Smad2
oncogene, tumor suppressor60.8001.333MH1 (PF03165): MH1 domain
MH2 (PF03166): MH2 domain
Smad6
interactor41.0000MH1 (PF03165): MH1 domain
MH2 (PF03166): MH2 domain
Smad7
interactor60.6673.667MH1 (PF03165): MH1 domain
MH2 (PF03166): MH2 domain
Snx1
interactor60.7001.667Sorting_nexin (PF03700): Sorting nexin, N-terminal domain
PX (PF00787): PX domain
Vps5 (PF09325): Vps5 C terminal like
Snx2
interactor50.7001.667Sorting_nexin (PF03700): Sorting nexin, N-terminal domain
PX (PF00787): PX domain
Vps5 (PF09325): Vps5 C terminal like
Snx6
interactor40.6671.333PX (PF00787): PX domain
Vps5 (PF09325): Vps5 C terminal like
Synj2bp
interactor100PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Tgfbr2
oncogene, tumor suppressor60.4677.167ecTbetaR2 (PF08917): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Tmem30a
interactor100CDC50 (PF03381): LEM3 (ligand-effect modulator 3) family / CDC50 family

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