Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Acvr2a (from a repository: Fri Apr 13 23:37:18 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins4 (17.39 %)
The number (and %) of the tumor suppressors2 (8.70 %)
Total number of binary PPIs (saturation %)44 (17.39 %)
The number (and %) of affected PPIs22 (50.00 %)
PPI diameter2
PPI radius1
The average degree of PPI3.130
Assortativity coefficient-0.6618
The network average Clustering coefficient0.368
The number (and %) of a zero Clustering coefficients12 (52.17 %)
The number (and %) of a zero Betweenness Centrality18 (78.26 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Acvr2a
user protein, oncogene220.061409.333Activin_recp (PF01064): Activin types I and II receptor domain
Pkinase (PF00069): Protein kinase domain
Acvr1
interactor90.42914.333Activin_recp (PF01064): Activin types I and II receptor domain
TGF_beta_GS (PF08515): Transforming growth factor beta type I GS-motif
Pkinase (PF00069): Protein kinase domain
Acvr1b
oncogene60.5336.000Activin_recp (PF01064): Activin types I and II receptor domain
TGF_beta_GS (PF08515): Transforming growth factor beta type I GS-motif
Pkinase (PF00069): Protein kinase domain
Bmp10
tumor suppressor100TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Bmp6
interactor100TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Bmp7
interactor41.0000TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Daam2
interactor100Drf_GBD (PF06371): Diaphanous GTPase-binding Domain
Drf_FH3 (PF06367): Diaphanous FH3 Domain
APG6 (PF04111): Autophagy protein Apg6
FH2 (PF02181): Formin Homology 2 Domain
MAT1 (PF06391): CDK-activating kinase assembly factor MAT1
Daxx
oncogene31.0000DUF1180 (PF06679): Protein of unknown function (DUF1180)
Daxx (PF03344): Daxx N-terminal Rassf1C-interacting domain
ATP11 (PF06644): ATP11 protein
SpoIIIAH (PF12685): SpoIIIAH-like protein
RF-1 (PF00472): RF-1 domain
Nop14 (PF04147): Nop14-like family
Eng
interactor50.8330.667Zona_pellucida (PF00100): Zona pellucida-like domain
Erbin
oncogene200LRR_8 (PF13855): Leucine rich repeat
LRR_4 (PF12799): Leucine Rich repeats (2 copies)
Neur_chan_memb (PF02932): Neurotransmitter-gated ion-channel transmembrane region
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Gdf2
interactor100TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Gdf5
interactor21.0000TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Havcr2
interactor100V-set (PF07686): Immunoglobulin V-set domain
Ig_2 (PF13895): Immunoglobulin domain
Inha
oncogene100TGF_beta (PF00019): Transforming growth factor beta like domain
Inhba
interactor31.0000TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Inhbb
interactor21.0000TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
LOC103736087
interactor200Cadherin_2 (PF08266): Cadherin-like
Cadherin_3 (PF16184): Cadherin-like
Cadherin (PF00028): Cadherin domain
Cadherin_C_2 (PF16492): Cadherin cytoplasmic C-terminal
Magi2
interactor100PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Guanylate_kin (PF00625): Guanylate kinase
MAGI_u1 (PF16663): Unstructured region on MAGI
MAGI_u5 (PF16666): Unstructured region on MAGI
WW (PF00397): WW domain
PDZ_2 (PF13180): PDZ domain
Herpes_DNAp_acc (PF04929): Herpes DNA replication accessory factor
Mrap2
interactor31.0000MRAP (PF15183): Melanocortin-2 receptor accessory protein family
Rnf11
interactor200zf-RING_2 (PF13639): Ring finger domain
zf-ANAPC11 (PF12861): Anaphase-promoting complex subunit 11 RING-H2 finger
Synj2bp
interactor100PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
Tgfbr2
oncogene, tumor suppressor50.6003.667ecTbetaR2 (PF08917): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Tlr2
interactor200LRR_8 (PF13855): Leucine rich repeat
LRR_4 (PF12799): Leucine Rich repeats (2 copies)
Methyltransf_31 (PF13847): Methyltransferase domain
LRRCT (PF01463): Leucine rich repeat C-terminal domain
TIR (PF01582): TIR domain

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