Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Acvr1b (from a repository: Thu Apr 19 06:39:27 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins6 (18.18 %)
The number (and %) of the tumor suppressors6 (18.18 %)
Total number of binary PPIs (saturation %)117 (22.16 %)
The number (and %) of affected PPIs32 (27.35 %)
PPI diameter2
PPI radius1
The average degree of PPI6.182
Assortativity coefficient-0.3902
The network average Clustering coefficient0.528
The number (and %) of a zero Clustering coefficients5 (15.15 %)
The number (and %) of a zero Betweenness Centrality8 (24.24 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Acvr1b
user protein, oncogene320.141652.367Activin_recp (PF01064): Activin types I and II receptor domain
TGF_beta_GS (PF08515): Transforming growth factor beta type I GS-motif
Pkinase (PF00069): Protein kinase domain
Acvr1
interactor130.40928.633Activin_recp (PF01064): Activin types I and II receptor domain
TGF_beta_GS (PF08515): Transforming growth factor beta type I GS-motif
Pkinase (PF00069): Protein kinase domain
Acvr2a
oncogene60.5334.500Activin_recp (PF01064): Activin types I and II receptor domain
Pkinase (PF00069): Protein kinase domain
Acvr2b
interactor110.29132.733Activin_recp (PF01064): Activin types I and II receptor domain
Pkinase (PF00069): Protein kinase domain
Bag6
interactor50.8330.667ubiquitin (PF00240): Ubiquitin family
FAP (PF07174): Fibronectin-attachment protein (FAP)
DUF2360 (PF10152): Predicted coiled-coil domain-containing protein (DUF2360)
DUF3538 (PF12057): Domain of unknown function (DUF3538)
Mito_fiss_reg (PF05308): Mitochondrial fission regulator
DUF3123 (PF11321): Protein of unknown function (DUF3123)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
Bambi
interactor41.0000BAMBI (PF06211): BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain
JIP_LZII (PF16471): JNK-interacting protein leucine zipper II
DUF1049 (PF06305): Protein of unknown function (DUF1049)
Bmpr2
tumor suppressor70.6004.667Activin_recp (PF01064): Activin types I and II receptor domain
Cadherin_C_2 (PF16492): Cadherin cytoplasmic C-terminal
Pkinase (PF00069): Protein kinase domain
Elavl1
oncogene80.4768.833RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fkbp1a
interactor40.6670.400FKBP_C (PF00254): FKBP-type peptidyl-prolyl cis-trans isomerase
Hsp90aa1
oncogene50.6671.500HATPase_c (PF02518): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183): Hsp90 protein
Inhba
interactor40.6670.733TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Inhbb
interactor30.6670.400TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Mrap2
interactor50.6001.900MRAP (PF15183): Melanocortin-2 receptor accessory protein family
Nedd4l
oncogene, tumor suppressor80.6674.300C2 (PF00168): C2 domain
WW (PF00397): WW domain
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Ntrk1
oncogene100.30623.500LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Otub1
interactor70.4767.567Peptidase_C65 (PF10275): Peptidase C65 Otubain
Rxra
oncogene31.0000Nuc_recep-AF1 (PF11825): Nuclear/hormone receptor activator site AF-1
zf-C4 (PF00105): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104): Ligand-binding domain of nuclear hormone receptor
Smad2
oncogene, tumor suppressor110.48916.333MH1 (PF03165): MH1 domain
MH2 (PF03166): MH2 domain
Smad3
oncogene70.7331.800MH1 (PF03165): MH1 domain
MH2 (PF03166): MH2 domain
Smad6
interactor110.49116.767MH1 (PF03165): MH1 domain
MH2 (PF03166): MH2 domain
Smad7
interactor130.42330.167MH1 (PF03165): MH1 domain
MH2 (PF03166): MH2 domain
Smurf1
interactor80.7142.867C2 (PF00168): C2 domain
WW (PF00397): WW domain
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Snx1
interactor50.8330.500Sorting_nexin (PF03700): Sorting nexin, N-terminal domain
PX (PF00787): PX domain
Vps5 (PF09325): Vps5 C terminal like
Snx2
interactor40.8330.500Sorting_nexin (PF03700): Sorting nexin, N-terminal domain
PX (PF00787): PX domain
Vps5 (PF09325): Vps5 C terminal like
Spint2
tumor suppressor100Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
Tgfbr2
oncogene, tumor suppressor70.5716.133ecTbetaR2 (PF08917): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Tsc22d1
tumor suppressor70.6673.567SelP_N (PF04592): Selenoprotein P, N terminal region
Chibby (PF14645): Chibby family
TSC22 (PF01166): TSC-22/dip/bun family
Tsnax
interactor100Translin (PF01997): Translin family
Tspan17
interactor100Tetraspannin (PF00335): Tetraspanin family
Tspan3
interactor100Tetraspannin (PF00335): Tetraspanin family
Hum_adeno_E3A (PF05393): Human adenovirus early E3A glycoprotein
Vps16
interactor21.0000Vps16_N (PF04841): Vps16, N-terminal region
Vps16_C (PF04840): Vps16, C-terminal region
Xiap
interactor40.6670.667BIR (PF00653): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
Znf644
interactor100zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2 (PF00096): Zinc finger, C2H2 type
zf-C2H2_8 (PF15909): C2H2-type zinc ribbon
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_11 (PF16622): zinc-finger C2H2-type
Zn-ribbon_8 (PF09723): Zinc ribbon domain

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