Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Acvr1 (from a repository: Thu Apr 12 00:13:10 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins3 (11.11 %)
The number (and %) of the tumor suppressors4 (14.81 %)
Total number of binary PPIs (saturation %)101 (28.77 %)
The number (and %) of affected PPIs27 (26.73 %)
PPI diameter2
PPI radius1
The average degree of PPI6.815
Assortativity coefficient-0.2502
The network average Clustering coefficient0.568
The number (and %) of a zero Clustering coefficients3 (11.11 %)
The number (and %) of a zero Betweenness Centrality7 (25.93 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Acvr1
user protein270.203354.867Activin_recp (PF01064): Activin types I and II receptor domain
TGF_beta_GS (PF08515): Transforming growth factor beta type I GS-motif
Pkinase (PF00069): Protein kinase domain
Acvr1b
oncogene120.40925.500Activin_recp (PF01064): Activin types I and II receptor domain
TGF_beta_GS (PF08515): Transforming growth factor beta type I GS-motif
Pkinase (PF00069): Protein kinase domain
Acvr2a
oncogene80.42911.167Activin_recp (PF01064): Activin types I and II receptor domain
Pkinase (PF00069): Protein kinase domain
Acvrl1
interactor50.4004.400TGF_beta_GS (PF08515): Transforming growth factor beta type I GS-motif
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Arv1
interactor100Arv1 (PF04161): Arv1-like family
Bambi
interactor60.6672.867BAMBI (PF06211): BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain
JIP_LZII (PF16471): JNK-interacting protein leucine zipper II
DUF1049 (PF06305): Protein of unknown function (DUF1049)
Bmp7
interactor70.5334.533TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Bmpr1a
oncogene, tumor suppressor160.36246.467Activin_recp (PF01064): Activin types I and II receptor domain
TGF_beta_GS (PF08515): Transforming growth factor beta type I GS-motif
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Bmpr2
tumor suppressor90.5716.367Activin_recp (PF01064): Activin types I and II receptor domain
Cadherin_C_2 (PF16492): Cadherin cytoplasmic C-terminal
Pkinase (PF00069): Protein kinase domain
Eng
interactor60.6002.833Zona_pellucida (PF00100): Zona pellucida-like domain
Gdf5
interactor40.6670.800TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Gramd1a
interactor100PRIMA1 (PF16101): Proline-rich membrane anchor 1
GRAM (PF02893): GRAM domain
DUF4782 (PF16016): Domain of unknown function (DUF4782)
Inhba
interactor40.6671.333TGFb_propeptide (PF00688): TGF-beta propeptide
TGF_beta (PF00019): Transforming growth factor beta like domain
Lrriq1
interactor21.0000IQ (PF00612): IQ calmodulin-binding motif
DUF87 (PF01935): Domain of unknown function DUF87
LRR_4 (PF12799): Leucine Rich repeats (2 copies)
LRR_8 (PF13855): Leucine rich repeat
Med16
interactor100WD40 (PF00400): WD domain, G-beta repeat
Med16 (PF11635): Mediator complex subunit 16
Mrap2
interactor60.5335.000MRAP (PF15183): Melanocortin-2 receptor accessory protein family
Otub1
interactor50.7001.000Peptidase_C65 (PF10275): Peptidase C65 Otubain
Rnf149
interactor21.0000PA (PF02225): PA domain
UPF0233 (PF06781): Uncharacterised protein family (UPF0233)
zf-RING_2 (PF13639): Ring finger domain
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
Smad1
interactor100.58310.500MH1 (PF03165): MH1 domain
MH2 (PF03166): MH2 domain
Smad5
interactor41.0000MH1 (PF03165): MH1 domain
MH2 (PF03166): MH2 domain
Smad6
interactor110.60011.367MH1 (PF03165): MH1 domain
MH2 (PF03166): MH2 domain
Smad7
interactor110.6189.100MH1 (PF03165): MH1 domain
MH2 (PF03166): MH2 domain
Smurf1
interactor100.6945.667C2 (PF00168): C2 domain
WW (PF00397): WW domain
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Tgfbr2
oncogene, tumor suppressor80.50011.267ecTbetaR2 (PF08917): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Tgfbrap1
interactor21.0000Rab15_effector (PF15208): Rab15 effector
CNH (PF00780): CNH domain
Clathrin (PF00637): Region in Clathrin and VPS
Vps39_1 (PF10366): Vacuolar sorting protein 39 domain 1
Vps39_2 (PF10367): Vacuolar sorting protein 39 domain 2
Tsc22d1
tumor suppressor70.8001.000SelP_N (PF04592): Selenoprotein P, N terminal region
Chibby (PF14645): Chibby family
TSC22 (PF01166): TSC-22/dip/bun family
Usp15
oncogene80.8101.967DUSP (PF06337): DUSP domain
Ubiquitin_3 (PF14836): Ubiquitin-like domain
UCH (PF00443): Ubiquitin carboxyl-terminal hydrolase

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