Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Acp2
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Visible interactors:

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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Acp2 (from a repository: Mon Apr 16 00:55:22 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	23
The number (and %) of the onco-proteins	5 (21.74 %)
The number (and %) of the tumor suppressors	0 (0.00 %)
Total number of binary PPIs (saturation %)	37 (14.62 %)
The number (and %) of affected PPIs	22 (59.46 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	2.783
Assortativity coefficient	-0.3418
The network average Clustering coefficient	0.509
The number (and %) of a zero Clustering coefficients	9 (39.13 %)
The number (and %) of a zero Betweenness Centrality	18 (78.26 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Acp2

XP_008841791.1

Domain structure obtained by HMM

Protein ID: XP_008841791.1 - lysosomal acid phosphatase
KEEG Ortholog ID: K14410

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
His_Phos_2	PF00328	383	1.1e-38	119.600	33	329	32	330	Histidine phosphatase superfamily (branch 2)

user protein

0.043

436.000

His_Phos_2 (PF00328): Histidine phosphatase superfamily (branch 2)

Atp6v0a2

XP_008837495.1

Domain structure obtained by HMM

Protein ID: XP_008837495.1 - V-type proton ATPase 116 kDa subunit a isoform X1
KEEG Ortholog ID: K02154

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
V_ATPase_I	PF01496	810	1.4e-307	1008.000	28	842	27	842	V-type ATPase 116kDa subunit family

interactor

0.667

1.000

V_ATPase_I (PF01496): V-type ATPase 116kDa subunit family

Atp6v0e1

XP_008848994.1

Domain structure obtained by HMM

Protein ID: XP_008848994.1 - V-type proton ATPase subunit e 1
KEEG Ortholog ID: K02153

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
ATP_synt_H	PF05493	62	1.3e-25	76.000	9	70	9	70	ATP synthase subunit H

interactor

1.000

ATP_synt_H (PF05493): ATP synthase subunit H

Dnajb11

XP_008821858.1

Domain structure obtained by HMM

Protein ID: XP_008821858.1 - dnaJ homolog subfamily B member 11
KEEG Ortholog ID: K09517

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DnaJ	PF00226	63	2.1e-32	97.400	25	87	25	87	DnaJ domain
DnaJ_C	PF01556	146	1.7e-37	115.000	135	327	134	327	DnaJ C terminal domain

interactor

1.000

DnaJ (PF00226): DnaJ domain
DnaJ_C (PF01556): DnaJ C terminal domain

Ippk

XP_008851096.1

Domain structure obtained by HMM

Protein ID: XP_008851096.1 - inositol-pentakisphosphate 2-kinase isoform X1
KEEG Ortholog ID: K10572

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Ins_P5_2-kin	PF06090	333	9.1e-98	313.800	13	454	13	455	Inositol-pentakisphosphate 2-kinase

interactor

1.000

Ins_P5_2-kin (PF06090): Inositol-pentakisphosphate 2-kinase

LOC103732819

XP_008829766.1

Domain structure obtained by HMM

Protein ID: XP_008829766.1 - F-box only protein 6 isoform X1
KEEG Ortholog ID: K10100

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
F-box-like	PF12937	48	0.0000000000064	31.500	4	51	4	51	F-box-like
FBA	PF04300	178	1.2e-38	118.900	70	162	70	168	F-box associated region

interactor

0.667

1.000

F-box-like (PF12937): F-box-like
FBA (PF04300): F-box associated region

LOC103737005

XP_008834903.1

Domain structure obtained by HMM

Protein ID: XP_008834903.1 - cytochrome b-c1 complex subunit Rieske, mitochondrial
KEEG Ortholog ID: K00411

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Ubiq-Cytc-red_N	PF09165	75	6.8e-31	93.400	2	77	2	77	Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM	PF02921	66	3.1e-35	106.800	80	145	80	145	Ubiquinol cytochrome reductase transmembrane region
Rieske	PF00355	89	4.6e-16	44.900	157	260	152	264	Rieske [2Fe-2S] domain

interactor

Ubiq-Cytc-red_N (PF09165): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921): Ubiquinol cytochrome reductase transmembrane region
Rieske (PF00355): Rieske [2Fe-2S] domain

Lgals3

XP_008837759.1

Domain structure obtained by HMM

Protein ID: XP_008837759.1 - galectin-3
KEEG Ortholog ID: K06831

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Gal-bind_lectin	PF00337	134	4.2e-42	129.100	138	265	137	267	Galactoside-binding lectin

oncogene

0.667

2.000

Gal-bind_lectin (PF00337): Galactoside-binding lectin

Lgals8

XP_017657700.1

Domain structure obtained by HMM

Protein ID: XP_017657700.1 - galectin-8 isoform X1
KEEG Ortholog ID: K06832

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Gal-bind_lectin	PF00337	134	7.1e-44	134.800	17	149	17	150	Galactoside-binding lectin
Gal-bind_lectin	PF00337	134	1.2e-39	121.100	180	308	180	310	Galactoside-binding lectin

interactor

1.000

Gal-bind_lectin (PF00337): Galactoside-binding lectin

Lman2l

XP_008836242.1

Domain structure obtained by HMM

Protein ID: XP_008836242.1 - VIP36-like protein isoform X1
KEEG Ortholog ID: K10083

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Lectin_leg-like	PF03388	230	8.2e-86	273.200	49	285	48	286	Legume-like lectin family
PMP1_2	PF08114	43	0.0000014	14.300	326	354	319	357	ATPase proteolipid family

interactor

Lectin_leg-like (PF03388): Legume-like lectin family
PMP1_2 (PF08114): ATPase proteolipid family

Lpar1

XP_008829336.1

Domain structure obtained by HMM

Protein ID: XP_008829336.1 - lysophosphatidic acid receptor 1 isoform X1
KEEG Ortholog ID: K04289

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
7tm_1	PF00001	268	4.2e-42	130.300	67	311	66	311	7 transmembrane receptor (rhodopsin family)

oncogene

0.667

2.000

7tm_1 (PF00001): 7 transmembrane receptor (rhodopsin family)

M6pr

XP_008823542.1

Domain structure obtained by HMM

Protein ID: XP_008823542.1 - cation-dependent mannose-6-phosphate receptor
KEEG Ortholog ID: K10089

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Man-6-P_recep	PF02157	278	8.1e-188	608.400	1	278	1	278	Mannose-6-phosphate receptor

interactor

1.000

Man-6-P_recep (PF02157): Mannose-6-phosphate receptor

Nif3l1

XP_008831456.1

Domain structure obtained by HMM

Protein ID: XP_008831456.1 - NIF3-like protein 1 isoform X1

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
NIF3	PF01784	245	1.6e-84	269.500	32	358	31	363	NIF3 (NGG1p interacting factor 3)

interactor

NIF3 (PF01784): NIF3 (NGG1p interacting factor 3)

P2ry12

XP_008843127.1

Domain structure obtained by HMM

Protein ID: XP_008843127.1 - P2Y purinoceptor 12
KEEG Ortholog ID: K04298

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
7tm_1	PF00001	268	1.5e-35	108.800	53	298	42	298	7 transmembrane receptor (rhodopsin family)

interactor

1.000

7tm_1 (PF00001): 7 transmembrane receptor (rhodopsin family)

Sgcd

XP_008844171.1

Domain structure obtained by HMM

Protein ID: XP_008844171.1 - delta-sarcoglycan
KEEG Ortholog ID: K12563

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Sarcoglycan_1	PF04790	260	1e-75	240.600	23	273	23	275	Sarcoglycan complex subunit protein

interactor

Sarcoglycan_1 (PF04790): Sarcoglycan complex subunit protein

Slc39a5

XP_008846939.1

Domain structure obtained by HMM

Protein ID: XP_008846939.1 - zinc transporter ZIP5
KEEG Ortholog ID: K14711

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Zip	PF02535	333	1.4e-71	227.400	210	527	209	527	ZIP Zinc transporter

interactor

Zip (PF02535): ZIP Zinc transporter

Slc7a1

XP_008823270.1

Domain structure obtained by HMM

Protein ID: XP_008823270.1 - high affinity cationic amino acid transporter 1
KEEG Ortholog ID: K13863

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
AA_permease_2	PF13520	425	7.8e-56	175.700	32	434	32	444	Amino acid permease
DUF4094	PF13334	87	0.000056	9.800	525	549	523	560	Domain of unknown function (DUF4094)
AA_permease_C	PF13906	51	4e-29	86.800	556	606	556	606	C-terminus of AA_permease

interactor

AA_permease_2 (PF13520): Amino acid permease
DUF4094 (PF13334): Domain of unknown function (DUF4094)
AA_permease_C (PF13906): C-terminus of AA_permease

Sppl2b

XP_008835317.1

Domain structure obtained by HMM

Protein ID: XP_008835317.1 - signal peptide peptidase-like 2B isoform X1
KEEG Ortholog ID: K09597

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PA	PF02225	93	0.000000000015	30.600	77	144	57	145	PA domain
DUF4079	PF13301	141	0.000021	10.900	169	243	166	317	Protein of unknown function (DUF4079)
Peptidase_A22B	PF04258	284	4.9e-88	281.400	208	495	207	498	Signal peptide peptidase

oncogene

1.000

PA (PF02225): PA domain
DUF4079 (PF13301): Protein of unknown function (DUF4079)
Peptidase_A22B (PF04258): Signal peptide peptidase

St8sia3

XP_008853596.1

Domain structure obtained by HMM

Protein ID: XP_008853596.1 - sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase
KEEG Ortholog ID: K06613

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Glyco_transf_29	PF00777	271	1.5e-77	246.700	114	374	113	376	Glycosyltransferase family 29 (sialyltransferase)

interactor

Glyco_transf_29 (PF00777): Glycosyltransferase family 29 (sialyltransferase)

Tnf

XP_008819768.2

Domain structure obtained by HMM

Protein ID: XP_008819768.2 - tumor necrosis factor isoform X1
KEEG Ortholog ID: K03156

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
TNF	PF00229	127	4.7e-43	132.400	183	312	183	313	TNF(Tumour Necrosis Factor) family

oncogene

1.000

TNF (PF00229): TNF(Tumour Necrosis Factor) family

Trhr

XP_008849722.1

Domain structure obtained by HMM

Protein ID: XP_008849722.1 - thyrotropin-releasing hormone receptor
KEEG Ortholog ID: K04282

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
ISK_Channel	PF02060	122	0.00013	8.000	6	65	1	70	Slow voltage-gated potassium channel
7tm_1	PF00001	268	2.7e-53	167.000	42	320	42	320	7 transmembrane receptor (rhodopsin family)
7tm_4	PF13853	280	0.0014	4.500	277	334	255	338	Olfactory receptor

oncogene

ISK_Channel (PF02060): Slow voltage-gated potassium channel
7tm_1 (PF00001): 7 transmembrane receptor (rhodopsin family)
7tm_4 (PF13853): Olfactory receptor

Ubc

XP_008837468.1

Domain structure obtained by HMM

Protein ID: XP_008837468.1 - polyubiquitin-C
KEEG Ortholog ID: K08770

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
ubiquitin	PF00240	72	2e-33	100.300	3	74	3	74	Ubiquitin family
ubiquitin	PF00240	72	3.4e-32	96.400	79	150	79	150	Ubiquitin family
ubiquitin	PF00240	72	3.4e-32	96.400	155	226	155	226	Ubiquitin family
ubiquitin	PF00240	72	3.4e-32	96.400	231	302	231	302	Ubiquitin family
ubiquitin	PF00240	72	3.4e-32	96.400	307	378	307	378	Ubiquitin family
ubiquitin	PF00240	72	2.9e-35	106.200	383	454	383	454	Ubiquitin family
ubiquitin	PF00240	72	0.0000031	13.200	459	483	459	486	Ubiquitin family

interactor

1.000

ubiquitin (PF00240): Ubiquitin family

Vti1b

XP_008850381.1

Domain structure obtained by HMM

Protein ID: XP_008850381.1 - vesicle transport through interaction with t-SNAREs homolog 1B
KEEG Ortholog ID: K08493

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
V-SNARE	PF05008	79	1.4e-23	69.500	18	96	18	97	Vesicle transport v-SNARE protein N-terminus
DUF3376	PF11856	499	0.000001	14.100	118	180	114	205	Protein of unknown function (DUF3376)
V-SNARE_C	PF12352	66	4.1e-25	74.200	137	202	137	202	Snare region anchored in the vesicle membrane C-terminus
Fusion_gly	PF00523	487	0.000001	13.300	171	223	134	223	Fusion glycoprotein F0

interactor

V-SNARE (PF05008): Vesicle transport v-SNARE protein N-terminus
DUF3376 (PF11856): Protein of unknown function (DUF3376)
V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus
Fusion_gly (PF00523): Fusion glycoprotein F0

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