Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Acp1 (from a repository: Wed Apr 11 08:12:38 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins7 (21.21 %)
The number (and %) of the tumor suppressors4 (12.12 %)
Total number of binary PPIs (saturation %)91 (17.23 %)
The number (and %) of affected PPIs33 (36.26 %)
PPI diameter2
PPI radius1
The average degree of PPI4.606
Assortativity coefficient-0.5081
The network average Clustering coefficient0.419
The number (and %) of a zero Clustering coefficients11 (33.33 %)
The number (and %) of a zero Betweenness Centrality16 (48.48 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Acp1
user protein330.089803.600LMWPc (PF01451): Low molecular weight phosphotyrosine protein phosphatase
Abracl
interactor100Costars (PF14705): Costars
Actb
oncogene80.4297.833Actin (PF00022): Actin
Actbl2
interactor40.6671.067Actin (PF00022): Actin
Ada
interactor40.6671.067A_deaminase (PF00962): Adenosine/AMP deaminase
Cops5
interactor80.28610.800JAB (PF01398): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
Ctnnb1
oncogene40.5001.733Arm (PF00514): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
DUF3361 (PF11841): Domain of unknown function (DUF3361)
Dnajc13
interactor100Adaptin_N (PF01602): Adaptin N terminal region
Arm (PF00514): Armadillo/beta-catenin-like repeat
DUF4339 (PF14237): Domain of unknown function (DUF4339)
DnaJ (PF00226): DnaJ domain
Arm_2 (PF04826): Armadillo-like
Dusp1
tumor suppressor200Rhodanese (PF00581): Rhodanese-like domain
DSPc (PF00782): Dual specificity phosphatase, catalytic domain
Dusp12
interactor200DSPc (PF00782): Dual specificity phosphatase, catalytic domain
Yippee-Mis18 (PF03226): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
Dusp2
oncogene200Rhodanese (PF00581): Rhodanese-like domain
DSPc (PF00782): Dual specificity phosphatase, catalytic domain
Dusp28
interactor200OGFr_III (PF04680): Opioid growth factor receptor repeat
DSPc (PF00782): Dual specificity phosphatase, catalytic domain
Epha2
oncogene, tumor suppressor31.0000Ephrin_lbd (PF01404): Ephrin receptor ligand binding domain
Laminin_EGF (PF00053): Laminin EGF domain
Ephrin_rec_like (PF07699): Putative ephrin-receptor like
fn3 (PF00041): Fibronectin type III domain
DUF2369 (PF10179): Uncharacterised conserved protein (DUF2369)
EphA2_TM (PF14575): Ephrin type-A receptor 2 transmembrane domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
Ephb1
interactor100Ephrin_lbd (PF01404): Ephrin receptor ligand binding domain
EGF_2 (PF07974): EGF-like domain
Ephrin_rec_like (PF07699): Putative ephrin-receptor like
cEGF (PF12662): Complement Clr-like EGF-like
fn3 (PF00041): Fibronectin type III domain
EphA2_TM (PF14575): Ephrin type-A receptor 2 transmembrane domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
Ephb2
tumor suppressor200Ephrin_lbd (PF01404): Ephrin receptor ligand binding domain
EGF_2 (PF07974): EGF-like domain
cEGF (PF12662): Complement Clr-like EGF-like
Ephrin_rec_like (PF07699): Putative ephrin-receptor like
fn3 (PF00041): Fibronectin type III domain
EphA2_TM (PF14575): Ephrin type-A receptor 2 transmembrane domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
SAM_1 (PF00536): SAM domain (Sterile alpha motif)
Fn1
oncogene80.5718.033fn1 (PF00039): Fibronectin type I domain
fn2 (PF00040): Fibronectin type II domain
fn3 (PF00041): Fibronectin type III domain
DUF2369 (PF10179): Uncharacterised conserved protein (DUF2369)
Fnbp1l
interactor100FCH (PF00611): Fes/CIP4, and EFC/F-BAR homology domain
DEDD_Tnp_IS110 (PF01548): Transposase
HR1 (PF02185): Hr1 repeat
CENP-Q (PF13094): CENP-Q, a CENPA-CAD centromere complex subunit
SH3_1 (PF00018): SH3 domain
Gadd45gip1
oncogene, tumor suppressor21.0000CR6_interact (PF10147): Growth arrest and DNA-damage-inducible proteins-interacting protein 1
Got1
interactor50.4005.667Aminotran_1_2 (PF00155): Aminotransferase class I and II
Itga4
interactor80.7621.867FG-GAP (PF01839): FG-GAP repeat
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
Integrin_alpha2 (PF08441): Integrin alpha
DUF1945 (PF09178): Domain of unknown function (DUF1945)
Integrin_alpha (PF00357): Integrin alpha cytoplasmic region
LOC103738088
interactor31.0000SH2 (PF00017): SH2 domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
LOC103748852
interactor80.33313.333Recep_L_domain (PF01030): Receptor L domain
Furin-like (PF00757): Furin-like cysteine rich region
GF_recep_IV (PF14843): Growth factor receptor domain IV
Mcm2
oncogene110.44419.333MCM2_N (PF12619): Mini-chromosome maintenance protein 2
MCM_N (PF14551): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
AAA_3 (PF07726): ATPase family associated with various cellular activities (AAA)
MCM (PF00493): MCM2/3/5 family
Mrpl20
interactor100Ribosomal_L20 (PF00453): Ribosomal protein L20
Pcbp1
oncogene90.47213.733KH_1 (PF00013): KH domain
KH_2 (PF07650): KH domain
Bac_chlorC (PF02043): Bacteriochlorophyll C binding protein
Pitpna
oncogene21.0000IP_trans (PF02121): Phosphatidylinositol transfer protein
Ppil3
interactor30.6670.667Pro_isomerase (PF00160): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Rpl12
interactor60.6672.233Ribosomal_L11_N (PF03946): Ribosomal protein L11, N-terminal domain
Ribosomal_L11 (PF00298): Ribosomal protein L11, RNA binding domain
Taldo1
interactor60.4677.167TAL_FSA (PF00923): Transaldolase/Fructose-6-phosphate aldolase
Tkt
interactor60.8001.167Transketolase_N (PF00456): Transketolase, thiamine diphosphate binding domain
Transket_pyr (PF02779): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780): Transketolase, C-terminal domain
Tktl2
interactor21.0000Transketolase_N (PF00456): Transketolase, thiamine diphosphate binding domain
TPP_enzyme_C (PF02775): Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
Transket_pyr (PF02779): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780): Transketolase, C-terminal domain
Vcam1
interactor70.6194.700I-set (PF07679): Immunoglobulin I-set domain
C2-set (PF05790): Immunoglobulin C2-set domain
ig (PF00047): Immunoglobulin domain
Ig_2 (PF13895): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
V-set (PF07686): Immunoglobulin V-set domain
Zbtb43
interactor200BTB (PF00651): BTB/POZ domain
zf-C2H2_8 (PF15909): C2H2-type zinc ribbon
zf-C2H2 (PF00096): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465): Zinc-finger double domain
DUF2256 (PF10013): Uncharacterized protein conserved in bacteria (DUF2256)

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