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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Acox1 (from a repository: Fri Apr 20 23:48:16 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)32
The number (and %) of the onco-proteins7 (21.88 %)
The number (and %) of the tumor suppressors3 (9.38 %)
Total number of binary PPIs (saturation %)49 (9.88 %)
The number (and %) of affected PPIs31 (63.27 %)
PPI diameter2
PPI radius1
The average degree of PPI2.500
Assortativity coefficient-0.3166
The network average Clustering coefficient0.260
The number (and %) of a zero Clustering coefficients21 (65.62 %)
The number (and %) of a zero Betweenness Centrality27 (84.38 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure		 Type Number
of PPI (degree)		 Clustering
Coefficient		 Betweenness
Centrality		 Domains (Pfam ID): description
Acox1

Domain structure obtained by HMM

Protein ID: XP_008829582.1 - peroxisomal acyl-coenzyme A oxidase 1 isoform X1
KEEG Ortholog ID: K00232
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Acyl-CoA_ox_NPF147491253.4e-39120.5001513215133Acyl-coenzyme A oxidase N-terminal
Acyl-CoA_dh_MPF02770970.000000000000009141.000136244135245Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_1PF004411500.0000002517.200321435276436Acyl-CoA dehydrogenase, C-terminal domain
ACOXPF017561803.2e-71224.800480657479659Acyl-CoA oxidase
user protein310.019894.000Acyl-CoA_ox_N (PF14749): Acyl-coenzyme A oxidase N-terminal
Acyl-CoA_dh_M (PF02770): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_1 (PF00441): Acyl-CoA dehydrogenase, C-terminal domain
ACOX (PF01756): Acyl-CoA oxidase
Acbd7

Domain structure obtained by HMM

Protein ID: XP_008832558.1 - acyl-CoA-binding domain-containing protein 7
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
ACBPPF00887855.9e-3192.900483484Acyl CoA binding protein
DUF2786PF10979400.00001111.60074886588Protein of unknown function (DUF2786)
interactor100ACBP (PF00887): Acyl CoA binding protein
DUF2786 (PF10979): Protein of unknown function (DUF2786)
Adamtsl1

Domain structure obtained by HMM

Protein ID: XP_008843766.1 - ADAMTS-like protein 1
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
TSP_1PF00090490.0000000009624.90038813781Thrombospondin type 1 domain
ADAM_spacer1PF059861140.00000009118.400188293186296ADAM-TS Spacer 1
TSP_1PF00090490.00115.500308322303359Thrombospondin type 1 domain
TSP_1PF00090490.00000001221.400383407381437Thrombospondin type 1 domain
TSP_1PF00090490.000000001324.500443483441492Thrombospondin type 1 domain
TSP_1PF00090490.0000000002426.900530575528583Thrombospondin type 1 domain
TSP_1PF00090490.000188.000616666612666Thrombospondin type 1 domain
TSP_1PF00090490.000000001224.600673698671728Thrombospondin type 1 domain
TSP_1PF00090490.0000000009824.900736788734788Thrombospondin type 1 domain
TSP_1PF00090490.000000004622.700795821790849Thrombospondin type 1 domain
Ig_3PF13927790.00000000006929.000892949887950Immunoglobulin domain
I-setPF07679900.000000000000007141.2001196126511791266Immunoglobulin I-set domain
Ig_3PF13927797.9e-1748.0001284135612841356Immunoglobulin domain
V-setPF076861090.0000005416.1001333136913241370Immunoglobulin V-set domain
I-setPF07679900.000000000000004541.8001404148513961485Immunoglobulin I-set domain
TSP_1PF00090490.0122.1001497154414941544Thrombospondin type 1 domain
TSP_1PF00090490.000000004122.9001551160615461606Thrombospondin type 1 domain
TSP_1PF00090490.00493.4001611166516101665Thrombospondin type 1 domain
TSP_1PF00090490.000138.5001672170316701729Thrombospondin type 1 domain
PLACPF08686320.00000000008728.7001729175817291759PLAC (protease and lacunin) domain
interactor100TSP_1 (PF00090): Thrombospondin type 1 domain
ADAM_spacer1 (PF05986): ADAM-TS Spacer 1
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
V-set (PF07686): Immunoglobulin V-set domain
PLAC (PF08686): PLAC (protease and lacunin) domain
Atoh1

Domain structure obtained by HMM

Protein ID: XP_008842844.1 - protein atonal homolog 1
KEEG Ortholog ID: K09083
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
HLHPF00010553.5e-2161.300156207156208Helix-loop-helix DNA-binding domain
interactor100HLH (PF00010): Helix-loop-helix DNA-binding domain
Boc

Domain structure obtained by HMM

Protein ID: XP_008845215.1 - brother of CDO isoform X3
KEEG Ortholog ID: K20020
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Ig_3PF13927790.000000000000635.6003610936109Immunoglobulin domain
Ig_3PF13927790.000000001724.500138204132204Immunoglobulin domain
V-setPF076861090.000001115.100182221172222Immunoglobulin V-set domain
Ig_3PF13927793e-1852.600236303230303Immunoglobulin domain
Izumo-IgPF16706880.0000569.500284320239323Izumo-like Immunoglobulin domain
I-setPF07679903e-2161.700323406323408Immunoglobulin I-set domain
ISET-FN3_linkerPF16625657e-3399.300409473409473Unstructured linking region I-set and fnIII on Brother of CDO
fn3PF00041850.000000000000834.900485559477561Fibronectin type III domain
Ig_3PF13927790.0550.500556586549621Immunoglobulin domain
fn3PF00041852.6e-1749.300608693607693Fibronectin type III domain
fn3PF00041850.00000000002130.300719802716802Fibronectin type III domain
oncogene100Ig_3 (PF13927): Immunoglobulin domain
V-set (PF07686): Immunoglobulin V-set domain
Izumo-Ig (PF16706): Izumo-like Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
ISET-FN3_linker (PF16625): Unstructured linking region I-set and fnIII on Brother of CDO
fn3 (PF00041): Fibronectin type III domain
Cat

Domain structure obtained by HMM

Protein ID: XP_008850582.1 - catalase
KEEG Ortholog ID: K03781
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
CatalasePF001993821.7e-200652.0002841028411Catalase
Catalase-relPF06628658.3e-2366.700436496434497Catalase-related immune-responsive
interactor, tumor suppressor40.6671.000Catalase (PF00199): Catalase
Catalase-rel (PF06628): Catalase-related immune-responsive
Ddx19b

Domain structure obtained by HMM

Protein ID: XP_017651060.1 - ATP-dependent RNA helicase DDX19B isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DEADPF002701760.000000000000009341.00025973100DEAD/DEAH box helicase
PhaP_BmegPF096021680.0220.9009413090142Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg)
Helicase_CPF002711115.3e-3193.600136250135250Helicase conserved C-terminal domain
PhaP_BmegPF096021680.0000459.600185281165287Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg)
interactor100DEAD (PF00270): DEAD/DEAH box helicase
PhaP_Bmeg (PF09602): Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg)
Helicase_C (PF00271): Helicase conserved C-terminal domain
Dusp14

Domain structure obtained by HMM

Protein ID: XP_008846310.1 - dual specificity protein phosphatase 14
KEEG Ortholog ID: K14165
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DSPcPF007821338.9e-41125.1003416234164Dual specificity phosphatase, catalytic domain
interactor100DSPc (PF00782): Dual specificity phosphatase, catalytic domain
Eci1

Domain structure obtained by HMM

Protein ID: XP_008843505.1 - enoyl-CoA delta isomerase 1, mitochondrial
KEEG Ortholog ID: K13238
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
ECH_1PF003782515.8e-89283.8004028539288Enoyl-CoA hydratase/isomerase
interactor100ECH_1 (PF00378): Enoyl-CoA hydratase/isomerase
Fam60a

Domain structure obtained by HMM

Protein ID: XP_017651998.1 - protein FAM60A
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
FAM60APF153962121.1e-86276.40021972198Protein Family FAM60A
interactor100FAM60A (PF15396): Protein Family FAM60A
Foxs1

Domain structure obtained by HMM

Protein ID: XP_008827610.1 - forkhead box protein S1
KEEG Ortholog ID: K09412
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
ForkheadPF00250821.7e-41126.8001810218103Forkhead domain
interactor100Forkhead (PF00250): Forkhead domain
Hnrnpf

Domain structure obtained by HMM

Protein ID: XP_008830911.1 - heterogeneous nuclear ribonucleoprotein F
KEEG Ortholog ID: K12898
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
RRM_1PF00076700.0000001817.20015831384RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14PF070841520.0131.9007010153117Thyroid hormone-inducible hepatic protein Spot 14
RRM_1PF00076702e-1645.900114181113182RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHFPF08080361.2e-2678.700255290255290RNPHF zinc finger
RRM_1PF00076700.0000000000007734.500293356291358RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
interactor21.0000RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080): RNPHF zinc finger
Khdrbs2

Domain structure obtained by HMM

Protein ID: XP_008844746.1 - KH domain-containing, RNA-binding, signal transduction-associated protein 2
KEEG Ortholog ID: K17843
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Sam68-YYPF16568546.3e-2470.900124178124178Tyrosine-rich domain of Sam68
interactor100Sam68-YY (PF16568): Tyrosine-rich domain of Sam68
LOC103729930

Domain structure obtained by HMM

Protein ID: XP_008826256.1 - cytochrome c oxidase subunit 6B1
KEEG Ortholog ID: K02267
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
COX6BPF02297764.8e-2367.60020811983Cytochrome oxidase c subunit VIb
interactor200COX6B (PF02297): Cytochrome oxidase c subunit VIb
Litaf

Domain structure obtained by HMM

Protein ID: XP_008828145.1 - lipopolysaccharide-induced tumor necrosis factor-alpha factor
KEEG Ortholog ID: K19363
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF3824PF128681480.0271.40023926108Domain of unknwon function (DUF3824)
zf-LITAF-likePF10601705.4e-3089.800104173103173LITAF-like zinc ribbon domain
tumor suppressor100DUF3824 (PF12868): Domain of unknwon function (DUF3824)
zf-LITAF-like (PF10601): LITAF-like zinc ribbon domain
M6pr

Domain structure obtained by HMM

Protein ID: XP_008823542.1 - cation-dependent mannose-6-phosphate receptor
KEEG Ortholog ID: K10089
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Man-6-P_recepPF021572788.1e-188608.40012781278Mannose-6-phosphate receptor
interactor100Man-6-P_recep (PF02157): Mannose-6-phosphate receptor
Mcm2

Domain structure obtained by HMM

Protein ID: XP_008826791.1 - DNA replication licensing factor MCM2 isoform X1
KEEG Ortholog ID: K02540
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
MCM2_NPF126191532.9e-2059.3006217650182Mini-chromosome maintenance protein 2
MCM_NPF145511049.1e-2057.500197285196288MCM N-terminal domain
MCM_OBPF172071264.8e-41125.800294420293422MCM OB domain
AAA_3PF077261310.000975.200421475401484ATPase family associated with various cellular activities (AAA)
MCMPF004933315.6e-144465.300461802460803MCM2/3/5 family
oncogene80.28615.000MCM2_N (PF12619): Mini-chromosome maintenance protein 2
MCM_N (PF14551): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
AAA_3 (PF07726): ATPase family associated with various cellular activities (AAA)
MCM (PF00493): MCM2/3/5 family
Mrpl12

Domain structure obtained by HMM

Protein ID: XP_008826719.1 - 39S ribosomal protein L12, mitochondrial
KEEG Ortholog ID: K02935
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Ribosomal_L12_NPF16320481e-1646.7006311563117Ribosomal protein L7/L12 dimerisation domain
Ribosomal_L12PF00542674.6e-2264.500135202135203Ribosomal protein L7/L12 C-terminal domain
interactor200Ribosomal_L12_N (PF16320): Ribosomal protein L7/L12 dimerisation domain
Ribosomal_L12 (PF00542): Ribosomal protein L7/L12 C-terminal domain
Nup62

Domain structure obtained by HMM

Protein ID: XP_008843343.1 - nuclear pore glycoprotein p62
KEEG Ortholog ID: K14306
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Nucleoporin_FGPF13634910.0560.7006772115Nucleoporin FG repeat region
Nucleoporin_FGPF13634910.0073.50010716989173Nucleoporin FG repeat region
Nucleoporin_FG2PF159675980.00491.400155322154339Nucleoporin FG repeated region
Nsp1_CPF050641161.3e-42130.600319424310424Nsp1-like C-terminal region
PUMAPF158261890.0000968.800418452395458Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
Laminin_IIPF060091380.00194.400431473417502Laminin Domain II
interactor31.0000Nucleoporin_FG (PF13634): Nucleoporin FG repeat region
Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
Nsp1_C (PF05064): Nsp1-like C-terminal region
PUMA (PF15826): Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
Laminin_II (PF06009): Laminin Domain II
Pex5

Domain structure obtained by HMM

Protein ID: XP_008823568.1 - peroxisomal biogenesis factor 5 isoform X1
KEEG Ortholog ID: K13342
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SHNi-TPRPF10516380.00323.3008610286104SHNi-TPR
Secretin_N_2PF07655950.00002611.100270302222309Secretin N-terminal domain
PRYPF13765490.0000349.800307340307346SPRY-associated domain
TPR_16PF13432680.00000008419.200343404341405Tetratricopeptide repeat
TPR_14PF13428440.00006610.200390412381414Tetratricopeptide repeat
TPR_1PF00515340.0000000001726.800491523490523Tetratricopeptide repeat
TPR_16PF13432680.0000000006126.000503556494558Tetratricopeptide repeat
TPR_12PF13424770.0000000007525.300526590522590Tetratricopeptide repeat
TPR_12PF13424770.0000002217.400561600556604Tetratricopeptide repeat
interactor21.0000SHNi-TPR (PF10516): SHNi-TPR
Secretin_N_2 (PF07655): Secretin N-terminal domain
PRY (PF13765): SPRY-associated domain
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_1 (PF00515): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Pnma1

Domain structure obtained by HMM

Protein ID: XP_008847991.1 - paraneoplastic antigen Ma1
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PNMAPF148933301.4e-137444.60013241325PNMA
oncogene21.0000PNMA (PF14893): PNMA
Ppwd1

Domain structure obtained by HMM

Protein ID: XP_008854349.2 - peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X1
KEEG Ortholog ID: K12736
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
WD40PF00400380.00002111.700130154122154WD domain, G-beta repeat
WD40PF00400380.000002414.700162198160198WD domain, G-beta repeat
WD40PF00400380.000001315.500321344313345WD domain, G-beta repeat
DUF505PF044586200.0000005614.300327424320431Protein of unknown function (DUF505)
Pro_isomerasePF001601597.5e-55171.700532681530682Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
interactor100WD40 (PF00400): WD domain, G-beta repeat
DUF505 (PF04458): Protein of unknown function (DUF505)
Pro_isomerase (PF00160): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Rab30

Domain structure obtained by HMM

Protein ID: XP_008842413.1 - ras-related protein Rab-30 isoform X1
KEEG Ortholog ID: K07917
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
RasPF000711621.6e-62196.0001116811172Ras family
oncogene100Ras (PF00071): Ras family
Rab6b

Domain structure obtained by HMM

Protein ID: XP_008849948.1 - ras-related protein Rab-6B
KEEG Ortholog ID: K07894
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
RasPF000711623.7e-63198.1001517315175Ras family
oncogene100Ras (PF00071): Ras family
Raf1

Domain structure obtained by HMM

Protein ID: XP_008853131.1 - RAF proto-oncogene serine/threonine-protein kinase isoform X1
KEEG Ortholog ID: K04366
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
RBDPF02196699.1e-3398.6005712957129Raf-like Ras-binding domain
C1_1PF00130533.3e-1645.300139186139187Phorbol esters/diacylglycerol binding domain (C1 domain)
Pkinase_TyrPF077142602.4e-67213.000371625369626Protein tyrosine kinase
oncogene31.0000RBD (PF02196): Raf-like Ras-binding domain
C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Reck

Domain structure obtained by HMM

Protein ID: XP_017657315.1 - LOW QUALITY PROTEIN: reversion-inducing cysteine-rich protein with Kazal motifs
KEEG Ortholog ID: K17461
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DBPF01682980.000257.70033561880DB module
DBPF01682980.000001514.800107203107204DB module
DBPF01682980.0440.500193245179270DB module
DNA_pol_E_BPF040422110.000006211.800234303224329DNA polymerase alpha/epsilon subunit B
Ldl_recept_aPF00057370.0221.400511529509532Low-density lipoprotein receptor domain class A
Pacifastin_IPF05375400.0141.500564582563587Pacifastin inhibitor (LCMII)
Pacifastin_IPF05375400.0000000004625.400596626595630Pacifastin inhibitor (LCMII)
Kazal_2PF07648420.0000002217.300639664639677Kazal-type serine protease inhibitor domain
Ldl_recept_aPF00057370.0000719.300706727701733Low-density lipoprotein receptor domain class A
Kazal_2PF07648420.0000001817.600722745722747Kazal-type serine protease inhibitor domain
Kazal_2PF07648420.0000003316.800763784760793Kazal-type serine protease inhibitor domain
VWCPF00093570.00175.000804834767834von Willebrand factor type C domain
tumor suppressor100DB (PF01682): DB module
DNA_pol_E_B (PF04042): DNA polymerase alpha/epsilon subunit B
Ldl_recept_a (PF00057): Low-density lipoprotein receptor domain class A
Pacifastin_I (PF05375): Pacifastin inhibitor (LCMII)
Kazal_2 (PF07648): Kazal-type serine protease inhibitor domain
VWC (PF00093): von Willebrand factor type C domain
Rida

Domain structure obtained by HMM

Protein ID: XP_008829763.1 - ribonuclease UK114
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Ribonuc_L-PSPPF010421212.9e-48149.1001312811129Endoribonuclease L-PSP
interactor200Ribonuc_L-PSP (PF01042): Endoribonuclease L-PSP
Rplp0

Domain structure obtained by HMM

Protein ID: XP_008838692.1 - 60S acidic ribosomal protein P0
KEEG Ortholog ID: K02941
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Ribosomal_L10PF004661003.4e-2677.60081045106Ribosomal protein L10
Ribosomal_60sPF00428888.1e-2573.60023131823131860s Acidic ribosomal protein
interactor21.0000Ribosomal_L10 (PF00466): Ribosomal protein L10
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
Slc2a4

Domain structure obtained by HMM

Protein ID: XP_008854062.1 - solute carrier family 2, facilitated glucose transporter member 4 isoform X1
KEEG Ortholog ID: K07191
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Sugar_trPF000834522.3e-157510.4002848327483Sugar (and other) transporter
interactor100Sugar_tr (PF00083): Sugar (and other) transporter
Tmed9

Domain structure obtained by HMM

Protein ID: XP_008829029.1 - transmembrane emp24 domain-containing protein 9
KEEG Ortholog ID: K20346
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
EMP24_GP25LPF011051828.6e-59184.7003723037230emp24/gp25L/p24 family/GOLD
interactor100EMP24_GP25L (PF01105): emp24/gp25L/p24 family/GOLD
Uba5

Domain structure obtained by HMM

Protein ID: XP_008830889.1 - ubiquitin-like modifier-activating enzyme 5 isoform X1
KEEG Ortholog ID: K12164
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Pox_A_type_incPF04508230.000001714.100320320Viral A-type inclusion protein repeat
ThiFPF008992448.8e-52162.0005330853310ThiF family
interactor40.6671.000Pox_A_type_inc (PF04508): Viral A-type inclusion protein repeat
ThiF (PF00899): ThiF family
Ube2d2

Domain structure obtained by HMM

Protein ID: XP_008842509.1 - ubiquitin-conjugating enzyme E2 D2
KEEG Ortholog ID: K06689
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
UQ_conPF001791404.1e-58181.20051415142Ubiquitin-conjugating enzyme
oncogene40.6671.000UQ_con (PF00179): Ubiquitin-conjugating enzyme

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