Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape.js taxid = 1026970 for: protein(s) Acot13 (from a repository: Wed Apr 11 19:27:28 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins4 (21.05 %)
The number (and %) of the tumor suppressors1 (5.26 %)
Total number of binary PPIs (saturation %)33 (19.30 %)
The number (and %) of affected PPIs19 (57.58 %)
PPI diameter2
PPI radius1
The average degree of PPI2.947
Assortativity coefficient-0.3505
The network average Clustering coefficient0.539
The number (and %) of a zero Clustering coefficients6 (31.58 %)
The number (and %) of a zero Betweenness Centrality14 (73.68 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure		 Type Number
of PPI (degree)		 Clustering
Coefficient		 Betweenness
Centrality		 Domains (Pfam ID): description
Acot13

Domain structure obtained by HMM

Protein ID: XP_008845316.1 - acyl-coenzyme A thioesterase 13
KEEG Ortholog ID: K17362
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF4442PF145391320.000001714.400299524137Domain of unknown function (DUF4442)
4HBTPF03061791.8e-2059.4005212552129Thioesterase superfamily
user protein190.065271.000DUF4442 (PF14539): Domain of unknown function (DUF4442)
4HBT (PF03061): Thioesterase superfamily
Atic

Domain structure obtained by HMM

Protein ID: XP_008823898.1 - bifunctional purine biosynthesis protein PURH
KEEG Ortholog ID: K00602
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
MGSPF02142951.2e-2782.3001613016130MGS-like domain
AICARFT_IMPCHasPF018082951.1e-99319.700135461135461AICARFT/IMPCHase bienzyme
oncogene30.6671.000MGS (PF02142): MGS-like domain
AICARFT_IMPCHas (PF01808): AICARFT/IMPCHase bienzyme
Eci2

Domain structure obtained by HMM

Protein ID: XP_008829886.1 - enoyl-CoA delta isomerase 2, mitochondrial isoform X3
KEEG Ortholog ID: K13239
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
ACBPPF00887851.2e-33101.5003811638118Acyl CoA binding protein
ECH_1PF003782511.9e-45141.200145386143390Enoyl-CoA hydratase/isomerase
interactor31.0000ACBP (PF00887): Acyl CoA binding protein
ECH_1 (PF00378): Enoyl-CoA hydratase/isomerase
Fn1

Domain structure obtained by HMM

Protein ID: XP_008823890.1 - fibronectin isoform X5
KEEG Ortholog ID: K05717
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
fn1PF00039400.00000000000006638.20053885388Fibronectin type I domain
fn1PF00039402.2e-1852.5009813698136Fibronectin type I domain
fn1PF00039404.1e-1748.500142180142180Fibronectin type I domain
fn1PF00039409.3e-1953.700187226187226Fibronectin type I domain
fn1PF00039404e-1954.900232271232271Fibronectin type I domain
fn1PF00039400.000000007822.000312341309343Fibronectin type I domain
fn2PF00040421.6e-2162.600361402361402Fibronectin type II domain
fn2PF00040428.8e-2160.300421462421462Fibronectin type II domain
fn1PF00039401.3e-1853.200471509471509Fibronectin type I domain
fn1PF00039401.2e-1647.000523556519556Fibronectin type I domain
fn1PF00039401.9e-1749.500562600562600Fibronectin type I domain
fn3PF00041854.8e-1645.200615689610692Fibronectin type III domain
fn3PF00041851.5e-1646.900727798722801Fibronectin type III domain
fn3PF00041851.5e-2266.100812888812891Fibronectin type III domain
DUF2369PF10179950.0000006616.100861921859926Uncharacterised conserved protein (DUF2369)
fn3PF00041853.5e-2058.500908986908988Fibronectin type III domain
fn3PF00041855.7e-2057.80099810769981078Fibronectin type III domain
fn3PF00041850.0000000001427.7001096115910931163Fibronectin type III domain
fn3PF00041857.6e-1851.0001175125411751258Fibronectin type III domain
fn3PF00041852.6e-1955.7001268134612681347Fibronectin type III domain
fn3PF00041851.1e-2163.3001360143713591439Fibronectin type III domain
fn3PF00041851.1e-2369.7001450153014491530Fibronectin type III domain
DUF2369PF10179950.00004810.1001498154014971578Uncharacterised conserved protein (DUF2369)
fn3PF00041852.1e-2265.6001543162215431623Fibronectin type III domain
fn3PF00041852.1e-1646.4001634171116331713Fibronectin type III domain
fn3PF00041858.6e-2160.5001723179817231803Fibronectin type III domain
fn3PF00041851.3e-1956.6001815189018151894Fibronectin type III domain
fn3PF00041852.6e-2162.1001904198219041984Fibronectin type III domain
fn3PF00041850.0000000000230.4002093215320852157Fibronectin type III domain
fn1PF00039405.6e-1851.2002181222021812220Fibronectin type I domain
fn1PF00039401.3e-1646.8002226226322262263Fibronectin type I domain
fn1PF00039400.0000000000007134.9002270230522702305Fibronectin type I domain
oncogene60.33310.000fn1 (PF00039): Fibronectin type I domain
fn2 (PF00040): Fibronectin type II domain
fn3 (PF00041): Fibronectin type III domain
DUF2369 (PF10179): Uncharacterised conserved protein (DUF2369)
Klc2

Domain structure obtained by HMM

Protein ID: XP_008820472.1 - kinesin light chain 2 isoform X1
KEEG Ortholog ID: K10407
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
TMF_TATA_bdPF123251150.0000003716.6007513771149TATA element modulatory factor 1 TATA binding
KASH_CCDPF146621910.00002410.4009217179175Coiled-coil region of CCDC155 or KASH
TPR_12PF13424778.3e-2160.400198272196272Tetratricopeptide repeat
TPR_12PF13424779.1e-2263.500281354280356Tetratricopeptide repeat
TPR_12PF13424773.1e-2058.600327395322397Tetratricopeptide repeat
TPR_10PF13374420.000001214.600450480450483Tetratricopeptide repeat
TPR_14PF13428440.120.000546562543568Tetratricopeptide repeat
interactor100TMF_TATA_bd (PF12325): TATA element modulatory factor 1 TATA binding
KASH_CCD (PF14662): Coiled-coil region of CCDC155 or KASH
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_10 (PF13374): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
Kpna2

Domain structure obtained by HMM

Protein ID: XP_008839829.1 - importin subunit alpha-1
KEEG Ortholog ID: K15043
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
IBBPF01749876.5e-35105.70013981398Importin beta binding domain
ArmPF00514410.000000000002732.700109149108149Armadillo/beta-catenin-like repeat
ArmPF00514410.000000000000003941.800151190151191Armadillo/beta-catenin-like repeat
ArmPF00514410.00000000000002639.200196238193238Armadillo/beta-catenin-like repeat
ArmPF00514410.00000000001130.800251279241280Armadillo/beta-catenin-like repeat
ArmPF00514410.00000000006528.400283321282322Armadillo/beta-catenin-like repeat
ArmPF00514410.000000000000001742.900324364324364Armadillo/beta-catenin-like repeat
ArmPF00514410.000000000002532.900367405366406Armadillo/beta-catenin-like repeat
ArmPF00514410.00000000002529.700410447409448Armadillo/beta-catenin-like repeat
Arm_3PF16186531.4e-2884.600458509458509Atypical Arm repeat
interactor21.0000IBB (PF01749): Importin beta binding domain
Arm (PF00514): Armadillo/beta-catenin-like repeat
Arm_3 (PF16186): Atypical Arm repeat
Lman2l

Domain structure obtained by HMM

Protein ID: XP_008836242.1 - VIP36-like protein isoform X1
KEEG Ortholog ID: K10083
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Lectin_leg-likePF033882308.2e-86273.2004928548286Legume-like lectin family
PMP1_2PF08114430.000001414.300326354319357ATPase proteolipid family
interactor100Lectin_leg-like (PF03388): Legume-like lectin family
PMP1_2 (PF08114): ATPase proteolipid family
Ndufaf2

Domain structure obtained by HMM

Protein ID: XP_008819676.1 - mimitin, mitochondrial isoform X2
KEEG Ortholog ID: K18160
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
NDUFA12PF05071962.3e-1646.8002210220160NADH ubiquinone oxidoreductase subunit NDUFA12
interactor100NDUFA12 (PF05071): NADH ubiquinone oxidoreductase subunit NDUFA12
Ndufs3

Domain structure obtained by HMM

Protein ID: XP_008841845.1 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
KEEG Ortholog ID: K03936
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Complex1_30kDaPF003291221.3e-48150.9008620685207Respiratory-chain NADH dehydrogenase, 30 Kd subunit
interactor50.5003.000Complex1_30kDa (PF00329): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
Pctp

Domain structure obtained by HMM

Protein ID: XP_017654907.1 - phosphatidylcholine transfer protein isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
STARTPF018522092.9e-3297.9001217010205START domain
interactor100START (PF01852): START domain
Pdia6

Domain structure obtained by HMM

Protein ID: XP_008848336.1 - protein disulfide-isomerase A6
KEEG Ortholog ID: K09584
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
ThioredoxinPF000851048e-35105.3002712526129Thioredoxin
FAD_binding_7PF034411890.00001610.70010813359135FAD binding domain of DNA photolyase
ThioredoxinPF000851044.6e-35106.000162263161267Thioredoxin
Thioredoxin_6PF138481840.000000001124.700209386201387Thioredoxin-like domain
interactor21.0000Thioredoxin (PF00085): Thioredoxin
FAD_binding_7 (PF03441): FAD binding domain of DNA photolyase
Thioredoxin_6 (PF13848): Thioredoxin-like domain
Ptpa

Domain structure obtained by HMM

Protein ID: XP_008824212.1 - serine/threonine-protein phosphatase 2A activator
KEEG Ortholog ID: K17605
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PTPAPF030953012.3e-129417.2002631626317Phosphotyrosyl phosphate activator (PTPA) protein
oncogene, tumor suppressor100PTPA (PF03095): Phosphotyrosyl phosphate activator (PTPA) protein
Pus7

Domain structure obtained by HMM

Protein ID: XP_008828961.1 - pseudouridylate synthase 7 homolog isoform X1
KEEG Ortholog ID: K06176
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
TruDPF011424160.0000001916.200155186154252tRNA pseudouridine synthase D (TruD)
TruDPF011424164.9e-73232.300299689286689tRNA pseudouridine synthase D (TruD)
interactor21.0000TruD (PF01142): tRNA pseudouridine synthase D (TruD)
Rbbp6

Domain structure obtained by HMM

Protein ID: XP_008847428.1 - E3 ubiquitin-protein ligase RBBP6 isoform X1
KEEG Ortholog ID: K10624
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DWNNPF08783748.5e-34102.100476476DWNN domain
zf-CCHC_2PF13696210.0000000000001736.500156176156176Zinc knuckle
U-boxPF04564730.0000000002426.800291363291365U-box domain
Ndc1_NupPF095316130.00113.800366476350522Nucleoporin protein Ndc1-Nup
DUF1777PF086481710.0231.100560675553722Protein of unknown function (DUF1777)
TMEM171PF154713200.00123.900642695636714Transmembrane protein family 171
IncAPF041561900.00462.900674718665735IncA protein
DUF936PF060756890.00262.700685796645870Plant protein of unknown function (DUF936)
FXMRP1_C_corePF122351360.00513.700913982891989Fragile X-related 1 protein core C terminal
PheromonePF08015690.0790.4001102112510891128Fungal mating-type pheromone
IncAPF041561900.0260.4001319142012691432IncA protein
Auxin_canalisPF057032550.0000828.7001654174716321753Auxin canalisation
IncAPF041561900.000187.5001713182817111840IncA protein
oncogene21.0000DWNN (PF08783): DWNN domain
zf-CCHC_2 (PF13696): Zinc knuckle
U-box (PF04564): U-box domain
Ndc1_Nup (PF09531): Nucleoporin protein Ndc1-Nup
DUF1777 (PF08648): Protein of unknown function (DUF1777)
TMEM171 (PF15471): Transmembrane protein family 171
IncA (PF04156): IncA protein
DUF936 (PF06075): Plant protein of unknown function (DUF936)
FXMRP1_C_core (PF12235): Fragile X-related 1 protein core C terminal
Pheromone (PF08015): Fungal mating-type pheromone
Auxin_canalis (PF05703): Auxin canalisation
Sbds

Domain structure obtained by HMM

Protein ID: XP_008837362.1 - ribosome maturation protein SBDS
KEEG Ortholog ID: K14574
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SBDSPF01172884.5e-37112.4001410114101Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_CPF093771161.5e-43133.800107224107225SBDS protein C-terminal domain
oncogene100SBDS (PF01172): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377): SBDS protein C-terminal domain
Snu13

Domain structure obtained by HMM

Protein ID: XP_008843015.1 - NHP2-like protein 1
KEEG Ortholog ID: K12845
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Ribosomal_L7AePF01248951.4e-2988.0002111120114Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
interactor40.6671.000Ribosomal_L7Ae (PF01248): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Trnt1

Domain structure obtained by HMM

Protein ID: XP_008852783.1 - CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PolyA_polPF017431262.5e-37114.4001914219142Poly A polymerase head domain
PolyA_pol_RNAbdPF12627640.000000000000007840.800178227176232Probable RNA and SrmB- binding site of polymerase A
Imm64PF156001950.00001311.100192312188316Immunity protein 64
interactor21.0000PolyA_pol (PF01743): Poly A polymerase head domain
PolyA_pol_RNAbd (PF12627): Probable RNA and SrmB- binding site of polymerase A
Imm64 (PF15600): Immunity protein 64
Tsfm

Domain structure obtained by HMM

Protein ID: XP_008842260.1 - elongation factor Ts, mitochondrial isoform X1
KEEG Ortholog ID: K02357
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
ARA70PF124891330.00000612.700649525188Nuclear coactivator
EF_TSPF008892087.1e-2573.900117269117275Elongation factor TS
EF_TSPF008892080.00000009418.000281318279318Elongation factor TS
interactor21.0000ARA70 (PF12489): Nuclear coactivator
EF_TS (PF00889): Elongation factor TS
Ube2n

Domain structure obtained by HMM

Protein ID: XP_017651379.1 - ubiquitin-conjugating enzyme E2 N
KEEG Ortholog ID: K10580
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
UQ_conPF001791404.6e-52161.60071427144Ubiquitin-conjugating enzyme
interactor31.0000UQ_con (PF00179): Ubiquitin-conjugating enzyme

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