Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Acot13
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Visible interactions:

Visible interactors:

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Visualization interactions

Cytoscape Web taxid = 1026970 for: protein(s) Acot13 (from a repository: Wed Apr 11 19:27:28 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	19
The number (and %) of the onco-proteins	4 (21.05 %)
The number (and %) of the tumor suppressors	1 (5.26 %)
Total number of binary PPIs (saturation %)	33 (19.30 %)
The number (and %) of affected PPIs	19 (57.58 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	2.947
Assortativity coefficient	-0.3505
The network average Clustering coefficient	0.539
The number (and %) of a zero Clustering coefficients	6 (31.58 %)
The number (and %) of a zero Betweenness Centrality	14 (73.68 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Acot13

XP_008845316.1

Domain structure obtained by HMM

Protein ID: XP_008845316.1 - acyl-coenzyme A thioesterase 13
KEEG Ortholog ID: K17362

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF4442	PF14539	132	0.0000017	14.400	29	95	24	137	Domain of unknown function (DUF4442)
4HBT	PF03061	79	1.8e-20	59.400	52	125	52	129	Thioesterase superfamily

user protein

0.065

271.000

DUF4442 (PF14539): Domain of unknown function (DUF4442)
4HBT (PF03061): Thioesterase superfamily

Atic

XP_008823898.1

Domain structure obtained by HMM

Protein ID: XP_008823898.1 - bifunctional purine biosynthesis protein PURH
KEEG Ortholog ID: K00602

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
MGS	PF02142	95	1.2e-27	82.300	16	130	16	130	MGS-like domain
AICARFT_IMPCHas	PF01808	295	1.1e-99	319.700	135	461	135	461	AICARFT/IMPCHase bienzyme

oncogene

0.667

1.000

MGS (PF02142): MGS-like domain
AICARFT_IMPCHas (PF01808): AICARFT/IMPCHase bienzyme

Eci2

XP_008829886.1

Domain structure obtained by HMM

Protein ID: XP_008829886.1 - enoyl-CoA delta isomerase 2, mitochondrial isoform X3
KEEG Ortholog ID: K13239

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
ACBP	PF00887	85	1.2e-33	101.500	38	116	38	118	Acyl CoA binding protein
ECH_1	PF00378	251	1.9e-45	141.200	145	386	143	390	Enoyl-CoA hydratase/isomerase

interactor

1.000

ACBP (PF00887): Acyl CoA binding protein
ECH_1 (PF00378): Enoyl-CoA hydratase/isomerase

Fn1

XP_008823890.1

Domain structure obtained by HMM

Protein ID: XP_008823890.1 - fibronectin isoform X5
KEEG Ortholog ID: K05717

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
fn1	PF00039	40	0.000000000000066	38.200	53	88	53	88	Fibronectin type I domain
fn1	PF00039	40	2.2e-18	52.500	98	136	98	136	Fibronectin type I domain
fn1	PF00039	40	4.1e-17	48.500	142	180	142	180	Fibronectin type I domain
fn1	PF00039	40	9.3e-19	53.700	187	226	187	226	Fibronectin type I domain
fn1	PF00039	40	4e-19	54.900	232	271	232	271	Fibronectin type I domain
fn1	PF00039	40	0.0000000078	22.000	312	341	309	343	Fibronectin type I domain
fn2	PF00040	42	1.6e-21	62.600	361	402	361	402	Fibronectin type II domain
fn2	PF00040	42	8.8e-21	60.300	421	462	421	462	Fibronectin type II domain
fn1	PF00039	40	1.3e-18	53.200	471	509	471	509	Fibronectin type I domain
fn1	PF00039	40	1.2e-16	47.000	523	556	519	556	Fibronectin type I domain
fn1	PF00039	40	1.9e-17	49.500	562	600	562	600	Fibronectin type I domain
fn3	PF00041	85	4.8e-16	45.200	615	689	610	692	Fibronectin type III domain
fn3	PF00041	85	1.5e-16	46.900	727	798	722	801	Fibronectin type III domain
fn3	PF00041	85	1.5e-22	66.100	812	888	812	891	Fibronectin type III domain
DUF2369	PF10179	95	0.00000066	16.100	861	921	859	926	Uncharacterised conserved protein (DUF2369)
fn3	PF00041	85	3.5e-20	58.500	908	986	908	988	Fibronectin type III domain
fn3	PF00041	85	5.7e-20	57.800	998	1076	998	1078	Fibronectin type III domain
fn3	PF00041	85	0.00000000014	27.700	1096	1159	1093	1163	Fibronectin type III domain
fn3	PF00041	85	7.6e-18	51.000	1175	1254	1175	1258	Fibronectin type III domain
fn3	PF00041	85	2.6e-19	55.700	1268	1346	1268	1347	Fibronectin type III domain
fn3	PF00041	85	1.1e-21	63.300	1360	1437	1359	1439	Fibronectin type III domain
fn3	PF00041	85	1.1e-23	69.700	1450	1530	1449	1530	Fibronectin type III domain
DUF2369	PF10179	95	0.000048	10.100	1498	1540	1497	1578	Uncharacterised conserved protein (DUF2369)
fn3	PF00041	85	2.1e-22	65.600	1543	1622	1543	1623	Fibronectin type III domain
fn3	PF00041	85	2.1e-16	46.400	1634	1711	1633	1713	Fibronectin type III domain
fn3	PF00041	85	8.6e-21	60.500	1723	1798	1723	1803	Fibronectin type III domain
fn3	PF00041	85	1.3e-19	56.600	1815	1890	1815	1894	Fibronectin type III domain
fn3	PF00041	85	2.6e-21	62.100	1904	1982	1904	1984	Fibronectin type III domain
fn3	PF00041	85	0.00000000002	30.400	2093	2153	2085	2157	Fibronectin type III domain
fn1	PF00039	40	5.6e-18	51.200	2181	2220	2181	2220	Fibronectin type I domain
fn1	PF00039	40	1.3e-16	46.800	2226	2263	2226	2263	Fibronectin type I domain
fn1	PF00039	40	0.00000000000071	34.900	2270	2305	2270	2305	Fibronectin type I domain

oncogene

0.333

10.000

fn1 (PF00039): Fibronectin type I domain
fn2 (PF00040): Fibronectin type II domain
fn3 (PF00041): Fibronectin type III domain
DUF2369 (PF10179): Uncharacterised conserved protein (DUF2369)

Klc2

XP_008820472.1

Domain structure obtained by HMM

Protein ID: XP_008820472.1 - kinesin light chain 2 isoform X1
KEEG Ortholog ID: K10407

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
TMF_TATA_bd	PF12325	115	0.00000037	16.600	75	137	71	149	TATA element modulatory factor 1 TATA binding
KASH_CCD	PF14662	191	0.000024	10.400	92	171	79	175	Coiled-coil region of CCDC155 or KASH
TPR_12	PF13424	77	8.3e-21	60.400	198	272	196	272	Tetratricopeptide repeat
TPR_12	PF13424	77	9.1e-22	63.500	281	354	280	356	Tetratricopeptide repeat
TPR_12	PF13424	77	3.1e-20	58.600	327	395	322	397	Tetratricopeptide repeat
TPR_10	PF13374	42	0.0000012	14.600	450	480	450	483	Tetratricopeptide repeat
TPR_14	PF13428	44	0.12	0.000	546	562	543	568	Tetratricopeptide repeat

interactor

TMF_TATA_bd (PF12325): TATA element modulatory factor 1 TATA binding
KASH_CCD (PF14662): Coiled-coil region of CCDC155 or KASH
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_10 (PF13374): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat

Kpna2

XP_008839829.1

Domain structure obtained by HMM

Protein ID: XP_008839829.1 - importin subunit alpha-1
KEEG Ortholog ID: K15043

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
IBB	PF01749	87	6.5e-35	105.700	13	98	13	98	Importin beta binding domain
Arm	PF00514	41	0.0000000000027	32.700	109	149	108	149	Armadillo/beta-catenin-like repeat
Arm	PF00514	41	0.0000000000000039	41.800	151	190	151	191	Armadillo/beta-catenin-like repeat
Arm	PF00514	41	0.000000000000026	39.200	196	238	193	238	Armadillo/beta-catenin-like repeat
Arm	PF00514	41	0.000000000011	30.800	251	279	241	280	Armadillo/beta-catenin-like repeat
Arm	PF00514	41	0.000000000065	28.400	283	321	282	322	Armadillo/beta-catenin-like repeat
Arm	PF00514	41	0.0000000000000017	42.900	324	364	324	364	Armadillo/beta-catenin-like repeat
Arm	PF00514	41	0.0000000000025	32.900	367	405	366	406	Armadillo/beta-catenin-like repeat
Arm	PF00514	41	0.000000000025	29.700	410	447	409	448	Armadillo/beta-catenin-like repeat
Arm_3	PF16186	53	1.4e-28	84.600	458	509	458	509	Atypical Arm repeat

interactor

1.000

IBB (PF01749): Importin beta binding domain
Arm (PF00514): Armadillo/beta-catenin-like repeat
Arm_3 (PF16186): Atypical Arm repeat

Lman2l

XP_008836242.1

Domain structure obtained by HMM

Protein ID: XP_008836242.1 - VIP36-like protein isoform X1
KEEG Ortholog ID: K10083

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Lectin_leg-like	PF03388	230	8.2e-86	273.200	49	285	48	286	Legume-like lectin family
PMP1_2	PF08114	43	0.0000014	14.300	326	354	319	357	ATPase proteolipid family

interactor

Lectin_leg-like (PF03388): Legume-like lectin family
PMP1_2 (PF08114): ATPase proteolipid family

Ndufaf2

XP_008819676.1

Domain structure obtained by HMM

Protein ID: XP_008819676.1 - mimitin, mitochondrial isoform X2
KEEG Ortholog ID: K18160

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
NDUFA12	PF05071	96	2.3e-16	46.800	22	102	20	160	NADH ubiquinone oxidoreductase subunit NDUFA12

interactor

NDUFA12 (PF05071): NADH ubiquinone oxidoreductase subunit NDUFA12

Ndufs3

XP_008841845.1

Domain structure obtained by HMM

Protein ID: XP_008841845.1 - NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
KEEG Ortholog ID: K03936

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Complex1_30kDa	PF00329	122	1.3e-48	150.900	86	206	85	207	Respiratory-chain NADH dehydrogenase, 30 Kd subunit

interactor

0.500

3.000

Complex1_30kDa (PF00329): Respiratory-chain NADH dehydrogenase, 30 Kd subunit

Pctp

XP_017654907.1

Domain structure obtained by HMM

Protein ID: XP_017654907.1 - phosphatidylcholine transfer protein isoform X2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
START	PF01852	209	2.9e-32	97.900	12	170	10	205	START domain

interactor

START (PF01852): START domain

Pdia6

XP_008848336.1

Domain structure obtained by HMM

Protein ID: XP_008848336.1 - protein disulfide-isomerase A6
KEEG Ortholog ID: K09584

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Thioredoxin	PF00085	104	8e-35	105.300	27	125	26	129	Thioredoxin
FAD_binding_7	PF03441	189	0.000016	10.700	108	133	59	135	FAD binding domain of DNA photolyase
Thioredoxin	PF00085	104	4.6e-35	106.000	162	263	161	267	Thioredoxin
Thioredoxin_6	PF13848	184	0.0000000011	24.700	209	386	201	387	Thioredoxin-like domain

interactor

1.000

Thioredoxin (PF00085): Thioredoxin
FAD_binding_7 (PF03441): FAD binding domain of DNA photolyase
Thioredoxin_6 (PF13848): Thioredoxin-like domain

Ptpa

XP_008824212.1

Domain structure obtained by HMM

Protein ID: XP_008824212.1 - serine/threonine-protein phosphatase 2A activator
KEEG Ortholog ID: K17605

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PTPA	PF03095	301	2.3e-129	417.200	26	316	26	317	Phosphotyrosyl phosphate activator (PTPA) protein

oncogene, tumor suppressor

PTPA (PF03095): Phosphotyrosyl phosphate activator (PTPA) protein

Pus7

XP_008828961.1

Domain structure obtained by HMM

Protein ID: XP_008828961.1 - pseudouridylate synthase 7 homolog isoform X1
KEEG Ortholog ID: K06176

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
TruD	PF01142	416	0.00000019	16.200	155	186	154	252	tRNA pseudouridine synthase D (TruD)
TruD	PF01142	416	4.9e-73	232.300	299	689	286	689	tRNA pseudouridine synthase D (TruD)

interactor

1.000

TruD (PF01142): tRNA pseudouridine synthase D (TruD)

Rbbp6

XP_008847428.1

Domain structure obtained by HMM

Protein ID: XP_008847428.1 - E3 ubiquitin-protein ligase RBBP6 isoform X1
KEEG Ortholog ID: K10624

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DWNN	PF08783	74	8.5e-34	102.100	4	76	4	76	DWNN domain
zf-CCHC_2	PF13696	21	0.00000000000017	36.500	156	176	156	176	Zinc knuckle
U-box	PF04564	73	0.00000000024	26.800	291	363	291	365	U-box domain
Ndc1_Nup	PF09531	613	0.0011	3.800	366	476	350	522	Nucleoporin protein Ndc1-Nup
DUF1777	PF08648	171	0.023	1.100	560	675	553	722	Protein of unknown function (DUF1777)
TMEM171	PF15471	320	0.0012	3.900	642	695	636	714	Transmembrane protein family 171
IncA	PF04156	190	0.0046	2.900	674	718	665	735	IncA protein
DUF936	PF06075	689	0.0026	2.700	685	796	645	870	Plant protein of unknown function (DUF936)
FXMRP1_C_core	PF12235	136	0.0051	3.700	913	982	891	989	Fragile X-related 1 protein core C terminal
Pheromone	PF08015	69	0.079	0.400	1102	1125	1089	1128	Fungal mating-type pheromone
IncA	PF04156	190	0.026	0.400	1319	1420	1269	1432	IncA protein
Auxin_canalis	PF05703	255	0.000082	8.700	1654	1747	1632	1753	Auxin canalisation
IncA	PF04156	190	0.00018	7.500	1713	1828	1711	1840	IncA protein

oncogene

1.000

DWNN (PF08783): DWNN domain
zf-CCHC_2 (PF13696): Zinc knuckle
U-box (PF04564): U-box domain
Ndc1_Nup (PF09531): Nucleoporin protein Ndc1-Nup
DUF1777 (PF08648): Protein of unknown function (DUF1777)
TMEM171 (PF15471): Transmembrane protein family 171
IncA (PF04156): IncA protein
DUF936 (PF06075): Plant protein of unknown function (DUF936)
FXMRP1_C_core (PF12235): Fragile X-related 1 protein core C terminal
Pheromone (PF08015): Fungal mating-type pheromone
Auxin_canalis (PF05703): Auxin canalisation

Sbds

XP_008837362.1

Domain structure obtained by HMM

Protein ID: XP_008837362.1 - ribosome maturation protein SBDS
KEEG Ortholog ID: K14574

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SBDS	PF01172	88	4.5e-37	112.400	14	101	14	101	Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C	PF09377	116	1.5e-43	133.800	107	224	107	225	SBDS protein C-terminal domain

oncogene

SBDS (PF01172): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377): SBDS protein C-terminal domain

Snu13

XP_008843015.1

Domain structure obtained by HMM

Protein ID: XP_008843015.1 - NHP2-like protein 1
KEEG Ortholog ID: K12845

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Ribosomal_L7Ae	PF01248	95	1.4e-29	88.000	21	111	20	114	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

interactor

0.667

1.000

Ribosomal_L7Ae (PF01248): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

Trnt1

XP_008852783.1

Domain structure obtained by HMM

Protein ID: XP_008852783.1 - CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PolyA_pol	PF01743	126	2.5e-37	114.400	19	142	19	142	Poly A polymerase head domain
PolyA_pol_RNAbd	PF12627	64	0.0000000000000078	40.800	178	227	176	232	Probable RNA and SrmB- binding site of polymerase A
Imm64	PF15600	195	0.000013	11.100	192	312	188	316	Immunity protein 64

interactor

1.000

PolyA_pol (PF01743): Poly A polymerase head domain
PolyA_pol_RNAbd (PF12627): Probable RNA and SrmB- binding site of polymerase A
Imm64 (PF15600): Immunity protein 64

Tsfm

XP_008842260.1

Domain structure obtained by HMM

Protein ID: XP_008842260.1 - elongation factor Ts, mitochondrial isoform X1
KEEG Ortholog ID: K02357

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
ARA70	PF12489	133	0.000006	12.700	64	95	25	188	Nuclear coactivator
EF_TS	PF00889	208	7.1e-25	73.900	117	269	117	275	Elongation factor TS
EF_TS	PF00889	208	0.000000094	18.000	281	318	279	318	Elongation factor TS

interactor

1.000

ARA70 (PF12489): Nuclear coactivator
EF_TS (PF00889): Elongation factor TS

Ube2n

XP_017651379.1

Domain structure obtained by HMM

Protein ID: XP_017651379.1 - ubiquitin-conjugating enzyme E2 N
KEEG Ortholog ID: K10580

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
UQ_con	PF00179	140	4.6e-52	161.600	7	142	7	144	Ubiquitin-conjugating enzyme

interactor

1.000

UQ_con (PF00179): Ubiquitin-conjugating enzyme

B a c k t o T o p ⇑