Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Acot12
Level of PPIs:		or Upload text file:	Update repository

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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Acot12 (from a repository: Thu Apr 12 16:33:20 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	6
The number (and %) of the onco-proteins	1 (16.67 %)
The number (and %) of the tumor suppressors	0 (0.00 %)
Total number of binary PPIs (saturation %)	6 (40.00 %)
The number (and %) of affected PPIs	5 (83.33 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	1.667
Assortativity coefficient	0
The network average Clustering coefficient	0.000
The number (and %) of a zero Clustering coefficients	6 (100.00 %)
The number (and %) of a zero Betweenness Centrality	5 (83.33 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Acot12

XP_008851534.1

Domain structure obtained by HMM

Protein ID: XP_008851534.1 - acyl-coenzyme A thioesterase 12
KEEG Ortholog ID: K01067

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
4HBT	PF03061	79	0.000000000000019	40.200	27	95	24	97	Thioesterase superfamily
4HBT	PF03061	79	5e-17	48.400	197	271	197	274	Thioesterase superfamily
START	PF01852	209	4.1e-22	64.700	355	512	350	514	START domain

user protein

20.000

4HBT (PF03061): Thioesterase superfamily
START (PF01852): START domain

Acot11

XP_008831214.1

Domain structure obtained by HMM

Protein ID: XP_008831214.1 - acyl-coenzyme A thioesterase 11 isoform X1
KEEG Ortholog ID: K12417

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
4HBT	PF03061	79	0.0000000000037	32.800	68	134	63	136	Thioesterase superfamily
4HBT	PF03061	79	8.5e-16	44.400	235	304	235	311	Thioesterase superfamily
START	PF01852	209	2.4e-38	117.700	386	551	385	554	START domain

interactor

4HBT (PF03061): Thioesterase superfamily
START (PF01852): START domain

Inppl1

XP_008852272.1

Domain structure obtained by HMM

Protein ID: XP_008852272.1 - phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1
KEEG Ortholog ID: K15909

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SH2	PF00017	77	1.4e-19	56.300	21	102	21	102	SH2 domain
Exo_endo_phos	PF03372	113	0.00000000024	26.900	430	719	430	719	Endonuclease/Exonuclease/phosphatase family
SAM_1	PF00536	64	0.000000000002	33.700	1203	1256	1201	1259	SAM domain (Sterile alpha motif)

oncogene

SH2 (PF00017): SH2 domain
Exo_endo_phos (PF03372): Endonuclease/Exonuclease/phosphatase family
SAM_1 (PF00536): SAM domain (Sterile alpha motif)

Spag9

XP_008836608.1

Domain structure obtained by HMM

Protein ID: XP_008836608.1 - C-Jun-amino-terminal kinase-interacting protein 4 isoform X1
KEEG Ortholog ID: K20317

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Jnk-SapK_ap_N	PF09744	156	3.1e-62	195.600	5	159	5	160	JNK_SAPK-associated protein-1
DUF501	PF04417	141	0.0017	4.400	116	175	95	182	Protein of unknown function (DUF501)
JIP_LZII	PF16471	71	5.6e-34	102.500	394	464	394	464	JNK-interacting protein leucine zipper II
DUF972	PF06156	102	0.00002	11.500	421	480	419	496	Protein of unknown function (DUF972)
ERM	PF00769	243	0.00015	7.700	437	628	416	629	Ezrin/radixin/moesin family
TACC	PF05010	201	0.00047	6.100	604	647	593	649	Transforming acidic coiled-coil-containing protein (TACC)
IncA	PF04156	190	0.000066	8.900	698	744	695	753	IncA protein
Alanine_zipper	PF11839	97	0.0005	6.700	832	889	827	901	Alanine-zipper, major outer membrane lipoprotein
FYDLN_acid	PF09538	106	0.036	1.100	862	898	837	937	Protein of unknown function (FYDLN_acid)

interactor

Jnk-SapK_ap_N (PF09744): JNK_SAPK-associated protein-1
DUF501 (PF04417): Protein of unknown function (DUF501)
JIP_LZII (PF16471): JNK-interacting protein leucine zipper II
DUF972 (PF06156): Protein of unknown function (DUF972)
ERM (PF00769): Ezrin/radixin/moesin family
TACC (PF05010): Transforming acidic coiled-coil-containing protein (TACC)
IncA (PF04156): IncA protein
Alanine_zipper (PF11839): Alanine-zipper, major outer membrane lipoprotein
FYDLN_acid (PF09538): Protein of unknown function (FYDLN_acid)

Tlr5

XP_008821970.1

Domain structure obtained by HMM

Protein ID: XP_008821970.1 - toll-like receptor 5
KEEG Ortholog ID: K10168

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
LRR_8	PF13855	61	0.000018	10.700	49	78	46	79	Leucine rich repeat
LRR_8	PF13855	61	2.7e-17	48.700	85	131	83	131	Leucine rich repeat
LRR_8	PF13855	61	0.0000000011	24.200	135	182	134	182	Leucine rich repeat
LRR_1	PF00560	23	0.019	2.400	171	190	171	198	Leucine Rich Repeat
LRR_6	PF13516	24	0.0016	5.100	227	237	225	237	Leucine Rich repeat
LRR_8	PF13855	61	0.00000000000027	35.800	291	348	288	348	Leucine rich repeat
LRR_8	PF13855	61	0.00000000000013	36.800	341	396	341	396	Leucine rich repeat
LRR_4	PF12799	43	0.000041	10.300	384	413	384	443	Leucine Rich repeats (2 copies)
LRR_4	PF12799	43	0.0000072	12.700	448	486	448	491	Leucine Rich repeats (2 copies)
LRR_4	PF12799	43	0.0000049	13.200	474	515	474	525	Leucine Rich repeats (2 copies)
LRR_8	PF13855	61	1e-16	46.800	492	538	491	538	Leucine rich repeat
LRR_8	PF13855	61	0.00000000037	25.800	528	580	527	581	Leucine rich repeat
LRR_1	PF00560	23	0.0035	4.700	570	583	570	593	Leucine Rich Repeat
TIR	PF01582	176	1.7e-33	102.000	693	846	692	857	TIR domain

interactor

LRR_8 (PF13855): Leucine rich repeat
LRR_1 (PF00560): Leucine Rich Repeat
LRR_6 (PF13516): Leucine Rich repeat
LRR_4 (PF12799): Leucine Rich repeats (2 copies)
TIR (PF01582): TIR domain

Zmym6

XP_008827460.1

Domain structure obtained by HMM

Protein ID: XP_008827460.1 - zinc finger MYM-type protein 6

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
zf-FCS	PF06467	41	0.00000017	17.400	79	109	75	110	MYM-type Zinc finger with FCS sequence motif
zf-FCS	PF06467	41	0.00000000000022	36.300	121	161	120	161	MYM-type Zinc finger with FCS sequence motif
DUF2116	PF09889	59	0.0018	4.600	149	166	145	173	Uncharacterized protein containing a Zn-ribbon (DUF2116)
zf-FCS	PF06467	41	0.001	5.400	211	227	199	228	MYM-type Zinc finger with FCS sequence motif
zf-FCS	PF06467	41	0.000017	11.100	241	272	238	275	MYM-type Zinc finger with FCS sequence motif
RPAP2_Rtr1	PF04181	75	0.0011	5.600	257	280	244	281	Rtr1/RPAP2 family
zf-FCS	PF06467	41	0.000000033	19.700	353	387	351	387	MYM-type Zinc finger with FCS sequence motif
zf-FCS	PF06467	41	0.00000000027	26.400	393	425	392	425	MYM-type Zinc finger with FCS sequence motif
zf-FCS	PF06467	41	0.00000079	15.300	439	474	438	474	MYM-type Zinc finger with FCS sequence motif
C1_1	PF00130	53	0.00026	7.200	466	489	452	490	Phorbol esters/diacylglycerol binding domain (C1 domain)
zf-FCS	PF06467	41	0.00000039	16.300	481	515	479	515	MYM-type Zinc finger with FCS sequence motif
zf-BED	PF02892	44	0.0000015	14.500	699	730	687	730	BED zinc finger
DUF4371	PF14291	236	0.000014	11.000	817	921	790	927	Domain of unknown function (DUF4371)

interactor

zf-FCS (PF06467): MYM-type Zinc finger with FCS sequence motif
DUF2116 (PF09889): Uncharacterized protein containing a Zn-ribbon (DUF2116)
RPAP2_Rtr1 (PF04181): Rtr1/RPAP2 family
C1_1 (PF00130): Phorbol esters/diacylglycerol binding domain (C1 domain)
zf-BED (PF02892): BED zinc finger
DUF4371 (PF14291): Domain of unknown function (DUF4371)

B a c k t o T o p ⇑