Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Aco2 (from a repository: Mon Apr 23 22:49:49 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins2 (7.14 %)
The number (and %) of the tumor suppressors1 (3.57 %)
Total number of binary PPIs (saturation %)84 (22.22 %)
The number (and %) of affected PPIs27 (32.14 %)
PPI diameter2
PPI radius1
The average degree of PPI5.429
Assortativity coefficient-0.4002
The network average Clustering coefficient0.692
The number (and %) of a zero Clustering coefficients1 (3.57 %)
The number (and %) of a zero Betweenness Centrality11 (39.29 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Aco2
user protein270.140454.200Aconitase (PF00330): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694): Aconitase C-terminal domain
Acaa2
interactor60.6003.967Thiolase_N (PF00108): Thiolase, N-terminal domain
Thiolase_C (PF02803): Thiolase, C-terminal domain
Acat1
interactor70.6004.333Thiolase_N (PF00108): Thiolase, N-terminal domain
Thiolase_C (PF02803): Thiolase, C-terminal domain
Ak3
interactor100ADK (PF00406): Adenylate kinase
Aldh5a1
interactor21.0000Aldedh (PF00171): Aldehyde dehydrogenase family
Aldoa
interactor130.33336.333Glycolytic (PF00274): Fructose-bisphosphate aldolase class-I
Aldoc
interactor70.6674.167Glycolytic (PF00274): Fructose-bisphosphate aldolase class-I
App
interactor70.4006.167APP_N (PF02177): Amyloid A4 N-terminal heparin-binding
APP_Cu_bd (PF12924): Copper-binding of amyloid precursor, CuBD
SDA1 (PF05285): SDA1
YtxH (PF12732): YtxH-like protein
Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2 (PF12925): E2 domain of amyloid precursor protein
Beta-APP (PF03494): Beta-amyloid peptide (beta-APP)
APP_amyloid (PF10515): beta-amyloid precursor protein C-terminus
Asb9
interactor21.0000Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525): SOCS box
Atp1b1
interactor41.0000Na_K-ATPase (PF00287): Sodium / potassium ATPase beta chain
Atp5j
interactor21.0000ATP-synt_F6 (PF05511): Mitochondrial ATP synthase coupling factor 6
Atxn1l
interactor31.0000AXH (PF08517): Ataxin-1 and HBP1 module (AXH)
Ckb
interactor60.6674.500ATP-gua_PtransN (PF02807): ATP:guanido phosphotransferase, N-terminal domain
ATP-gua_Ptrans (PF00217): ATP:guanido phosphotransferase, C-terminal catalytic domain
Esd
interactor31.0000Esterase (PF00756): Putative esterase
Gpd1
interactor21.0000NAD_Gly3P_dh_N (PF01210): NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
Gpd1l
interactor50.7003.000NAD_Gly3P_dh_N (PF01210): NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
NAD_Gly3P_dh_C (PF07479): NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
Gpd2
interactor21.0000Pyr_redox_2 (PF07992): Pyridine nucleotide-disulphide oxidoreductase
DAO (PF01266): FAD dependent oxidoreductase
DAO_C (PF16901): C-terminal domain of alpha-glycerophosphate oxidase
EF-hand_7 (PF13499): EF-hand domain pair
Idh3a
interactor30.6671.000Iso_dh (PF00180): Isocitrate/isopropylmalate dehydrogenase
Idh3g
interactor21.0000Iso_dh (PF00180): Isocitrate/isopropylmalate dehydrogenase
Itga4
interactor60.7001.300FG-GAP (PF01839): FG-GAP repeat
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
Integrin_alpha2 (PF08441): Integrin alpha
DUF1945 (PF09178): Domain of unknown function (DUF1945)
Integrin_alpha (PF00357): Integrin alpha cytoplasmic region
Myh7b
interactor50.9000.500Myosin_N (PF02736): Myosin N-terminal SH3-like domain
Myosin_head (PF00063): Myosin head (motor domain)
YkuI_C (PF10388): EAL-domain associated signalling protein domain
Myosin_tail_1 (PF01576): Myosin tail
Ntrk1
oncogene150.24263.133LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Psmd4
interactor50.5003.900VWA_2 (PF13519): von Willebrand factor type A domain
VWA (PF00092): von Willebrand factor type A domain
UIM (PF02809): Ubiquitin interaction motif
Sin3a
oncogene31.0000PAH (PF02671): Paired amphipathic helix repeat
Sin3_corepress (PF08295): Sin3 family co-repressor
Sin3a_C (PF16879): C-terminal domain of Sin3a protein
Sod2
tumor suppressor70.4676.567Sod_Fe_N (PF00081): Iron/manganese superoxide dismutases, alpha-hairpin domain
Sod_Fe_C (PF02777): Iron/manganese superoxide dismutases, C-terminal domain
Srrm2
interactor30.6670.400cwf21 (PF08312): cwf21 domain
RR_TM4-6 (PF06459): Ryanodine Receptor TM 4-6
Plasmodium_Vir (PF05795): Plasmodium vivax Vir protein
CTD (PF12815): Spt5 C-terminal nonapeptide repeat binding Spt4
ICAP-1_inte_bdg (PF10480): Beta-1 integrin binding protein
Pannexin_like (PF12534): Pannexin-like TM region of LRRC8
Pap_E4 (PF02711): E4 protein
Secretin_N_2 (PF07655): Secretin N-terminal domain
CCDC106 (PF15794): Coiled-coil domain-containing protein 106
Vapa
interactor70.4299.233Motile_Sperm (PF00635): MSP (Major sperm protein) domain
DUF972 (PF06156): Protein of unknown function (DUF972)
UL45 (PF05473): UL45 protein, carbohydrate-binding C-type lectin-like
Vcam1
interactor50.7001.300I-set (PF07679): Immunoglobulin I-set domain
C2-set (PF05790): Immunoglobulin C2-set domain
ig (PF00047): Immunoglobulin domain
Ig_2 (PF13895): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
V-set (PF07686): Immunoglobulin V-set domain

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