Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Aco1
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Visible interactors:

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Visualization interactions

Cytoscape Web taxid = 1026970 for: protein(s) Aco1 (from a repository: Sun Apr 22 01:06:01 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	17
The number (and %) of the onco-proteins	2 (11.76 %)
The number (and %) of the tumor suppressors	0 (0.00 %)
Total number of binary PPIs (saturation %)	43 (31.62 %)
The number (and %) of affected PPIs	16 (37.21 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	4.118
Assortativity coefficient	-0.5482
The network average Clustering coefficient	0.560
The number (and %) of a zero Clustering coefficients	3 (17.65 %)
The number (and %) of a zero Betweenness Centrality	7 (41.18 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Aco1

XP_008849314.1

Domain structure obtained by HMM

Protein ID: XP_008849314.1 - cytoplasmic aconitate hydratase
KEEG Ortholog ID: K01681

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Aconitase	PF00330	462	7.2e-186	604.600	62	564	60	564	Aconitase family (aconitate hydratase)
Aconitase_C	PF00694	131	0.0072	2.900	592	629	586	643	Aconitase C-terminal domain
Aconitase_C	PF00694	131	1.2e-50	157.500	693	818	692	821	Aconitase C-terminal domain

user protein

0.158

167.500

Aconitase (PF00330): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694): Aconitase C-terminal domain

App

XP_017657176.1

Domain structure obtained by HMM

Protein ID: XP_017657176.1 - amyloid beta A4 protein
KEEG Ortholog ID: K04520

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
APP_N	PF02177	100	8.1e-49	150.500	31	131	31	131	Amyloid A4 N-terminal heparin-binding
APP_Cu_bd	PF12924	57	1.8e-29	88.600	132	188	132	188	Copper-binding of amyloid precursor, CuBD
SDA1	PF05285	347	0.0000059	12.000	193	270	155	307	SDA1
YtxH	PF12732	75	0.0048	3.800	251	291	245	298	YtxH-like protein
Kunitz_BPTI	PF00014	53	1.4e-23	69.200	291	342	291	343	Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2	PF12925	190	1e-78	249.500	365	547	365	547	E2 domain of amyloid precursor protein
YtxH	PF12732	75	0.029	1.300	520	565	516	576	YtxH-like protein
Beta-APP	PF03494	39	3.3e-28	83.600	676	712	674	712	Beta-amyloid peptide (beta-APP)
APP_amyloid	PF10515	52	3.7e-29	87.400	715	765	715	765	beta-amyloid precursor protein C-terminus

interactor

1.000

APP_N (PF02177): Amyloid A4 N-terminal heparin-binding
APP_Cu_bd (PF12924): Copper-binding of amyloid precursor, CuBD
SDA1 (PF05285): SDA1
YtxH (PF12732): YtxH-like protein
Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2 (PF12925): E2 domain of amyloid precursor protein
Beta-APP (PF03494): Beta-amyloid peptide (beta-APP)
APP_amyloid (PF10515): beta-amyloid precursor protein C-terminus

Ctps1

XP_008833650.1

Domain structure obtained by HMM

Protein ID: XP_008833650.1 - CTP synthase 1
KEEG Ortholog ID: K01937

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
CTP_synth_N	PF06418	266	1.1e-137	443.700	2	272	2	272	CTP synthase N-terminus
GATase	PF00117	190	4.3e-57	179.100	311	542	309	546	Glutamine amidotransferase class-I

interactor

1.000

CTP_synth_N (PF06418): CTP synthase N-terminus
GATase (PF00117): Glutamine amidotransferase class-I

Dcps

XP_008832837.1

Domain structure obtained by HMM

Protein ID: XP_008832837.1 - m7GpppX diphosphatase
KEEG Ortholog ID: K12584

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DcpS	PF05652	104	5.7e-24	71.300	44	145	42	145	Scavenger mRNA decapping enzyme (DcpS) N-terminal
DcpS_C	PF11969	114	5.4e-36	109.800	173	290	173	293	Scavenger mRNA decapping enzyme C-term binding

interactor

1.000

DcpS (PF05652): Scavenger mRNA decapping enzyme (DcpS) N-terminal
DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding

Fbxl5

XP_008825109.1

Domain structure obtained by HMM

Protein ID: XP_008825109.1 - F-box/LRR-repeat protein 5 isoform X1
KEEG Ortholog ID: K10271

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Hemerythrin	PF01814	131	0.00000000014	28.100	8	138	6	138	Hemerythrin HHE cation binding domain
Hemerythrin	PF01814	131	0.0000008	16.000	104	150	83	178	Hemerythrin HHE cation binding domain
F-box-like	PF12937	48	5.9e-20	57.300	204	248	204	249	F-box-like
LRR_4	PF12799	43	0.00000000091	25.100	355	400	355	402	Leucine Rich repeats (2 copies)
LRR_4	PF12799	43	0.0000099	12.300	601	635	599	644	Leucine Rich repeats (2 copies)
LRR_6	PF13516	24	0.000041	10.000	625	646	623	647	Leucine Rich repeat

interactor

Hemerythrin (PF01814): Hemerythrin HHE cation binding domain
F-box-like (PF12937): F-box-like
LRR_4 (PF12799): Leucine Rich repeats (2 copies)
LRR_6 (PF13516): Leucine Rich repeat

Fubp1

XP_008846885.1

Domain structure obtained by HMM

Protein ID: XP_008846885.1 - far upstream element-binding protein 1
KEEG Ortholog ID: K13210

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
KH_1	PF00013	66	1.2e-22	65.900	71	134	71	135	KH domain
KH_1	PF00013	66	2.4e-21	61.700	157	222	156	222	KH domain
KH_1	PF00013	66	1.3e-18	53.000	249	309	246	310	KH domain
KH_1	PF00013	66	2e-20	58.700	350	414	347	414	KH domain
DUF1897	PF09005	36	0.0014	4.500	503	511	494	517	Domain of unknown function (DUF1897)
CYSTM	PF12734	43	0.034	0.900	513	537	511	546	Cysteine-rich TM module stress tolerance
DUF1897	PF09005	36	0.0000000067	21.500	546	564	541	568	Domain of unknown function (DUF1897)
DUF1897	PF09005	36	0.000000000065	27.900	573	591	571	595	Domain of unknown function (DUF1897)

oncogene

0.667

1.000

KH_1 (PF00013): KH domain
DUF1897 (PF09005): Domain of unknown function (DUF1897)
CYSTM (PF12734): Cysteine-rich TM module stress tolerance

Gbe1

XP_008830446.1

Domain structure obtained by HMM

Protein ID: XP_008830446.1 - 1,4-alpha-glucan-branching enzyme
KEEG Ortholog ID: K00700

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
CBM_48	PF02922	83	1.4e-21	63.000	76	161	75	161	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
Alpha-amylase	PF00128	337	1.9e-16	46.600	224	304	220	338	Alpha amylase, catalytic domain
Alpha-amylase	PF00128	337	0.0008	5.100	328	364	322	483	Alpha amylase, catalytic domain
Alpha-amylase_C	PF02806	96	3e-28	84.500	603	697	603	698	Alpha amylase, C-terminal all-beta domain

interactor

CBM_48 (PF02922): Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
Alpha-amylase (PF00128): Alpha amylase, catalytic domain
Alpha-amylase_C (PF02806): Alpha amylase, C-terminal all-beta domain

LOC103732255

XP_008829031.1

Domain structure obtained by HMM

Protein ID: XP_008829031.1 - alpha-enolase
KEEG Ortholog ID: K01689

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Enolase_N	PF03952	131	2.8e-65	204.600	3	134	3	134	Enolase, N-terminal domain
Enolase_C	PF00113	296	9.1e-162	523.300	143	430	142	432	Enolase, C-terminal TIM barrel domain

interactor

0.667

1.500

Enolase_N (PF03952): Enolase, N-terminal domain
Enolase_C (PF00113): Enolase, C-terminal TIM barrel domain

LOC103746136

XP_008846505.1

Domain structure obtained by HMM

Protein ID: XP_008846505.1 - core histone macro-H2A.1 isoform X1
KEEG Ortholog ID: K11251

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Histone	PF00125	132	3.9e-18	52.400	5	85	2	88	Core histone H2A/H2B/H3/H4
Histone_H2A_C	PF16211	35	3.3e-22	64.300	89	123	89	123	C-terminus of histone H2A
DUF1764	PF08576	101	0.00000099	15.900	119	195	115	200	Eukaryotic protein of unknown function (DUF1764)
Macro	PF01661	118	6.2e-33	99.600	216	329	216	330	Macro domain

interactor

0.400

7.667

Histone (PF00125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211): C-terminus of histone H2A
DUF1764 (PF08576): Eukaryotic protein of unknown function (DUF1764)
Macro (PF01661): Macro domain

Lgals1

XP_008849516.1

Domain structure obtained by HMM

Protein ID: XP_008849516.1 - galectin-1
KEEG Ortholog ID: K06830

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Gal-bind_lectin	PF00337	134	4.4e-33	99.900	10	133	5	134	Galactoside-binding lectin

interactor

0.667

1.000

Gal-bind_lectin (PF00337): Galactoside-binding lectin

Mov10

XP_008832189.1

Domain structure obtained by HMM

Protein ID: XP_008832189.1 - putative helicase MOV-10 isoform X1
KEEG Ortholog ID: K18422

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
AAA_11	PF13086	262	0.0000000000000074	41.400	500	569	499	592	AAA domain
AAA_11	PF13086	262	0.00000000000012	37.500	611	691	593	692	AAA domain
AAA_12	PF13087	200	1.2e-50	158.100	700	923	699	924	AAA domain

interactor

0.667

1.167

AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain

Ntrk1

XP_008851531.1

Domain structure obtained by HMM

Protein ID: XP_008851531.1 - high affinity nerve growth factor receptor isoform X1
KEEG Ortholog ID: K03176

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
LRR_8	PF13855	61	0.0011	5.000	65	98	62	102	Leucine rich repeat
LRR_8	PF13855	61	7.9e-17	47.100	92	150	91	150	Leucine rich repeat
TPKR_C2	PF16920	45	0.0000000000000013	43.700	151	194	151	194	Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3	PF13927	79	0.0000000041	23.300	196	271	196	271	Immunoglobulin domain
I-set	PF07679	90	0.0000000087	21.700	305	379	292	381	Immunoglobulin I-set domain
Pkinase_Tyr	PF07714	260	4.9e-97	310.300	514	783	512	783	Protein tyrosine kinase

oncogene

0.357

16.667

LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase

Nxf1

XP_008835719.1

Domain structure obtained by HMM

Protein ID: XP_008835719.1 - nuclear RNA export factor 1
KEEG Ortholog ID: K14284

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Tap-RNA_bind	PF09162	83	6.8e-43	130.800	116	197	115	197	Tap, RNA-binding
LRR_8	PF13855	61	0.0000000031	22.800	264	326	264	326	Leucine rich repeat
NTF2	PF02136	120	7.5e-33	99.900	386	534	385	535	Nuclear transport factor 2 (NTF2) domain
TAP_C	PF03943	49	2.9e-29	86.800	568	616	568	616	TAP C-terminal domain

interactor

0.667

Tap-RNA_bind (PF09162): Tap, RNA-binding
LRR_8 (PF13855): Leucine rich repeat
NTF2 (PF02136): Nuclear transport factor 2 (NTF2) domain
TAP_C (PF03943): TAP C-terminal domain

Psmg1

XP_008825135.1

Domain structure obtained by HMM

Protein ID: XP_008825135.1 - proteasome assembly chaperone 1 isoform X1
KEEG Ortholog ID: K11875

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
PAC1	PF16094	284	9.9e-134	431.000	3	288	2	288	Proteasome assembly chaperone 4

interactor

1.000

PAC1 (PF16094): Proteasome assembly chaperone 4

Shmt2

XP_008842308.1

Domain structure obtained by HMM

Protein ID: XP_008842308.1 - serine hydroxymethyltransferase, mitochondrial
KEEG Ortholog ID: K00600

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
SHMT	PF00464	399	2e-212	691.000	49	448	49	448	Serine hydroxymethyltransferase

interactor

0.667

1.500

SHMT (PF00464): Serine hydroxymethyltransferase

Strap

XP_008854253.1

Domain structure obtained by HMM

Protein ID: XP_008854253.1 - serine-threonine kinase receptor-associated protein
KEEG Ortholog ID: K13137

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
WD40	PF00400	38	0.000073	10.000	8	40	4	43	WD domain, G-beta repeat
ANAPC4_WD40	PF12894	92	0.018	1.700	26	55	8	69	Anaphase-promoting complex subunit 4 WD40 domain
WD40	PF00400	38	0.000012	12.500	52	87	49	87	WD domain, G-beta repeat
WD40	PF00400	38	0.0000000072	22.700	94	128	91	128	WD domain, G-beta repeat
WD40	PF00400	38	0.00000011	19.000	138	170	134	170	WD domain, G-beta repeat
ANAPC4_WD40	PF12894	92	0.0012	5.500	178	222	151	232	Anaphase-promoting complex subunit 4 WD40 domain
WD40	PF00400	38	0.00021	8.500	216	247	214	251	WD domain, G-beta repeat
WD40	PF00400	38	0.000000000000036	39.500	256	292	255	293	WD domain, G-beta repeat
ANAPC4_WD40	PF12894	92	0.000019	11.200	267	301	262	310	Anaphase-promoting complex subunit 4 WD40 domain

interactor

0.600

3.333

WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain

Txndc17

XP_008853873.1

Domain structure obtained by HMM

Protein ID: XP_008853873.1 - thioredoxin domain-containing protein 17

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Glutaredoxin	PF00462	60	0.0042	3.700	3	25	1	28	Glutaredoxin
DUF953	PF06110	119	8.6e-52	160.100	9	122	8	122	Eukaryotic protein of unknown function (DUF953)

interactor

Glutaredoxin (PF00462): Glutaredoxin
DUF953 (PF06110): Eukaryotic protein of unknown function (DUF953)

B a c k t o T o p ⇑