Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Acly (from a repository: Wed Apr 11 18:45:03 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)58
The number (and %) of the onco-proteins9 (15.52 %)
The number (and %) of the tumor suppressors8 (13.79 %)
Total number of binary PPIs (saturation %)308 (18.63 %)
The number (and %) of affected PPIs57 (18.51 %)
PPI diameter2
PPI radius1
The average degree of PPI9.517
Assortativity coefficient-0.4125
The network average Clustering coefficient0.576
The number (and %) of a zero Clustering coefficients4 (6.90 %)
The number (and %) of a zero Betweenness Centrality13 (22.41 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure		 Type Number
of PPI (degree)		 Clustering
Coefficient		 Betweenness
Centrality		 Domains (Pfam ID): description
Acly

Domain structure obtained by HMM

Protein ID: XP_008833489.1 - ATP-citrate synthase isoform X1
KEEG Ortholog ID: K01648
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
ATP-grasp_2PF084422020.0000000005525.200512076207ATP-grasp domain
Citrate_bindPF161141782.6e-96306.400244420244421ATP citrate lyase citrate-binding
CoA_bindingPF02629963.2e-1646.100497600495600CoA binding domain
Ligase_CoAPF005491531.1e-1750.500660784660785CoA-ligase
Citrate_syntPF002853620.000176.800841883832888Citrate synthase, C-terminal domain
Citrate_syntPF002853625e-2471.00088710818801086Citrate synthase, C-terminal domain
user protein570.1371838.567ATP-grasp_2 (PF08442): ATP-grasp domain
Citrate_bind (PF16114): ATP citrate lyase citrate-binding
CoA_binding (PF02629): CoA binding domain
Ligase_CoA (PF00549): CoA-ligase
Citrate_synt (PF00285): Citrate synthase, C-terminal domain
Ahsa1

Domain structure obtained by HMM

Protein ID: XP_017655303.1 - activator of 90 kDa heat shock protein ATPase homolog 1 isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
MdcGPF106201990.00001311.2005110743111Phosphoribosyl-dephospho-CoA transferase MdcG
AHSA1PF083271253.9e-3090.9008219681197Activator of Hsp90 ATPase homolog 1-like protein
interactor100.5569.652MdcG (PF10620): Phosphoribosyl-dephospho-CoA transferase MdcG
AHSA1 (PF08327): Activator of Hsp90 ATPase homolog 1-like protein
App

Domain structure obtained by HMM

Protein ID: XP_017657176.1 - amyloid beta A4 protein
KEEG Ortholog ID: K04520
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
APP_NPF021771008.1e-49150.5003113131131Amyloid A4 N-terminal heparin-binding
APP_Cu_bdPF12924571.8e-2988.600132188132188Copper-binding of amyloid precursor, CuBD
SDA1PF052853470.000005912.000193270155307SDA1
YtxHPF12732750.00483.800251291245298YtxH-like protein
Kunitz_BPTIPF00014531.4e-2369.200291342291343Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2PF129251901e-78249.500365547365547E2 domain of amyloid precursor protein
YtxHPF12732750.0291.300520565516576YtxH-like protein
Beta-APPPF03494393.3e-2883.600676712674712Beta-amyloid peptide (beta-APP)
APP_amyloidPF10515523.7e-2987.400715765715765beta-amyloid precursor protein C-terminus
interactor200.27585.472APP_N (PF02177): Amyloid A4 N-terminal heparin-binding
APP_Cu_bd (PF12924): Copper-binding of amyloid precursor, CuBD
SDA1 (PF05285): SDA1
YtxH (PF12732): YtxH-like protein
Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2 (PF12925): E2 domain of amyloid precursor protein
Beta-APP (PF03494): Beta-amyloid peptide (beta-APP)
APP_amyloid (PF10515): beta-amyloid precursor protein C-terminus
Asb15

Domain structure obtained by HMM

Protein ID: XP_017651544.1 - ankyrin repeat and SOCS box protein 15
KEEG Ortholog ID: K10337
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Ank_2PF12796840.00002111.400509742103Ankyrin repeats (3 copies)
Ank_2PF12796840.0000000000001337.70011016991174Ankyrin repeats (3 copies)
Ank_2PF12796840.000000000000436.100142207137207Ankyrin repeats (3 copies)
Ank_2PF12796840.00000000006629.000176236167240Ankyrin repeats (3 copies)
Ank_2PF12796840.000000000000001344.100215296214304Ankyrin repeats (3 copies)
Ank_2PF12796840.000000000000001144.300247336247337Ankyrin repeats (3 copies)
Ank_2PF12796840.0000000000008635.100306378298380Ankyrin repeats (3 copies)
Ank_2PF12796840.00000000004529.600354442354447Ankyrin repeats (3 copies)
SOCS_boxPF07525350.00000000000003939.100534574534575SOCS box
interactor100Ank_2 (PF12796): Ankyrin repeats (3 copies)
SOCS_box (PF07525): SOCS box
Bag3

Domain structure obtained by HMM

Protein ID: XP_008825526.1 - BAG family molecular chaperone regulator 3
KEEG Ortholog ID: K09557
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
WWPF00397310.00000000000002639.20024542454WW domain
RNA_pol_Rpc4PF051321480.000158.50014320886215RNA polymerase III RPC4
DUF4124PF13511560.0281.100354382353383Domain of unknown function (DUF4124)
BAGPF02179752.5e-2265.400425495424496BAG domain
Rib_recp_KP_regPF051041560.0341.400528562482571Ribosome receptor lysine/proline rich region
oncogene80.4766.917WW (PF00397): WW domain
RNA_pol_Rpc4 (PF05132): RNA polymerase III RPC4
DUF4124 (PF13511): Domain of unknown function (DUF4124)
BAG (PF02179): BAG domain
Rib_recp_KP_reg (PF05104): Ribosome receptor lysine/proline rich region
Cand1

Domain structure obtained by HMM

Protein ID: XP_008845182.1 - cullin-associated NEDD8-dissociated protein 1
KEEG Ortholog ID: K17263
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
HEAT_2PF13646880.00000005119.500101048111HEAT repeats
Cnd1PF127171620.00000214.1004614324159non-SMC mitotic condensation complex subunit 1
HEAT_EZPF13513550.00000008319.000151202148202HEAT-like repeat
DUF3385PF118651610.00000003719.600215284172286Domain of unknown function (DUF3385)
Vac14_Fab1_bdPF12755970.0000003717.000236304230315Vacuolar 14 Fab1-binding region
HEATPF02985310.000006912.600344362342363HEAT repeat
MMS19_NPF145002610.000008811.500348478341486Dos2-interacting transcription regulator of RNA-Pol-II
MMS19_CPF124604170.000000002522.700433523427527RNAPII transcription regulator C-terminal
Adaptin_NPF016025240.00001110.200476721342744Adaptin N terminal region
TIP120PF086231661.8e-69218.9001040120210401203TATA-binding protein interacting (TIP20)
interactor210.41163.350HEAT_2 (PF13646): HEAT repeats
Cnd1 (PF12717): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
DUF3385 (PF11865): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
HEAT (PF02985): HEAT repeat
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
MMS19_C (PF12460): RNAPII transcription regulator C-terminal
Adaptin_N (PF01602): Adaptin N terminal region
TIP120 (PF08623): TATA-binding protein interacting (TIP20)
Cry1

Domain structure obtained by HMM

Protein ID: XP_008841338.1 - cryptochrome-1
KEEG Ortholog ID: K02295
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DNA_photolyasePF008751641.1e-48151.50051585170DNA photolyase
FAD_binding_7PF034411896.4e-74233.700288486286486FAD binding domain of DNA photolyase
interactor60.8000.472DNA_photolyase (PF00875): DNA photolyase
FAD_binding_7 (PF03441): FAD binding domain of DNA photolyase
Cry2

Domain structure obtained by HMM

Protein ID: XP_008832371.1 - cryptochrome-2
KEEG Ortholog ID: K02295
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DNA_photolyasePF008751641e-50158.1002317523187DNA photolyase
FAD_binding_7PF034411893.6e-72228.000306504304504FAD binding domain of DNA photolyase
interactor90.7142.662DNA_photolyase (PF00875): DNA photolyase
FAD_binding_7 (PF03441): FAD binding domain of DNA photolyase
Cs

Domain structure obtained by HMM

Protein ID: XP_008846941.1 - citrate synthase, mitochondrial
KEEG Ortholog ID: K01647
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Citrate_syntPF002853621.9e-110355.4007145071450Citrate synthase, C-terminal domain
interactor60.6672.250Citrate_synt (PF00285): Citrate synthase, C-terminal domain
Cth

Domain structure obtained by HMM

Protein ID: XP_008844303.1 - cystathionine gamma-lyase
KEEG Ortholog ID: K01758
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Cys_Met_Meta_PPPF010533823.5e-159515.4001839418394Cys/Met metabolism PLP-dependent enzyme
interactor31.0000Cys_Met_Meta_PP (PF01053): Cys/Met metabolism PLP-dependent enzyme
Cul2

Domain structure obtained by HMM

Protein ID: XP_017653864.1 - cullin-2
KEEG Ortholog ID: K03870
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
CullinPF008886056.6e-178579.1001464414644Cullin family
Cullin_Nedd8PF10557636.6e-3192.500675735675737Cullin protein neddylation domain
tumor suppressor130.53821.060Cullin (PF00888): Cullin family
Cullin_Nedd8 (PF10557): Cullin protein neddylation domain
Cul3

Domain structure obtained by HMM

Protein ID: XP_008824048.1 - cullin-3
KEEG Ortholog ID: K03869
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
CullinPF008886051.1e-228746.7003466534665Cullin family
WAC_Acf1_DNA_bdPF105371010.00005110.100679737649740ATP-utilising chromatin assembly and remodelling N-terminal
Cullin_Nedd8PF10557639e-3295.300698760698760Cullin protein neddylation domain
interactor200.43345.256Cullin (PF00888): Cullin family
WAC_Acf1_DNA_bd (PF10537): ATP-utilising chromatin assembly and remodelling N-terminal
Cullin_Nedd8 (PF10557): Cullin protein neddylation domain
Cul7

Domain structure obtained by HMM

Protein ID: XP_008827320.1 - cullin-7 isoform X2
KEEG Ortholog ID: K10613
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Cul7PF11515783e-36109.900359432359433Mouse development and cellular proliferation protein Cullin-7
ANAPC10PF032561850.00000000001930.000848964827984Anaphase-promoting complex, subunit 10 (APC10)
CullinPF008886057e-2573.70097015069401522Cullin family
Cullin_Nedd8PF10557630.0000000007725.0001561163815611639Cullin protein neddylation domain
interactor150.45118.891Cul7 (PF11515): Mouse development and cellular proliferation protein Cullin-7
ANAPC10 (PF03256): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888): Cullin family
Cullin_Nedd8 (PF10557): Cullin protein neddylation domain
Ddias

Domain structure obtained by HMM

Protein ID: XP_008842415.1 - DNA damage-induced apoptosis suppressor protein
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Rep_fac-A_CPF086461460.00000000000008537.70010967117Replication factor-A C terminal domain
FYVEPF01363680.0161.700187195180203FYVE zinc finger
YgbA_NOPF117561070.00002311.000312377309389Nitrous oxide-stimulated promoter
Peptidase_A2BPF123841770.0033.300449503445521Ty3 transposon peptidase
Peptidase_A2BPF123841770.000276.700641672625679Ty3 transposon peptidase
interactor100Rep_fac-A_C (PF08646): Replication factor-A C terminal domain
FYVE (PF01363): FYVE zinc finger
YgbA_NO (PF11756): Nitrous oxide-stimulated promoter
Peptidase_A2B (PF12384): Ty3 transposon peptidase
Derl1

Domain structure obtained by HMM

Protein ID: XP_008836212.1 - derlin-1
KEEG Ortholog ID: K11519
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DER1PF045111971.1e-69220.2001120411204Der1-like family
interactor60.7000.765DER1 (PF04511): Der1-like family
Eef1d

Domain structure obtained by HMM

Protein ID: XP_008832737.1 - elongation factor 1-delta isoform X1
KEEG Ortholog ID: K15410
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Cytochrom_C_2PF013221210.00434.200540254Cytochrome C'
PGA2PF075431380.00154.7001680899Protein trafficking PGA2
UPF0565PF105612990.0000339.3004812219136Uncharacterised protein family UPF0565
Cytochrom_C_2PF013221210.00001811.900120214108214Cytochrome C'
EF-1_beta_acidPF10587281.4e-1647.000527554527554Eukaryotic elongation factor 1 beta central acidic region
EF1_GNEPF00736903.2e-40122.600565649565649EF-1 guanine nucleotide exchange domain
interactor130.51511.560Cytochrom_C_2 (PF01322): Cytochrome C'
PGA2 (PF07543): Protein trafficking PGA2
UPF0565 (PF10561): Uncharacterised protein family UPF0565
EF-1_beta_acid (PF10587): Eukaryotic elongation factor 1 beta central acidic region
EF1_GNE (PF00736): EF-1 guanine nucleotide exchange domain
Fn1

Domain structure obtained by HMM

Protein ID: XP_008823890.1 - fibronectin isoform X5
KEEG Ortholog ID: K05717
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
fn1PF00039400.00000000000006638.20053885388Fibronectin type I domain
fn1PF00039402.2e-1852.5009813698136Fibronectin type I domain
fn1PF00039404.1e-1748.500142180142180Fibronectin type I domain
fn1PF00039409.3e-1953.700187226187226Fibronectin type I domain
fn1PF00039404e-1954.900232271232271Fibronectin type I domain
fn1PF00039400.000000007822.000312341309343Fibronectin type I domain
fn2PF00040421.6e-2162.600361402361402Fibronectin type II domain
fn2PF00040428.8e-2160.300421462421462Fibronectin type II domain
fn1PF00039401.3e-1853.200471509471509Fibronectin type I domain
fn1PF00039401.2e-1647.000523556519556Fibronectin type I domain
fn1PF00039401.9e-1749.500562600562600Fibronectin type I domain
fn3PF00041854.8e-1645.200615689610692Fibronectin type III domain
fn3PF00041851.5e-1646.900727798722801Fibronectin type III domain
fn3PF00041851.5e-2266.100812888812891Fibronectin type III domain
DUF2369PF10179950.0000006616.100861921859926Uncharacterised conserved protein (DUF2369)
fn3PF00041853.5e-2058.500908986908988Fibronectin type III domain
fn3PF00041855.7e-2057.80099810769981078Fibronectin type III domain
fn3PF00041850.0000000001427.7001096115910931163Fibronectin type III domain
fn3PF00041857.6e-1851.0001175125411751258Fibronectin type III domain
fn3PF00041852.6e-1955.7001268134612681347Fibronectin type III domain
fn3PF00041851.1e-2163.3001360143713591439Fibronectin type III domain
fn3PF00041851.1e-2369.7001450153014491530Fibronectin type III domain
DUF2369PF10179950.00004810.1001498154014971578Uncharacterised conserved protein (DUF2369)
fn3PF00041852.1e-2265.6001543162215431623Fibronectin type III domain
fn3PF00041852.1e-1646.4001634171116331713Fibronectin type III domain
fn3PF00041858.6e-2160.5001723179817231803Fibronectin type III domain
fn3PF00041851.3e-1956.6001815189018151894Fibronectin type III domain
fn3PF00041852.6e-2162.1001904198219041984Fibronectin type III domain
fn3PF00041850.0000000000230.4002093215320852157Fibronectin type III domain
fn1PF00039405.6e-1851.2002181222021812220Fibronectin type I domain
fn1PF00039401.3e-1646.8002226226322262263Fibronectin type I domain
fn1PF00039400.0000000000007134.9002270230522702305Fibronectin type I domain
oncogene140.46217.077fn1 (PF00039): Fibronectin type I domain
fn2 (PF00040): Fibronectin type II domain
fn3 (PF00041): Fibronectin type III domain
DUF2369 (PF10179): Uncharacterised conserved protein (DUF2369)
Gsk3b

Domain structure obtained by HMM

Protein ID: XP_008841124.1 - glycogen synthase kinase-3 beta isoform X1
KEEG Ortholog ID: K03083
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PkinasePF000692641.9e-72229.9005635356353Protein kinase domain
oncogene, tumor suppressor40.6670.667Pkinase (PF00069): Protein kinase domain
Hdac5

Domain structure obtained by HMM

Protein ID: XP_008836377.1 - histone deacetylase 5 isoform X1
KEEG Ortholog ID: K11406
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
HDAC4_GlnPF12203913.9e-36109.5008617486174Glutamine rich N terminal domain of histone deacetylase 4
TFIIAPF031534150.00001611.100393607335688Transcription factor IIA, alpha/beta subunit
PTPRCAPPF157131480.000945.700561640552648Protein tyrosine phosphatase receptor type C-associated
Hist_deacetylPF008503069.1e-84267.60071110297111029Histone deacetylase domain
interactor80.5245.833HDAC4_Gln (PF12203): Glutamine rich N terminal domain of histone deacetylase 4
TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
PTPRCAP (PF15713): Protein tyrosine phosphatase receptor type C-associated
Hist_deacetyl (PF00850): Histone deacetylase domain
Hgs

Domain structure obtained by HMM

Protein ID: XP_008826739.1 - hepatocyte growth factor-regulated tyrosine kinase substrate isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
VHSPF007901416.5e-52161.30071393139VHS domain
FYVEPF01363686.4e-2263.800162220158221FYVE zinc finger
UIMPF02809170.00001211.600258274258274Ubiquitin interaction motif
EF-1_beta_acidPF10587280.00683.200273283270284Eukaryotic elongation factor 1 beta central acidic region
DUF3306PF117481210.00096.400332414328420Protein of unknown function (DUF3306)
Hrs_helicalPF12210952e-42130.000404498404498Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZOPF159172270.0000289.800472570464578Piezo
interactor50.7000.715VHS (PF00790): VHS domain
FYVE (PF01363): FYVE zinc finger
UIM (PF02809): Ubiquitin interaction motif
EF-1_beta_acid (PF10587): Eukaryotic elongation factor 1 beta central acidic region
DUF3306 (PF11748): Protein of unknown function (DUF3306)
Hrs_helical (PF12210): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917): Piezo
Hnrnpk

Domain structure obtained by HMM

Protein ID: XP_008847628.1 - heterogeneous nuclear ribonucleoprotein K isoform X1
KEEG Ortholog ID: K12886
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
ROKNTPF08067441.2e-3091.800143143ROKNT (NUC014) domain
KH_1PF00013660.0000000000000239.5004510144105KH domain
KH_1PF00013669e-1643.800147210146211KH domain
KH_1PF00013662.4e-2471.300389452389453KH domain
oncogene250.362110.631ROKNT (PF08067): ROKNT (NUC014) domain
KH_1 (PF00013): KH domain
Huwe1

Domain structure obtained by HMM

Protein ID: XP_017657841.1 - E3 ubiquitin-protein ligase HUWE1
KEEG Ortholog ID: K10592
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF908PF060123589.6e-3296.8009036788368Domain of Unknown Function (DUF908)
DUF913PF060253667.1e-120386.300430814430814Domain of Unknown Function (DUF913)
PBP_sp32PF072222430.0180.6001198125211961256Proacrosin binding protein sp32
UBAPF00627370.00000000005328.6001318135213171352UBA/TS-N domain
U1snRNP70_NPF12220930.00037.7001381143013491433U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
FdhEPF042162870.000466.2001403150513891520Protein involved in formate dehydrogenase formation
WWEPF02825695e-1748.6001617167816151679WWE domain
BSP_IIPF054322990.020.7001679173516461753Bone sialoprotein II (BSP-II)
Ku_CPF03730880.0000939.4001947199419442019Ku70/Ku80 C-terminal arm
RNA_pol_Rpc4PF051321480.0251.2002021206119722078RNA polymerase III RPC4
TFIIAPF031534150.000005412.6002175246121162471Transcription factor IIA, alpha/beta subunit
Tim54PF117113740.00113.8002411247923972506Inner membrane protein import complex subunit Tim54
Nop14PF041478750.000554.2002619274626022787Nop14-like family
DUF4414PF143771161.5e-3298.6002969308029693080Domain of unknown function (DUF4414)
FdhEPF042162870.00154.5003022311730213126Protein involved in formate dehydrogenase formation
MucinPF014561430.000197.6003472355334513577Mucin-like glycoprotein
BUD22PF090734320.00542.1003753384037163929BUD22
HABP4_PAI-RBP1PF047741170.060.5003795385737773871Hyaluronan / mRNA binding family
HECTPF006323073.4e-98315.0004070437440684375HECT-domain (ubiquitin-transferase)
oncogene190.41241.708DUF908 (PF06012): Domain of Unknown Function (DUF908)
DUF913 (PF06025): Domain of Unknown Function (DUF913)
PBP_sp32 (PF07222): Proacrosin binding protein sp32
UBA (PF00627): UBA/TS-N domain
U1snRNP70_N (PF12220): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
FdhE (PF04216): Protein involved in formate dehydrogenase formation
WWE (PF02825): WWE domain
BSP_II (PF05432): Bone sialoprotein II (BSP-II)
Ku_C (PF03730): Ku70/Ku80 C-terminal arm
RNA_pol_Rpc4 (PF05132): RNA polymerase III RPC4
TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
Tim54 (PF11711): Inner membrane protein import complex subunit Tim54
Nop14 (PF04147): Nop14-like family
DUF4414 (PF14377): Domain of unknown function (DUF4414)
Mucin (PF01456): Mucin-like glycoprotein
BUD22 (PF09073): BUD22
HABP4_PAI-RBP1 (PF04774): Hyaluronan / mRNA binding family
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Ikbke

Domain structure obtained by HMM

Protein ID: XP_017651137.1 - inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PkinasePF000692641.2e-50158.400102319301Protein kinase domain
zf-RING_9PF139012060.00214.200485520447564Putative zinc-RING and/or ribbon
TPR_MLP1_2PF079261290.000003413.400597646559659TPR/MLP1/MLP2-like protein
interactor31.0000Pkinase (PF00069): Protein kinase domain
zf-RING_9 (PF13901): Putative zinc-RING and/or ribbon
TPR_MLP1_2 (PF07926): TPR/MLP1/MLP2-like protein
Isg15

Domain structure obtained by HMM

Protein ID: XP_008850780.1 - ubiquitin-like protein ISG15
KEEG Ortholog ID: K12159
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
ubiquitinPF00240722.1e-1645.700574576Ubiquitin family
ubiquitinPF00240729.2e-2675.8008315483154Ubiquitin family
tumor suppressor40.8330.500ubiquitin (PF00240): Ubiquitin family
Kat2b

Domain structure obtained by HMM

Protein ID: XP_008831385.1 - histone acetyltransferase KAT2B
KEEG Ortholog ID: K06062
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PCAF_NPF064662511.7e-101325.1004226638266PCAF (P300/CBP-associated factor) N-terminal domain
Acetyltransf_1PF005831170.00000000000004838.900475558447558Acetyltransferase (GNAT) family
BromodomainPF00439841.8e-2781.600669750668751Bromodomain
interactor31.0000PCAF_N (PF06466): PCAF (P300/CBP-associated factor) N-terminal domain
Acetyltransf_1 (PF00583): Acetyltransferase (GNAT) family
Bromodomain (PF00439): Bromodomain
Kpna2

Domain structure obtained by HMM

Protein ID: XP_008839829.1 - importin subunit alpha-1
KEEG Ortholog ID: K15043
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
IBBPF01749876.5e-35105.70013981398Importin beta binding domain
ArmPF00514410.000000000002732.700109149108149Armadillo/beta-catenin-like repeat
ArmPF00514410.000000000000003941.800151190151191Armadillo/beta-catenin-like repeat
ArmPF00514410.00000000000002639.200196238193238Armadillo/beta-catenin-like repeat
ArmPF00514410.00000000001130.800251279241280Armadillo/beta-catenin-like repeat
ArmPF00514410.00000000006528.400283321282322Armadillo/beta-catenin-like repeat
ArmPF00514410.000000000000001742.900324364324364Armadillo/beta-catenin-like repeat
ArmPF00514410.000000000002532.900367405366406Armadillo/beta-catenin-like repeat
ArmPF00514410.00000000002529.700410447409448Armadillo/beta-catenin-like repeat
Arm_3PF16186531.4e-2884.600458509458509Atypical Arm repeat
interactor140.47320.402IBB (PF01749): Importin beta binding domain
Arm (PF00514): Armadillo/beta-catenin-like repeat
Arm_3 (PF16186): Atypical Arm repeat
Kpna4

Domain structure obtained by HMM

Protein ID: XP_008845538.1 - importin subunit alpha-3
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
IBBPF01749873.3e-2781.00011931193Importin beta binding domain
ArmPF00514412.1e-1645.800104144103144Armadillo/beta-catenin-like repeat
ArmPF00514419.4e-1850.100146184146186Armadillo/beta-catenin-like repeat
ArmPF00514410.0000000000927.900189229188229Armadillo/beta-catenin-like repeat
ArmPF00514410.0000000009624.700233270232271Armadillo/beta-catenin-like repeat
ArmPF00514412.9e-1645.400274312273313Armadillo/beta-catenin-like repeat
ArmPF00514410.000000000002432.900315355315355Armadillo/beta-catenin-like repeat
ArmPF00514410.000000000000001643.000357396357397Armadillo/beta-catenin-like repeat
ArmPF00514410.00000000001230.700402438400440Armadillo/beta-catenin-like repeat
Arm_3PF16186531e-2781.800448498447499Atypical Arm repeat
interactor60.7331.486IBB (PF01749): Importin beta binding domain
Arm (PF00514): Armadillo/beta-catenin-like repeat
Arm_3 (PF16186): Atypical Arm repeat
LOC103730663

Domain structure obtained by HMM

Protein ID: XP_008827157.1 - cyclin-dependent kinase 4 inhibitor B-like
KEEG Ortholog ID: K06621
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Ank_4PF13637550.0000000005326.100741442Ankyrin repeats (many copies)
AnkPF00023320.0000001118.60036653566Ankyrin repeat
Ank_5PF13857560.000000001424.5005410954109Ankyrin repeats (many copies)
Ank_4PF13637550.00000001421.5007112169122Ankyrin repeats (many copies)
interactor80.5717.548Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank (PF00023): Ankyrin repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
Mcm2

Domain structure obtained by HMM

Protein ID: XP_008826791.1 - DNA replication licensing factor MCM2 isoform X1
KEEG Ortholog ID: K02540
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
MCM2_NPF126191532.9e-2059.3006217650182Mini-chromosome maintenance protein 2
MCM_NPF145511049.1e-2057.500197285196288MCM N-terminal domain
MCM_OBPF172071264.8e-41125.800294420293422MCM OB domain
AAA_3PF077261310.000975.200421475401484ATPase family associated with various cellular activities (AAA)
MCMPF004933315.6e-144465.300461802460803MCM2/3/5 family
oncogene260.347107.732MCM2_N (PF12619): Mini-chromosome maintenance protein 2
MCM_N (PF14551): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
AAA_3 (PF07726): ATPase family associated with various cellular activities (AAA)
MCM (PF00493): MCM2/3/5 family
Mcm6

Domain structure obtained by HMM

Protein ID: XP_008831880.1 - DNA replication licensing factor MCM6
KEEG Ortholog ID: K02542
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
MCM_NPF145511043.4e-1955.7002710327131MCM N-terminal domain
MCM_OBPF172071263.4e-38116.600122251122252MCM OB domain
MCMPF004933316.8e-142458.400334656333657MCM2/3/5 family
Jnk-SapK_ap_NPF097441560.0112.200732775726785JNK_SAPK-associated protein-1
YmgBPF10798590.00003310.000753785750789Biofilm development protein YmgB/AriR
interactor120.41813.080MCM_N (PF14551): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
MCM (PF00493): MCM2/3/5 family
Jnk-SapK_ap_N (PF09744): JNK_SAPK-associated protein-1
YmgB (PF10798): Biofilm development protein YmgB/AriR
Naprt

Domain structure obtained by HMM

Protein ID: XP_008832745.1 - nicotinate phosphoribosyltransferase
KEEG Ortholog ID: K00763
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
NAPRTasePF040952410.000001114.500315416308434Nicotinate phosphoribosyltransferase (NAPRTase) family
interactor21.0000NAPRTase (PF04095): Nicotinate phosphoribosyltransferase (NAPRTase) family
Ncl

Domain structure obtained by HMM

Protein ID: XP_008836296.1 - nucleolin
KEEG Ortholog ID: K11294
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PBP1_TMPF14812850.000003813.600862468Transmembrane domain of transglycosylase PBP1 at N-terminal
YL1PF057642420.00002710.50024967135YL1 nuclear protein
Myc_NPF010563320.0000639.0007717745190Myc amino-terminal region
ANAPC15PF15243900.00125.600194221176225Anaphase-promoting complex subunit 15
Sigma70_nerPF045462040.0000649.000246297240343Sigma-70, non-essential region
RRM_1PF00076700.0000000000001237.000316384316384RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1PF11608880.00583.100358392316398Limkain b1
RRM_1PF00076701.4e-1646.400405466402467RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_1PF00076706e-2057.200494560494560RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_1PF00076701.1e-2162.800580646580647RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
interactor210.44748.971PBP1_TM (PF14812): Transmembrane domain of transglycosylase PBP1 at N-terminal
YL1 (PF05764): YL1 nuclear protein
Myc_N (PF01056): Myc amino-terminal region
ANAPC15 (PF15243): Anaphase-promoting complex subunit 15
Sigma70_ner (PF04546): Sigma-70, non-essential region
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608): Limkain b1
Nme1

Domain structure obtained by HMM

Protein ID: XP_008836624.1 - nucleoside diphosphate kinase A isoform X1
KEEG Ortholog ID: K00940
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
NDKPF003341354.1e-59184.6005018350184Nucleoside diphosphate kinase
tumor suppressor60.8001.067NDK (PF00334): Nucleoside diphosphate kinase
Ntrk1

Domain structure obtained by HMM

Protein ID: XP_008851531.1 - high affinity nerve growth factor receptor isoform X1
KEEG Ortholog ID: K03176
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
LRR_8PF13855610.00115.000659862102Leucine rich repeat
LRR_8PF13855617.9e-1747.1009215091150Leucine rich repeat
TPKR_C2PF16920450.000000000000001343.700151194151194Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3PF13927790.000000004123.300196271196271Immunoglobulin domain
I-setPF07679900.000000008721.700305379292381Immunoglobulin I-set domain
Pkinase_TyrPF077142604.9e-97310.300514783512783Protein tyrosine kinase
oncogene250.341102.894LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Nup107

Domain structure obtained by HMM

Protein ID: XP_008845190.1 - nuclear pore complex protein Nup107
KEEG Ortholog ID: K14301
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Nup84_Nup100PF041216922.9e-220719.000210908209908Nuclear pore protein 84 / 107
interactor70.3815.600Nup84_Nup100 (PF04121): Nuclear pore protein 84 / 107
Nup210l

Domain structure obtained by HMM

Protein ID: XP_008853374.2 - LOW QUALITY PROTEIN: nuclear pore membrane glycoprotein 210-like
KEEG Ortholog ID: K14314
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
T2SS-T3SS_pil_NPF13629720.0000718.900309335308340Pilus formation protein N terminal region
Big_2PF02368790.0000002117.100491524481534Bacterial Ig-like domain (group 2)
T2SS-T3SS_pil_NPF13629720.0270.6001045106410291073Pilus formation protein N terminal region
Big_2PF02368790.000000000006331.6001080115210791155Bacterial Ig-like domain (group 2)
Big_2PF02368790.0231.0001245126112411268Bacterial Ig-like domain (group 2)
interactor100T2SS-T3SS_pil_N (PF13629): Pilus formation protein N terminal region
Big_2 (PF02368): Bacterial Ig-like domain (group 2)
Obsl1

Domain structure obtained by HMM

Protein ID: XP_008824019.1 - obscurin-like protein 1 isoform X2
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
I-setPF07679901.6e-2162.5001210112101Immunoglobulin I-set domain
Herpes_gEPF024804320.0000289.0006712240152Alphaherpesvirus glycoprotein E
I-setPF07679900.000000000000002442.700130229130229Immunoglobulin I-set domain
Herpes_gEPF024804320.000514.900195248170260Alphaherpesvirus glycoprotein E
I-setPF07679907.9e-1953.900255339251339Immunoglobulin I-set domain
I-setPF07679900.0000000003126.400345421344429Immunoglobulin I-set domain
I-setPF07679900.000317.100435505432513Immunoglobulin I-set domain
fn3PF00041850.0000001418.100533605519606Fibronectin type III domain
I-setPF07679900.00001811.100624696619698Immunoglobulin I-set domain
I-setPF07679900.00000000001330.800731793723805Immunoglobulin I-set domain
Ig_3PF13927790.000000000006932.200807884807885Immunoglobulin domain
I-setPF07679900.0000000001727.200921984911987Immunoglobulin I-set domain
Ig_3PF13927790.00000001121.90099410669891067Immunoglobulin domain
BiPBP_CPF06832890.00353.7001080112410741137Penicillin-Binding Protein C-terminus Family
I-setPF07679900.00000000003929.2001102116110931172Immunoglobulin I-set domain
Ig_3PF13927790.0000000006725.8001183124911781250Immunoglobulin domain
I-setPF07679900.00000000002330.0001282134612761351Immunoglobulin I-set domain
I-setPF07679900.0000000000002336.4001366143813631447Immunoglobulin I-set domain
I-setPF07679900.00000000005328.8001454152614521532Immunoglobulin I-set domain
Ig_4PF16680760.0370.8001517153814841541T-cell surface glycoprotein CD3 delta chain
I-setPF07679900.00000002420.3001547161515431621Immunoglobulin I-set domain
I-setPF07679900.000000000000009540.8001633170716321718Immunoglobulin I-set domain
I-setPF07679900.000000000004532.2001724179517221806Immunoglobulin I-set domain
I-setPF07679900.000000000000001843.2001816188718121896Immunoglobulin I-set domain
Ig_4PF16680760.00393.9001867189518441898T-cell surface glycoprotein CD3 delta chain
interactor130.51511.295I-set (PF07679): Immunoglobulin I-set domain
Herpes_gE (PF02480): Alphaherpesvirus glycoprotein E
fn3 (PF00041): Fibronectin type III domain
Ig_3 (PF13927): Immunoglobulin domain
BiPBP_C (PF06832): Penicillin-Binding Protein C-terminus Family
Ig_4 (PF16680): T-cell surface glycoprotein CD3 delta chain
Ppp6c

Domain structure obtained by HMM

Protein ID: XP_008823013.1 - serine/threonine-protein phosphatase 6 catalytic subunit
KEEG Ortholog ID: K15498
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
MetallophosPF001492041.5e-40126.0004723846241Calcineurin-like phosphoesterase
interactor31.0000Metallophos (PF00149): Calcineurin-like phosphoesterase
Prkab1

Domain structure obtained by HMM

Protein ID: XP_008822639.1 - 5'-AMP-activated protein kinase subunit beta-1
KEEG Ortholog ID: K07199
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
AMPK1_CBMPF16561851.2e-38117.5007916178161Glycogen recognition site of AMP-activated protein kinase
AMPKBIPF04739759.5e-3295.5002012691992695'-AMP-activated protein kinase beta subunit, interaction domain
interactor, oncogene30.6670.500AMPK1_CBM (PF16561): Glycogen recognition site of AMP-activated protein kinase
AMPKBI (PF04739): 5'-AMP-activated protein kinase beta subunit, interaction domain
Prmt1

Domain structure obtained by HMM

Protein ID: XP_008843306.1 - protein arginine N-methyltransferase 1 isoform X1
KEEG Ortholog ID: K11434
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Methyltransf_25PF13649970.0000000000007135.5009218992189Methyltransferase domain
Methyltransf_23PF134891650.0350.200215230202289Methyltransferase domain
interactor180.51526.623Methyltransf_25 (PF13649): Methyltransferase domain
Methyltransf_23 (PF13489): Methyltransferase domain
Pygb

Domain structure obtained by HMM

Protein ID: XP_008849402.1 - glycogen phosphorylase, brain form
KEEG Ortholog ID: K00688
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PhosphorylasePF0034371201156.000114828113828Carbohydrate phosphorylase
interactor60.7000.806Phosphorylase (PF00343): Carbohydrate phosphorylase
Rpe

Domain structure obtained by HMM

Protein ID: XP_008844462.1 - ribulose-phosphate 3-epimerase isoform X1
KEEG Ortholog ID: K01783
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Ribul_P_3_epimPF008341982.1e-71225.60062006201Ribulose-phosphate 3 epimerase family
OMPdecasePF002152250.000002413.400171209133212Orotidine 5'-phosphate decarboxylase / HUMPS family
interactor31.0000Ribul_P_3_epim (PF00834): Ribulose-phosphate 3 epimerase family
OMPdecase (PF00215): Orotidine 5'-phosphate decarboxylase / HUMPS family
Sdha

Domain structure obtained by HMM

Protein ID: XP_008850704.1 - succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
KEEG Ortholog ID: K00234
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
FAD_binding_2PF008904177.4e-132426.3006345763457FAD binding domain
Succ_DH_flav_CPF029101281.9e-44137.000512664512664Fumarate reductase flavoprotein C-term
tumor suppressor120.47016.902FAD_binding_2 (PF00890): FAD binding domain
Succ_DH_flav_C (PF02910): Fumarate reductase flavoprotein C-term
Sdhb

Domain structure obtained by HMM

Protein ID: XP_008820855.1 - succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
KEEG Ortholog ID: K00235
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
Fer2_3PF130851091.6e-37114.10042147411482Fe-2S iron-sulfur cluster binding domain
Fer4_8PF13183650.000001614.800156198911994Fe-4S dicluster domain
Fer4_17PF13534610.0000000000001137.8001852581852584Fe-4S dicluster domain
oncogene, tumor suppressor60.8001.300Fer2_3 (PF13085): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
Shc1

Domain structure obtained by HMM

Protein ID: XP_008852870.1 - SHC-transforming protein 1 isoform X1
KEEG Ortholog ID: K06279
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
PIDPF006401404.6e-51158.700162317162318Phosphotyrosine interaction domain (PTB/PID)
SH2PF00017779.1e-2263.300489560489560SH2 domain
oncogene40.6670.182PID (PF00640): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017): SH2 domain
Sirt2

Domain structure obtained by HMM

Protein ID: XP_008852158.1 - NAD-dependent protein deacetylase sirtuin-2
KEEG Ortholog ID: K11412
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SIR2PF021461778.2e-62194.4008426884268Sir2 family
tumor suppressor100SIR2 (PF02146): Sir2 family
Sirt6

Domain structure obtained by HMM

Protein ID: XP_008835222.1 - NAD-dependent protein deacetylase sirtuin-6 isoform X1
KEEG Ortholog ID: K11416
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
SIR2PF021461770.000000001624.1008310483112Sir2 family
SIR2PF021461771.6e-2266.400117252111252Sir2 family
TPP_enzyme_MPF002051370.000001614.100231296226296Thiamine pyrophosphate enzyme, central domain
tumor suppressor21.0000SIR2 (PF02146): Sir2 family
TPP_enzyme_M (PF00205): Thiamine pyrophosphate enzyme, central domain
Sirt7

Domain structure obtained by HMM

Protein ID: XP_008826596.1 - NAD-dependent protein deacetylase sirtuin-7
KEEG Ortholog ID: K11417
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF563PF045772090.000008712.100151133119Protein of unknown function (DUF563)
SIR2PF021461770.00000004219.400108132108140Sir2 family
SIR2PF021461771.3e-2473.200142275133276Sir2 family
interactor120.31822.098DUF563 (PF04577): Protein of unknown function (DUF563)
SIR2 (PF02146): Sir2 family
Srrt

Domain structure obtained by HMM

Protein ID: XP_017653432.1 - serrate RNA effector molecule homolog isoform X1
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF3546PF120661102.5e-44136.300153262153262Domain of unknown function (DUF3546)
MIP-T3PF102435410.0000637.900258402235418Microtubule-binding protein MIP-T3
TRAP_alphaPF038962850.000465.500367426345438Translocon-associated protein (TRAP), alpha subunit
RRM_1PF00076700.000002513.600421490421491RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF4187PF13821540.00001810.800604638594639Domain of unknown function (DUF4187)
ARS2PF049591953.6e-95304.000644849644849Arsenite-resistance protein 2
interactor90.6116.787DUF3546 (PF12066): Domain of unknown function (DUF3546)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
TRAP_alpha (PF03896): Translocon-associated protein (TRAP), alpha subunit
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF4187 (PF13821): Domain of unknown function (DUF4187)
ARS2 (PF04959): Arsenite-resistance protein 2
Stau1

Domain structure obtained by HMM

Protein ID: XP_008833789.1 - double-stranded RNA-binding protein Staufen homolog 1 isoform X1
KEEG Ortholog ID: K17597
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
dsrmPF00035670.0000007316.10046961296Double-stranded RNA binding motif
dsrmPF00035670.0000000000004836.000147196127196Double-stranded RNA binding motif
dsrmPF00035670.000000000000001743.800234299234299Double-stranded RNA binding motif
Staufen_CPF164821111.2e-54169.500394504393504Staufen C-terminal domain
interactor120.6734.474dsrm (PF00035): Double-stranded RNA binding motif
Staufen_C (PF16482): Staufen C-terminal domain
Stip1

Domain structure obtained by HMM

Protein ID: XP_008837186.1 - stress-induced-phosphoprotein 1
KEEG Ortholog ID: K09553
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
TPR_11PF13414420.00000000000233.00011521152TPR repeat
TPR_2PF07719340.00001411.50040593870Tetratricopeptide repeat
TPR_17PF13431340.0192.00066926393Tetratricopeptide repeat
TPR_1PF00515340.000001314.5007310572105Tetratricopeptide repeat
WtapPF170981560.00762.40012916678174WTAP/Mum2p family
DREPPPF055582060.011.800191244158261DREPP plasma membrane polypeptide
TPR_1PF00515340.0000000005925.100230258228258Tetratricopeptide repeat
TPR_12PF13424770.00000000000001740.200262328256328Tetratricopeptide repeat
TPR_11PF13414420.0000000000005834.700367406367407TPR repeat
TPR_1PF00515340.000000000003732.000394427394427Tetratricopeptide repeat
TPR_1PF00515340.0000000002426.300429460428461Tetratricopeptide repeat
WtapPF170981560.00001411.300475523405529WTAP/Mum2p family
interactor80.5714.771TPR_11 (PF13414): TPR repeat
TPR_2 (PF07719): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_1 (PF00515): Tetratricopeptide repeat
Wtap (PF17098): WTAP/Mum2p family
DREPP (PF05558): DREPP plasma membrane polypeptide
TPR_12 (PF13424): Tetratricopeptide repeat
Terf1

Domain structure obtained by HMM

Protein ID: XP_008847104.1 - telomeric repeat-binding factor 1 isoform X1
KEEG Ortholog ID: K11110
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
TRFPF085582392.4e-33101.8006625663259Telomere repeat binding factor (TRF)
Myb_DNA-bindingPF00249470.00000000000002239.700369416369417Myb-like DNA-binding domain
interactor90.5367.672TRF (PF08558): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249): Myb-like DNA-binding domain
Terf2

Domain structure obtained by HMM

Protein ID: XP_008832044.1 - telomeric repeat-binding factor 2
KEEG Ortholog ID: K11111
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
TRFPF085582391.3e-39122.3009428993292Telomere repeat binding factor (TRF)
TERF2_RBMPF16772411e-2472.000319357317357Telomeric repeat-binding factor 2 Rap1-binding motif
Myb_DNA-bind_6PF13921600.0291.000438455424459Myb-like DNA-binding domain
Myb_DNA-bindingPF00249472.4e-1646.000487534487535Myb-like DNA-binding domain
interactor70.7331.648TRF (PF08558): Telomere repeat binding factor (TRF)
TERF2_RBM (PF16772): Telomeric repeat-binding factor 2 Rap1-binding motif
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
Myb_DNA-binding (PF00249): Myb-like DNA-binding domain
Tfe3

Domain structure obtained by HMM

Protein ID: XP_008840796.1 - transcription factor E3 isoform X1
KEEG Ortholog ID: K09105
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
MITF_TFEB_C_3_NPF159511536.3e-59185.200113266113266MITF/TFEB/TFEC/TFE3 N-terminus
HLHPF00010552.5e-2058.600347400347400Helix-loop-helix DNA-binding domain
DUF3371PF118511265e-2265.500432572432572Domain of unknown function (DUF3371)
oncogene31.0000MITF_TFEB_C_3_N (PF15951): MITF/TFEB/TFEC/TFE3 N-terminus
HLH (PF00010): Helix-loop-helix DNA-binding domain
DUF3371 (PF11851): Domain of unknown function (DUF3371)
Ubc

Domain structure obtained by HMM

Protein ID: XP_008837468.1 - polyubiquitin-C
KEEG Ortholog ID: K08770
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
ubiquitinPF00240722e-33100.300374374Ubiquitin family
ubiquitinPF00240723.4e-3296.4007915079150Ubiquitin family
ubiquitinPF00240723.4e-3296.400155226155226Ubiquitin family
ubiquitinPF00240723.4e-3296.400231302231302Ubiquitin family
ubiquitinPF00240723.4e-3296.400307378307378Ubiquitin family
ubiquitinPF00240722.9e-35106.200383454383454Ubiquitin family
ubiquitinPF00240720.000003113.200459483459486Ubiquitin family
interactor180.42650.131ubiquitin (PF00240): Ubiquitin family
Ubr4

Domain structure obtained by HMM

Protein ID: XP_017650758.1 - E3 ubiquitin-protein ligase UBR4 isoform X4
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
FAM176PF148511440.00154.400533587525606FAM176 family
CAP_NPF012133170.00193.800601633580640Adenylate cyclase associated (CAP) N terminal
zf-UBRPF02207700.00000000007728.4001661171916601725Putative zinc finger in N-recognin (UBR box)
PheromonePF08015690.0580.8001725176717211784Fungal mating-type pheromone
FAM176PF148511440.00433.0002720277027152804FAM176 family
Ribosomal_60sPF00428880.0000002517.500334134073336341260s Acidic ribosomal protein
AP3D1PF063751580.00066.3003385342333683427AP-3 complex subunit delta-1
RecRPF02132400.0190.9003554356435503565RecR protein
DZRPF12773490.00001411.4003686373036863730Double zinc ribbon
DZRPF12773490.0370.4003827390738213910Double zinc ribbon
E3_UbLigase_R4PF1376481001129.8004393518943935189E3 ubiquitin-protein ligase UBR4
interactor40.6670.508FAM176 (PF14851): FAM176 family
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
zf-UBR (PF02207): Putative zinc finger in N-recognin (UBR box)
Pheromone (PF08015): Fungal mating-type pheromone
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
AP3D1 (PF06375): AP-3 complex subunit delta-1
RecR (PF02132): RecR protein
DZR (PF12773): Double zinc ribbon
E3_UbLigase_R4 (PF13764): E3 ubiquitin-protein ligase UBR4
Usp13

Domain structure obtained by HMM

Protein ID: XP_008836878.1 - ubiquitin carboxyl-terminal hydrolase 13 isoform X1
KEEG Ortholog ID: K11836
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
zf-UBPPF02148640.0142.10061914694Zn-finger in ubiquitin-hydrolases and other protein
zf-UBPPF02148642e-1852.800209281209282Zn-finger in ubiquitin-hydrolases and other protein
UCHPF004432578.6e-53165.500334853334853Ubiquitin carboxyl-terminal hydrolase
interactor21.0000zf-UBP (PF02148): Zn-finger in ubiquitin-hydrolases and other protein
UCH (PF00443): Ubiquitin carboxyl-terminal hydrolase
Znf746

Domain structure obtained by HMM

Protein ID: XP_008832022.2 - zinc finger protein 746
KEEG Ortholog ID: K09228
DomainsPfam IDlengthE-valueScorealifromalitoenvfromenvtoDescription
DUF3669PF12417720.0000000000001736.90036912292Zinc finger protein
KRABPF01352420.00000000000005737.900118147117147KRAB box
zf-H2C2_2PF13465260.0000779.500451472446472Zinc-finger double domain
zf-C2H2PF00096230.000001315.100463483463484Zinc finger, C2H2 type
Period_CPF121141950.00193.900478515466526Period protein 2/3C-terminal region
zf-C2H2_11PF16622290.000000002423.100516540516542zinc-finger C2H2-type
zf-H2C2_2PF13465260.000000001324.600534558534559Zinc-finger double domain
zf-C2H2PF00096230.00000007419.000548570548570Zinc finger, C2H2 type
zf-H2C2_2PF13465260.0000000002426.900565585562587Zinc-finger double domain
zf-C2H2PF00096230.0000000001327.800576598576598Zinc finger, C2H2 type
interactor70.4005.519DUF3669 (PF12417): Zinc finger protein
KRAB (PF01352): KRAB box
zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2 (PF00096): Zinc finger, C2H2 type
Period_C (PF12114): Period protein 2/3C-terminal region
zf-C2H2_11 (PF16622): zinc-finger C2H2-type

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