Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Acly (from a repository: Wed Apr 11 18:45:03 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)58
The number (and %) of the onco-proteins9 (15.52 %)
The number (and %) of the tumor suppressors8 (13.79 %)
Total number of binary PPIs (saturation %)308 (18.63 %)
The number (and %) of affected PPIs57 (18.51 %)
PPI diameter2
PPI radius1
The average degree of PPI9.517
Assortativity coefficient-0.4125
The network average Clustering coefficient0.576
The number (and %) of a zero Clustering coefficients4 (6.90 %)
The number (and %) of a zero Betweenness Centrality13 (22.41 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Acly
user protein570.1371838.567ATP-grasp_2 (PF08442): ATP-grasp domain
Citrate_bind (PF16114): ATP citrate lyase citrate-binding
CoA_binding (PF02629): CoA binding domain
Ligase_CoA (PF00549): CoA-ligase
Citrate_synt (PF00285): Citrate synthase, C-terminal domain
Ahsa1
interactor100.5569.652MdcG (PF10620): Phosphoribosyl-dephospho-CoA transferase MdcG
AHSA1 (PF08327): Activator of Hsp90 ATPase homolog 1-like protein
App
interactor200.27585.472APP_N (PF02177): Amyloid A4 N-terminal heparin-binding
APP_Cu_bd (PF12924): Copper-binding of amyloid precursor, CuBD
SDA1 (PF05285): SDA1
YtxH (PF12732): YtxH-like protein
Kunitz_BPTI (PF00014): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_E2 (PF12925): E2 domain of amyloid precursor protein
Beta-APP (PF03494): Beta-amyloid peptide (beta-APP)
APP_amyloid (PF10515): beta-amyloid precursor protein C-terminus
Asb15
interactor100Ank_2 (PF12796): Ankyrin repeats (3 copies)
SOCS_box (PF07525): SOCS box
Bag3
oncogene80.4766.917WW (PF00397): WW domain
RNA_pol_Rpc4 (PF05132): RNA polymerase III RPC4
DUF4124 (PF13511): Domain of unknown function (DUF4124)
BAG (PF02179): BAG domain
Rib_recp_KP_reg (PF05104): Ribosome receptor lysine/proline rich region
Cand1
interactor210.41163.350HEAT_2 (PF13646): HEAT repeats
Cnd1 (PF12717): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
DUF3385 (PF11865): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
HEAT (PF02985): HEAT repeat
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
MMS19_C (PF12460): RNAPII transcription regulator C-terminal
Adaptin_N (PF01602): Adaptin N terminal region
TIP120 (PF08623): TATA-binding protein interacting (TIP20)
Cry1
interactor60.8000.472DNA_photolyase (PF00875): DNA photolyase
FAD_binding_7 (PF03441): FAD binding domain of DNA photolyase
Cry2
interactor90.7142.662DNA_photolyase (PF00875): DNA photolyase
FAD_binding_7 (PF03441): FAD binding domain of DNA photolyase
Cs
interactor60.6672.250Citrate_synt (PF00285): Citrate synthase, C-terminal domain
Cth
interactor31.0000Cys_Met_Meta_PP (PF01053): Cys/Met metabolism PLP-dependent enzyme
Cul2
tumor suppressor130.53821.060Cullin (PF00888): Cullin family
Cullin_Nedd8 (PF10557): Cullin protein neddylation domain
Cul3
interactor200.43345.256Cullin (PF00888): Cullin family
WAC_Acf1_DNA_bd (PF10537): ATP-utilising chromatin assembly and remodelling N-terminal
Cullin_Nedd8 (PF10557): Cullin protein neddylation domain
Cul7
interactor150.45118.891Cul7 (PF11515): Mouse development and cellular proliferation protein Cullin-7
ANAPC10 (PF03256): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888): Cullin family
Cullin_Nedd8 (PF10557): Cullin protein neddylation domain
Ddias
interactor100Rep_fac-A_C (PF08646): Replication factor-A C terminal domain
FYVE (PF01363): FYVE zinc finger
YgbA_NO (PF11756): Nitrous oxide-stimulated promoter
Peptidase_A2B (PF12384): Ty3 transposon peptidase
Derl1
interactor60.7000.765DER1 (PF04511): Der1-like family
Eef1d
interactor130.51511.560Cytochrom_C_2 (PF01322): Cytochrome C'
PGA2 (PF07543): Protein trafficking PGA2
UPF0565 (PF10561): Uncharacterised protein family UPF0565
EF-1_beta_acid (PF10587): Eukaryotic elongation factor 1 beta central acidic region
EF1_GNE (PF00736): EF-1 guanine nucleotide exchange domain
Fn1
oncogene140.46217.077fn1 (PF00039): Fibronectin type I domain
fn2 (PF00040): Fibronectin type II domain
fn3 (PF00041): Fibronectin type III domain
DUF2369 (PF10179): Uncharacterised conserved protein (DUF2369)
Gsk3b
oncogene, tumor suppressor40.6670.667Pkinase (PF00069): Protein kinase domain
Hdac5
interactor80.5245.833HDAC4_Gln (PF12203): Glutamine rich N terminal domain of histone deacetylase 4
TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
PTPRCAP (PF15713): Protein tyrosine phosphatase receptor type C-associated
Hist_deacetyl (PF00850): Histone deacetylase domain
Hgs
interactor50.7000.715VHS (PF00790): VHS domain
FYVE (PF01363): FYVE zinc finger
UIM (PF02809): Ubiquitin interaction motif
EF-1_beta_acid (PF10587): Eukaryotic elongation factor 1 beta central acidic region
DUF3306 (PF11748): Protein of unknown function (DUF3306)
Hrs_helical (PF12210): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917): Piezo
Hnrnpk
oncogene250.362110.631ROKNT (PF08067): ROKNT (NUC014) domain
KH_1 (PF00013): KH domain
Huwe1
oncogene190.41241.708DUF908 (PF06012): Domain of Unknown Function (DUF908)
DUF913 (PF06025): Domain of Unknown Function (DUF913)
PBP_sp32 (PF07222): Proacrosin binding protein sp32
UBA (PF00627): UBA/TS-N domain
U1snRNP70_N (PF12220): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
FdhE (PF04216): Protein involved in formate dehydrogenase formation
WWE (PF02825): WWE domain
BSP_II (PF05432): Bone sialoprotein II (BSP-II)
Ku_C (PF03730): Ku70/Ku80 C-terminal arm
RNA_pol_Rpc4 (PF05132): RNA polymerase III RPC4
TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
Tim54 (PF11711): Inner membrane protein import complex subunit Tim54
Nop14 (PF04147): Nop14-like family
DUF4414 (PF14377): Domain of unknown function (DUF4414)
Mucin (PF01456): Mucin-like glycoprotein
BUD22 (PF09073): BUD22
HABP4_PAI-RBP1 (PF04774): Hyaluronan / mRNA binding family
HECT (PF00632): HECT-domain (ubiquitin-transferase)
Ikbke
interactor31.0000Pkinase (PF00069): Protein kinase domain
zf-RING_9 (PF13901): Putative zinc-RING and/or ribbon
TPR_MLP1_2 (PF07926): TPR/MLP1/MLP2-like protein
Isg15
tumor suppressor40.8330.500ubiquitin (PF00240): Ubiquitin family
Kat2b
interactor31.0000PCAF_N (PF06466): PCAF (P300/CBP-associated factor) N-terminal domain
Acetyltransf_1 (PF00583): Acetyltransferase (GNAT) family
Bromodomain (PF00439): Bromodomain
Kpna2
interactor140.47320.402IBB (PF01749): Importin beta binding domain
Arm (PF00514): Armadillo/beta-catenin-like repeat
Arm_3 (PF16186): Atypical Arm repeat
Kpna4
interactor60.7331.486IBB (PF01749): Importin beta binding domain
Arm (PF00514): Armadillo/beta-catenin-like repeat
Arm_3 (PF16186): Atypical Arm repeat
LOC103730663
interactor80.5717.548Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank (PF00023): Ankyrin repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
Mcm2
oncogene260.347107.732MCM2_N (PF12619): Mini-chromosome maintenance protein 2
MCM_N (PF14551): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
AAA_3 (PF07726): ATPase family associated with various cellular activities (AAA)
MCM (PF00493): MCM2/3/5 family
Mcm6
interactor120.41813.080MCM_N (PF14551): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
MCM (PF00493): MCM2/3/5 family
Jnk-SapK_ap_N (PF09744): JNK_SAPK-associated protein-1
YmgB (PF10798): Biofilm development protein YmgB/AriR
Naprt
interactor21.0000NAPRTase (PF04095): Nicotinate phosphoribosyltransferase (NAPRTase) family
Ncl
interactor210.44748.971PBP1_TM (PF14812): Transmembrane domain of transglycosylase PBP1 at N-terminal
YL1 (PF05764): YL1 nuclear protein
Myc_N (PF01056): Myc amino-terminal region
ANAPC15 (PF15243): Anaphase-promoting complex subunit 15
Sigma70_ner (PF04546): Sigma-70, non-essential region
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608): Limkain b1
Nme1
tumor suppressor60.8001.067NDK (PF00334): Nucleoside diphosphate kinase
Ntrk1
oncogene250.341102.894LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Nup107
interactor70.3815.600Nup84_Nup100 (PF04121): Nuclear pore protein 84 / 107
Nup210l
interactor100T2SS-T3SS_pil_N (PF13629): Pilus formation protein N terminal region
Big_2 (PF02368): Bacterial Ig-like domain (group 2)
Obsl1
interactor130.51511.295I-set (PF07679): Immunoglobulin I-set domain
Herpes_gE (PF02480): Alphaherpesvirus glycoprotein E
fn3 (PF00041): Fibronectin type III domain
Ig_3 (PF13927): Immunoglobulin domain
BiPBP_C (PF06832): Penicillin-Binding Protein C-terminus Family
Ig_4 (PF16680): T-cell surface glycoprotein CD3 delta chain
Ppp6c
interactor31.0000Metallophos (PF00149): Calcineurin-like phosphoesterase
Prkab1
interactor, oncogene30.6670.500AMPK1_CBM (PF16561): Glycogen recognition site of AMP-activated protein kinase
AMPKBI (PF04739): 5'-AMP-activated protein kinase beta subunit, interaction domain
Prmt1
interactor180.51526.623Methyltransf_25 (PF13649): Methyltransferase domain
Methyltransf_23 (PF13489): Methyltransferase domain
Pygb
interactor60.7000.806Phosphorylase (PF00343): Carbohydrate phosphorylase
Rpe
interactor31.0000Ribul_P_3_epim (PF00834): Ribulose-phosphate 3 epimerase family
OMPdecase (PF00215): Orotidine 5'-phosphate decarboxylase / HUMPS family
Sdha
tumor suppressor120.47016.902FAD_binding_2 (PF00890): FAD binding domain
Succ_DH_flav_C (PF02910): Fumarate reductase flavoprotein C-term
Sdhb
oncogene, tumor suppressor60.8001.300Fer2_3 (PF13085): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
Shc1
oncogene40.6670.182PID (PF00640): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017): SH2 domain
Sirt2
tumor suppressor100SIR2 (PF02146): Sir2 family
Sirt6
tumor suppressor21.0000SIR2 (PF02146): Sir2 family
TPP_enzyme_M (PF00205): Thiamine pyrophosphate enzyme, central domain
Sirt7
interactor120.31822.098DUF563 (PF04577): Protein of unknown function (DUF563)
SIR2 (PF02146): Sir2 family
Srrt
interactor90.6116.787DUF3546 (PF12066): Domain of unknown function (DUF3546)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
TRAP_alpha (PF03896): Translocon-associated protein (TRAP), alpha subunit
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF4187 (PF13821): Domain of unknown function (DUF4187)
ARS2 (PF04959): Arsenite-resistance protein 2
Stau1
interactor120.6734.474dsrm (PF00035): Double-stranded RNA binding motif
Staufen_C (PF16482): Staufen C-terminal domain
Stip1
interactor80.5714.771TPR_11 (PF13414): TPR repeat
TPR_2 (PF07719): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_1 (PF00515): Tetratricopeptide repeat
Wtap (PF17098): WTAP/Mum2p family
DREPP (PF05558): DREPP plasma membrane polypeptide
TPR_12 (PF13424): Tetratricopeptide repeat
Terf1
interactor90.5367.672TRF (PF08558): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249): Myb-like DNA-binding domain
Terf2
interactor70.7331.648TRF (PF08558): Telomere repeat binding factor (TRF)
TERF2_RBM (PF16772): Telomeric repeat-binding factor 2 Rap1-binding motif
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
Myb_DNA-binding (PF00249): Myb-like DNA-binding domain
Tfe3
oncogene31.0000MITF_TFEB_C_3_N (PF15951): MITF/TFEB/TFEC/TFE3 N-terminus
HLH (PF00010): Helix-loop-helix DNA-binding domain
DUF3371 (PF11851): Domain of unknown function (DUF3371)
Ubc
interactor180.42650.131ubiquitin (PF00240): Ubiquitin family
Ubr4
interactor40.6670.508FAM176 (PF14851): FAM176 family
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
zf-UBR (PF02207): Putative zinc finger in N-recognin (UBR box)
Pheromone (PF08015): Fungal mating-type pheromone
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
AP3D1 (PF06375): AP-3 complex subunit delta-1
RecR (PF02132): RecR protein
DZR (PF12773): Double zinc ribbon
E3_UbLigase_R4 (PF13764): E3 ubiquitin-protein ligase UBR4
Usp13
interactor21.0000zf-UBP (PF02148): Zn-finger in ubiquitin-hydrolases and other protein
UCH (PF00443): Ubiquitin carboxyl-terminal hydrolase
Znf746
interactor70.4005.519DUF3669 (PF12417): Zinc finger protein
KRAB (PF01352): KRAB box
zf-H2C2_2 (PF13465): Zinc-finger double domain
zf-C2H2 (PF00096): Zinc finger, C2H2 type
Period_C (PF12114): Period protein 2/3C-terminal region
zf-C2H2_11 (PF16622): zinc-finger C2H2-type

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