Find Protein-Protein Interactions (PPI) Network

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Protein/NCBI_ID(s): Refseq_ID(s): KEGG_KO(s):	Ackr3
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Visualization interactions

Cytoscape.js taxid = 1026970 for: protein(s) Ackr3 (from a repository: Sat Apr 28 10:38:08 2018)

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Statistics and Network structure information

Statistics of PPI	Value(s)
The number of interactors (fusion and proteins)	12
The number (and %) of the onco-proteins	0 (0.00 %)
The number (and %) of the tumor suppressors	0 (0.00 %)
Total number of binary PPIs (saturation %)	22 (33.33 %)
The number (and %) of affected PPIs	11 (50.00 %)
PPI diameter	2
PPI radius	1
The average degree of PPI	3.500
Assortativity coefficient	-0.6030
The network average Clustering coefficient	0.432
The number (and %) of a zero Clustering coefficients	6 (50.00 %)
The number (and %) of a zero Betweenness Centrality	11 (91.67 %)

ACTIVE INTERACTORS

List of active interactors

Interactor,
Domain structure

Type

Number
of PPI (degree)

Clustering
Coefficient

Betweenness
Centrality

Domains (Pfam ID): description

Ackr3

XP_008821884.1

Domain structure obtained by HMM

Protein ID: XP_008821884.1 - atypical chemokine receptor 3
KEEG Ortholog ID: K04304

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
DUF912	PF06024	103	0.012	2.300	39	57	14	75	Nucleopolyhedrovirus protein of unknown function (DUF912)
DUF996	PF06195	135	0.01	2.300	46	103	28	108	Protein of unknown function (DUF996)
7tm_1	PF00001	268	7.7e-49	152.400	62	315	61	315	7 transmembrane receptor (rhodopsin family)

user protein, oncogene

0.182

90.000

DUF912 (PF06024): Nucleopolyhedrovirus protein of unknown function (DUF912)
DUF996 (PF06195): Protein of unknown function (DUF996)
7tm_1 (PF00001): 7 transmembrane receptor (rhodopsin family)

Atp13a2

XP_017650973.1

Domain structure obtained by HMM

Protein ID: XP_017650973.1 - probable cation-transporting ATPase 13A2 isoform X2

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
P5-ATPase	PF12409	125	6.8e-29	86.800	38	174	35	175	P5-type ATPase cation transporter
Cation_ATPase_N	PF00690	69	0.00000061	15.400	194	246	187	250	Cation transporter/ATPase, N-terminus
E1-E2_ATPase	PF00122	221	1e-41	128.800	262	496	260	501	E1-E2 ATPase
Hydrolase	PF00702	210	4.5e-20	58.900	507	850	506	850	haloacid dehalogenase-like hydrolase
MARVEL	PF01284	144	0.03	0.500	884	939	855	976	Membrane-associating domain
MARVEL	PF01284	144	0.011	1.900	1033	1093	1006	1099	Membrane-associating domain

interactor

P5-ATPase (PF12409): P5-type ATPase cation transporter
Cation_ATPase_N (PF00690): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122): E1-E2 ATPase
Hydrolase (PF00702): haloacid dehalogenase-like hydrolase
MARVEL (PF01284): Membrane-associating domain

Atp5a1

XP_008824135.1

Domain structure obtained by HMM

Protein ID: XP_008824135.1 - ATP synthase subunit alpha, mitochondrial
KEEG Ortholog ID: K02132

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
ATP-synt_ab_N	PF02874	69	1.3e-20	60.100	69	135	67	135	ATP synthase alpha/beta family, beta-barrel domain
ATP-synt_ab	PF00006	213	5.9e-79	250.800	192	415	192	415	ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C	PF00306	126	2e-51	159.800	422	547	422	547	ATP synthase alpha/beta chain, C terminal domain

interactor

1.000

ATP-synt_ab_N (PF02874): ATP synthase alpha/beta family, beta-barrel domain
ATP-synt_ab (PF00006): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306): ATP synthase alpha/beta chain, C terminal domain

Atp5b

XP_008826611.1

Domain structure obtained by HMM

Protein ID: XP_008826611.1 - ATP synthase subunit beta, mitochondrial
KEEG Ortholog ID: K02133

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
ATP-synt_ab_N	PF02874	69	5.9e-26	77.100	65	131	65	131	ATP synthase alpha/beta family, beta-barrel domain
ATP-synt_ab	PF00006	213	1.3e-68	217.000	188	407	188	407	ATP synthase alpha/beta family, nucleotide-binding domain
AAA	PF00004	132	0.041	0.600	421	451	385	475	ATPase family associated with various cellular activities (AAA)

interactor

1.000

ATP-synt_ab_N (PF02874): ATP synthase alpha/beta family, beta-barrel domain
ATP-synt_ab (PF00006): ATP synthase alpha/beta family, nucleotide-binding domain
AAA (PF00004): ATPase family associated with various cellular activities (AAA)

Atp5d

XP_008835398.1

Domain structure obtained by HMM

Protein ID: XP_008835398.1 - ATP synthase subunit delta, mitochondrial
KEEG Ortholog ID: K02134

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
ATP-synt_DE_N	PF02823	80	1e-20	59.800	39	120	39	120	ATP synthase, Delta/Epsilon chain, beta-sandwich domain
Fil_haemagg	PF05594	77	0.0000083	12.600	100	160	100	165	Haemagluttinin repeat

interactor

1.000

ATP-synt_DE_N (PF02823): ATP synthase, Delta/Epsilon chain, beta-sandwich domain
Fil_haemagg (PF05594): Haemagluttinin repeat

Atp5h

XP_008829658.1

Domain structure obtained by HMM

Protein ID: XP_008829658.1 - ATP synthase subunit d, mitochondrial isoform X2
KEEG Ortholog ID: K02138

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Mt_ATP-synt_D	PF05873	154	8.3e-70	219.800	3	155	3	155	ATP synthase D chain, mitochondrial (ATP5H)

interactor

1.000

Mt_ATP-synt_D (PF05873): ATP synthase D chain, mitochondrial (ATP5H)

Atp5o

XP_008834159.1

Domain structure obtained by HMM

Protein ID: XP_008834159.1 - ATP synthase subunit O, mitochondrial
KEEG Ortholog ID: K02137

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
OSCP	PF00213	172	3.5e-49	153.400	37	209	37	209	ATP synthase delta (OSCP) subunit

interactor

1.000

OSCP (PF00213): ATP synthase delta (OSCP) subunit

Espl1

XP_008836757.1

Domain structure obtained by HMM

Protein ID: XP_008836757.1 - separin
KEEG Ortholog ID: K02365

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Peptidase_C50	PF03568	395	2.3e-96	309.400	1717	2063	1714	2063	Peptidase family C50

interactor

Peptidase_C50 (PF03568): Peptidase family C50

Hectd2

XP_008847857.1

Domain structure obtained by HMM

Protein ID: XP_008847857.1 - probable E3 ubiquitin-protein ligase HECTD2
KEEG Ortholog ID: K12232

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
HECT	PF00632	307	1.8e-89	286.300	617	926	616	926	HECT-domain (ubiquitin-transferase)

interactor

HECT (PF00632): HECT-domain (ubiquitin-transferase)

LOC103726726

XP_008822566.1

Domain structure obtained by HMM

Protein ID: XP_008822566.1 - gap junction beta-2 protein
KEEG Ortholog ID: K07621

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Connexin	PF00029	226	7.7e-91	290.000	2	214	2	215	Connexin

interactor

Connexin (PF00029): Connexin

Mrpl4

XP_008848283.1

Domain structure obtained by HMM

Protein ID: XP_008848283.1 - 39S ribosomal protein L4, mitochondrial isoform X1
KEEG Ortholog ID: K02926

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
Ribosomal_L4	PF00573	192	5e-59	185.300	81	272	80	272	Ribosomal protein L4/L1 family

interactor

Ribosomal_L4 (PF00573): Ribosomal protein L4/L1 family

Ubr7

XP_008819934.1

Domain structure obtained by HMM

Protein ID: XP_008819934.1 - putative E3 ubiquitin-protein ligase UBR7 isoform X1
KEEG Ortholog ID: K11979

Domains	Pfam ID	length	E-value	Score	alifrom	alito	envfrom	envto	Description
zf-UBR	PF02207	70	7.1e-17	47.700	46	112	45	113	Putative zinc finger in N-recognin (UBR box)
PHD	PF00628	52	0.000000011	21.200	134	187	134	188	PHD-finger

interactor

zf-UBR (PF02207): Putative zinc finger in N-recognin (UBR box)
PHD (PF00628): PHD-finger

B a c k t o T o p ⇑