Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Acd (from a repository: Wed Apr 11 06:30:54 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)55
The number (and %) of the onco-proteins13 (23.64 %)
The number (and %) of the tumor suppressors5 (9.09 %)
Total number of binary PPIs (saturation %)238 (16.03 %)
The number (and %) of affected PPIs54 (22.69 %)
PPI diameter2
PPI radius1
The average degree of PPI7.891
Assortativity coefficient-0.5077
The network average Clustering coefficient0.749
The number (and %) of a zero Clustering coefficients2 (3.64 %)
The number (and %) of a zero Betweenness Centrality26 (47.27 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Acd
user protein540.1141253.947TPP1 (PF10341): Shelterin complex subunit, TPP1/ACD
Actb
oncogene50.6670.619Actin (PF00022): Actin
Adprh
tumor suppressor100ADP_ribosyl_GH (PF03747): ADP-ribosylglycohydrolase
Afap1l2
tumor suppressor51.0000PH (PF00169): PH domain
DUF2730 (PF10805): Protein of unknown function (DUF2730)
THOC7 (PF05615): Tho complex subunit 7
Mod_r (PF07200): Modifier of rudimentary (Mod(r)) protein
BCL_N (PF04714): BCL7, N-terminal conserver region
Aipl1
interactor31.0000FKBP_C (PF00254): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_11 (PF13414): TPR repeat
TPR_2 (PF07719): Tetratricopeptide repeat
Ankmy2
interactor31.0000Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_3 (PF13606): Ankyrin repeat
zf-C6H2 (PF15801): zf-MYND-like zinc finger, mRNA-binding
zf-MYND (PF01753): MYND finger
Bag3
oncogene120.6189.375WW (PF00397): WW domain
RNA_pol_Rpc4 (PF05132): RNA polymerase III RPC4
DUF4124 (PF13511): Domain of unknown function (DUF4124)
BAG (PF02179): BAG domain
Rib_recp_KP_reg (PF05104): Ribosome receptor lysine/proline rich region
Ckb
interactor41.0000ATP-gua_PtransN (PF02807): ATP:guanido phosphotransferase, N-terminal domain
ATP-gua_Ptrans (PF00217): ATP:guanido phosphotransferase, C-terminal catalytic domain
Cttn
oncogene31.0000HS1_rep (PF02218): Repeat in HS1/Cortactin
FadA (PF09403): Adhesion protein FadA
SH3_9 (PF14604): Variant SH3 domain
Cul5
tumor suppressor70.3816.086Cullin (PF00888): Cullin family
GlutR_dimer (PF00745): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557): Cullin protein neddylation domain
Dcx
interactor41.0000Pheromone (PF08015): Fungal mating-type pheromone
DCX (PF03607): Doublecortin
Dpysl3
interactor40.8330.286Amidohydro_3 (PF07969): Amidohydrolase family
Amidohydro_1 (PF01979): Amidohydrolase family
Eif3g
interactor31.0000eIF3g (PF12353): Eukaryotic translation initiation factor 3 subunit G
CDV3 (PF15359): Carnitine deficiency-associated protein 3
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Eif4b
interactor90.5718.190RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3774 (PF12609): Wound-induced protein
Eno2
interactor80.6794.867Enolase_N (PF03952): Enolase, N-terminal domain
Enolase_C (PF00113): Enolase, C-terminal TIM barrel domain
Ensa
interactor31.0000MAS20 (PF02064): MAS20 protein import receptor
Endosulfine (PF04667): cAMP-regulated phosphoprotein/endosulfine conserved region
Fam131b
interactor31.0000FAM131 (PF15010): Putative cell signalling
Fkbp6
interactor31.0000FKBP_C (PF00254): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
Fis1_TPR_C (PF14853): Fis1 C-terminal tetratricopeptide repeat
Gapdh
interactor, oncogene100.6675.575Gp_dh_N (PF00044): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
Gp_dh_C (PF02800): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Hsp90ab1
oncogene150.46228.409HATPase_c (PF02518): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183): Hsp90 protein
Ipo5
interactor40.8330.182HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
IBN_N (PF03810): Importin-beta N-terminal domain
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
AAA_30 (PF13604): AAA domain
DUF3385 (PF11865): Domain of unknown function (DUF3385)
PBP1_TM (PF14812): Transmembrane domain of transglycosylase PBP1 at N-terminal
RTP1_C1 (PF10363): Required for nuclear transport of RNA pol II C-terminus 1
HEAT (PF02985): HEAT repeat
Ivl
interactor31.0000Involucrin_N (PF10583): Involucrin of squamous epithelia N-terminus
Involucrin2 (PF06994): Involucrin
Exonuc_VII_L (PF02601): Exonuclease VII, large subunit
LOC103735029
interactor41.0000Annexin (PF00191): Annexin
Lasp1
oncogene51.0000LIM (PF00412): LIM domain
Nebulin (PF00880): Nebulin repeat
SH3_9 (PF14604): Variant SH3 domain
Ldha
interactor70.8001.019Ldh_1_N (PF00056): lactate/malate dehydrogenase, NAD binding domain
Ldh_1_C (PF02866): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Lgalsl
interactor31.0000Gal-bind_lectin (PF00337): Galactoside-binding lectin
Lrrc25
oncogene100LRR_8 (PF13855): Leucine rich repeat
Ncdn
interactor40.6670.348Neurochondrin (PF05536): Neurochondrin
Nudc
interactor41.0000Nudc_N (PF14050): N-terminal conserved domain of Nudc.
NuDC (PF16273): Nuclear distribution C domain
CS (PF04969): CS domain
Vfa1 (PF08432): AAA-ATPase Vps4-associated protein 1
Nudcd2
interactor51.0000CS (PF04969): CS domain
DUF3110 (PF11360): Protein of unknown function (DUF3110)
Pdlim2
interactor31.0000PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
DUF4749 (PF15936): Domain of unknown function (DUF4749)
LIM (PF00412): LIM domain
Pex5
interactor40.6670.348SHNi-TPR (PF10516): SHNi-TPR
Secretin_N_2 (PF07655): Secretin N-terminal domain
PRY (PF13765): SPRY-associated domain
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_1 (PF00515): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Pgm2
interactor51.0000PGM_PMM_I (PF02878): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PGM_PMM_II (PF02879): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PGM_PMM_III (PF02880): Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PGM_PMM_IV (PF00408): Phosphoglucomutase/phosphomannomutase, C-terminal domain
Pot1
interactor450.142591.513POT1 (PF02765): Telomeric single stranded DNA binding POT1/CDC13
POT1PC (PF16686): ssDNA-binding domain of telomere protection protein
Zn_Tnp_IS1 (PF03811): InsA N-terminal domain
tRNA_anti-codon (PF01336): OB-fold nucleic acid binding domain
Rbks
interactor21.0000PfkB (PF00294): pfkB family carbohydrate kinase
Recql4
oncogene41.0000Drc1-Sld2 (PF11719): DNA replication and checkpoint protein
zf-CCHC (PF00098): Zinc knuckle
DEAD (PF00270): DEAD/DEAH box helicase
Helicase_C (PF00271): Helicase conserved C-terminal domain
Rpsa
interactor70.7142.215Ribosomal_S2 (PF00318): Ribosomal protein S2
40S_SA_C (PF16122): 40S ribosomal protein SA C-terminus
Sbds
oncogene41.0000SBDS (PF01172): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377): SBDS protein C-terminal domain
Stip1
interactor60.8001.133TPR_11 (PF13414): TPR repeat
TPR_2 (PF07719): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_1 (PF00515): Tetratricopeptide repeat
Wtap (PF17098): WTAP/Mum2p family
DREPP (PF05558): DREPP plasma membrane polypeptide
TPR_12 (PF13424): Tetratricopeptide repeat
Stub1
tumor suppressor90.8571.533ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_20 (PF14561): Tetratricopeptide repeat
U-box (PF04564): U-box domain
Sult1b1
interactor51.0000DUF1699 (PF08004): Protein of unknown function (DUF1699)
Sulfotransfer_1 (PF00685): Sulfotransferase domain
Tagln
oncogene, tumor suppressor60.8001.233Calponin (PF00402): Calponin family repeat
CH (PF00307): Calponin homology (CH) domain
Tbcd
interactor50.8000.786HEAT (PF02985): HEAT repeat
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TFCD_C (PF12612): Tubulin folding cofactor D C terminal
Adaptin_N (PF01602): Adaptin N terminal region
Terf1
interactor300.239177.468TRF (PF08558): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249): Myb-like DNA-binding domain
Terf2
interactor100.7503.686TRF (PF08558): Telomere repeat binding factor (TRF)
TERF2_RBM (PF16772): Telomeric repeat-binding factor 2 Rap1-binding motif
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
Myb_DNA-binding (PF00249): Myb-like DNA-binding domain
Terf2ip
interactor120.49117.134BRCT_2 (PF16589): BRCT domain, a BRCA1 C-terminus domain
Myb_DNA-bind_2 (PF08914): Rap1 Myb domain
KMP11 (PF03037): Kinetoplastid membrane protein 11
HATPase_c_2 (PF13581): Histidine kinase-like ATPase domain
Rap1_C (PF11626): TRF2-interacting telomeric protein/Rap1 - C terminal domain
Tinf2
interactor380.165368.805TINF2_N (PF14973): TERF1-interacting nuclear factor 2 N-terminus
Trim16
interactor41.0000zf-B_box (PF00643): B-box zinc finger
PRY (PF13765): SPRY-associated domain
SPRY (PF00622): SPRY domain
Tubb1
interactor90.6434.575Tubulin (PF00091): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953): Tubulin C-terminal domain
ART (PF01129): NAD:arginine ADP-ribosyltransferase
Tubb4b
interactor80.6433.375Tubulin (PF00091): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953): Tubulin C-terminal domain
Usp7
oncogene31.0000MATH (PF00917): MATH domain
UCH (PF00443): Ubiquitin carboxyl-terminal hydrolase
USP7_C2 (PF14533): Ubiquitin-specific protease C-terminal
USP7_ICP0_bdg (PF12436): ICP0-binding domain of Ubiquitin-specific protease 7
Xpo1
interactor130.32126.675IBN_N (PF03810): Importin-beta N-terminal domain
Xpo1 (PF08389): Exportin 1-like protein
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
Hydrolase_3 (PF08282): haloacid dehalogenase-like hydrolase
CRM1_C (PF08767): CRM1 C terminal
Xrcc6
oncogene100.50010.586Ku_N (PF03731): Ku70/Ku80 N-terminal alpha/beta domain
Ku (PF02735): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730): Ku70/Ku80 C-terminal arm
SAP (PF02037): SAP domain
Ywhae
oncogene90.5835.68614-3-3 (PF00244): 14-3-3 protein
Zfp36l1
oncogene50.8000.348Tis11B_N (PF04553): Tis11B like protein, N terminus
zf-CCCH (PF00642): Zinc finger C-x8-C-x5-C-x3-H type (and similar)

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