Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Acat1 (from a repository: Fri Apr 13 00:50:35 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)91
The number (and %) of the onco-proteins16 (17.58 %)
The number (and %) of the tumor suppressors7 (7.69 %)
Total number of binary PPIs (saturation %)468 (11.43 %)
The number (and %) of affected PPIs91 (19.44 %)
PPI diameter2
PPI radius1
The average degree of PPI9.670
Assortativity coefficient-0.3083
The network average Clustering coefficient0.494
The number (and %) of a zero Clustering coefficients11 (12.09 %)
The number (and %) of a zero Betweenness Centrality25 (27.47 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Acat1
user protein910.0875497.656Thiolase_N (PF00108): Thiolase, N-terminal domain
Thiolase_C (PF02803): Thiolase, C-terminal domain
Abcb7
interactor21.0000ABC_membrane (PF00664): ABC transporter transmembrane region
ABC_tran (PF00005): ABC transporter
SMC_N (PF02463): RecF/RecN/SMC N terminal domain
AAA_23 (PF13476): AAA domain
Abce1
interactor130.42419.066RLI (PF04068): Possible Fer4-like domain in RNase L inhibitor, RLI
Fer4 (PF00037): 4Fe-4S binding domain
Fer4_7 (PF12838): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
ABC_tran (PF00005): ABC transporter
SMC_N (PF02463): RecF/RecN/SMC N terminal domain
Acaa2
interactor70.5248.233Thiolase_N (PF00108): Thiolase, N-terminal domain
Thiolase_C (PF02803): Thiolase, C-terminal domain
Aco2
interactor60.6003.072Aconitase (PF00330): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694): Aconitase C-terminal domain
Agxt
interactor21.0000Aminotran_5 (PF00266): Aminotransferase class-V
Ahcyl2
interactor160.36239.933SR-25 (PF10500): Nuclear RNA-splicing-associated protein
AdoHcyase (PF05221): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
Akt1
oncogene40.6671.000PH (PF00169): PH domain
Pkinase (PF00069): Protein kinase domain
Pkinase_C (PF00433): Protein kinase C terminal domain
Aldh9a1
interactor100Aldedh (PF00171): Aldehyde dehydrogenase family
Atp1b1
interactor100.53313.086Na_K-ATPase (PF00287): Sodium / potassium ATPase beta chain
Atp1b3
interactor50.5003.186Na_K-ATPase (PF00287): Sodium / potassium ATPase beta chain
Bag3
oncogene100.25017.276WW (PF00397): WW domain
RNA_pol_Rpc4 (PF05132): RNA polymerase III RPC4
DUF4124 (PF13511): Domain of unknown function (DUF4124)
BAG (PF02179): BAG domain
Rib_recp_KP_reg (PF05104): Ribosome receptor lysine/proline rich region
Cops5
interactor220.48135.733JAB (PF01398): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
Crip1
interactor30.6670.500LIM (PF00412): LIM domain
Cse1l
oncogene90.3616.732IBN_N (PF03810): Importin-beta N-terminal domain
Xpo1 (PF08389): Exportin 1-like protein
Cse1 (PF08506): Cse1
CAS_CSE1 (PF03378): CAS/CSE protein, C-terminus
Cul1
oncogene, tumor suppressor220.46237.211Cullin (PF00888): Cullin family
Cullin_Nedd8 (PF10557): Cullin protein neddylation domain
Cul3
interactor270.33890.527Cullin (PF00888): Cullin family
WAC_Acf1_DNA_bd (PF10537): ATP-utilising chromatin assembly and remodelling N-terminal
Cullin_Nedd8 (PF10557): Cullin protein neddylation domain
Cul7
interactor210.32156.347Cul7 (PF11515): Mouse development and cellular proliferation protein Cullin-7
ANAPC10 (PF03256): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888): Cullin family
Cullin_Nedd8 (PF10557): Cullin protein neddylation domain
Ddb1
interactor150.35235.167MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
CPSF_A (PF03178): CPSF A subunit region
Dld
interactor100.48913.653Pyr_redox_2 (PF07992): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
Dus3l
interactor100zf-CCCH (PF00642): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Dus (PF01207): Dihydrouridine synthase (Dus)
Eef1a1
oncogene, tumor suppressor180.50727.637GTP_EFTU (PF00009): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143): Elongation factor Tu C-terminal domain
Eif1b
oncogene100SUI1 (PF01253): Translation initiation factor SUI1
Ercc1
oncogene21.0000Rad10 (PF03834): Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
HHH_5 (PF14520): Helix-hairpin-helix domain
Ercc2
oncogene30.6670.667ResIII (PF04851): Type III restriction enzyme, res subunit
DEAD_2 (PF06733): DEAD_2
SesA (PF17107): N-terminal domain on NACHT_NTPase and P-loop NTPases
HBB (PF06777): Helical and beta-bridge domain
Helicase_C_2 (PF13307): Helicase C-terminal domain
TIR_2 (PF13676): TIR domain
Ewsr1
oncogene260.313125.701Keratin_2_head (PF16208): Keratin type II head
SVS_QK (PF10578): Seminal vesicle protein repeat
FoP_duplication (PF13865): C-terminal duplication domain of Friend of PRMT1
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RanBP (PF00641): Zn-finger in Ran binding protein and others
Fh
oncogene, tumor suppressor90.27819.967Lyase_1 (PF00206): Lyase
DUF4288 (PF14119): Domain of unknown function (DUF4288)
FumaraseC_C (PF10415): Fumarase C C-terminus
Flot1
interactor40.5001.800Band_7 (PF01145): SPFH domain / Band 7 family
Flot (PF15975): Flotillin
CrtC (PF07143): CrtC N-terminal lipocalin domain
Fus
oncogene, tumor suppressor210.47643.144Chorion_3 (PF05387): Chorion family 3
SVS_QK (PF10578): Seminal vesicle protein repeat
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608): Limkain b1
Keratin_2_head (PF16208): Keratin type II head
zf-RanBP (PF00641): Zn-finger in Ran binding protein and others
Gcn1
interactor100.4009.046CLASP_N (PF12348): CLASP N terminal
HEAT_2 (PF13646): HEAT repeats
IL34 (PF15036): Interleukin 34
TFCD_C (PF12612): Tubulin folding cofactor D C terminal
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
UME (PF08064): UME (NUC010) domain
HEAT_EZ (PF13513): HEAT-like repeat
Cnd1 (PF12717): non-SMC mitotic condensation complex subunit 1
HEAT (PF02985): HEAT repeat
MMS19_C (PF12460): RNAPII transcription regulator C-terminal
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
Hadh
interactor21.0000Pyr_redox_2 (PF07992): Pyridine nucleotide-disulphide oxidoreductase
3HCDH_N (PF02737): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
3HCDH (PF00725): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
Hdac5
interactor140.32114.306HDAC4_Gln (PF12203): Glutamine rich N terminal domain of histone deacetylase 4
TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
PTPRCAP (PF15713): Protein tyrosine phosphatase receptor type C-associated
Hist_deacetyl (PF00850): Histone deacetylase domain
Hexa
interactor31.0000Glycohydro_20b2 (PF14845): beta-acetyl hexosaminidase like
Glyco_hydro_20b (PF02838): Glycosyl hydrolase family 20, domain 2
Glyco_hydro_20 (PF00728): Glycosyl hydrolase family 20, catalytic domain
Hmgb3
interactor40.5001.900HMG_box_2 (PF09011): HMG-box domain
HMG_box (PF00505): HMG (high mobility group) box
Ribosomal_60s (PF00428): 60s Acidic ribosomal protein
Ilvbl
interactor90.41712.872TPP_enzyme_N (PF02776): Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
TPP_enzyme_M (PF00205): Thiamine pyrophosphate enzyme, central domain
TPP_enzyme_C (PF02775): Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
Itga4
interactor260.253109.894FG-GAP (PF01839): FG-GAP repeat
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
Integrin_alpha2 (PF08441): Integrin alpha
DUF1945 (PF09178): Domain of unknown function (DUF1945)
Integrin_alpha (PF00357): Integrin alpha cytoplasmic region
LOC103732819
interactor180.30744.193F-box-like (PF12937): F-box-like
FBA (PF04300): F-box associated region
LOC103737005
interactor90.50012.519Ubiq-Cytc-red_N (PF09165): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921): Ubiquinol cytochrome reductase transmembrane region
Rieske (PF00355): Rieske [2Fe-2S] domain
LOC103740800
interactor40.5002.500Cytochrom_C (PF00034): Cytochrome c
LOC103745565
interactor90.44417.682Cpn10 (PF00166): Chaperonin 10 Kd subunit
LOC103747034
interactor80.5008.852UcrQ (PF02939): UcrQ family
Mars
oncogene90.3893.728GST_N_2 (PF13409): Glutathione S-transferase, N-terminal domain
GST_C (PF00043): Glutathione S-transferase, C-terminal domain
tRNA-synt_1g (PF09334): tRNA synthetases class I (M)
Anticodon_1 (PF08264): Anticodon-binding domain of tRNA
WHEP-TRS (PF00458): WHEP-TRS domain
Med20
interactor21.0000Med20 (PF08612): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
Mlst8
interactor100WD40 (PF00400): WD domain, G-beta repeat
Hira (PF07569): TUP1-like enhancer of split
Nup160 (PF11715): Nucleoporin Nup120/160
Ntrk1
oncogene430.165526.003LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Ola1
interactor60.6671.803MMR_HSR1 (PF01926): 50S ribosome-binding GTPase
Roc (PF08477): Ras of Complex, Roc, domain of DAPkinase
YchF-GTPase_C (PF06071): Protein of unknown function (DUF933)
Pabpc1
oncogene170.45020.265RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YflT (PF11181): Heat induced stress protein YflT
PABP (PF00658): Poly-adenylate binding protein, unique domain
Papss1
interactor80.42911.622DUF258 (PF03193): Protein of unknown function, DUF258
APS_kinase (PF01583): Adenylylsulphate kinase
PUA_2 (PF14306): PUA-like domain
ATP-sulfurylase (PF01747): ATP-sulfurylase
Pcbp1
oncogene170.46335.915KH_1 (PF00013): KH domain
KH_2 (PF07650): KH domain
Bac_chlorC (PF02043): Bacteriochlorophyll C binding protein
Pcbp2
interactor170.6089.983KH_1 (PF00013): KH domain
KH_2 (PF07650): KH domain
Bac_chlorC (PF02043): Bacteriochlorophyll C binding protein
MAGE_N (PF12440): Melanoma associated antigen family N terminal
Pdha1
interactor120.53014.333E1_dh (PF00676): Dehydrogenase E1 component
Pdp1
interactor31.0000PP2C (PF00481): Protein phosphatase 2C
Pex7
interactor100WD40 (PF00400): WD domain, G-beta repeat
Pfdn4
interactor100Prefoldin_2 (PF01920): Prefoldin subunit
Pir
interactor40.6672.000Pirin (PF02678): Pirin
Pirin_C (PF05726): Pirin C-terminal cupin domain
Pkm
interactor, oncogene150.47620.181PK (PF00224): Pyruvate kinase, barrel domain
HpcH_HpaI (PF03328): HpcH/HpaI aldolase/citrate lyase family
PK_C (PF02887): Pyruvate kinase, alpha/beta domain
Ppp4r3a
interactor21.0000WH1 (PF00568): WH1 domain
SMK-1 (PF04802): Component of IIS longevity pathway SMK-1
Collagen (PF01391): Collagen triple helix repeat (20 copies)
PBP1_TM (PF14812): Transmembrane domain of transglycosylase PBP1 at N-terminal
Prrc1
interactor100NTPase_I-T (PF01931): Protein of unknown function DUF84
Psat1
interactor50.5002.519Aminotran_5 (PF00266): Aminotransferase class-V
Ptbp1
oncogene160.55212.700RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Rad21
oncogene80.6077.693Rad21_Rec8_N (PF04825): N terminus of Rad21 / Rec8 like protein
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
Rad21_Rec8 (PF04824): Conserved region of Rad21 / Rec8 like protein
Safb
tumor suppressor70.7141.791SAP (PF02037): SAP domain
Spt5_N (PF11942): Spt5 transcription elongation factor, acidic N-terminal
DUF4228 (PF14009): Domain of unknown function (DUF4228)
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Sdha
tumor suppressor160.40040.227FAD_binding_2 (PF00890): FAD binding domain
Succ_DH_flav_C (PF02910): Fumarate reductase flavoprotein C-term
Sdhb
oncogene, tumor suppressor130.43624.991Fer2_3 (PF13085): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
Sfpq
oncogene130.5768.101TFIIA (PF03153): Transcription factor IIA, alpha/beta subunit
CYSTM (PF12734): Cysteine-rich TM module stress tolerance
RRM_1 (PF00076): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
NOPS (PF08075): NOPS (NUC059) domain
zf-C4H2 (PF10146): Zinc finger-containing protein
GRP (PF07172): Glycine rich protein family
Sfxn1
interactor70.5247.733Mtc (PF03820): Tricarboxylate carrier
Sfxn3
interactor40.8330.333Mtc (PF03820): Tricarboxylate carrier
Sigmar1
interactor100ERG2_Sigma1R (PF04622): ERG2 and Sigma1 receptor like protein
Sirt7
interactor160.31739.040DUF563 (PF04577): Protein of unknown function (DUF563)
SIR2 (PF02146): Sir2 family
Spr
interactor21.0000adh_short (PF00106): short chain dehydrogenase
Ssbp1
interactor110.6228.763SSB (PF00436): Single-strand binding protein family
Ssu72
interactor21.0000Ssu72 (PF04722): Ssu72-like protein
Terf1
interactor80.3336.530TRF (PF08558): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249): Myb-like DNA-binding domain
Timm44
interactor21.0000RecG_N (PF17190): RecG N-terminal helical domain
AIM3 (PF17096): Altered inheritance of mitochondria protein 3
Tim44 (PF04280): Tim44-like domain
Tkfc
interactor100Dak1 (PF02733): Dak1 domain
Dak2 (PF02734): DAK2 domain
Tmem65
interactor21.0000TMEM65 (PF10507): Transmembrane protein 65
Tomm7
interactor40.8330.667Tom7 (PF08038): TOM7 family
Topbp1
interactor60.4005.667PTCB-BRCT (PF12738): twin BRCT domain
BRCT (PF00533): BRCA1 C Terminus (BRCT) domain
RTT107_BRCT_5 (PF16770): Regulator of Ty1 transposition protein 107 BRCT domain
BRCT_2 (PF16589): BRCT domain, a BRCA1 C-terminus domain
DUF521 (PF04412): Protein of unknown function (DUF521)
Trappc8
interactor31.0000TRAPPC-Trs85 (PF12739): ER-Golgi trafficking TRAPP I complex 85 kDa subunit
SNAP (PF14938): Soluble NSF attachment protein, SNAP
Ttc39c
interactor100DUF3808 (PF10300): Protein of unknown function (DUF3808)
TPR_2 (PF07719): Tetratricopeptide repeat
Ttf2
interactor100zf-GRF (PF06839): GRF zinc finger
SNF2_N (PF00176): SNF2 family N-terminal domain
Helicase_C (PF00271): Helicase conserved C-terminal domain
Tubb1
interactor140.42325.278Tubulin (PF00091): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953): Tubulin C-terminal domain
ART (PF01129): NAD:arginine ADP-ribosyltransferase
Tubb3
interactor70.4764.680Tubulin (PF00091): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953): Tubulin C-terminal domain
Uba3
interactor41.0000ThiF (PF00899): ThiF family
E2_bind (PF08825): E2 binding domain
Ubap2l
interactor90.5005.106DUF3484 (PF11983): Membrane-attachment and polymerisation-promoting switch
UBA_4 (PF14555): UBA-like domain
CUE (PF02845): CUE domain
API5 (PF05918): Apoptosis inhibitory protein 5 (API5)
MDFI (PF15316): MyoD family inhibitor
DUF3697 (PF12478): Ubiquitin-associated protein 2
Comm (PF15957): Commissureless
Ube2l3
interactor60.5004.333UQ_con (PF00179): Ubiquitin-conjugating enzyme
Ubl4a
interactor110.45511.713ubiquitin (PF00240): Ubiquitin family
Ubxn1
interactor110.42218.591UBA (PF00627): UBA/TS-N domain
eIF3_subunit (PF08597): Translation initiation factor eIF3 subunit
Selenoprotein_S (PF06936): Selenoprotein S (SelS)
UBX (PF00789): UBX domain
Vasp
interactor60.7001.583WH1 (PF00568): WH1 domain
CAP_N (PF01213): Adenylate cyclase associated (CAP) N terminal
ASD2 (PF08687): Apx/Shroom domain ASD2
VASP_tetra (PF08776): VASP tetramerisation domain
Vcam1
interactor180.35338.612I-set (PF07679): Immunoglobulin I-set domain
C2-set (PF05790): Immunoglobulin C2-set domain
ig (PF00047): Immunoglobulin domain
Ig_2 (PF13895): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
V-set (PF07686): Immunoglobulin V-set domain
Ywhae
oncogene170.28756.46014-3-3 (PF00244): 14-3-3 protein

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