Find Protein-Protein Interactions (PPI) Network

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Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Acadm (from a repository: Fri Apr 13 07:54:29 2018)
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Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)48
The number (and %) of the onco-proteins4 (8.33 %)
The number (and %) of the tumor suppressors4 (8.33 %)
Total number of binary PPIs (saturation %)267 (23.67 %)
The number (and %) of affected PPIs47 (17.60 %)
PPI diameter2
PPI radius1
The average degree of PPI10.625
Assortativity coefficient-0.2650
The network average Clustering coefficient0.561
The number (and %) of a zero Clustering coefficients4 (8.33 %)
The number (and %) of a zero Betweenness Centrality7 (14.58 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Acadm
user protein, oncogene470.1921035.708Acyl-CoA_dh_N (PF02771): Acyl-CoA dehydrogenase, N-terminal domain
Acyl-CoA_dh_M (PF02770): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_1 (PF00441): Acyl-CoA dehydrogenase, C-terminal domain
Aass
interactor100AlaDh_PNT_N (PF05222): Alanine dehydrogenase/PNT, N-terminal domain
AlaDh_PNT_C (PF01262): Alanine dehydrogenase/PNT, C-terminal domain
Sacchrp_dh_NADP (PF03435): Saccharopine dehydrogenase NADP binding domain
Sacchrp_dh_C (PF16653): Saccharopine dehydrogenase C-terminal domain
Ahsa1
interactor120.51515.840MdcG (PF10620): Phosphoribosyl-dephospho-CoA transferase MdcG
AHSA1 (PF08327): Activator of Hsp90 ATPase homolog 1-like protein
Arf1
tumor suppressor41.0000Arf (PF00025): ADP-ribosylation factor family
Arf4
interactor50.9000.250Arf (PF00025): ADP-ribosylation factor family
Arf5
interactor60.6003.200Arf (PF00025): ADP-ribosylation factor family
Atp1a1
interactor160.61717.001Cation_ATPase_N (PF00690): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122): E1-E2 ATPase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
Hydrolase_3 (PF08282): haloacid dehalogenase-like hydrolase
Cation_ATPase_C (PF00689): Cation transporting ATPase, C-terminus
Atp5c1
interactor140.64812.716ACT_4 (PF13291): ACT domain
ATP-synt (PF00231): ATP synthase
Atp6v1a
interactor110.7454.971ATP-synt_ab_N (PF02874): ATP synthase alpha/beta family, beta-barrel domain
ATP-synt_ab_Xtn (PF16886): ATPsynthase alpha/beta subunit N-term extension
ATP-synt_ab (PF00006): ATP synthase alpha/beta family, nucleotide-binding domain
Atp9a
interactor100PhoLip_ATPase_N (PF16209): Phospholipid-translocating ATPase N-terminal
E1-E2_ATPase (PF00122): E1-E2 ATPase
Hydrolase (PF00702): haloacid dehalogenase-like hydrolase
Hydrolase_3 (PF08282): haloacid dehalogenase-like hydrolase
PhoLip_ATPase_C (PF16212): Phospholipid-translocating P-type ATPase C-terminal
Calm1
interactor30.6671.000EF-hand_7 (PF13499): EF-hand domain pair
Cand1
interactor110.6895.011HEAT_2 (PF13646): HEAT repeats
Cnd1 (PF12717): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
DUF3385 (PF11865): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
HEAT (PF02985): HEAT repeat
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
MMS19_C (PF12460): RNAPII transcription regulator C-terminal
Adaptin_N (PF01602): Adaptin N terminal region
TIP120 (PF08623): TATA-binding protein interacting (TIP20)
Canx
interactor170.50727.756TRAP_alpha (PF03896): Translocon-associated protein (TRAP), alpha subunit
Calreticulin (PF00262): Calreticulin family
DUF1510 (PF07423): Protein of unknown function (DUF1510)
Cct6b
interactor100.44414.800Cpn60_TCP1 (PF00118): TCP-1/cpn60 chaperonin family
Ctsd
interactor70.6672.538A1_Propeptide (PF07966): A1 Propeptide
Asp (PF00026): Eukaryotic aspartyl protease
Cul3
interactor230.38185.412Cullin (PF00888): Cullin family
WAC_Acf1_DNA_bd (PF10537): ATP-utilising chromatin assembly and remodelling N-terminal
Cullin_Nedd8 (PF10557): Cullin protein neddylation domain
Ddost
interactor150.63816.002DDOST_48kD (PF03345): Oligosaccharyltransferase 48 kDa subunit beta
Ddx39b
interactor80.7142.622DEAD (PF00270): DEAD/DEAH box helicase
Helicase_C (PF00271): Helicase conserved C-terminal domain
Dnaja1
interactor90.6944.252DnaJ (PF00226): DnaJ domain
DnaJ_C (PF01556): DnaJ C terminal domain
Etfa
interactor160.36744.962ETF (PF01012): Electron transfer flavoprotein domain
ETF_alpha (PF00766): Electron transfer flavoprotein FAD-binding domain
Faf2
interactor100.4449.788UBA_4 (PF14555): UBA-like domain
Thioredoxin_7 (PF13899): Thioredoxin-like
DUF1682 (PF07946): Protein of unknown function (DUF1682)
UBX (PF00789): UBX domain
Faxc
interactor200GST_N_4 (PF17172): Glutathione S-transferase N-terminal domain
GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
Gfpt1
interactor70.6672.936GATase_6 (PF13522): Glutamine amidotransferase domain
SIS (PF01380): SIS domain
Gfpt2
interactor50.8000.619GATase_6 (PF13522): Glutamine amidotransferase domain
SIS (PF01380): SIS domain
Hdac1
tumor suppressor60.5004.167Hist_deacetyl (PF00850): Histone deacetylase domain
FSAP_sig_propep (PF03032): Frog skin active peptide family signal and propeptide
Hibch
interactor100ECH_2 (PF16113): Enoyl-CoA hydratase/isomerase
Hsp90b1
heat shock, oncogene, tumor suppressor130.57714.031Sigma70_ner (PF04546): Sigma-70, non-essential region
HATPase_c (PF02518): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183): Hsp90 protein
CobT (PF06213): Cobalamin biosynthesis protein CobT
Idh3a
interactor100.5339.460Iso_dh (PF00180): Isocitrate/isopropylmalate dehydrogenase
LOC103742750
interactor190.46245.241Peptidase_M16 (PF00675): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193): Peptidase M16 inactive domain
Ldha
interactor160.41033.321Ldh_1_N (PF00056): lactate/malate dehydrogenase, NAD binding domain
Ldh_1_C (PF02866): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldhb
interactor150.48426.405Ldh_1_N (PF00056): lactate/malate dehydrogenase, NAD binding domain
Ldh_1_C (PF02866): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Nfs1
interactor40.6670.786Aminotran_5 (PF00266): Aminotransferase class-V
Ntrk1
oncogene290.362140.763LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Ppp2r1a
oncogene140.45133.918HEAT_2 (PF13646): HEAT repeats
HEAT_PBS (PF03130): PBS lyase HEAT-like repeat
HEAT (PF02985): HEAT repeat
TAF6_C (PF07571): TAF6 C-terminal HEAT repeat domain
Ppp2r1b
tumor suppressor60.8001.333HEAT_2 (PF13646): HEAT repeats
Cnd1 (PF12717): non-SMC mitotic condensation complex subunit 1
HEAT (PF02985): HEAT repeat
Vac14_Fab1_bd (PF12755): Vacuolar 14 Fab1-binding region
Prkcsh
interactor70.7141.955PRKCSH-like (PF12999): Glucosidase II beta subunit-like
EF-hand_5 (PF13202): EF hand
Pox_Ag35 (PF03286): Pox virus Ag35 surface protein
DUF3391 (PF11871): Domain of unknown function (DUF3391)
PRKCSH_1 (PF13015): Glucosidase II beta subunit-like protein
Psmc2
interactor130.50017.490AAA (PF00004): ATPase family associated with various cellular activities (AAA)
Rab2a
oncogene90.5566.542Ras (PF00071): Ras family
Rpn1
oncogene210.49547.836Ribophorin_I (PF04597): Ribophorin I
DNA_repr_REX1B (PF14966): DNA repair REX1-B
Sec63
interactor31.0000DnaJ (PF00226): DnaJ domain
Sec63 (PF02889): Sec63 Brl domain
DNA_pol_phi (PF04931): DNA polymerase phi
Slc25a3
interactor130.66710.828Mito_carr (PF00153): Mitochondrial carrier protein
Strap
interactor40.6670.667WD40 (PF00400): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894): Anaphase-promoting complex subunit 4 WD40 domain
Sucla2
interactor80.4298.752ATP-grasp_2 (PF08442): ATP-grasp domain
Ligase_CoA (PF00549): CoA-ligase
nsp7 (PF08716): nsp7 replicase
Suclg2
interactor110.49112.758ATP-grasp_2 (PF08442): ATP-grasp domain
Ligase_CoA (PF00549): CoA-ligase
Tecr
interactor140.7148.215ubiquitin (PF00240): Ubiquitin family
Steroid_dh (PF02544): 3-oxo-5-alpha-steroid 4-dehydrogenase
Usp20
interactor31.0000zf-UBP (PF02148): Zn-finger in ubiquitin-hydrolases and other protein
UCH (PF00443): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337): DUSP domain
C1_2 (PF03107): C1 domain
Vdac1
interactor110.8552.522Porin_3 (PF01459): Eukaryotic porin
Vdac2
interactor120.71211.625Porin_3 (PF01459): Eukaryotic porin

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