Find Protein-Protein Interactions (PPI) Network

Choose & Enter
Choose animal: Visualization driver:
Protein/NCBI_ID(s):
Refseq_ID(s):
KEGG_KO(s):


Level of PPIs:
or Upload text file:
Update repository

Visible interactions: Visible interactors: Size of node:

Visualization interactions

Powered by Cytoscape Web taxid = 1026970 for: protein(s) Acad9 (from a repository: Fri Apr 13 15:06:31 2018)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistics of PPI Value(s)
The number of interactors (fusion and proteins)60
The number (and %) of the onco-proteins4 (6.67 %)
The number (and %) of the tumor suppressors2 (3.33 %)
Total number of binary PPIs (saturation %)229 (12.94 %)
The number (and %) of affected PPIs59 (25.76 %)
PPI diameter2
PPI radius1
The average degree of PPI7.200
Assortativity coefficient-0.4808
The network average Clustering coefficient0.600
The number (and %) of a zero Clustering coefficients11 (18.33 %)
The number (and %) of a zero Betweenness Centrality29 (48.33 %)

ACTIVE INTERACTORS


List of active interactors

Interactor,
Domain structure
Type Number
of PPI (degree)
Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam ID): description
Acad9
user protein590.0922628.550Acyl-CoA_dh_N (PF02771): Acyl-CoA dehydrogenase, N-terminal domain
Acyl-CoA_dh_M (PF02770): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_1 (PF00441): Acyl-CoA dehydrogenase, C-terminal domain
A2ml1
interactor100A2M_N (PF01835): MG2 domain
A2M_N_2 (PF07703): Alpha-2-macroglobulin family N-terminal region
A2M (PF00207): Alpha-2-macroglobulin family
SVA (PF05326): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569): Alpha-macro-globulin thiol-ester bond-forming region
A2M_comp (PF07678): A-macroglobulin complement component
A2M_recep (PF07677): A-macroglobulin receptor
Abcf2
interactor30.6670.667VIT1 (PF01988): VIT family
ABC_tran (PF00005): ABC transporter
Rop (PF01815): Rop protein
AAA_24 (PF13479): AAA domain
ABC_tran_Xtn (PF12848): ABC transporter
AAA_21 (PF13304): AAA domain, putative AbiEii toxin, Type IV TA system
Agmat
interactor100Arginase (PF00491): Arginase family
Asph
interactor31.0000Asp-B-Hydro_N (PF05279): Aspartyl beta-hydroxylase N-terminal region
LUC7 (PF03194): LUC7 N_terminus
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_2 (PF07719): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
TPR_8 (PF13181): Tetratricopeptide repeat
TPR_11 (PF13414): TPR repeat
Asp_Arg_Hydrox (PF05118): Aspartyl/Asparaginyl beta-hydroxylase
C3ar1
oncogene41.00007tm_1 (PF00001): 7 transmembrane receptor (rhodopsin family)
7TM_GPCR_Srw (PF10324): Serpentine type 7TM GPCR chemoreceptor Srw
DUF4199 (PF13858): Protein of unknown function (DUF4199)
Cdc42
oncogene200Ras (PF00071): Ras family
Dlat
interactor60.6005.167Biotin_lipoyl (PF00364): Biotin-requiring enzyme
Stm1_N (PF09598): Stm1
E3_binding (PF02817): e3 binding domain
2-oxoacid_dh (PF00198): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Ecsit
interactor220.42983.498ECSIT (PF06239): Evolutionarily conserved signalling intermediate in Toll pathway
ECSIT_C (PF14784): C-terminal domain of the ECSIT protein
Eral1
interactor30.6670.250MMR_HSR1 (PF01926): 50S ribosome-binding GTPase
GTP_EFTU (PF00009): Elongation factor Tu GTP binding domain
KH_2 (PF07650): KH domain
Evpl
interactor21.0000TMPIT (PF07851): TMPIT-like protein
Spectrin (PF00435): Spectrin repeat
OmpH (PF03938): Outer membrane protein (OmpH-like)
SH3_9 (PF14604): Variant SH3 domain
DASH_Hsk3 (PF08227): DASH complex subunit Hsk3 like
Fez1 (PF06818): Fez1
DUF1192 (PF06698): Protein of unknown function (DUF1192)
DUF4211 (PF13926): Domain of unknown function (DUF4211)
Jnk-SapK_ap_N (PF09744): JNK_SAPK-associated protein-1
TolA_bind_tri (PF16331): TolA binding protein trimerisation
DUF724 (PF05266): Protein of unknown function (DUF724)
Spc24 (PF08286): Spc24 subunit of Ndc80
Pox_A_type_inc (PF04508): Viral A-type inclusion protein repeat
DUF972 (PF06156): Protein of unknown function (DUF972)
CENP-H (PF05837): Centromere protein H (CENP-H)
Lge1 (PF11488): Transcriptional regulatory protein LGE1
Plectin (PF00681): Plectin repeat
Eya2
interactor41.0000Hydrolase (PF00702): haloacid dehalogenase-like hydrolase
Faf2
interactor70.6673.833UBA_4 (PF14555): UBA-like domain
Thioredoxin_7 (PF13899): Thioredoxin-like
DUF1682 (PF07946): Protein of unknown function (DUF1682)
UBX (PF00789): UBX domain
Gls
interactor30.6670.500Glutaminase (PF04960): Glutaminase
Ank_2 (PF12796): Ankyrin repeats (3 copies)
Ippk
interactor31.0000Ins_P5_2-kin (PF06090): Inositol-pentakisphosphate 2-kinase
Ivl
interactor200Involucrin_N (PF10583): Involucrin of squamous epithelia N-terminus
Involucrin2 (PF06994): Involucrin
Exonuc_VII_L (PF02601): Exonuclease VII, large subunit
LOC103739521
interactor21.0000E3_binding (PF02817): e3 binding domain
2-oxoacid_dh (PF00198): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
PDZ (PF00595): PDZ domain (Also known as DHR or GLGF)
LOC103742997
interactor80.8570.727NDUF_C2 (PF06374): NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)
Marveld2
interactor31.0000MARVEL (PF01284): Membrane-associating domain
MAP17 (PF15807): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
Occludin_ELL (PF07303): Occludin homology domain
Mrpl58
interactor120.34829.709RF-1 (PF00472): RF-1 domain
Mtrf1l
interactor100PCRF (PF03462): PCRF domain
RF-1 (PF00472): RF-1 domain
ND6
interactor41.0000Oxidored_q3 (PF00499): NADH-ubiquinone/plastoquinone oxidoreductase chain 6
Ndufa13
interactor140.7695.956GRIM-19 (PF06212): GRIM-19 protein
Ndufa2
interactor80.6433.418L51_S25_CI-B8 (PF05047): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
Ndufa4
interactor160.53336.184B12D (PF06522): NADH-ubiquinone reductase complex 1 MLRQ subunit
Ndufa8
interactor130.62814.248Pet191_N (PF10203): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731): Pathogenicity locus
CHCH (PF06747): CHCH domain
Ndufaf1
interactor180.46452.641CIA30 (PF08547): Complex I intermediate-associated protein 30 (CIA30)
Ndufaf3
interactor160.63321.131DUF498 (PF04430): Protein of unknown function (DUF498/DUF598)
Ndufaf4
interactor130.8186.821UPF0240 (PF06784): Uncharacterised protein family (UPF0240)
Ndufb11
interactor120.7275.133ESSS (PF10183): ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)
Ndufb5
interactor150.65713.536NDUF_B5 (PF09781): NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit
Ndufs2
interactor170.52935.731NiFeSe_Hases (PF00374): Nickel-dependent hydrogenase
Complex1_49kDa (PF00346): Respiratory-chain NADH dehydrogenase, 49 Kd subunit
Ndufs3
interactor200.57934.607Complex1_30kDa (PF00329): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
Ndufs5
interactor150.72410.932Ndufs5 (PF10200): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
Ndufs7
interactor190.58245.254Oxidored_q6 (PF01058): NADH ubiquinone oxidoreductase, 20 Kd subunit
Nfatc1
oncogene21.0000RNA_pol_Rpb1_R (PF05001): RNA polymerase Rpb1 C-terminal repeat
RHD_DNA_bind (PF00554): Rel homology DNA-binding domain
RHD_dimer (PF16179): Rel homology dimerisation domain
Nfs1
interactor21.0000Aminotran_5 (PF00266): Aminotransferase class-V
Ntrk1
oncogene110.28928.333LRR_8 (PF13855): Leucine rich repeat
TPKR_C2 (PF16920): Tyrosine-protein kinase receptor C2 Ig-like domain
Ig_3 (PF13927): Immunoglobulin domain
I-set (PF07679): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714): Protein tyrosine kinase
Ocln
interactor21.0000MARVEL (PF01284): Membrane-associating domain
EphA2_TM (PF14575): Ephrin type-A receptor 2 transmembrane domain
Occludin_ELL (PF07303): Occludin homology domain
Otud7b
interactor100UBA_4 (PF14555): UBA-like domain
SinI (PF08671): Anti-repressor SinI
OTU (PF02338): OTU-like cysteine protease
CCDC106 (PF15794): Coiled-coil domain-containing protein 106
zf-A20 (PF01754): A20-like zinc finger
P2ry12
interactor21.00007tm_1 (PF00001): 7 transmembrane receptor (rhodopsin family)
Pdk1
interactor70.6004.667BCDHK_Adom3 (PF10436): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
HATPase_c (PF02518): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Pdk2
interactor41.0000BCDHK_Adom3 (PF10436): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
HATPase_c (PF02518): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Pdk3
interactor60.6004.119BCDHK_Adom3 (PF10436): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
HATPase_c (PF02518): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Pdss1
interactor21.0000polyprenyl_synt (PF00348): Polyprenyl synthetase
Pnpt1
interactor30.6670.333RNase_PH (PF01138): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725): 3' exoribonuclease family, domain 2
PNPase (PF03726): Polyribonucleotide nucleotidyltransferase, RNA binding domain
KH_1 (PF00013): KH domain
S1 (PF00575): S1 RNA binding domain
Pof1b
interactor100HIP1_clath_bdg (PF16515): Clathrin-binding domain of Huntingtin-interacting protein 1
ATG16 (PF08614): Autophagy protein 16 (ATG16)
ADIP (PF11559): Afadin- and alpha -actinin-Binding
Ppl
interactor21.0000FliT (PF05400): Flagellar protein FliT
ZapB (PF06005): Cell division protein ZapB
Spectrin (PF00435): Spectrin repeat
CENP-Q (PF13094): CENP-Q, a CENPA-CAD centromere complex subunit
Mnd1 (PF03962): Mnd1 family
TMF_TATA_bd (PF12325): TATA element modulatory factor 1 TATA binding
Snapin_Pallidin (PF14712): Snapin/Pallidin
ATG16 (PF08614): Autophagy protein 16 (ATG16)
TMF_DNA_bd (PF12329): TATA element modulatory factor 1 DNA binding
MS_channel (PF00924): Mechanosensitive ion channel
DUF4200 (PF13863): Domain of unknown function (DUF4200)
DUF1664 (PF07889): Protein of unknown function (DUF1664)
Plectin (PF00681): Plectin repeat
Rpl26l1
interactor100Ribosomal_L26 (PF16906): Ribosomal proteins L26 eukaryotic, L24P archaeal
Sdha
tumor suppressor80.50011.250FAD_binding_2 (PF00890): FAD binding domain
Succ_DH_flav_C (PF02910): Fumarate reductase flavoprotein C-term
Serpinb13
interactor100Serpin (PF00079): Serpin (serine protease inhibitor)
Serpinb5
oncogene, tumor suppressor100Serpin (PF00079): Serpin (serine protease inhibitor)
Serpinb6
interactor31.0000Serpin (PF00079): Serpin (serine protease inhibitor)
Ssr1
interactor21.0000TRAP_alpha (PF03896): Translocon-associated protein (TRAP), alpha subunit
Iso_dh (PF00180): Isocitrate/isopropylmalate dehydrogenase
Timm50
interactor40.5002.400NIF (PF03031): NLI interacting factor-like phosphatase
Timmdc1
interactor150.7528.287Tim17 (PF02466): Tim17/Tim22/Tim23/Pmp24 family
TraT (PF05818): Enterobacterial TraT complement resistance protein
Trmt61b
interactor60.3339.000GCD14 (PF08704): tRNA methyltransferase complex GCD14 subunit
Methyltransf_25 (PF13649): Methyltransferase domain
Tubb1
interactor200Tubulin (PF00091): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953): Tubulin C-terminal domain
ART (PF01129): NAD:arginine ADP-ribosyltransferase
Vamp2
interactor21.0000PRIMA1 (PF16101): Proline-rich membrane anchor 1
Synaptobrevin (PF00957): Synaptobrevin
Vdac1
interactor40.5001.119Porin_3 (PF01459): Eukaryotic porin

B a c k    t o    T o p ⇑